Interactions with Entry & Integrase Inhibitors

www.hiv-druginteractions.org

Interactions with Entry & Integrase Inhibitors Charts revised July 2018. Full information available at www.hiv-druginteractions.org Page 1 of 4 Please note that if a drug is not listed it cannot automatically be assumed it is safe to coadminister.

BIC/ E/C/F/ E/C/F/ BIC/ E/C/F/ E/C/F/ F/TAF DTG TAF TDF MVC RAL F/TAF DTG TAF TDF MVC RAL Anaesthetics & Muscle Relaxants Antibacterials (continued) Alcuronium       Ertapenem       Bupivacaine       Erythromycin       Cisatracurium       Ethambutol       Desflurane       Ethionamide       Dexmedetomidine       Flucloxacillin       Enflurane       Gentamicin       Ephedrine       Imipenem/Cilastatin       Halothane       Isoniazid       Isoflurane       Kanamycin       Levofloxacin Ketamine             Linezolid       Nitrous oxide       Meropenem      

Propofol       Metronidazole       Rocuronium       Moxifloxacin       Sevoflurane       Nitrofurantoin       Sufentanil       Ofloxacin       Suxamethonium (succinylcholine)       Para-aminosalicylic acid       Tetracaine       Penicillins       Thiopental       Pyrazinamide       Tizanidine       Rifabutin       Vecuronium       Rifampicin       Analgesics Rifapentine       Alfentanil       Rifaximin       Aspirin       Spectinomycin       Buprenorphine       Streptomycin       Celecoxib       Sulfadiazine       Telithromycin Codeine             Tetracyclines       Dextropropoxyphene       Trimethoprim/Sulfamethoxazole       Diamorphine (diacetylmorphine)       Vancomycin       Diclofenac       Dihydrocodeine       Anti-coagulant, Anti-platelet and Fibrinolytic Fentanyl       Acenocoumarol       Hydrocodone       Apixaban       Aspirin (anti-platelet)       Hydromorphone       Clopidogrel       Ibuprofen       Dabigatran       Mefenamic acid       Dalteparin       Methadone       Dipyridamole       Morphine       Edoxaban       Naproxen       Eltrombopag       istribution. For personal use only. Not for distribution. for Not only. use For personal istribution. Nimesulide       Enoxaparin       Oxycodone       Fondaparinux       Paracetamol (Acetaminophen)       Heparin       Pethidine (Meperidine)       Phenprocoumon       Piroxicam       Prasugrel       Tramadol       Rivaroxaban       Anthelmintics Streptokinase       Albendazole       Ticagrelor       Diethylcarbamazine       Warfarin       Ivermectin       Anticonvulsants Levamisole (Ergamisol)       Carbamazepine       Mebendazole       Clonazepam       Niclosamide       Ethosuximide       Oxamniquine       Gabapentin       Lacosamide      

Praziquantel       for d Not only. use For personal Lamotrigine       Pyrantel       Suramin sodium       Levetiracetam       Oxcarbazepine       Triclabendazole       Phenobarbital (Phenobarbitone)       Antiarrhythmics Phenytoin       Amiodarone       Pregabalin       Bepridil       Topiramate       Disopyramide       Valproate (Divalproex)       Dofetilide       Vigabatrin       Flecainide       Zonisamide       Lidocaine (Lignocaine)       Antidepressants Mexiletine       Agomelatine       Propafenone       Amitriptyline       Quinidine       Bupropion       Antibacterials Citalopram       Amikacin       Clomipramine       Amoxicillin       Desipramine       Ampicillin       Doxepin       Azithromycin       Duloxetine       Bedaquiline       Escitalopram       Capreomycin       Fluoxetine       Fluvoxamine      

Cefalexin       for distribution. Not only. use For personal Imipramine Cefazolin             Lithium       Cefixime       Maprotiline       Cefotaxime       Mianserin       Ceftazidime       Milnacipran       Ceftriaxone       Mirtazapine       Chloramphenicol       Nefazodone       Ciprofloxacin       Nortriptyline       Clarithromycin       Paroxetine       Clavulanic acid       Phenelzine       Clindamycin       Reboxetine       Clofazimine       Sertraline       Cloxacillin       Tranylcypromine       Cycloserine       Trazodone       Dapsone       Trimipramine       Doxycycline       Venlafaxine      

Key to abbreviations Key to symbols Where advice differs between countries, and/or between boosted and Bictegravir + Emtricitabine +  These drugs should not be coadministered BIC/F/TAF Tenofovir alafenamide (Biktarvy®) unboosted regimens, the charts reflect the more cautious option. ® Potential interaction – may require close monitoring, DTG Dolutegravir (Tivicay )  alteration of drug dosage or timing of administration © Liverpool Drug Interactions Group, University of Liverpool Elvitegravir + Cobicistat + Emtricitabine + Potential interaction likely to be of weak intensity. Pharmacology Research Labs, 1st Floor Block H, 70 Pembroke Place, LIVERPOOL, L69 3GF E/C/F/TAF Tenofovir alafenamide (Genvoya®) Additional action/monitoring or dosage adjustment is We aim to ensure that information is accurate and consistent with current knowledge Elvitegravir + Cobicistat + Emtricitabine + unlikely to be required E/C/F/TDF ® and practice. However, the University of Liverpool and its servants or agents shall not Tenofovir disoproxil fumarate (Strilbild )  No clinically significant interaction expected be responsible or in any way liable for the continued currency of information in this ® ® publication whether arising from negligence or otherwise howsoever or for any MVC Maraviroc (Celsentri , Selzentry ) There are no clear data, actual or theoretical, to indicate ®  consequences arising therefrom. The University of Liverpool expressly exclude RAL Raltegravir (Isentress ) whether an interaction will occur liability for errors, omissions or inaccuracies to the fullest extent permitted by law.

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Interactions with Entry & Integrase Inhibitors Charts revised July 2018. Full information available at www.hiv-druginteractions.org Page 2 of 4 Please note that if a drug is not listed it cannot automatically be assumed it is safe to coadminister.

BIC/ E/C/F/ E/C/F/ BIC/ E/C/F/ E/C/F/ F/TAF DTG TAF TDF MVC RAL F/TAF DTG TAF TDF MVC RAL Anti-diabetics Antipsychotics/Neuroleptics (continued) Acarbose       Paliperidone       Empagliflozin       Perazine       Exanatide       Periciazine       Glibenclamide (Glyburide)       Perphenazine       Gliclazide       Pimozide       Glimepiride       Pipotiazine       Glipizide       Quetiapine       Risperidone Insulin             Sulpiride       Linagliptin       Thioridazine       Liraglutide       Tiapride       Metformin       Ziprasidone       Nateglinide       Zotepine       Pioglitazone       Zuclopenthixol       Repaglinide       Antivirals Rosiglitazone       Aciclovir       Saxagliptin       Adefovir       Sitagliptin       Amantadine       Tolbutamide       Boceprevir       Vildagliptin       Cidofovir       Antifungals Daclatasvir       Amphotericin B       Elbasvir/Grazoprevir       Anidulafungin       Entecavir       Caspofungin       Famciclovir       Fluconazole       Foscarnet       Flucytosine       Ganciclovir       Griseofulvin       Glecaprevir/Pibrentasvir       Itraconazole       Ledipasvir/Sofosbuvir       Ketoconazole       Ombitasvir/Paritaprevir/r       Miconazole       Ombitasvir/Paritaprevir/r + Dasabuvir       Nystatin       Oseltamivir       Posaconazole       Ribavirin             Terbinafine       Rimantadine Simeprevir       Voriconazole       Sofosbuvir       Antihistamines Sofosbuvir/Velpatasvir       Astemizole       Sofosbuvir/Velpatasvir/Voxilaprevir       istribution. For personal use only. Not for distribution. for Not only. use For personal istribution. Cetirizine       Telaprevir       Chlorphenamine       Telbivudine       Diphenhydramine       Valaciclovir       Fexofenadine       Zanamivir       Levocetirizine       Anxiolytics/Hypnotics/ Sedatives Loratadine       Alprazolam       Promethazine       Bromazepam       Terfenadine       Buspirone       Antimigraine Agents Chlordiazepoxide       Clorazepate       Almotriptan       Diazepam       Dihydroergotamine       Estazolam       Ergotamine       Flunitrazepam       Rizatriptan       Flurazepam       Sumatriptan       for d Not only. use For personal Hydroxyzine      

Antiprotozoals Lorazepam       Lormetazepam Amodiaquine             Midazolam (oral)       Artemisinin       Midazolam (parenteral)       Atovaquone       Oxazepam       Benznidazole       Temazepam       Chloroquine       Triazolam       Diloxanide       Zaleplon       Eflornithine       Zolpidem       Halofantrine       Zopiclone       Lumefantrine       Beta Blockers Mefloquine       Atenolol       Meglumine antimoniate       Bisoprolol       Melarsoprol       Carvedilol       Miltefosine       Metoprolol       Nifurtimox       Nebivolol       Paromomycin       Oxprenolol       Pentamidine       Pindolol       Primaquine       Propranolol       Proguanil       Timolol       For personal use only. Not for distribution. for distribution. Not only. use For personal Pyrimethamine       Bronchodilators Quinine       Aclidinium bromide       Sodium stibogluconate       Aminophylline       Sulfadoxine       Formoterol       Antipsychotics/Neuroleptics Glycopyrronium bromide       Indacaterol       Amisulpride       Ipratropium bromide       Aripiprazole       Montelukast       Asenapine       Olodaterol       Chlorpromazine       Roflumilast       Clozapine       Salbutamol       Fluphenazine       Salmeterol       Haloperidol       Theophylline       Iloperidone       Tiotropium bromide       Levomepromazine       Umeclidinium bromide       Olanzapine       Vilanterol      

Key to abbreviations Key to symbols Where advice differs between countries, and/or between boosted and Bictegravir + Emtricitabine +  These drugs should not be coadministered BIC/F/TAF Tenofovir alafenamide (Biktarvy®) unboosted regimens, the charts reflect the more cautious option. ® Potential interaction – may require close monitoring, DTG Dolutegravir (Tivicay )  alteration of drug dosage or timing of administration © Liverpool Drug Interactions Group, University of Liverpool Elvitegravir + Cobicistat + Emtricitabine + Potential interaction likely to be of weak intensity. Pharmacology Research Labs, 1st Floor Block H, 70 Pembroke Place, LIVERPOOL, L69 3GF E/C/F/TAF Tenofovir alafenamide (Genvoya®) Additional action/monitoring or dosage adjustment is We aim to ensure that information is accurate and consistent with current knowledge Elvitegravir + Cobicistat + Emtricitabine + unlikely to be required E/C/F/TDF ® and practice. However, the University of Liverpool and its servants or agents shall not Tenofovir disoproxil fumarate (Strilbild )  No clinically significant interaction expected be responsible or in any way liable for the continued currency of information in this ® ® publication whether arising from negligence or otherwise howsoever or for any MVC Maraviroc (Celsentri , Selzentry ) There are no clear data, actual or theoretical, to indicate ®  consequences arising therefrom. The University of Liverpool expressly exclude RAL Raltegravir (Isentress ) whether an interaction will occur liability for errors, omissions or inaccuracies to the fullest extent permitted by law.

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Interactions with Entry & Integrase Inhibitors Charts revised July 2018. Full information available at www.hiv-druginteractions.org Page 3 of 4 Please note that if a drug is not listed it cannot automatically be assumed it is safe to coadminister.

BIC/ E/C/F/ E/C/F/ BIC/ E/C/F/ E/C/F/ F/TAF DTG TAF TDF MVC RAL F/TAF DTG TAF TDF MVC RAL Calcium Channel Blockers Erectile Dysfunctional Agents Amlodipine       Sildenafil (Erectile Dysfunction)       Diltiazem       Tadalafil (Erectile Dysfunction)       Felodipine       Vardenafil       Nicardipine       Nifedipine       Gastrointestinal Agents Nisoldipine       Alosetron       Nitrendipine       Antacids       Verapamil       Bisacodyl       Cancer Therapies Cimetidine       Anastrozole       Cisapride       Asparaginase       Esomeprazole       Bexarotene       Bleomycin       Famotidine       Bortezomib       Lactulose       Capecitabine       Lansoprazole       Carboplatin       Loperamide       Chlorambucil       Mesalazine       Cisplatin       Cyclophosphamide       Omeprazole       Cytarabine       Pantoprazole       Dacarbazine       Prucalopride       Dactinomycin       Rabeprazole       Dasatinib       Ranitidine       Daunorubicin       Senna       Docetaxel       Doxorubicin       Gastrointestinal Agents (anti-emetics) Droloxifene       Aprepitant       Epirubicin       Dolasetron       Erlotinib       Domperidone       Estramustine       Dronabinol       Etoposide       Everolimus       Granisetron       Exemestane       Metoclopramide       Fludarabine       Ondansetron       Fluorouracil       Prochlorperazine       Formestane       Herbals/Supplements/Vitamins Gefitinib       Gemcitabine       African potato       Ifosfamide       distribution. for Not only. use For personal istribution. Aloe vera       Imatinib       Ascorbic Acid (vitamin C)       Irinotecan       Calcium supplements       Lapatinib       Cat’s claw (Uncaria tomentosa)       Letrozole       Colecalciferol (vitamin D3)       Mercaptopurine       Mesna       Cubeb pepper (Piper cubeba)       Methotrexate       Cyanocobalamin       Mitoxantrone       Echinacea       Nilotinib       Eucalyptus globulus       Oxaliplatin       Folic acid       Paclitaxel       Garlic       Pazopanib       Procarbazine       Ginger (Zinigiber officinale)       Rituximab       Ginkgo biloba       Sorafenib       for d Not only. use For personal

Goldenseal root (Hydrastis canadensis)       Sunitinib       Grapefruit juice       Tamoxifen       Hops (Humulus lupulus)       Temsirolimus       Topotecan       Inula racemosa       Toremifene       Iodine       Vinblastine       Iron supplements       Vincristine       Liquorice (Glycyrrhiza glabra)       Vorinostat       Magnesium supplements       Contraceptives/HRT Malabar nut tree       Desogestrel (COC)       Menthol       Desogestrel (POP)       Milk thistle (silymarin) Drospirenone (COC)             Drospirenone (HRT)       Multivitamins       Dydrogesterone (HRT)       Nicotinamide       Estradiol       Phytomenadione (vitamin K)       Ethinylestradiol       Pyridoxine (vitamin B6)       Etonogestrel (implant)       Quercetin       Etonogestrel (vaginal ring)       Gestodene (COC)       Retinol (vitamin A)       Levonorgestrel (COC)       Riboflavin (vitamin B2)       Levonorgestrel (emergency contraception)       for distribution. Not only. use For personal Saw palmetto (Serenoa repens)       Levonorgestrel (HRT)       Seville orange juice       Levonorgestrel (implant)       St John's Wort       Levonorgestrel (IUD)       Thiamine (vitamin B1)       Levonorgestrel (POP)       Medroxyprogesterone (depot injection)       Turmeric (Curcuma longa)       Medroxyprogesterone (oral)       Valerian       Norelgestromin (patch)       Vitamin E       Norethisterone [Norethindrone] (COC)       Norethisterone [Norethindrone] (HRT)       Norethisterone [Norethindrone] (IM depot)       Norethisterone [Norethindrone] (POP)       Norgestimate (COC)       Norgestrel (COC)       Norgestrel (HRT)       Ulipristal      

Key to abbreviations Key to symbols Where advice differs between countries, and/or between boosted and Bictegravir + Emtricitabine +  These drugs should not be coadministered BIC/F/TAF Tenofovir alafenamide (Biktarvy®) unboosted regimens, the charts reflect the more cautious option. ® Potential interaction – may require close monitoring, DTG Dolutegravir (Tivicay )  alteration of drug dosage or timing of administration © Liverpool Drug Interactions Group, University of Liverpool Elvitegravir + Cobicistat + Emtricitabine + Potential interaction likely to be of weak intensity. Pharmacology Research Labs, 1st Floor Block H, 70 Pembroke Place, LIVERPOOL, L69 3GF E/C/F/TAF Tenofovir alafenamide (Genvoya®) Additional action/monitoring or dosage adjustment is We aim to ensure that information is accurate and consistent with current knowledge Elvitegravir + Cobicistat + Emtricitabine + unlikely to be required E/C/F/TDF ® and practice. However, the University of Liverpool and its servants or agents shall not Tenofovir disoproxil fumarate (Strilbild )  No clinically significant interaction expected be responsible or in any way liable for the continued currency of information in this ® ® publication whether arising from negligence or otherwise howsoever or for any MVC Maraviroc (Celsentri , Selzentry ) There are no clear data, actual or theoretical, to indicate ®  consequences arising therefrom. The University of Liverpool expressly exclude RAL Raltegravir (Isentress ) whether an interaction will occur liability for errors, omissions or inaccuracies to the fullest extent permitted by law.

www.hiv-druginteractions.org

Interactions with Entry & Integrase Inhibitors Charts revised July 2018. Full information available at www.hiv-druginteractions.org Page 4 of 4 Please note that if a drug is not listed it cannot automatically be assumed it is safe to coadminister.

BIC/ E/C/F/ E/C/F/ BIC/ E/C/F/ E/C/F/ F/TAF DTG TAF TDF MVC RAL F/TAF DTG TAF TDF MVC RAL Hypertension / Heart Failure Agents Other Aliskiren       Acetazolamide       Ambrisentan       Acitretin       Amiloride       Adrenaline (Epinephrine)       Bendroflumethiazide       Alendronic Acid       Bosentan       Alfuzosin       Candesartan       Allopurinol       Captopril       Atropine       Chlortalidone       Baclofen       Cilazapril       Clonidine       Biperiden       Digoxin       Caffeine citrate       Dopamine       Carbimazole      

Doxazosin       Clomifene       Enalapril       Colchicine       Eplerenone       Cyproterone acetate       Epoprostenol       Denosumab       Eprosartan       Disulfiram       Furosemide       Dutasteride       Hydralazine       Finasteride       Hydrochlorothiazide       Flibanserin       Iloprost       Goserelin       Indapamide       Ibandronic acid       Irbesartan       Isotretinoin       Isosorbide dinitrate       Leuprorelin       Ivabradine       Levothyroxine       Labetalol       Mannitol Lacidipine             Lercanidipine       Methylphenidate       Lisinopril       Modafinil       Losartan       Naftidrofuryl       Macitentan       Naltrexone       Methyldopa       Neostigmine       Metolazone       Nicorandil       Olmesartan       Orlistat       Perindopril       Penicillamine       Prazosin       Pentoxifylline       Quinapril       Pilocarpine       Ramipril       Potassium       Ranolazine       Probenecid       Riociguat       Propylthiouracil       istribution. For personal use only. Not for distribution. for Not only. use For personal istribution. Sacubitril       Protamine sulphate       Selexipag       Pyridostigmine       Sildenafil (PAH)       Strontium ranelate       Sodium nitroprusside       Spironolactone       Sulfasalazine       Tadalafil (PAH)       Tamsulosin       Telmisartan       Thalidomide       Terazosin       Tranexamic acid       Torasemide       Varenicline       Trandolapril       Zoledronic acid       Treprostinil       Overactive Bladder Agents Valsartan       Darifenacin       Xipamide       Fesoterodine       Illicit/Recreational Mirabegron       Alcohol       Oxybutnin       Amphetamine       for d Not only. use For personal Solifenacin       Cannabis       Tolterodine       Cocaine       Trospium       Ecstasy (MDMA)       GHB (Gamma-hydroxybutyrate_       Oxytocics Heroin       Ergometrine (Ergonovine)       LSD (Lysergic acid diethylamide)       Mifepristone       Mephedrone       Misoprostol       Methamphetamine       Oxytocin       Phencyclidine (PCP)       Parkinsonism Agents Poppers(Amyl nitrate)       Apomorphine       Immune Modulators Benserazide       Hydroxyurea (Hydroxycarbamide)       Carbidopa       Interferon alpha       Levodopa       Interleukin 2 (Aldesleukin)       Pramipexole       Peginterferon alfa-2a       Rasagiline       Immunosuppressants Ropinirole       Anti-thymocyte globulin       Steroids Azathioprine       Beclometasone       Basiliximab       Betamethasone       Belatacept       Budesonide       Ciclosporin       Mycophenolate       for distribution. Not only. use For personal Clobetasol       Sirolimus       Dexamethasone       Tacrolimus       Fludrocortisone       Lipid Lowering Agents Fluocinolone       Fluticasone       Atorvastatin       Hydrocortisone (oral) Bezafibrate             Clofibrate       Hydrocortisone (topical)       Ezetimibe       Megestrol acetate       Fenofibrate       Methylprednisolone       Fish oils       Mometasone       Fluvastatin       Nandrolone       Gemfibrozil       Oxandrolone       Lovastatin       Prednisolone       Pitavastatin       Prednisone       Pravastatin       Stanazolol       Rosuvastatin       Testosterone       Simvastatin       Triamcinolone      

Key to abbreviations Key to symbols Where advice differs between countries, and/or between boosted and Bictegravir + Emtricitabine +  These drugs should not be coadministered BIC/F/TAF Tenofovir alafenamide (Biktarvy®) unboosted regimens, the charts reflect the more cautious option. ® Potential interaction – may require close monitoring, DTG Dolutegravir (Tivicay )  alteration of drug dosage or timing of administration © Liverpool Drug Interactions Group, University of Liverpool Elvitegravir + Cobicistat + Emtricitabine + Potential interaction likely to be of weak intensity. Pharmacology Research Labs, 1st Floor Block H, 70 Pembroke Place, LIVERPOOL, L69 3GF E/C/F/TAF Tenofovir alafenamide (Genvoya®) Additional action/monitoring or dosage adjustment is We aim to ensure that information is accurate and consistent with current knowledge Elvitegravir + Cobicistat + Emtricitabine + unlikely to be required E/C/F/TDF ® and practice. However, the University of Liverpool and its servants or agents shall not Tenofovir disoproxil fumarate (Strilbild )  No clinically significant interaction expected be responsible or in any way liable for the continued currency of information in this ® ® publication whether arising from negligence or otherwise howsoever or for any MVC Maraviroc (Celsentri , Selzentry ) There are no clear data, actual or theoretical, to indicate ®  consequences arising therefrom. The University of Liverpool expressly exclude RAL Raltegravir (Isentress ) whether an interaction will occur liability for errors, omissions or inaccuracies to the fullest extent permitted by law.