Human CD Antigens
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Human CD antigens Molec. Molec. Molec. Molec. Antigen Alternate names Expression Function Ligand/receptor Antigen Alternate names Expression Function Ligand/receptor Antigen Alternate names Expression Function Ligand/receptor Antigen Alternate names Expression Function Ligand/receptor mass mass mass mass CD1a T6, Leu-6, R4, HTA1 49 kDa Cortical thymocytes, Langerhans cells, DCs Antigen presentation with β-2-microglobin CD1-restricted TCR CD66b CD67, CGM6, NCA-95, 95–100 Granulocytes Adhesion, neutrophil activation CD66c CD158g KIR2DS5 – NK and T cell subsets Activation of NK cell cytolytic activity, MHC class I– – CD269 BCMA, TNFRSF13B 20 kDa Mature B cells (membrane and perinuclear) B cell survival and proliferation CD256, CD257 CEACAM8 kDa specific NK receptor CD270 TNFRSF14, tumor 30 kDa Broad, Bhi cells Viral entry, signal transduction CD258, CD272, HSV-1, CD1b R1, T6 45 kDa Cortical thymocytes, Langerhans cells, DCs Antigen presentation with β-2-microglobin CD1-restricted TCR CD66c NCA, CEACAM6 90 kDa Neutrophils, colon carcinoma Adhesion CD62E, CD66a, CD66b, CD158h KIR2DS1 50 kDa NK and T cell subsets Activation of NK cell cytolytic activity, MHC class I– HLA-C necrosis factor receptor HSV-2 CD1c BDCA-1, R7, T6, M241 43 kDa Cortical thymocytes, Langerhans cells, DCs, B Antigen presentation with β-2-microglobin CD1-restricted TCR CD66c, CD66e specific NK receptor superfamily, member cell subsets 14 (herpes virus entry CD66d CGM1, CEACAM3 35 kDa Granulocytes Putative role in cell adhesion and signaling – CD158i KIR2DS4 35, 58 NK and T cell subsets Activation of NK cell cytolytic activity, MHC class I– HLA-C mediator), TR2, ATAR, CD1d R3 49 kDa Intestinal epithelial cells, B cell subsets, Antigen presentation with β-2-microglobin CD1-restricted TCR kDa specific NK receptor HVEA, HVEM, LIGHTR low monocytes , DCs CD66e CEA, CEACAM5 180–200 Colon epithelial cells, colon cancer Adhesion CD66a, CD66c, CD66e CD158j KIR2DS2 50 kDa NK and T cell subsets Activation of NK cell cytolytic activity, MHC class I– HLA-C CD271 NGFR, p75(NTR) 45 kDa Neurons (Schwann cells, growing neurites), bone Tumor suppressor; cell survival and death NGF, BDNF, NT-3, NT-4 kDa CD1e R4 28 kDa DCs Antigen presentation with β-2-microglobin – specific NK receptor marrow mesenchymal cells CD66f PSG, Sp-1 54–72 Pregnancy-specific glycoprotein, placental Immune regulation, protection of fetus from maternal – CD2 T11, LFA-2, SRBC-R 50 kDa Thymocytes, T cells, NK cells Adhesion, T cell activation CD58 CD158k KIR3DL2 70 kDa NK and T cell subsets Inhibition of NK cell cytolytic activity, MHC class I– – CD272 BTLA 33 kDa Lymphocytes, macrophages, progenitor B and Inhibitory response CD270 kDa syncytiotrophoblasts, fetal liver immune system specific NK receptor T cells, mature BM DCs CD2R T11-3 50 kDa Tact cells Activation-dependent form of CD2 – CD68 Macrosialin, GP110 110 kDa Intracellularly in monocytes, macrophages, Scavenger receptor, antigen processing, phagocytosis Oxidized LDL CD158z KIR3DL3 NK and T cell subsets Inhibition of NK cell cytolytic activity, MHC class I– – CD273 B7DC, PD-L2, 25 kDa DC subsets, monocytes, macrophages Co-stimulation or suppression of T cell proliferation CD279 CD3ε T3 20 kDa T cells, thymocyte subsets With TCR, TCR surface expression/signal transduction – neutrophils, basophils, large lymphocytes, mast specific NK receptor PDCD1L2 cells, DCs, myeloid progenitors, liver CD4 T4, Leu3a 55 kDa Thymocyte subsets, T cell subsets, monocytes, MHC class II co-receptor, HIV receptor, MHC class II, HIV CD159a NKG2A 43 kDa T cell subsets, NK cells With CD94, NK cell receptor HLA-E CD274 B7-H1, PD-L1 33 kDa Leukocytes, broad Co-stimulation of lymphocytes CD279 macrophages T cell differentiation/activation CD69 Activation inducer 28, 32 Tact, Bact, and NKact cells; granulocytesact, resting Signal transduction – marker (AIM), very early kDa BM memory T cells, thymocytes, Langerhan DCs CD159c NKG2C 40 kDa NK cells With MHC class I HLA-E molecules, forms heterodimer HLA-E CD275 B7-H2, ICOSL, B7-RP1, 60 kDa B cells, DCs, monocytes Co-stimulation, cytokine production CD278 CD5 T1, Tp67, Leu1, Ly-1 67 kDa Thymocytes, T cells, B cell subsets, B cell TCR or BCR signaling, T and B cell interaction CD72 activation (VEA) with CD94 GL50 chronic lymphocytic leukemia act act CD160 BY55 27 kDa NK and T cell subsets Co-stimulation HLA-C CD70 Ki-24, CD27L, TNFSF7 50, 70, B and T cells T and B cell co-stimulation CD27 CD276 B7-H3 40–45 In vitro–cultured DCs and monocytes, Tact cells, Co-stimulation, T cell activation – CD6 T12 100–130 Thymocytes, T cells, B cell subsets T cell differentiation/co-stimulation CD166 90, 160 CD161 NKR-P1A 40 kDa NK cell–mediated cytotoxicity Lectin-like transcript 1 kDa mammary tissue kDa kDa T cell subsets (TH17, CD8 subsets, γδ, CD3 thymocytes), NK cells CD277 BT3.1, butyrophilin SF3 56 kDa T, B, and NK cells; monocytes, DCs, endothelial T cell activation – CD7 Leu9, gp40 40 kDa Hematopoietic progenitors, thymocytes, T cells, T cell co-stimulation K12 in epithelial cells CD71 Transferrin receptor 95 kDa Proliferating cells, reticulocytes, erythroid Iron uptake Transferrin A1, BTF5 cells, CD34+ cells, tumor cell lines, CD14+ cells NK cells (TFR), T9 precursors CD162 PSGL-1 120 kDa Monocytes, neutrophils, granulocytes, Adhesion, rolling CD62P, CD62E, CD62L peripheral T cells, Blow cells, and a subset of CD278 ICOS, AILIM 55–60 Tact and Th2 cells T cell co-stimulation CD275 CD8a T8, Leu-2, Ly-2 32–34 Thymocyte subsets, T cell subsets, NK cells MHC class I co-receptor, receptor for some mutated MHC class I + CD72 Lyb-2 42 kDa B cells, follicular DCs B cell proliferation CD5, CD100 CD34 hematopoietic progenitor cells (HPCs) in kDa kDa HIV-1, T cell differentiation/activation bone marrow CD73 NT5E, Ecto-5'- 69 kDa B cell subsets, Treg subsets, epithelial cells Ecto-5´-nucleotidase, nucleoside uptake, AMP CD279 PD1, SLEB2 55 kDa Tact and Bact cells Autoimmune disease and peripheral tolerance, CD273, CD274 CD8b Lyt-3 30–32 Thymocyte subsets, T cell subsets MHC class I co-receptor, receptor for some mutated MHC class I nucleotidase T cell co-stimulation, lymphocyte adhesion CD163 Hemoglobin scavenger 130 kDa Monocytes, macrophages Clearance of hemoglobin Hemoglobin checkpoint in tumors kDa HIV-1, T cell differentiation/activation receptor, macrophage CD74 Ii, invariant chain, 33, 35, B cells, macrophages, monocytes, Langerhans MHC class II traffic and function, binding to MIF, MIF marker CD280 ENDO180, UPARAP 180 kDa Chondrocytes, fibroblasts, endothelial cells, Collagen matrix remodeling and endocytic recycling Collagen, mannose, CD9 p24, MRP-1, DRAP-27 22–27 Pre-B cells, eosinophils, basophils, platelets, Cellular adhesion and migration PSG17, TGF-α HLA class II 41, 43 cells, DCs, Tact cells maturation of follicular B cells act macrophages fucose on glycans kDa T cells, neurons, glial cells in the peripheral histocompatibility kDa CD164 MGC-24, MUC24 80 kDa Hematopoietic progenitors, cell–stromal cell Putative role in intracellular adhesion – nervous system antigen γ chain, HLA- interaction CD281 TLR1 90 kDa Low levels in peripheral blood mononuclear Innate immunity with TLR2 Lipoprotein, lipopeptide cells, monocytes, possibly DCs CD10 CALLA, NEP, gp100 100 kDa B cell precursors, T cell precursors, neutrophils, Zinc-binding metalloproteinase, B cell development DR antigens-associated invariant chain CD165 AD2, gp37 42 kDa Mesothelial cells, T-cell acute lymphoblastic Putative role in intracellular adhesion – acute lymphoblastic leukemias leukemia (T-ALL) cells, epithelial cells, CD282 TLR2 90 kDa Monocytes, neutrophils, upregulated in Response to bacterial lipoproteins, innate immunity Lipoproteins and glycans, CD75 Lactosamines 67, 85 B cell subsets, epithelial cells Lactosamines – fibroblasts, platelets macrophages pathogen-associated CD11a LFA-1, integrin L 180 kDa Lymphocytes, granulocytes, monocytes, CD11a/CD18 receptor for ICAM-1, -2, and -3; CD50, CD54, CD102 kDa molecular patterns macrophages intercellular adhesion; T cell co-stimulation CD166 ALCAM 105 kDa Neurons, monocytes, epithelial cells, fibroblasts, Adhesion CD6 CD75s Sialylated CD75 – B cell subsets, T cell subsets -2,6-sialylated lactosamines (previously CDw75 and – Tact cells CD283 TLR3 100 kDa Monocyte-derived DCs (may be intracellular) Innate immunity dsRNA CD11b Mac-1, integrin M 170 kDa Myeloid cells, NK cells iC3 adhesion CD54, CD102, iC3b, α CDw76) fibrinogen, CD23 CD167a Discoidin domain 120 kDa Epithelial cells, myoblasts Tyrosine kinase, adhesion to collagen Collagen CD284 TLR4 100 kDa Peripheral blood mononuclear cells (weak in Innate immunity, association with MD2 and CD14 LPS CD77 Gb3, Pk blood group Germinal center B cells, Burkitt’s lymphomashigh, Apoptosis Shiga toxin, verotoxin 1 receptor family-1 (DDR1) monocytes, immature DCs, and neutrophils) CD11c p150, 95, CR4, integrin 150 kDa DCs, macrophages, monocytes, granulocytes, iC3 adhesion CD54, iC3b, fibrinogen, follicular lymphomaslow X, LeuM5 NK cells, T and B cell subsets, leukemia cells CD23 CD168 Hyaluronan-mediated 84–88 Monocytes, T cell subsets, thymocyte subsets, Adhesion, tumor migration, metastasis – CD285 TLR5 98 kDa DCs, monocytes, epithelial cell subsets Innate recognition to bacteria Flagellin CD79a Ig, MB-1 33, 45 Myeloid subsets Component of BCR, BCR surface expression, and signal – motility receptor kDa intracellularly in breast cancer cells CD13 Aminopeptidase N, APN, 150–170 Monocytes, granulocytes, some macrophages, Zinc-binding metalloproteinase, antigen processing, Coronavirus