Human CD

Molec. Molec. Molec. Molec. Alternate names Expression Function Ligand/receptor Antigen Alternate names Expression Function Ligand/receptor Antigen Alternate names Expression Function Ligand/receptor Antigen Alternate names Expression Function Ligand/receptor mass mass mass mass

CD1a T6, Leu-6, R4, HTA1 49 kDa Cortical , Langerhans cells, DCs Antigen presentation with β-2-microglobin CD1-restricted TCR CD66b CD67, CGM6, NCA-95, 95–100 Granulocytes Adhesion, neutrophil activation CD66c CD158g KIR2DS5 – NK and T cell subsets Activation of NK cell cytolytic activity, MHC class I– – CD269 BCMA, TNFRSF13B 20 kDa Mature B cells (membrane and perinuclear) B cell survival and proliferation CD256, CD257 CEACAM8 kDa specific NK receptor CD270 TNFRSF14, tumor 30 kDa Broad, Bhi cells Viral entry, signal transduction CD258, CD272, HSV‑1, CD1b R1, T6 45 kDa Cortical thymocytes, Langerhans cells, DCs Antigen presentation with β-2-microglobin CD1-restricted TCR CD66c NCA, CEACAM6 90 kDa Neutrophils, colon carcinoma Adhesion CD62E, CD66a, CD66b, CD158h KIR2DS1 50 kDa NK and T cell subsets Activation of NK cell cytolytic activity, MHC class I– HLA-C necrosis factor receptor HSV-2 CD1c BDCA-1, R7, T6, M241 43 kDa Cortical thymocytes, Langerhans cells, DCs, B Antigen presentation with β-2-microglobin CD1-restricted TCR CD66c, CD66e specific NK receptor superfamily, member cell subsets 14 (herpes virus entry CD66d CGM1, CEACAM3 35 kDa Granulocytes Putative role in and signaling – CD158i KIR2DS4 35, 58 NK and T cell subsets Activation of NK cell cytolytic activity, MHC class I– HLA-C mediator), TR2, ATAR, CD1d R3 49 kDa Intestinal epithelial cells, B cell subsets, Antigen presentation with β-2-microglobin CD1-restricted TCR kDa specific NK receptor HVEA, HVEM, LIGHTR low , DCs CD66e CEA, CEACAM5 180–200 Colon epithelial cells, colon cancer Adhesion CD66a, CD66c, CD66e CD158j KIR2DS2 50 kDa NK and T cell subsets Activation of NK cell cytolytic activity, MHC class I– HLA-C CD271 NGFR, p75(NTR) 45 kDa Neurons (Schwann cells, growing neurites), bone Tumor suppressor; cell survival and death NGF, BDNF, NT-3, NT-4 kDa CD1e R4 28 kDa DCs Antigen presentation with β-2-microglobin – specific NK receptor marrow mesenchymal cells CD66f PSG, Sp-1 54–72 Pregnancy-specific , placental Immune regulation, protection of fetus from maternal – CD2 T11, LFA-2, SRBC-R 50 kDa Thymocytes, T cells, NK cells Adhesion, T cell activation CD58 CD158k KIR3DL2 70 kDa NK and T cell subsets Inhibition of NK cell cytolytic activity, MHC class I– – CD272 BTLA 33 kDa Lymphocytes, macrophages, progenitor B and Inhibitory response CD270 kDa syncytiotrophoblasts, fetal liver specific NK receptor T cells, mature BM DCs CD2R T11-3 50 kDa Tact cells Activation-dependent form of CD2 – CD68 Macrosialin, GP110 110 kDa Intracellularly in monocytes, macrophages, Scavenger receptor, antigen processing, phagocytosis Oxidized LDL CD158z KIR3DL3 NK and T cell subsets Inhibition of NK cell cytolytic activity, MHC class I– – CD273 B7DC, PD-L2, 25 kDa DC subsets, monocytes, macrophages Co-stimulation or suppression of T cell proliferation CD279 CD3ε T3 20 kDa T cells, subsets With TCR, TCR surface expression/signal transduction – neutrophils, basophils, large lymphocytes, mast specific NK receptor PDCD1L2 cells, DCs, myeloid progenitors, liver CD4 T4, Leu3a 55 kDa Thymocyte subsets, T cell subsets, monocytes, MHC class II co-receptor, HIV receptor, MHC class II, HIV CD159a NKG2A 43 kDa T cell subsets, NK cells With CD94, NK cell receptor HLA-E CD274 B7-H1, PD- 33 kDa Leukocytes, broad Co-stimulation of lymphocytes CD279 macrophages T cell differentiation/activation CD69 Activation inducer 28, 32 Tact, Bact, and NKact cells; granulocytesact, resting Signal transduction – marker (AIM), very early kDa BM memory T cells, thymocytes, Langerhan DCs CD159c NKG2C 40 kDa NK cells With MHC class I HLA-E molecules, forms heterodimer HLA-E CD275 B7-H2, ICOSL, B7-RP1, 60 kDa B cells, DCs, monocytes Co-stimulation, cytokine production CD278 CD5 T1, Tp67, Leu1, Ly-1 67 kDa Thymocytes, T cells, B cell subsets, B cell TCR or BCR signaling, T and B cell interaction CD72 activation (VEA) with CD94 GL50 chronic lymphocytic leukemia act act CD160 BY55 27 kDa NK and T cell subsets Co-stimulation HLA-C CD70 Ki-24, CD27L, TNFSF7 50, 70, B and T cells T and B cell co-stimulation CD27 CD276 B7-H3 40–45 In vitro–cultured DCs and monocytes, Tact cells, Co-stimulation, T cell activation – CD6 T12 100–130 Thymocytes, T cells, B cell subsets T cell differentiation/co-stimulation CD166 90, 160 CD161 NKR-P1A 40 kDa NK cell–mediated cytotoxicity -like transcript 1 kDa mammary tissue kDa kDa T cell subsets (TH17, CD8 subsets, γδ, CD3 thymocytes), NK cells CD277 BT3.1, butyrophilin SF3 56 kDa T, B, and NK cells; monocytes, DCs, endothelial T cell activation – CD7 Leu9, gp40 40 kDa Hematopoietic progenitors, thymocytes, T cells, T cell co-stimulation K12 in epithelial cells CD71 95 kDa Proliferating cells, reticulocytes, erythroid Iron uptake Transferrin A1, BTF5 cells, CD34+ cells, tumor cell lines, CD14+ cells NK cells (TFR), T9 precursors CD162 PSGL-1 120 kDa Monocytes, neutrophils, granulocytes, Adhesion, rolling CD62P, CD62E, CD62L peripheral T cells, Blow cells, and a subset of CD278 ICOS, AILIM 55–60 Tact and Th2 cells T cell co-stimulation CD275 CD8a T8, Leu-2, Ly-2 32–34 Thymocyte subsets, T cell subsets, NK cells MHC class I co-receptor, receptor for some mutated MHC class I + CD72 Lyb-2 42 kDa B cells, follicular DCs B cell proliferation CD5, CD100 CD34 hematopoietic progenitor cells (HPCs) in kDa kDa HIV-1, T cell differentiation/activation bone marrow CD73 NT5E, Ecto-5'- 69 kDa B cell subsets, Treg subsets, epithelial cells Ecto-5´-nucleotidase, nucleoside uptake, AMP CD279 PD1, SLEB2 55 kDa Tact and Bact cells Autoimmune disease and peripheral tolerance, CD273, CD274 CD8b Lyt-3 30–32 Thymocyte subsets, T cell subsets MHC class I co-receptor, receptor for some mutated MHC class I nucleotidase T cell co-stimulation, lymphocyte adhesion CD163 Hemoglobin scavenger 130 kDa Monocytes, macrophages Clearance of hemoglobin Hemoglobin checkpoint in tumors kDa HIV-1, T cell differentiation/activation receptor, macrophage CD74 Ii, invariant chain, 33, 35, B cells, macrophages, monocytes, Langerhans MHC class II traffic and function, binding to MIF, MIF marker CD280 ENDO180, UPARAP 180 kDa Chondrocytes, fibroblasts, endothelial cells, Collagen matrix remodeling and endocytic recycling Collagen, mannose, CD9 p24, MRP-1, DRAP-27 22–27 Pre-B cells, eosinophils, basophils, platelets, Cellular adhesion and migration PSG17, TGF-α HLA class II 41, 43 cells, DCs, Tact cells maturation of follicular B cells act macrophages fucose on glycans kDa T cells, neurons, glial cells in the peripheral histocompatibility kDa CD164 MGC-24, MUC24 80 kDa Hematopoietic progenitors, cell–stromal cell Putative role in intracellular adhesion – nervous system antigen γ chain, HLA- interaction CD281 TLR1 90 kDa Low levels in peripheral blood mononuclear Innate immunity with TLR2 Lipoprotein, lipopeptide cells, monocytes, possibly DCs CD10 CALLA, NEP, gp100 100 kDa B cell precursors, T cell precursors, neutrophils, Zinc-binding metalloproteinase, B cell development DR antigens-associated invariant chain CD165 AD2, gp37 42 kDa Mesothelial cells, T-cell acute lymphoblastic Putative role in intracellular adhesion – acute lymphoblastic leukemias leukemia (T-ALL) cells, epithelial cells, CD282 TLR2 90 kDa Monocytes, neutrophils, upregulated in Response to bacterial lipoproteins, innate immunity Lipoproteins and glycans, CD75 Lactosamines 67, 85 B cell subsets, epithelial cells Lactosamines – fibroblasts, platelets macrophages pathogen-associated CD11a LFA-1, integrin L 180 kDa Lymphocytes, granulocytes, monocytes, CD11a/CD18 receptor for ICAM-1, -2, and -3; CD50, CD54, CD102 kDa molecular patterns macrophages intercellular adhesion; T cell co-stimulation CD166 ALCAM 105 kDa Neurons, monocytes, epithelial cells, fibroblasts, Adhesion CD6 CD75s Sialylated CD75 – B cell subsets, T cell subsets -2,6-sialylated lactosamines (previously CDw75 and – Tact cells CD283 TLR3 100 kDa -derived DCs (may be intracellular) Innate immunity dsRNA CD11b Mac-1, integrin M 170 kDa Myeloid cells, NK cells iC3 adhesion CD54, CD102, iC3b, α CDw76) fibrinogen, CD23 CD167a Discoidin domain 120 kDa Epithelial cells, myoblasts Tyrosine kinase, adhesion to collagen Collagen CD284 TLR4 100 kDa Peripheral blood mononuclear cells (weak in Innate immunity, association with MD2 and CD14 LPS CD77 Gb3, Pk blood group Germinal center B cells, Burkitt’s lymphomashigh, Apoptosis Shiga toxin, verotoxin 1 receptor family-1 (DDR1) monocytes, immature DCs, and neutrophils) CD11c p150, 95, CR4, integrin 150 kDa DCs, macrophages, monocytes, granulocytes, iC3 adhesion CD54, iC3b, fibrinogen, follicular lymphomaslow X, LeuM5 NK cells, T and B cell subsets, leukemia cells CD23 CD168 Hyaluronan-mediated 84–88 Monocytes, T cell subsets, thymocyte subsets, Adhesion, tumor migration, metastasis – CD285 TLR5 98 kDa DCs, monocytes, epithelial cell subsets Innate recognition to bacteria Flagellin CD79a Ig, MB-1 33, 45 Myeloid subsets Component of BCR, BCR surface expression, and signal – motility receptor kDa intracellularly in breast cancer cells CD13 Aminopeptidase N, APN, 150–170 Monocytes, granulocytes, some macrophages, Zinc-binding metalloproteinase, antigen processing, Coronavirus receptor CD286 TLR6 90 kDa Macrophages, monocytes, epithelial cells, Innate immune response to bacterial LPS, association LPS kDa transduction (HMMR) GP150 kDa connective tissue receptor for coronavirus strains endothelial cells with MD2 and CD14 CD79b 37 kDa B cells Component of BCR, BCR surface expression, and signal – CD169 , Siglec-1 185 kDa Tissue macrophage subsets, DCs Adhesion, cell–cell and cell–matrix interactions, binding CD43, CD206, CD227, CD14 LPS-R 53–55 Monocytes, macrophages, Langerhans cells, Innate response via LPS binding and TLR signaling LPS Igβ, B29 CD288 TLR8 110 kDa Leukocytes, monocytes, DCs Pathogen recognition, activation of innate immunity Bacterial diacyl- transduction with CD227 on breast cancer cells and CD43 on T cells hyaluronan kDa granulocyteslow lipopeptides act act CD170 Siglec-5, CD33-like-2 140 kDa Macrophage subsets, neutrophils, eosinophils Adhesion 2,3- and 2,6-linked CD80 B7, B7-1, BB1 60 kDa B cells, T cells, macrophages, DCs T cell co-stimulation CD28, CD152 CD289 TLR9 120 kDa pDCs (intracellular) Innate immunity Pathogen-associated CD15 3-FAL, X-hapten, – Granulocytes, neutrophils, eosinophils, Carbohydrate interaction CD62E, sialic acid Lewis-X, Lex antigen, monocytes, stem cells CD81 TAPA-1 26 kDa T, B, and NK cells; thymocytes, DCs, endothelial Complex with CD19 and CD21, signaling, – molecular patterns, CpG SSEA-1 cells, fibroblasts, neuroblastomas, melanomas T cell co-stimulation CD171 L1 cell adhesion 200–210 CNS, PNS, glial cells, monocytes, T cell subsets, Kidney morphogenesis, lymph node architecture, T cell CD9, CD24, CD56, DNA found in bacteria molecule kDa B cells, DCs, several human tumor cells co-stimulation, neurohistogenesis, homotypic interaction CD142, CD166, CD171, & viruses CD15s Sialyl-Lewis X – Neutrophils, eosinophils, monocytes, memory Adhesion CD62L, CD62P CD82 R2, 4F9, C33, Kai1 50–53 Leukocytes, fibroblasts, epithelial cells, Signal transduction – neurocan, phosphocan, act CD290 TLR10 90 kDa B cells, monocytes, Treg cells, pDCs Pathogen recognition, activation of innate immunity – helper T cells, T cells, B cells, NK cells, high kDa endothelial cells laminin endothelial venule CD292 BMPR1A, ALK3 57 kDa Bone progenitor Bone development BMP-2, BMP-4 CD83 HB15 43 kDa Bact cells, Tact cells, DCs, Langerhans cells DC marker – CD172a SIRP 110 kDa Monocytes, T cell subsets, stem cells Adhesion CD47 CD15u Sulfated-Lewis X – Myeloid subsets Adhesion – CD293 BMPR1B, ALK6 57 kDa Bone progenitor Bone development BMP-7, GDF5 CD84 GR6, SLAMF5 73 kDa Monocytes, platelets, B cells, T cell subsets, Putative role in adhesion, co-stimulation – CD172b 50 kDa Monocytes, DCs Negative regulation of RTK-coupled signaling CD16 FcgRIIIB 48 kDa Neutrophils, monocyte subsets, dendritic cells, Component of low-affinity Fc receptor, phagocytosis, IgG SIRPβ, SIRB1 macrophage subsets CD294 CRTH2, GPR44 55–70 Th2 cells, eosinophils, basophils, T cell subsets Stimulatory effects on Th2 cells, allergic inflammation Prostaglandin D2 macrophages, NK cell subsets and antibody-dependent cell-mediated cytotoxicity CD172g 45–50 mRNA: liver and at lower levels in many tissues – CD47 CD85a LIR3, ILT5, HL9, LILRB3 110 kDa Monocytes Signaling through FCg – SIRPγ, SIRPB2 kDa CD17 Lactosylceramide Neutrophils, monocytes, platelets Unknown function – kDa CD85b ILT8, LILRA6 – NK cells, T cell subsets, monocytes, Activation of NK cell–mediated cytotoxicity, association – CD295 LeptinR, LEPR 132 kDa Broad Adipose metabolism, immune dysfunction in obesity Leptin CD18 95 kDa Broad, all leukocytes Heterodimer with CD11a, b, or c; adhesion CD50, CD54, CD102, CD173 Blood group H type 2 – Erythrocytes, stem cell subsets, platelets Putative role in homing immature stem cells to bone – Integrin β2, ITGB2 macrophages, DCs, B cells with FcRγ CD296 ART1, RT6, ART2 37 kDa Heart and skeletal muscle, peripheral T cells, Modification of integrins during differentiation, ADP – iC3b, fibrinogen marrow CD85c LIR8, LILRB5 – NK cells, T cell subsets, monocytes, Activation of NK cell–mediated cytotoxicity, association – NK cell subsets ribosylation of target CD19 B4 95 kDa B cells, follicular DCs Complex with CD21 and CD81; BCR co-receptor; HMG-box CD174 Lewis Y – Stem cell subsets, epithelial cells Putative role as cofactor to pro-coagulant y – macrophages, DCs, B cells with FcRγ CD297 ART4, Dombrock blood 38 kDa Erythroid, monocytesact ADP ribosylation of target proteins – B cell activation/differentiation CD175 Tn – Stem cell subsets CD175 precursor for ABO antigen – CD85d LIR2, ILT4, MIR10, ILT8 110 kDa NK cells, monocytes, macrophages Suppression of NK cell–mediated cytotoxicity group low CD20 B1, Bp35, Ly-44 33–37 B cells, T cell subsets B cell activation – CD175s Sialyl-Tn – Erythroblasts, myeloid leukemias, carcinoma Putative role in tumor metastasis – + + Cd85e ILT6, LIR4, LILRA3 – B and NK cells Activation of NK cell–mediated cytotoxicity, association – CD298 Na+/K+-ATPase β3 52 kDa Broad Transport Na and K ions across membrane – kDa cells with FcRγ subunit CD21 C3DR, CR2, EBV-R 110, 145 B cells, follicular DCs, T cell subsets Complement C3δ and EBV receptor, complex with CD19 C3d, CD23, EBV CD176 Thomson Friedrenreich – Stem cell subsets, carcinoma cells Putative role in tumor metastasis – CD85f ILT11, LIR9, LILRA5 – Monocytes, neutrophils, macrophages, DCs Activation of NK cell–mediated cytotoxicity, association – CD299 DC-SIGN-related, 45 kDa Endothelial subsets, DCs, macrophages Co-receptor with DC-SIGN, HIV infection CD50, HIV-1 gp120 kDa and CD81, BCR co-receptor antigen with FcRγ LSIGN, DC-SIGN2 CD22 BL-CAM, Siglec-2, 150 kDa B cells Adhesion; B and T cell interactions 2,6-linked sialic acid CD177 NB1 56–62 Neutrophil subsets Migration – α CD85g LIR4, ILT7 5 kDa Plasmacytoid DCs Signaling for cytokine production – CD300a CMRF35H, IRC1, IRp60 60 kDa NK cells, monocytes, neutrophils, T and B cell Unknown – Leu-14 kDa glycans on proteins, CLM-8, MAIR-1, LMIR-1 subsets, lymphocytic cell lines, AML CD22, B cell receptor IgM CD85h LIR7, ILT1, LILRA2 53 kDa Monocytes Activation of NK cell–mediated cytotoxicity MHC class I antigens CD178 FasL, CD95L 38–42 Tact cells, testis, neutrophils, monocytes, NK cells Apoptosis, immune privilege, soluble form in serum CD95 CD300c CMRF35A, LIR 23 kDa Monocytes, neutrophil monocytic cell lines, B Unknown – act kDa CD23 FceRII, BLAST-2 45 kDa B cells, macrophages , follicular DCs, platelets, CD19–CD21–CD81 receptor, IgE low-affinity receptor, IgE, CD21, CD11b, CD11c CD85i LIR6, LILRA1 – T cell subsets, monocytes, macrophages, Activation of NK cell–mediated cytotoxicity, association – and T cell subsets T cell subsets, eosinophils signal transduction DCs, B cells with FcR γ CD179a Vpre-B 16–18 Pro- and pre-B cells B cell differentiation/signaling with IgM – CD300e CMRF35L 45 kDa Monocytes, macrophages, DCs Unknown – CD24 BA-1, HSA (heat-stable 35–45 Thymocytes, erythrocytes, granulocytes, GPI-linked receptor for signal transduction CD62P CD85j LIR1, ILT2, MIR7 110 kDa NK cells, DCs, monocytes, T cells Inhibitory receptor for MHC class I antigens – kDa antigen) kDa B cells CD300f IREM1, MAIR-V 60 kDa Myeloid Inhibitory receptor – CD85k LIR5, ILT3, HM18, 60 kDa DCs, macrophages, monocytes, Putative inhibitory receptor CD179b Lambda 5 22 kDa Pro- and pre-B cells B cell differentiation/signaling with IgM – CD25 Tac, p55 55 kDa Tact cells, Bact cells, lymphocyte progenitors, IL-2 LILRB4 plasmacytoid DCs CD301 MGL, HML2, DCASGPR, 38 kDa Immature DCs Binding of Tn antigen, uptake of glycosylated antigens – IL-2Rα, with IL-2Rβ and IL-2Rγ to form high-affinity CD180 RP-105 95–105 B cell subsets, monocytes, DCs B cell activation, LPS signaling with MD-1 – Treg cells CLECSF13, CLECSF14 complex for IL-2, signal transduction kDa CD85l ILT9, LILRP1 – NK cells, T cell subsets, monocytes, Association with FcRγ – act macrophages, DCs, B cells CD302 DCL1, BIMLEC 19–28 Some myeloid and Hodgkin’s cell lines A fusion protein in Hodgkin’s lymphoma with DEC-205 – CD26 Dipeptidyl peptidase IV 110 kDa Thymocyte subsets, T cells (soluble form), Peptidase role, T cell co-stimulation/activation, FAP, HIV Tat, collagen, CD181 CXCR1, IL-8R A 39 kDa Neutrophils, basophils, NK cells, T cell subsets, Binding of IL-8 induces chemotaxis of neutrophils, IL-8 kDa (DD IV), Ta1 B cells, NK cells HIV entry, glucose metabolism CD45 monocytes phospholipase D activation, respiratory burst CD85m ILT10 – NK cells, T cell subsets, monocytes, Association with FcRγ – CD27 S152, S152. LPFS2, 50–55 Medullary thymocytes, T cells, B cell subsets, T cell co-stimulation CD70 macrophages, DCs, B cells CD303 BDCA2, HECL, CLEC4C 38 kDa pDCs Inhibition of IFN-α production – CD182 CXCR2, IL-8RB 40 kDa Neutrophils, basophils, NK cells, T cell subsets, Binding of IL-8 induces chemotaxis of neutrophils IL-8, GRO-α, β, γ, and T14, TNFRSF7, Tp55 kDa NK cell subsets CD86 B70, B7-2 80 kDa Monocytes, DCs, Bact cells, Tact cells T cell co-stimulation CD28, CD152 monocytes NAP-2 CD304 BDCA4, 1, 130 kDa Neurons, CD4+/CD25+ Treg cells, pDCs, Interaction with VEGF165 and semaphorins, co-receptor Semaphorin-3A, CD28 Tp44, T44 44 kDa Most T cells, thymocytes, plasma cells T cell co-stimulation CD80, CD86 VEGF165R endothelial cells, tumor cells with plexin, axonal guidance, angiogenesis, cell survival, vascular endothelial CD87 Urokinase plasminogen 39–66 Granulocytes, monocytes, NK cells, Tact cells, Inflammatory cell invasion, metastasis uPA, CD183 CXCR3 40 kDa Eosinophils, T cells, NK cells, GM-CSF– T cell recruitment to inflammatory sites, enhancement of CXCL10 (IP-10), CXCL9 migration growth factor A, plexin-1 low activator (uPA), PLAUR kDa endothelial cells, fibroblasts activated CD34+ progenitors Th1 response, chemotaxis (MIG), CXCL11 (I-TAC) CD29 Integrin β1, platelet 130 kDa Lymphocytes, monocytes, granulocytes , Heterodimer with CD49a–f to form VLA-1 through CD106, MAdCAM-1, ECM platelets, mast cells, fibroblasts, endothelial VLA-6; adhesion, differentiation proteins CD305 LAIR1 32–40 NK, B, and T cells; monocytes, DCs, eosinophils, Inhibitory receptor on NK and T cells – GPIIa, MSK12, VLAB CD88 C5aR 40 kDa Granulocytes, monocytes, DCs Granulocyte activation CD184 CXCR4, fusin 45 kDa B cells, DCs, T cell subsets, monocytes, Inhibition of chemotaxis and Ca2+ flux induced by SDF1 CXCL12, HIV-1 (X4 tropic) cells, nerve, connective tissue kDa basophils, mast cells endothelial cells next to HIV CD89 FcaR 55–75 Monocytes, macrophages, granulocytes, Phagocytosis, degranulation, respiratory burst IgA1, IgA2 CD30 Ki-1, Ber-H2, TNFRSF8 105–120 Bact, Tact, and NKact cells; Reed–Sternberg cells, Lymphocyte proliferation/apoptosis CD153 CD306 LAIR2 16 kDa Monocytes Soluble, mucosal tolerance – kDa neutrophils, B cell subsets, T cell subsets CD185 CXCR5, BLR1 45 kDa Mature B cells, Burkitt lymphoma cells, With chemokine BLC, possible regulatory function in CXCL13 kDa anaplastic large-cell lymphoma T follicular helper cells Burkitt lymphomagenesis and/or B cell differentiation, CD307 IRTA2, FcRL5, CD307e, 55–105 B cell subsets, B cell lymphomas B cell development, translocation in some lymphomas – CD90 Thy-1 25–35 CD34+ hematopoietic subsets, neurons Hematopoietic stem cell and neuron differentiation, CD11b/CD18 CD31 Platelet endothelial 130–140 Monocytes, platelets, granulocytes, endothelial Adhesion, signal transduction CD31, CD38 activation of mature B cells BXMAS1 kDa kDa adhesion, signal transduction cell adhesion molecule kDa cells, lymphocyte subsets CD186 CXCR6, BONZO 40 kDa Tact cells – CXCL16 SIV, receptor for CD307a FCRL1, Fc receptor- 50 kDa Mature B cells Putative role in B cell activation and differentiation – (PECAM-1), endoCAM CD91 LPR1, A2MR 600 kDa Monocytes, macrophages, neurons, fibroblasts, Ligand clearance α-2-macroglobulin, LDLs, CXCL16 and co-receptor like 1, FCRH1, IFGP1, DCs CD32 FcgRII 40 kDa Monocytes, granulocytes, B cells, platelets Low-affinity Fc receptor for aggregated Ig and immune Polymeric or aggregated HSP96 for SIV, strains of HIV-2 IRTA5, FCRL1 complexes IgG and m-tropic HIV-1 CD92 Choline transporter- 70 kDa Neutrophils, monocytes, platelets, endothelial Putative choline transporter for phospholipid Choline CD307b FCRL2, Fc receptor- 55 kDa Memory B cells Putative role in B cell development – CD33 gp67, Siglec-3 67 kDa Myeloid progenitors, monocytes, granulocytes, Adhesion Sialic acid like protein 1 (CTL-1), cells, fibroblasts biosynthesis CD191 CCR1, MIP-1 receptor, 39 kDa T cells, monocytes, stem cell subsets Binding of CC-type chemokines and transduction of CCL4, CCL5, CCL6, like 2, FCRH2, IFGP4, DCs, mast cells CHTL1 RANTES receptor signal by increasing intracellular calcium ion levels CCL14, CCL15, CCL16, IRTA4, SPAP1, SPAP1A, CCL23 SPAP1B, SPAP1C CD34 MY10, mucosialin, 105–120 Hematopoietic precursors, capillary endothelial Stem cell marker, adhesion CD62L CD93 C1qRp 120 kDa Neutrophils, monocytes, endothelial cells Clearance of apoptotic cells C1q, MBL2, SPA CD192 CCR2, MCP-1 receptor 40 kDa Monocytes, macrophage subset (M1), NKact Alternative co-receptor with CD4 for HIV-1 infection CCL2, CCL8, CCL16 CD307c FCRL3, Fc receptor- 89 kDa B and NK cells – – gp105-120 kDa cells, embryonic fibroblasts CD94 KP43, KLRD1 43 kDa NK cells, T cell subsets Complex with NKG2, inhibition of NK function – cells, basophils, Tact cell subsets, Bact cells, like 3, FCRH3, IFGP3, CD35 Complement receptor 250 kDa Erythrocytes, B cells, monocytes, neutrophils, , adhesion, phagocytosis C3b, C4b CD95 Apo-1, Fas, TNFRSF6 45 kDa Lymphocytesact, monocytes, neutrophils Apoptosis CD178 (FasL) endothelial cells IRTA3, SPAP2 1 (CR1) eosinophils, follicular dendritic cells, T cell subsets CD96 TACTILE 160 kDa NK cells, Tact cells Adhesion of activated T and NK cells CD155 CD193 CCR3, CKR3 45 kDa Eosinophils, basophils, mast cells, lower Alternative co-receptor with CD4 for HIV-1 infection, CCL11, CCL26, CCL7, CD307d FCRL4, Fc receptor-like 57 kDa Memory B cells May inhibit B cell receptor – expression in neutrophils and monocytes, eosinophil migration CCL13, CCL15, CCL24, 4, FCRH4, IGFP2, IRTA1 CD36 GPIV, GPIIIb, fatty acid 88 kDa Platelets, monocytes, macrophages, endothelial ECM receptor, adhesion, phagocytosis Collagen (I, IV, V), CD97 BL-KDAD/F12 74, 80, 90 Bact cells, Tact cells, monocytes, granulocytes – CD55 T cell subsets (Th2) CCL5, CCL28 translocase, SCARB3, cells, early erythrocytes thrombospondin, kDa CD307e FCRL5, Fc receptor-like 106 kDa B cells Putative role in B cell development and differentiation – GP88 oxidized LDL CD195 CCR5 45 kDa Monocytes, T cell subsets, mDCs, pDCs R5 HIV-1 co-receptor, chemotaxis CCL2, CCL3, CCL4, 5, CD307, FCRH5, CD98 4F2, CD98hc 40, 80 T, B, and NK cells; granulocytes, all human Activation – CCL5, CCL11, CCL13, IRTA2, BXMAS1, low low CD37 gp40-52, TSPAN26 40–52 B cells, T cells, myeloid B cell activation, signal transduction – kDa cell lines CCL14, CCL16 PRO820 kDa CD99 MIC2, E2 32 kDa Leukocytes T cell activation, adhesion – CD196 CCR6, LARC receptor, 45 kDa T cell subsets, B cells, DC subsets Inflammation, differentiation CCL20 CD309 VEGFR2, KDAR 230 kDa Endothelial cells, angiogenic precursor cells, Regulation of adhesion and cell signaling (annexin A5 VEGF CD38 T10, cyclic ADP ribose 45 kDa Variable levels on majority of hematopoietic Ecto-ADP-ribosyl cyclase, cell activation, adhesion, CD31, hyaluronic acid CD99R E2 32 kDa T, NK, and myeloid cells Isoform of CD99 – DRY6 hemangioblasts and SHC1 binding also published) hydrolase cells; high expression on plasma, B, and Tact cells proliferation CD100 Sema4D 150 kDa Hematopoietic cells except immature bone Adhesion, activation CD72, plexin B1 CD197 CCR7, EBI-1 45 kDa T cell subsets, DC subsets, B cell subsets T cell migration CCL19, CCL21 CD312 EMR2 90 kDa Monocytes, macrophages, monocyte-derived Cell adhesion and migration for phagocytosis , CD39 ENTPD-1, Gp80, 78 kDa B cells, NK cells, macrophages, Langerhans Ectoenzyme to remove extracellular ATP, support ATP DCs, granulocyteslow glycosaminoglycan, CD55 marrow cells, RBCs, and platelets high EC3.6.1.5 cells, DCs, Treg cells, Tact cell subset immune responses to anti-inflammatory CD198 CCR8, GPRCY6, TER1 50 kDa T cells, Th2 , NK cells, monocytes Allergic inflammation, alternative co-receptor with CD4 CCL1 + CD101 V7, p126 120 kDa Monocytes, granulocytes, DCs, T cells T cell activation – for HIV-1 infection CD314 NKG2D, KLR 42 kDa NK cells, CD8 activated; some myeloid cells Activation of cytolysis and cytokine production, MICA, MICB, ULBP1, CD40 Bp50, TNFRSF5 48 kDa B cells, monocytes, macrophages, follicular DCs, B cell differentiation/co-stimulation, isotype switching, CD154 co-stimulation ULBP2, ULBP3 endothelial cells, T cell subsets rescues B cells from apoptosis CD102 ICAM-2 55–65 Leukocytes, endothelial cells Co-stimulation CD11a/CD18 CD199 CCR9, GPR-9-6 43 kDa Thymic progenitors, T cell subsets Alternative co-receptor with CD4 for HIV-1 infection CCL25 (TECK) CD315 CD9P1, SMAP6, FPRP, 135 kDa B cell subsets, monocytesact Associates with CD81 and CD9 – kDa CD200 OX-2 45–50 Thymocytes, endothelial cells, B cells, Tact cells Inhibition of immune response OX-2R CD41 GPIIb, IIb integrin, 125 kDa Platelets, megakaryocytes Heterodimer with CD61; binding of fibrinogen, Vitronectin, fibrinogen, PTGFRN ITGA2B fibronectin, vWF, and thrombospondin; platelet activation fibronectin, vWF, act kDa CD103 HML-1, a6, integrin E 25, 150 Intra-epithelial cells, lymphocytes , lymphocyte Complex with integrin β7, binds E-cadherin, lymphocyte E-cadherin and aggregation thrombospondin CD316 EWI2, PGRL, CD81P3, 63–75 B cells, T cells, low on NK cells Associates with CD81 and CD9, involved in cell – kDa subsets, Treg cells homing/retention CD200R OX2R 48 kDa Hematopoietic cells Inhibitory receptor, inhibition of TNF secretion CD200 KASP kDa migration CD42a Glycoprotein IX, GP9 22 kDa Platelets, megakaryocytes Complex with CD42b, c, and d; receptor for vWF and vWF, thrombin CD104 220 kDa Epithelial cells, Schwann cells, keratinocytes, Complex with integrin 6 (CD49f), cell adhesion, Laminin CD201 EPC-R 50 kDa Endothelial cell subsets Activated protein receptor; role in coagulation, thrombin; platelet adhesion to sub-endothelial matrices β4 integrin CD317 BST2, HM1.24 30–36 B, T, and NK cells; monocytes, DCs, fibroblast Pre-B cell growth, overexpressed in multiple myeloma – some tumor cells differentiation, metastasis inflammation, migration kDa cell lines, myeloma cells CD42b GPIb 145 kDa Platelets, megakaryocytes Complex with CD42a, c, and d; binds to vWF and vWF, thrombin CD105 95 kDa Endothelial cells, bone marrow subsets, CD202b Tie2, Tek 150 kDa Stem cells, endothelial cells Angiogenesis, hematopoiesis Angiopoietin-1 thrombin; platelet adhesion/activation Cellular response to TGF-β1, adhesion, embryonic TGFβ1, TGFβ3 CD318 CDCP1, SIMA135 135 kDa HSCs (subset of CD34+), tumors Adhesion with ECM – macrophagesact angiogenesis CD203c NPP3/PDNP3, ENpp1, 130–150 Basophils, mast cells, glioma cells, Ectoenzyme, binding to and clearance of extracellular Nucleotides CD42c 24 kDa Platelets, megakaryocytes Complex with CD42a, b, d vWF, thrombin CD319 CRACC, SLAMF7 66 kDa T cell, B cell, and DC subsets; NK cells; Regulate T and NK cells – GPIbβ PD-1 kDa megakaryocytes nucleotides CD106 VCAM-1 110 kDa Activated endothelial cells, follicular DCs Leukocyte adhesion, migration, co-stimulation CD49d/CD29, CD49d/β7 β upregulated in DCs CD42d gpV 82 kDa Platelets, megakaryocytes Complex with CD42a–c vWF, thrombin CD204 Macrophage scavenger 220 kDa Macrophages (M2) Endocytosis of macromolecules LDL CD107a LAMP-1 110 kDa Activated platelets, T cells, endothelial cells, Lysosomal membrane protein, metastasis -3, CD62L, CD320 8D6A, 8D6 30 kDa Follicular DCs, germinal centers B cell proliferation, tumor formation – CD43 Leukosialin, sialophorin 115–135 Leukocytes except resting B cells; plateletslow Inhibition of T cell interaction, adhesion CD54, hyaluronic acid metastatic tumors CD62E, CD62P receptor CD321 JAM1, 35 kDa Platelet receptor, epithelial cells, endothelial Tight junctions, involved in retrovirus entry into cells CD11a/CD18, reovirus kDa CD205 DEC-205 205 kDa DCs, thymic epithelial cells Mediates antigen processing and presentation – CD107b LAMP-2 120 kDa Activated platelets, T cells, endothelial cells, Lysosomal membrane protein Galectin-3, CD62L, cells, platelets CD44 H-CAM, Pgp-1, Hermes 80–95 Hematopoietic and nonhematopoietic cells Adhesion Hyaluronin, osteopontin, metastatic tumors CD62E, CD62P CD206 Macrophage mannose 180 kDa DC subsets, macrophages, monocytes Phagocytosis and pinocytosis of mannose-containing Oligomannose-containing CD322 JAM2, VE-JAM 43 kDa High endothelial venule, other endothelial cells Adhesion, lymphocyte homing to secondary lymphoid PAR-3, CD49d/CD29 antigen, lymphocyte kDa except platelets; hepatocytes, testis fibronectin receptor molecules carbohydrates homing receptor, ECM- CD108 SEMA7A 80 kDa Erythrocytes, lymphoblasts, resting Putative role in inflammation CD232 organs low lymphoblasts CD207 40 kDa Langerhans cells Endocytosis, antigen processing Mannose-bearing III, hyaluronate receptor, CD324 E-cadherin, uvomorulin 120 kDa Non-neural epithelial cells Adhesion, homotypic interaction, and binding of aE/b7 CD103, PS1, catenins, HUTCH-1 act + and CD109 Platelet-specific Gov 170 kDa T cells, platelets, CD34 subsets, endothelial Negative regulator of TGF-β in keratinocytes TGF-β internalin antigen cells glycolipids CD44std CD44 variant 1–10 – Heterogeneous expression on CD44 variants; Adhesion, metastasis Hyaluronin, osteopontin, CD325 N-cadherin, NCAD 140 kDa Brain, skeletal, cardiac muscle Adhesion, neuronal recognition N-cadherin, catenins, CD208 DC-LAMP 70–90 Activated DCs, interdigitating DCs Putative role in sorting MHC class II – constitutive expression on epithelial cells, fibronectin CD110 TPO-R, C-mpl 82–84 Megakaryocytes, platelets, some CD34+ stem Megakaryocyte progenitor cell growth/differentiation FGFR, PS1 monocytes; upregulated on activated leukocytes kDa cellslow kDa CD326 Ep-CAM, Ly74, tumor- 35–40 Most epithelial cells, cell membranes, some Adhesion, metastatic carcinoma cell marker CD305, CD306 CD209 DC-SIGN 44 kDa DC subsets HIV-1 binding protein, recognition of pathogens, CD50, CD102 CD44var (v4) CD44 variant 1–10 – Heterogeneous expression; constitutive Adhesion, metastasis Hyaluronin CD111 PRR1, Nectin-1 64–72 Stem cell subsets, macrophages, neutrophils Intercellular adhesion CD112, CD113, CD155, associated calcium kDa tumors signal transduction expression on epithelial cells, monocytes, and kDa nectin-4 signal transducer 1 act leukocytes (TACSTD1) CD112 PRR2, Nectin-2 64–72 Monocytes, neutrophils, CD34+ subsets, Adhesion CD111, CD113, CD155 CD210 IL-10Ra 90–110 T, B, and NK cells; monocytes, macrophages Signal transduction IL-10 kDa CD44var (var10) CD44 variant 1–10 – Heterogeneous expression; constitutive Adhesion, metastasis Hyaluronin kDa megakaryocytes, endothelial cells, epithelial CD327 SIGLEC6 49 kDa Placenta, spleen, B cells, sialic acid dependent Adhesion, membrane-bound and secreted forms, sialic Sialyl-Tn motifs, leptin expression on epithelial cells, monocytes, and cells CD210b T, B, and NK cells; monocytes, macrophages – IL-10, IL-22 acid-dependent leukocytesact IL10RB, IL-10Rβ CD113 PVRL3, Nectin3 83 kDa Testis, placenta Adhesion molecule that interacts with CD111, CD112, CD155 CD328 SIGLEC7, AIRM-1 75 kDa Resting and activated NK cells; placenta, Sialic acid–dependent adhesion, inhibition of NK cell 2,3- and 2,6-linked CD212 100 kDa Tact and NK cells Binding of IL-12 with high affinity, association with IL-12 IL-12 CD44var (v7–v8) CD44 variant 1–10 – Heterogeneous expression; constitutive Adhesion, metastasis Hyaluronin IL-12Rβ1 liver, and spleen; lower in granulocytes and activation, hemopoiesis sialic acid CD114 GCSFR 95, 139 Myeloid cells, endothelial cells Myeloid differentiation/proliferation G-CSF receptor β2, signal transduction expression on epithelial cells, monocytes, and monocytes act kDa leukocytes CD213a1 IL-13R1 65 kDa B cells, monocytes, fibroblasts, endothelial cells Binding of IL-13 with low affinity, association with IL-13 CD329 SIGLEC9 50 kDa Neutrophils, monocytes Sialic acid–dependent adhesion molecule 2,3- and 2,6-linked CD115 MCSFR, c-fms 150 kDa Monocytes, macrophages, monocytic Monocytic differentiation/proliferation M-CSF CD124, signal transduction CD44 (v6) CD44 variant 1–10 – Heterogeneous expression; constitutive Adhesion, metastasis Hyaluronin sialic acid progenitors expression on epithelial cells, monocytes, and CD213a2 IL-13R2 65 kDa B cells, monocytes Binding of IL-13 with high affinity, signal transduction IL-13 leukocytesact CD331 FGFR1, fms-like tyrosine 30 kDa Fibroblasts, epithelial cells High-affinity receptor for fibroblast growth factors aFGF, bFGF CD116 GMCSFR 70–85 Monocytes, granulocytes, DCs, endothelial cells Association with CD131, myeloid differentiation/ GM-CSF CD215 IL15R, interleukin 15 28 kDa Brain tissue, activated monocytes, High-affinity receptor for IL-15, signal transduction, IL-15 kinase-2, KAL2, N-SAM CD44 (v3) CD44 variant 1–10 – Heterogeneous expression; constitutive Adhesion, metastasis Hyaluronin kDa proliferation receptor α macrophages, NK cells development and survival of NK cells expression on epithelial cells, monocytes, and CD332 FGFR2, BEK, KGFR 115–135 Fibroblasts, epithelial cells High-affinity receptor for fibroblast growth factors aFGF, bFGF CD117 c-, SCFR 145 kDa Hematopoietic progenitors, mast cells Hematopoietic progenitor development/differentiation SCF leukocytesact CD217 IL-17R 120 kDa Broad, granulocytes Signal transduction IL-17 kDa CD118 LIFR, gp190 190 kDa Epithelial cells in adults and embryos Membrane-bound involved in signal transduction; LIF CD44 (v5) CD44 variant 1–10 – Heterogeneous expression; constitutive Adhesion, metastasis Hyaluronin CD218a IL-18R, IL-1Rrp 70 kDa T cell subset (Th1 and Tc17), NK cells, DCs, Activation of NF-κB IL-18 CD333 FGFR3, ACH, CEK2 115 kDa Fibroblasts, epithelial cells High-affinity receptor for fibroblast growth factors aFGF, bFGF soluble form inhibits activity of LIF expression on epithelial cells, monocytes, and neutrophils CD334 FGFR4, JTK2, TKF 110 kDa Fibroblasts, epithelial cells High-affinity receptor for fibroblast growth factors aFGF, bFGF leukocytesact CD119 90–100 Macrophages, monocytes, B cells, T cells, IFNGR1, IFN-γR Complexes with IFN-γR, with IFN-γ AF-1, host defense IFN-γ CD218b 70 kDa T cell subset (Th1 and Tc17), NK cells, DCs, Heterodimeric receptor with IL-18R to enhance IL-18 IL-18 kDa NK cells, neutrophils, endothelial cells IL-18Rβ, IL18RAP CD335 NKp46, Ly-94 homolog 46 kDa NK cells Activates NK cells upon non-MHC ligand binding Viral HA, CD44 (v7) CD44 variant 1–10 – Heterogeneous expression; constitutive Adhesion, metastasis Hyaluronin neutrophils, endothelial binding expression on epithelial cells, monocytes, and CD120a TNFR-I, p55 50–60 Hematopoietic and nonhematopoietic cells Signal transduction TNF, TNF act β CD220 140, 70 Broad Signal transduction via kinase domain Insulin leukocytes kDa CD336 NKp44, Ly-95 homolog 44 kDa NKact cells, T cell subsets Activates NK cells upon non-MHC ligand binding Viral HA kDa CD45 LCA, protein tyrosine 180–240 Hematopoietic cells, multiple isoforms from Tyrosine phosphatase, enhanced TCR and BCR signals – CD120b TNFR-II, p75 75–85 Hematopoietic and nonhematopoietic cells Signal transduction CD337 NKp30, Ly117 30 kDa NK cells Activates NK cells upon non-MHC ligand binding Membrane-associated TNF, TNFβ CD221 IGF-1R 70, 140 Broad Binding of IGF with high affinity, signaling, cell IGF-I, IGF-II, insulin phosphatase receptor kDa alternative splicing kDa heparan sulfate kDa proliferation/differentiation type C200 (PTPRC) proteoglycans CD121a IL-1R type I 80 kDa Weakly expressed on many cells Signaling IL-1, IL-1β, IL-1R CD222 IGF-IIR, mannose-6 250 kDa Broad, mainly intracellular Adhesion, tumor growth CD45R B220 – B cells, T cell subsets Protein tyrosine phosphatase receptor – TGFβ-LAP, plasminogen, CD338 ABCG2, BCRP, Bcrp1, 73 kDa Stem cell subsets (side population) Multidrug resistance transporter – CD121b IL-1R, type II 60–70 B cells, macrophages, monocytes, T cell subsets Negative signals phosphate-R proliferin, LIF, IGFII, HSV CD45RA gp220 205–220 B cells, naïve T cells, monocytes Exon A isoforms of CD45 – IL-1, IL-1β, IL-1R MXR kDa act act kDa CD223 LAG-3 70 kDa T cells, Treg cells, NK cells Downregulation of TCR signal transduction MHC class II CD339 Jagged-1, JAG1, 135 kDa Stromal cells, epithelial cells, AML Hematopoiesis Notch 1, Notch 2, Notch 3 CD122 75 kDa NK cells, T cells, B cells, monocytes Signal transduction IL-2, IL-15 CD45RB – 190–220 B cells, T cell subsets, monocytes, Exon B isoforms of CD45 – IL-2Rβ CD224 Gamma- 27, 68 Leukocytes, stem cells Maintenance of cellular redox – JAGL1, hJ1 glutamyltransferase 1 kDa macrophages, granulocytes CD123 IL-3R 70 kDa Lymphocyte subsets, basophils, hematopoietic Complex with CD131, signal transduction IL-3 kDa CD340 HER2/neu, ERBB2, 185 kDa Bone marrow mesenchymal stem cells Member of the ERBB family of receptor tyrosines, – (GGT1) CD45RC – 190–220 B cells, T cell subsets, NK cells Exon C isoforms of CD45 – progenitors, macrophages, DCs, p185HER2 involved in a wide range of cellular responses kDa megakaryocytes, plasmacytoid DCs CD225 Leu-13 17 kDa Broad B cell activation – CD344 Frizzled-4, Fz-4, hFz-4, 59 kDa Adult kidney, lung, brain, liver, fetal neuronal Activation of the Wnt/β-catenin pathway, regulation of Wnt, norrin low CD45RO gp180, UCHL1 180 kDa Tact cells, memory T cells, B cell subsets, Isoform of CD45 lacking A, B, and C exons CD22 CD124 IL-4R 140 kDa Lymphocytes , monocytes, hematopoietic Complex with CD132 or CD213a, T cell growth/ IL-4, IL-13 CD226 DNAM-1, PTA-1, TLiSA1 65 kDa T and NK cells, monocytes, platelets, activated Activation of cell-mediated cytotoxicity, soluble form CD112, CD155 FzE4 cells, intestinal cells tissue and cell polarity monocytes, macrophages, granulocytes precursors, fibroblasts, epithelial cells differentiation human umbilical vein endothelial cells (50 kDa) found in normal serum CD349 Frizzled-9, Fz-9, hFz-9 65 kDa Adult and fetal brain; testis, eye, skeletal Activation of the Wnt/β-catenin pathway, regulation of Wnt-2, Wnt-7a CD125 IL-5R 60 kDa Eosinophils, basophils Complex with CD131, signal transduction IL-5 CD46 Membrane cofactor 56, 66 Nucleated cells Membrane cofactor protein, degradation by Factor I C3b, C4b, measles virus CD227 MUC1, EMA 300 kDa Epithelial cells, stem cell subsets, follicular DCs, Adhesion, signaling CD54, CD169, selectins muscle, and kidney; bone marrow mesenchymal tissue and cell polarity stem cells protein (MCP) kDa receptor CD126 IL-6R 80 kDa T cells, Bact cells, macrophages, granulocytes, Complex with CD130, signal transduction IL-6 monocytes, B cell subsets, some myelomas fibroblasts, epithelial cells CD47 Integrin-associated 47–52 Hematopoietic cells, epithelial cells, endothelial Leukocyte adhesion, migration, activation, Thrombospondin CD228 80–95 Stem cells, melanomas Iron transport, migration of endothelial cells Iron, pro-UPA, CD350 Frizzled-10, Fz-10, 65 kDa Placenta and kidney; fetal lung and brain Activation of the Wnt/β-catenin pathway, regulation of Wnt hFz-10 protein (IAP) kDa cells, fibroblasts, other tissues thrombospondin receptor CD127 IL-7R 65–75 T cells, pro-B cells, downregulated on Treg cells Complex with CD132, B and T cell development IL-7 kDa plasminogen tissue and cell polarity kDa CD47R MEM-133 120 kDa New designation for CDw149; similar distribution – – CD229 Ly-9 95, 110 T and B cells Adhesion CD229 CD351 FCAMR, Fc receptor of 57 kDa Mesangial cell – IgA, IgM as CD47 but dimmer CD128 see CD181 and CD182 – – – IL-9 kDa IgA and IgM, FCA/MR, FKSG87 CD48 Blast-1, BCM1, 45 kDa Broad, most leukocytes; absent on granulocytes, GPI-linked receptor, adhesion, activation CD2 (low-affinity), CD244 act CD230 Prion protein 35 kDa Lymphocytes, monocytes Homeostasis under oxidative stress, signal transduction – CD130 IL-6Rβ, gp130 130 kDa B cells, plasma cells, Signal transduction Oncostatin M, IL-6, LIF Sgp-60, SLAMF2 erythrocytes, and platelets low CD352 SLAMF6, SLAM family 37 kDa NK, T, and B cells Triggers cytolytic activity of NK cells – leukocytes(maj) , endothelial cells CD231 TALLA-1, A15, TSPAN7 30–45 T cell leukemias, neuroblastomas, brain neurons Marker for T-cell acute lymphoblastic leukemia – member 6, KALI, NTBA, CD49a VLA-1, integrin 1 210 kDa Tact cells, memory T cell subset, monocytes, Adhesion; CD49a/CD29 binds collagen and laminin Collagen, laminin kDa CD131 Common β 95–120 Monocytes, granulocytes, early B cells Complex with α subunits of IL-3R, IL-5R, and GM-CSFR; – KALIb, Ly108, NTB-A, NK cell subset, smooth muscle cells, endothelial kDa signal transduction CD232 Virus-encoded 200 kDa Broad Possible role in DC function – SF2000 cells, mesenchymal stem cells semaphorin protein CD132 64 kDa T, B, and NK cells; monocytes, granulocytes Subunit of IL-2R, IL-4R, IL-7R, IL-9R, and IL-15R; – CD353 SLAMF8, SLAM family 32 kDa Lymph node, spleen, thymus, bone marrow Putative role in B cell signaling and differentiation – CD49b VLA-2, integrin 2 165 kDa B cells, monocytes, platelets, Tact cells, Adhesion; CD49b/CD29 binds collagen and laminin Collagen, laminin Common γ receptor (VESP-R) signal transduction member 8, BLAME, megakaryocytes, nonhematopoietic, cancer cells CD233 Band 3, SLC4A1 90 kDa Erythrocytes Anion exchanger pump, transport of CO , linking red cell – SBBI42 CD133 AC133, prominin-like 1 120 kDa Hematopoietic stem cell subsets, epithelial cells, Unknown function – 2 CD49c VLA-3, integrin 3 125 kDa Most adherent cells, B cell lymphoma Adhesion; CD49c/CD29 binds laminin, fibronectin, Collagen, laminin, membrane to cytoskeleton endothelial cells, leukemias, tumor cells CD354 TREM1, triggering 26 kDa Myeloid, hepatocytes, osteoclasts, microglia Stimulation of neutrophils and monocytes – and collagen fibronectin CD234 Duffy, DARC 35–45 Erythrocytes Decoy receptor, inflammation CXCL1, CXCL5, CXCL8, receptor expressed on CD134 OX-40 48–50 Tact cells T cell activation, differentiation, apoptosis CD252 CD49d VLA-4, integrin 4 150 kDa T, B, and NK cells; thymocytes, monocytes, Adhesion; CD49d/CD29 binds fibronectin, CD106 CD106, fibronectin, kDa CCL2, CCL5, CCL7 myeloid cells 1, TREM-1 kDa eosinophils, mast cells, DCs (VCAM-1), and MAdCAM-1 MAdCAM-1 CD235a A 36 kDa Erythrocytes Major glycoprotein of erythrocyte cell membrane CD170, influenza virus, CD355 CRTAM, cytotoxic 45 kDa NKact cells, CD8act cells, γδ T cells, Purkinje Cytotoxicity, tumor rejection Necl-2 CD135 Flt3/Flk2 130–150 Myelomonocytic, primitive B progenitors, mDCs Tyrosine kinase, early lymphocyte development FLT3 ligand CD49e VLA-5, integrin 5 25, 135 Thymocytes, T cells, monocytes, platelets, Adhesion, CD49e/CD29 binds fibronectin Fibronectin erythrocyte binding and regulatory T cell neurons kDa kDa early and Bact cells antigen (EBA-175) of molecule CD136 MSP-R, RON 180 kDa Epithelial cells, CNS, PNS, hematopoietic Migration, morphological change and proliferation of MSP, HG F1 Plasmodium falciparum CD49f VLA-6, integrin 6 125 kDa Memory T cells, thymocytes, monocytes, Adhesion, CD49f/CD29 binds laminin Laminin, merosin CD357 AITR, GITR, TNFRSF18, 26 kDa Activated lymphocytes, T cell subsets Cross-talk of lymphocytes and endothelial cells, T cell TNFSF18 (AITRL) subsets different target cells platelets, megakaryocytes, epithelial and CD235b Glycophorin B 20 kDa Erythrocytes Major of erythrocyte membrane for – activation endothelial cells CD137 4-1BB 30 kDa Tact, T, and B cells; DCs, macrophages T cell co-stimulation 4-1BB ligand structure maintenance receptor superfamily, member 18, GITR-D CD50 ICAM-3 110–120 Hematopoietic cells, endothelial cells, epidermal Adhesion, co-stimulation CD11a/CD18, integrin CD138 Syndecan-1 80–150 Plasma cells, pre-B cells, basolateral surface of Cell morphology, adhesion ECM CD236 /D 32, 23 Erythrocytes, stem cell subsets – – kDa Langerhans cells d/CD18, CD209 kDa epithelial cells, neurons kDa CD358 TNFRSF21, tumor 72 kDa Fetal spinal cord, brain Promotion of apoptosis, elevated in Alzheimer’s disease APP necrosis factor receptor CD51 Vitronectin receptor, 24, 125 Plateletslow, endothelial cells, osteoblasts, Adhesion; CD51/CD61 binds vitronectin, vWF, Vitronectin, CD139 228 kDa B cells, monocytes, granulocytes, – – CD236R Glycophorin C 32 kDa Erythrocytes, stem cell subsets – – superfamily, member integrin V kDa melanomas fibrinogen, and thrombospondin vWF, fibrinogen, erythrocyteslow, follicular DCs CD238 Kell 93 kDa Erythrocytes, stem cell subsets Zinc endopeptidase – 21, DR6, BM-018 thrombospondin CD140a 180 kDa Fibroblasts, smooth muscle glial cells, Signal transduction PDGF-A, PDGF-B, PDGFR α CD239 B-CAM 78–85kDa Erythrocytes, stem cell subsets; endothelial, – Laminin 5 chain CD360 IL21R, interleukin 21 59 kDa B, T, and NK cells; DCs Signal transduction IL-21 CD52 Cambridge pathology 21–28 Thymocytes, T cells, B cells (not plasma cells), Unknown function Siglec-10 chondrocytes PDGF-C epithelial cells receptor, NILR antigen 1 (CAMPATH-1), kDa monocytes, macrophages, Treg cells CD140b 180 kDa Fibroblasts, smooth muscle glial cells, Signal transduction PDGF-B HE5 PDGFRβ CD240CE Rh30CE 30–32 Erythrocytes – – CD361 EVI2B, ecotropic viral 47 kDa Bone marrow, PBMCs, fibroblasts – – chondrocytes kDa integration site 2B, CD53 OX-44, TSPAN25 35–42 Leukocytes, DCs, osteoblasts, osteoclasts Signal transduction – EVDB, D17S376 CD141 100 kDa Monocytes, neutrophils, endothelial cells, Initiation of protein C anticoagulant signal Thrombin kDa CD240D Rh30D 30–32 Erythrocytes – – smooth muscle cells, DC subset kDa CD362 SDC2, syndecan 2, 22 kDa Cell surface proteogylcan that bears heparan sulfate CD267 CD54 ICAM-1 90–110 Endothelial cells, monocytes, lymphocytes (high Adhesion CD11a/CD18, HSPG, HSPG1, SYND2 CD142 45 kDa Monocytes, endothelial cells, keratinocytes, Binding of clotting factor VIIa, initiator of clotting Factor VIIa kDa upon activation) CD11b/CD18, rhinovirus CD241 RhAg, Rh50 50 kDa Erythrocytes Formation of complex with CD47, LW, glycophorin B – epithelial cells CD363 S1PR1, sphingosine-1- 42 kDa Lymphocytes, B cells, NK cells, monocytes/ T cell migration S1P CD55 DAF, Decay accelerating 60–70 Hematopoietic cells, endothelial cells, soluble Complement regulation C3b, C4b, CD97, CD242 ICAM-4 42 kDa Erythrocytes Adhesion, Landsteiner-Wiener blood group CD11a/CD18, CD11b/ phosphate receptor 1, macrophages, endothelial cells, neural CD143 Angiotensin-converting 170 kDa Endothelial cells, epithelial cells, neurons, Angiotensin-converting enzyme, angiotensin II, and Angiotensin I, bradykinin factor kDa in plasma echovirus, coxsackie B CD18, CD51, CD29, EDG1, S1P1, ECGF1, progenitors, neurons, astrocytes, enzyme (ACE) fibroblasts, activated macrophages bradykinin metabolism integrin β5 EDG-1, CHEDG1 oligodendrocytes CD56 NCAM, Leu-19, NKH-1 175–185 NK cells, NKT cells, neurons, some large Adhesion Chondroitin sulfate CD144 VE-cadherin, cadherin-5 130 kDa Endothelial cells, stem cells Adhesion Homotypic binding to kDa granular lymphocyte leukemias, myeloid proteoglycans CD243 MDR-1, p170, P-gp 180 kDa Stem cells, small intestine, kidney stem cells Efflux transporter of various drugs – CD364 PI16, peptidase inhibitor 49 kDa Prostate, testis, ovary, intestine Putative serine protease inhibitor – leukemias CD144, β-catenin 16, dJ90K10.5, CD244 2B4, p38 70 kDa NK cells, T cell subsets, monocytes, basophils, NK cell activation, co-stimulatory ligand for NK and CD48 CD146 MUC18, S-endo 113–118 Endothelial cells, melanomas, follicular DCs, Adhesion Netrin-1 MGC45378, MSMBBP CD57 HNK-1, Leu-7 110 kDa NK cell subsets, NKT cells, CD8 subsets Adhesion CD62L, CD62P mast cells, eosinophils T cells act kDa T cells CD365 TIM-1, HAVCR1, 38 kDa Activated CD4+ T cells Role in Th cell development, involved in hepatitis A virus – CD58 LFA-3 55–70 Hematopoietic, nonhematopoietic cells Adhesion CD2 CD245 p220/240 220–240 Granulocytes, resting peripheral blood Signal transduction, co-stimulation of T and NK cells – CD147 Neurothelin, basoglin, 28 kDa Leukocytes, erythrocytes, platelets, Adhesion, T cell activation, thymocyte cycling CD62E HAVCR-1, TIMD1 entry into cells kDa kDa lymphocytes, platelets, monocytes, NK cells EMMPRIN endothelial cells CD366 TIM-3, HAVCR2, TIMD3 33 kDa Th1 cells, DC subsets Inhibitory receptor on Th1 cells – CD59 Protectin, H19, 1F-5Ag, 19 kDa Hematopoietic, nonhematopoietic cells Blocking of assembly of membrane attack complex C8, C9 CD246 ALK 80 kDa Anaplastic T cell leukemias, small intestine, Brain development, implicated in ALK lymphomas Pleiotrophin, midkine CD148 PTPRJ, PTP-eta 240–260 Granulocytes, monocytes, DCs, Tact cells Tyrosine phosphatase receptor type III – HRF, MAC-inhibitor testis, brain, not on normal lymphocytes CD367 CLEC4A, DCIR, DDB27, 27 kDa pDCs, myeloid cells, B cells Inhibitory receptor on DCs and B cells Mannose/fucose-binding protein, MAC-IP, kDa CLECSF6 lectin CD247 CD3 zeta 16 kDa T and NK cells TCR complex subunit, coupling of antigen recognition – membrane inhibitor of CD150 SLAM 75–95 T cell subsets (high upon activation); B, DC, and Co-stimulation, proliferation, Ig production, measles CD150 reactive lysis, MIRL to signaling kDa endothelial cells virus receptor, T and B cell activation CD368 CLEC4D, MCL, 24 kDa Monocytes, macrophages Endocytic receptor – CD60a GD3 90–120 T cell subsets, platelets, thymic epithelial Co-stimulation – CD248 TEM1, endosialin 175 kDa Endothelial tissue, stromal fibroblasts Tumor progression and angiogenesis – CLECSF8, CLEC-6, CD151 PETA-3 32 kDa Endothelial cells, megakaryocytes, platelets, Adhesion α3β1, α6β1 kDa cells, astrocytes, tumor cells, T cell leukemic epithelial cells CD249 Aminopeptidase A 160 kDa Epithelial cells, endothelial cells Renin–angiotensin system – MPCL lymphoblasts CD152 CTLA-4 33 kDa Tact and Bact cells, Treg cells Negative regulation of T cell co-stimulation CD80, CD86 CD252 OX-40 ligand, gp34 34 kDa Bact cells, cardiac myocytes T cell co-stimulation CD134 CD369 CLEC7A, DECTIN-1, 27 kDa Monocytes, macrophages, DCs, neutrophils, TLR2-mediated inflammatory response β glycans CD60b 9-O-sialyl GD3 – T cell subsets, Bact cells – – CLECSF12, lymphocyteslow CD153 CD30L 40 kDa Neutrophils, B cells, Tact cells, macrophages T cell co-stimulation CD30 CD253 TRAIL, Apo-2L, TL2, 32 kDa Tact cells, many tissues, B cells, NK cells Death CD261, CD262, CD263, CD60c 7-O-sialyl GD3 – T cell subsets – – TNFSF10 CD264, OPG CD370 CLEC9A, HEEE9341, 27 kDa DC subsets, monocyte subsets Endocytic receptor – CD154 CD40L, gp39, TRAP 32–39 Tact cells B cell and DC co-stimulation CD40 UNQ9341, DNGR1 CD61 gpIIIa, Integrin β3 105 kDa Platelets, megakaryocytes, macrophages, Heterodimerizes with CD41- or CD51-mediated adhesion Vitronectin, vWF, kDa CD254 TRANCE, RANKL, OPGL 35 kDa Lymph node, bone marrow stroma, Tact cells Osteoclast differentiation, enhancement of DCs to CD265, OPG endothelial cells to ECM fibrinogen, and fibronectin stimulate naïve T cell proliferation, regulation of Bcl-XL CD371 CLEC12A, CLL-1, 30 kDa Neutrophils, eosinophils, monocytes, DCs Signal transduction – CD155 Polio virus receptor 80–90 Monocytes, macrophages, CD34+ thymocytes Adherens junctions between epithelial cells Polio virus, CD96 expression myeloid inhibitory C-type CD62E E-, ELAM-1, 97, Endothelial Cell rolling, metastasis CD15s, CD162 (PVR) kDa lectin-like receptor LECAM-2 107–115 CD255 TNFSF12, TWEAK, 18, 30–35 Endothelial cells, smooth muscle, fibroblasts Induces apoptosis, promotes angiogenesis CD266 (MICL), DCAL-2 CD156a ADAM8 69 kDa Neutrophils, monocytes Leukocyte extravasation – kDa APO3L kDa CD156b TACE/ADAM 17 100 kDa Broad Cleavage of membrane proteins (TNF, TGF) to generate – CD62L L-selectin, LECAM-1, 74, 95 B cells, naïve and memory T cells, monocytes, Leukocyte homing, tethering, and rolling CD15s,CD34, CD57, CD256 APRIL, TALL-2 16 kDa Monocytes, macrophages B cell proliferation, induction of cell death CD267, CD269 LAM-1 kDa granulocytes, NK cells, thymocytes CD162, GlyCAM-1, soluble forms MAdCAM-1 CD257 BLYS, BAFF, TALL-1 31 kDa Monocytesact, soluble form B cell growth factor and co-stimulator of Ig production CD267, CD268, CD269 CD156c ADAM10 98 kDa Lymphoid organs, peripheral blood leukocytes, Proteolytic cleavage of cell-surface molecules including – Abbreviations act act CD62P P-selectin, GMP-140, 140 kDa Platelets , endothelial cells Adhesion, neutrophil rolling, platelet-neutrophil and CD15s, CD162 cartilage, chondrocytes, fetal liver Notch, TNF, APP, and ephrin-A2 CD258 LIGHT, HVEM-L 28 kDa T cells, immature DCs T cell proliferation CD270, LTβR PADGEM platelet-monocyte interactions DC: HSC: hematopoietic stem cell CD157 BST-1 42–45 Granulocytes, monocytes, B progenitor cells, ADP-ribosyl cyclase and ADP-ribose hydrolase activities, NAD CD261 TRAIL-R1, DR4 57 kDa Tact cells, peripheral blood leukocytes Presence of death domain, apoptosis via FADD and CD253 CD63 LIMP, MLA1, LAMP-3 53 kDa Intracellular on resting platelets and basophils; Lysosomal membrane protein, moves to cell surface Integrins, TIMP-1 kDa endothelial cells, bone marrow stromal cells pre-B cell growth caspase-8 surface on basophilsact, plateletsact, monocytesact, after activation HSA: heat-stable antigen MHC: major histocompatibility complex macrophagesact, granulocytesact, endothelial CD158a p58.1 50–58 NK and T cell subsets Inhibition of NK cell cytolytic activity, MHC class I– HLA-C CD262 TR AIL-R2, DR5 60 kDa Widely expressed, peripheral blood lymphocytes Presence of death domain, apoptosis via FADD and CD253 cells, fibroblasts, smooth muscle cells kDa specific NK receptor caspase-8 NK: natural killer AML: acute myeloid leukemia CD64 FcgRI 72 kDa Monocytes, macrophages, DCs; interferon- or High-affinity receptor for IgG, phagocytosis, and ADCC Monomeric and CD158b p58.2 50–58 NK and T cell subsets Inhibition of NK cell cytolytic activity, MHC class I– HLA-C CD263 TRAIL-R3, DcR1, LIT 65 kDa Peripheral blood lymphocytes Lack of death domain in receptor CD253 G-CSF–activated granulocytes aggregated IgG kDa specific NK receptor Th: T helper HA: hemagglutinin CD264 TRAIL-R4, TRUNDD, 35 kDa Peripheral blood leukocytes Presence of truncated death domain CD253 CD65 VIM2, ceramide- – Granulocytes, monocyte subsets, myeloid Adhesion, extravasation CD62E (E-selectin) CD158b2 KIR2DL3, p58.2 50–58 NK and T cell subsets Inhibition of NK cell cytolytic activity, MHC class I– HLA-C DcR2 dodecasaccharide, leukemias kDa specific NK receptor Treg: regulatory T TCR: T cell receptor CD265 RANK, TRANCE-R, 97 kDa Broad expression, DCs Osteoclastogenesis, T cell–DC interactions CD254 fucoganglioside Type II CD158d KIR2DL4 41 kDa NK and T cell subsets Inhibition of NK cell cytolytic activity, MHC class I– HLA-G ODFR PBMC: peripheral blood mononuclear cell BCR: B cell receptor CD65s VIM2, sialylated CD65 – Granulocytes, monocytes, myeloid leukemias Phagocytosis – specific NK receptor CD266 TWEAK-R, FGF- 14 kDa Heart, placenta, and kidney; human umbilical Cell–matrix interactions; growth and migration of CD255 CD66a BGP-1, NCA-160, 160–180 Neutrophils, epithelial cells Adhesion CD62E, CD66a, CD66c, CD158e KIR3DL1 70 kDa NK and T cell subsets Inhibition of NK cell cytolytic activity, MHC class I– HLA-B inducible 14 vein endothelial cells endothelial cells CEACAM1 kDa CD66e specific NK receptor CD267 TACI, TNFR, SF13B 32 kDa B and Tact cells B cell development CD256, CD257 CD158f KIR2DL5 50–58 NK and T cell subsets Inhibition of NK cell cytolytic activity, MHC class I– HLA-B kDa specific NK receptor CD268 BAFFR, TR13C 25 kDa B cells Mature B cell survival CD257

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