Global Enterprise & Partnership Advancing Patient-Centered Science

2011 Progress Report EXPANDING GLOBAL RESEARCH & PARTNERSHIP

Table of Contents The Prostate Cancer Foundation (PCF) is the world’s largest private funder of prostate cancer research, accelerating the Founder-CEO Letter 1 world’s most promising research and delivering better patient 95 PCF Young Investigators 3 outcomes. In the past 2 years, 5 new medicines that extend the

The Promise of MDV3100 6 lives of men with metastatic prostate cancer have been approved by the FDA. PCF initiated and supported academic treatment China Scientists Join PCF science that fast-forwarded every one of these approvals. Global Enterprise 8 PCF China Committee members visited the Beijing Genomics Institute in Shenzhen in March 2012. Irish YIs Pursue Biomarkers Since 1993, PCF donors have given over $479 million to fund more of Aggressive Cancers 10 than 1,600 research projects at nearly 200 institutions in 15 Dear Friends: 2011 By the Numbers 12 countries. Our continually expanding global research enterprise Men diagnosed with prostate cancer have more • Ipilimumab (Yervoy by Bristol-Myers Squibb), an brings together the brightest minds in prostate cancer research Special Interview: A Decade reason for hope than ever before. Progress funded immunotherapy that has already proven effective of Safeway Support 14 and other scientific areas to collaborate across borders and and accelerated by the Prostate Cancer Foundation for melanoma patients and may soon be available institutional lines. Together, we spark and accelerate innovative means they can expect to live longer, more for prostate cancer patients. Special Interview: productive lives. We are closer than ever to living in Movember’s Unique DNA 18 projects that deliver life-saving results. an age when prostate cancer is considered a chronic • MDV3100 (Enzalutamide by Medivation and Astellas 2011 Donor Roll 21 condition, not a life-threatening disease. Pharma), which inhibits the androgen signaling PCF is widely acknowledged as the source of hope for more than 16 pathway and has shown a 37 percent reduction in A Patient’s Appeal for million men and their families around the world who are affected Just two decades ago, the outlook for this disease the risk of death compared to placebo; and Support 29 by prostate cancer. In 2011, our patient-centered science made was much different. In the early 1990s, many • XL184 (Cabozantinib by Exelixis), an orally important advances toward overtreating less and curing more so health analysts were predicting that—with the Supporting Cures 30 administered tyrosine kinase inhibitor (TKI) that we can ultimately eliminate death and suffering from prostate aging of the baby boomers—prostate cancer would Financial Statements 31 soon kill far greater numbers of American men shows unprecedented promise in reducing bone cancer for every man affected. In 2012, our progress continues. than the more than 40,000 who succumbed each metastases for many patients; PCF Supporting Partners 35 year. Thanks to research here and around the Thinking Globally Board of Directors & 5-Year Revenue History 2011 Spending world—and to increased awareness, both largely Leadership Team 37 $Millions Per Dollar driven by PCF—the reality is much brighter. Today, PCF expanded its global research network and prostate cancer claims at least 40 percent fewer partnerships in 2011 through two important steps: the lives than had been predicted. establishment of the Coalition to Cure Prostate Cancer Expanding Global (CCPC) in Canada and the launch of PCF China. Research & Partnership And the outlook gets brighter every day. Over the past Since our founding, we have two years, four new treatments were approved to treat The Canadian entity will monitor national research worked to build a vibrant global prostate cancer: Provenge (Dendreon), Zytiga (Janssen progress at Canadian cancer centers and universities, and research enterprise by Pharmaceuticals, a Johnson & Johnson company), it will provide benefits for Canadian donors, enabling us to investing in human capital and Xgeva (Amgen) and Jevtana (Sanofi-Aventis). Today, 97 use transformational gifts to expand research efforts. strategic partnerships to fast- drugs are in Phase I or II trials, and four more PCF- forward the ongoing supported therapeutics are rapidly working their way Our China initiative will identify, fund and promote advancement of prostate cancer through Phase III clinical trials: innovative research projects benefitting men around the science. We continue to expand world. China historically had low rates of the disease, these efforts and celebrate the • Alpharadin (radium-223 chloride by Algeta and but the number of new cases is rising in urban centers recent establishment of the Coalition to Cure Prostate Bayer Pharma AG), a novel radiotherapy that where Chinese men are adopting more Westernized Cancer in Canada and our PCF disperses small amounts of radiation to kill lifestyles; and when the disease does strike, it’s often China initiatives. metastasized cells while sparing healthy cells; more virulent and aggressive. The Chinese government

2011 progress report 1 is thus committed to investing in and expanding its 1,600 patient-centered research projects in genomics, prostate cancer research efforts; not only is this good epigenetics, drug development, biomarkers, immunology, 95 PCF Young Investigators in 7 Countries for China, but it also provides a unique opportunity to imaging technologies and nutritional research. study the effects of diet and environmental changes on Changing the Future of Prostate Cancer Research prostate cancer incidence worldwide. In March 2012, Thanks to generous support, last year PCF we presented our first two Young Investigator awards invested in 10 new Challenge Awards, 14 Creativity to Chinese scientists at the inaugural China Prostate Awards and 24 new Young Investigator Awards. In 2011 and early 2012, through the generosity of its donors, PCF added 45 new Young Cancer Symposium in Beijing. Moving forward, we’ll By early 2012, we announced 21 additional Young Investigators (YIs) to its global research enterprise. These young scientists are bringing fresh work with established Chinese institutions such as Investigators, bringing the total since 2007 to 95. The ideas and approaches to bear on pivotal aspects of prostate cancer research. They represent the the Chinese Urological Association to expand cancer innovative thinking of our Young Investigators—and future leaders in research. In total, PCF has funded nearly 100 Young Investigators since 2007. research and encourage sustainable collaborations. their drive to achieve the impossible—continues to accelerate progress against prostate and other Closer to home, PCF announced the first prostate cancers. We’re proud to have cultivated one of cancer reasearch Dream Teams in April 2012, funded the largest and most productive teams of cancer Advances in healthcare have accounted for as much Three generations of PCF YIs have built a foundation jointly by PCF and Stand Up to Cancer, in association researchers ever assembled. as half of all economic growth in the past several of knowledge upon which future scientists and with the American Association for Cancer Research. decades. Today, investments in medical research clinicians can expand discovery. They represent a These three-year, $10 million Translational Cancer We Are Not Letting Up promise the greatest long-term economic stimulus distinguished community of scientific mentors who and the greatest hope for patients. As previously can guide and inspire the work of future generations Research Grants provide funding to address therapeutic We continue to advocate for increased national stated, the National Cancer Institute estimates that of cancer researchers. interventions in advanced metastatic prostate cancer. commitments to medical research where, with This global competition resulted in the selection of two if research could reduce the cancer death rate by 20 greater investment, we can save millions of lives and Here are a few recent examples of Young teams of researchers: one led by Dr. Charles Sawyers percent, it would add $20 trillion to the U.S. economy. trillions of dollars. For example, the National Cancer Investigator discoveries that are improving clinical at New York’s Memorial Sloan-Kettering Cancer Center Institute estimates that a 20 percent reduction in This kind of progress often emerges from the fertile practice for this disease. (MSKCC) and Dr. Arul Chinnaiyan at the University of cancer mortality would be worth $20 trillion to the minds of young researchers. Einstein, Salk, Curie, Michigan, Ann Arbor and the second led by Dr. Eric U.S. economy—far more than the national debt. Watson, Newton, Galileo and others reshaped history Small at UCSF and Dr. Owen Witte at UCLA. All four • Scott Tomlins, MD, PhD (2007 YI), at the by age 30. Yet, today’s young medical investigators University of Michigan, developed a simple received PCF research awards earlier in their careers. PCF remains a source of hope for all men and their receive only one percent of federal research funding, families. With your continued support, we will urine test that can detect cancer earlier down from 10 percent in 1980. Last year, more federal and eliminate thousands of unneeded The Michigan-MSKCC Dream Team will focus on precision move patient-focused science forward even faster. therapy for metastatic prostate cancer. The UCSF-UCLA grants went to researchers older than 70 than to biopsies each year. Together, we can and will speed progress toward those younger than 30. team, funded in part by Movember—an annual campaign ending the suffering and death caused by this that raises awareness and funding for men’s health devastating disease. Since 1993, the Prostate Cancer Foundation has • Steve Cho, MD (2008 YI), at Johns Hopkins issues—will investigate pathways of treatment resistance supported three generations of young investigators School of Medicine, created a molecular and identify new treatment approaches. We are pleased With sincere appreciation, dedicated to accelerating scientific discovery. The imaging technology that can see smaller that Paul Villanti, Movember’s first chairman, joined our first two generations, sponsored between 1993 and tumors earlier than current CT and x-ray Board of Directors in 2011. 2006, have been involved in every significant prostate imaging systems. cancer breakthrough. Many of them now lead major Our emphasis on global collaboration and our support medical centers. of public-private partnerships continue to accelerate Michael Milken Jonathan W. Simons, MD • Himisha Beltran, MD (2010 YI), at Weill discovery and expand access to patient information, Founder and Chairman President and In 2007, PCF launched a third generation of YIs with a Cornell Medical College, discovered an leading to highly personalized treatment plans so we Chief Executive Officer goal of funding 100 researchers by the end of 2012. unanticipated pathway (aurora kinase) active David H. Koch Chair can overtreat less and cure more. in the most lethal variety of high-grade Young Thinkers Delivering prostate cancer and is developing new New Donors, New Ways to Support PCF specific treatments with drugs in development Game-Changing Discoveries targeting prostate, colon and lung cancers. The PCF team enhanced our digital footprint considerably in 2011. Unique visits to pcf.org were up 10 PCF YIs, typically under age 35, are innovative percent. Facebook followers were up 30 percent, and research leaders who are moving prostate cancer • Robert Den, MD (2010 YI), at Thomas PCF reached more than 5 million through its Facebook research toward cures. Our Young Investigator Jefferson University, deciphered a cause of community. Our list of Twitter followers increased 10 Awards offer career and project support for early resistance to radiation therapy. percent. The world is taking note of our work. career researchers who have achieved junior faculty positions and are committing their lives to the In 2011, 54,000 PCF donors—including 24,000 new field of prostate cancer. Each YI is mentored by a supporters—contributed $43.1 million to maintain the recognized senior investigator. These are not just novel ideas. They are real, momentum of discovery. Since 1993, 170,000 donors In the first part of 2012, we announced our first two life-saving discoveries made possible by our have contributed $479 million to support more than Jonathan Simons, MD (left), and Mike Milken at the launch of PCF China in Beijing YIs in China and four new YIs in Canada. generous supporters.

2 2011 progress report 2011 progress report 3 45 new young investigators in 2011 & 2012 Barbara Lelj-Garolla Di Bard, PhD – 2012 Karen Sfanos, PhD – 2012 Vancouver Prostate Centre Johns Hopkins School of Medicine Donor: Pier Luigi Tolaini Donors: R. Christian B. and Felicia Evensen Joshi Alumkal, MD – 2011 Terence Friedlander, MD – 2012 Oregon Health and Science University, University of California, San Francisco Shyh-Dar Li, PhD – 2012 Yusuke Shiozawa, MD, PhD – 2011 University of Michigan, Ann Arbor Knight Cancer Institute Donor: Lowell Milken Ontario Institute for Cancer Research Donor: Todd Boehly Donors: John and Jana Scarpa– Donor: Pier Luigi Tolaini The John F. Scarpa Foundation Matthew Galsky, MD – 2012 Mount Sinai School of Medicine Tamara Lotan, MD – 2011 Timothy Showalter, MD – 2011 David L. Bajor, MD – 2011 Donor: Mortimer Sackler Johns Hopkins School of Medicine Thomas Jefferson University Donor: Ben Franklin Award University of Pennsylvania Donor: Elaine Wynn Donors: Reina and Emilio Bassini Andrew Goldstein, PhD – 2011 University of California, Los Angeles Heather Montie, PhD – 2012 Abhishek Srivastava, MD – 2011 Christopher Barbieri, MD, PhD – 2011 Donors: Todd Boehly, Bonnie Pfeifer Evans, Thomas Jefferson University, Weill Cornell Medical College Donor: The Richard S. and Karen LeFrak Weill Cornell Medical College Joe and Ali Torre Jefferson Medical College Charitable Foundation Donors: Peter and Laurie Grauer Donors: John A. and Carol Moran Michael Haffner, MD – 2011 Tarek Bismar, MD – 2012 Johns Hopkins School of Medicine David Mulholland, PhD – 2012 Barry Taylor, PhD – 2011 Memorial Sloan-Kettering Cancer Center University of Calgary Donors: Ellen and Richard V. Sandler University of California, Los Angeles Donor: Reggie’s Team Donor: The Robbins Family Donor: Lori Milken Corinne Joshu, PhD – 2011 Hans David Ulmert, MD, PhD – 2012 John Chadwick Brenner, MSc, PhD – 2011 Johns Hopkins School of Medicine Paul Nguyen, MD – 2012 Memorial Sloan-Kettering Cancer Center University of Michigan, Ann Arbor Donor: Kovler Family Foundation Dana-Farber Cancer Institute, Donors: David H. and Julia Koch Donors: Cayre Family Foundation, Harvard University Mr. and Mrs. Albert Fuss, Robert Kraft Anthony Michael Joshua, MBBS, PhD – 2012 Donor: Heritage Medical Research Institute Princess Margaret Hospital Alexander Wyatt, PhD – 2012 Vancouver Prostate Centre Dimple Chakravarty, PhD, DVM – 2012 Donor: Pier Luigi Tolaini Kathryn L. Penney, ScD – 2011 Donor: Pier Luigi Tolaini Weill Cornell Medical College Harvard Medical School Donor: Sternlicht Family Foundation Kalpana Kannan, PhD – 2012 In Honor of Joel M. Pashcow Baylor College of Medicine Kexin Xu, PhD – 2011 Yu Chen, MD, PhD – 2011 Donors: Leon and Debra Black Antoinette Perry, PhD – 2011 Dana-Farber Cancer Institute, Harvard University Donor: Progenics, in Honor of Dr. Stephen Morris Memorial Sloan-Kettering Cancer Center Trinity College Dublin, Institute of Donors: David H. and Julia Koch Maria Karlou, PhD – 2011 Molecular Medicine Donor: The Handler Family Fund University of Athens Timothy Yap, MBBS, PhD – 2011 Matthew Cooperberg, MD – 2011 Donor: PCF-Hellenic Fund The Institute of Cancer Research, The Royal Marsden Hospital University of California, San Francisco Dana Rathkopf, MD – 2011 Donors: The Honorable Earle I. and Carol Mack, Donors: Judy and Ronald Baron Stacey Kenfield, ScD – 2012 Memorial Sloan-Kettering Cancer Center Donor: Lori Milken B. Scott Minerd Brigham and Women’s Hospital, Farshid Dayyani, MD, PhD – 2011 Harvard University The University of Texas Donor: Michael Milken Shancheng Ren, MD, PhD – 2012 Yuxi Zhang, MD, PhD – 2012 First Hospital of China Medical University MD Anderson Cancer Center Shanghai Changhai Hospital Donor: Shmuel Meitar Donor: John H. Tyson Hung-Ming Lam, PhD – 2012 Donor: Shmuel Meitar University of Cincinnati Junjie Feng, PhD – 2012 Donor: Steve Wynn Sameek Roychowdhury, MD, PhD – 2011 Wake Forest University University of Michigan, Ann Arbor Donors: John A. and Carol Moran Jihyun Lee, PhD – 2011 Donor: Foundation 14 University of Pennsylvania Stephen Finn, MBBS, PhD – 2012 Donor: Ben Franklin Award Luke Selth, PhD – 2012 For more information on PCF Young Investigators Trinity College Dublin, Institute of University of Adelaide, Dame Roma Mitchell and their funded projects, go to: Molecular Medicine Richard Lee, MD, PhD – 2011 Cancer Research Laboratories www.pcf.org/YoungInvestigators Donor: Foundation 14 Donor: Steve Wynn Massachusetts General Hospital Cancer Center Donors: Alexandra M. and Steven A. Cohen

4 2011 progress report 2011 progress report 5 PCF’s Venture Philanthropy and Global Clinical Trials Network Deliver the Promise of MDV3100

MDV3100 (Enzalutamide) recently moved out of Phase III clinical trials at the close of 2011 and is awaiting approval from the U.S. Food and Drug Administration (FDA). This new therapeutic for inhibiting the androgen receptor has five times the affinity of Casodex for binding to androgen receptors and holds promise for men who have failed hormone and chemotherapies. PCF support through every step of development—from idea through clinical trials—is helping this new drug make its way to castration-resistant patients in record time. It is a unique story of investing in and fostering academic and commercial cooperation.

Fast on the heels of five new prostate cancer “The clinical advancement of MDV3100 is one of the drugs approved for patients with advanced disease most important events in the history of prostate in the past two years, a promising new drug, cancer research and PCF,” says Howard Soule, MDV3100 (developed by Medivation and partner, PCF’s chief scientist. “For men whose disease Astellas) could soon be approved by the FDA. The has progressed since receiving hormone and development of MDV3100 began with a PCF Board chemotherapies, MDV3100 should provide a new of Directors meeting at UCLA where the world’s treatment option to extend survival.” top cancer scientists in leukemia were invited to apply for funding and work on prostate cancer. What Both MDV3100 and Zytiga are being evaluated in ensued was a 2002 competitive CaP CURE (PCF) Phase III trials in patients who have failed hormone research award to Owen Witte, MD, Michael Jung, therapy but have not undergone chemotherapy. PhD, and Charles Sawyers, MD. There, Michael Results are not yet available, but the trend will Jung, a professor in organic chemistry, discovered be to investigate both medications earlier in the the compound after working with Dr. Sawyers on the natural history of the disease. They are also being mechanisms of androgen resistance. tested in the pre-surgical setting (funded by PCF Challenge Awards) with curative intent for primary MDV3100 has a novel mechanism of action, inhibiting high-risk prostate cancer. the androgen receptor (AR) at three distinct points in the signaling pathway. MDV3100 directly blocks the Many additional clinical trials are needed to activity of the androgen receptor, the engine of prostate determine the optimal sequence or combination of cancer progression. In its Phase III clinical study, Zytiga and MDV3100 and to determine if combinations MDV3100 increased median survival by 4.8 months, of MDV3100 with other experimental targeted providing a 37 percent reduction in the risk of death therapies are synergistic. compared to placebo. Some patients have very durable remissions well beyond average, while some do not From Test Tube to Patients Urgently respond. Thus, the median survival is a statistical The research and development period for MDV3100 description for the FDA and clinical researchers. has been a comparatively short nine years. PCF’s total investment of $14.75 million in MDV3100, supported by The MDV3100 clinical trial marks the second time the the PCF’s investment in the Prostate Cancer Clinical trial of a prostate cancer drug was stopped early and the Trials Consortium and the guidance of PCF-funded drug was offered to patients in the placebo arm due to its researchers, Dr. Howard Scher (Memorial Sloan- effectiveness and patient tolerance. The first incidence Kettering Cancer Center, New York) and Dr. Johann was with Zytiga (abiraterone) which was approved in de Bono (The Royal Marsden Hospital, London), April 2011. Zytiga affects prostate cancer progression by accelerated the Phase III development of the drug. shutting off the supply of fuel—testosterone. Having both FDA approval of MDV3100 is expected within a year. drugs available to patients will represent an important Michael Jung, PhD, at UCLA’s Molecular advance in patient treatment. Sciences Center Photography: Bliese Paul

6 2011 progress report DONOR PERSPECTIVE CHINESE SCIENTISTS JOIN PCF’S David Judy Fleischer GLOBAL RESEARCH enterprise

In a part of the world that has historically experienced low rates of prostate cancer— including entire regions where prostate cancer appeared to be nonexistent—China is now reporting increases in incidence in China’s urban areas. In Shanghai alone, new cases are increasing at a rate of 13 percent annually. This, coupled with a government commitment to stem the rise of new cases, makes China a unique area in which PCF can support research and expand its investments in human capital.

In August 2011, the Dr. Ren has identified Prostate Cancer a novel gene fusion in Foundation launched prostate cancer patients its PCF China initiative. in China that results The program is designed in the juxtaposition to identify, fund and of the SDK1 and the promote innovative AMACR genes. He research projects proposes to study the within China. Working relative prevalence and with leading Chinese clinical significance organizations, such as of this SDK1-AMACR the Chinese Urological Chinese cancer research scientists met with PCF Chief Science gene fusion in Chinese Association, PCF China Officer, Howard Soule, PhD, at the first Annual PCF China Scientific patients and to will stimulate and help Symposium Awards Ceremony in Beijing, China. investigate this gene build the prostate cancer fusion as a novel, non- research enterprise in China as well as encourage invasive marker for the detection of prostate cancer sustainable collaborations throughout the PCF in Chinese patients. TMPRSS2-ERG gene fusions that worldwide knowledge exchange. In March, PCF China are a hallmark of prostate cancer in approximately 50 hosted its first Annual Prostate Cancer Symposium at percent of Caucasian patients occur at a much lower Peking University’s Wu Jieping Urology Center, featuring frequency of approximately 15-20 percent in prostate scientific presentations and discussions with Chinese cancer patients in China. cancer scientists and their American counterparts. Dr. Zhang will investigate why most prostate cancer PCF China also announced its first Young Investigator patients ultimately become resistant to hormone therapy. (YI) awards in China featuring three-year grants for This stage of prostate cancer is termed castration- two Chinese scientists, Shancheng Ren, MD, PhD, at resistant prostate cancer (CRPC) and increases risk for Shanghai Changhai Hospital and Yuxi Zhang, MD, PhD, death. Recently identified prostate cancer-specific stem at The First Hospital of China Medical University. These cells (PrCSC) may play a major role in the development of two YIs are sponsored by Shmuel Meitar, a PCF Board treatment resistance and progression of prostate cancer. member who saw the potential of China to contribute important solutions to prostate cancer research. Studies of PrCSCs have shown that they are capable of self-renewal, possess enhanced tumor-initiating “PCF-supported Young Investigators have changed the capabilities, do not rely on androgens for growth and scope of prostate cancer research, advancing treatment survival and are more resistant to treatment than sciences and improving the lives of patients worldwide. other cancerous cells. Dr. Zhang has identified a sub- It is an honor to support PCF’s expansion and sponsor population of PrCSCs that increase in numbers upon these scientists in China,” says our donor. “They will treatment with androgen deprivation therapy (ADT). help accelerate our mission of responding to the ever- Dr. Zhang proposes to study prostate cancer-specific changing research landscape and to fund high-risk, stem cells that lead to the development of disease high-patient benefit programs that also facilitate data progression and treatment resistance. These studies Yuxi Zhang, MD, PhD, at The First Hospital sharing through PCF’s global scientific network.” will help in the identification of potential drug targets of China Medical University in Shenyang that prevent CRPC development. City (left) and Shancheng Ren, MD, PhD, at

Image Credit: Shanghai skyline at night – shuiyuansu, istock photography Shanghai Changhai Hospital

8 2011 progress report IRISH YOUNG INVESTIGATORS PURSUE biomarkers of AGGRESSIVE CANCERs

First-time PCF Young Investigators in Ireland are researching molecular differences between aggressive and low Gleason-grade cancers.

From its inception, PCF has cancer diagnostics and focused heavily on investing patient risk stratification. in human capital, particularly Dr. Perry is developing new in the form of young scientists blood and urine biomarkers with innovative approaches for the non-invasive and tenacity. Our support of detection of aggressive nearly 100 young investigators prostate cancer. Dr. Perry’s around the world since 2008 goal of identifying epigenetic underscores this commitment. patterns of DNA alterations that are specifically One of the biggest challenges associated with aggressive in diagnosing and treating prostate cancers holds the more than 27 known promise for alleviating the varieties of prostate cancer burden of overtreatment for is discerning between the Drs. Stephen Finn, and Antoinette Perry, at Trinity College’s Institute of Molecular Medicine in Dublin indolent disease. most aggressive forms of this cancer, varieties that Another PCF Young Investigator at Trinity College’s represent intermediate levels of aggressiveness, Institute of Molecular Medicine is Stephen Finn, MBBS, and those that are indolent, or non-life-threatening. PhD, sponsored by PCF donor Steve Wynn. Genetic The ability to distinguish between these would information flows outward from our genes on DNA as greatly reduce overtreatment, sparing men from the follows: gene (DNA) to RNA to protein. This sequence of side effects of treatment, and enable us to deliver genetic transcription is known as the Central Dogma. personalized treatments that are best suited to a RNAs, the products of DNA, either give rise to proteins specific genotype or variety. called coding RNAs or non-coding RNAs. Despite their name, non-coding RNAs (ncRNAs) are functional Two of PCF’s newest Young Investigators, the first molecules that perform specialized roles in the cell, such ever in Ireland, are working on this very problem at as regulation of gene expression. Recent reports have Trinity College in Dublin. provided evidence for the role of small, non-coding RNAs Antoinette Perry, PhD, at Trinity College’s Institute in the development and progression of prostate cancer. of Molecular Medicine—using a award sponsored Dr. Finn proposes to identify those non-coding by The Handler Family Fund—is working to address RNAs that are associated with aggressive prostate the critical, unmet need of identifying aggressive cancer as defined by failure to respond to Androgen tumors at an early stage while they are potentially Deprivation Therapy (ADT), disease-specific mortality curable and distinguishing them from indolent, low- and other factors. His research will identify the role grade tumors which can be treated with proactive of non-coding RNAs in aggressive prostate cancer surveillance to avoid overtreatment of clinically and correlate these to prostate cancer-specific insignificant disease. To this aim, Dr. Perry is outcomes, laying the groundwork for the design of new studying the chemical modifications to DNA’s outer therapeutics that will target specific non-coding RNAs. shell, known as epigenetics. These studies may provide reliable biomarkers of Prostate cancer is driven by several epigenetic aggressiveness which can help in patient stratification alterations and genetic abnormalities. Epigenetic for treatment and more efficient disease monitoring. alterations can be detected non-invasively with high sensitivity in peripheral blood and urine. Therefore, Antoinette Perry, PhD, detecting prostate cancer-specific epigenetic View a video on the work of Drs. Perry and Finn at: and Stephen Finn, MBBS, PhD, at Trinity College, alterations holds potential for both improved prostate www.pcf.org/2011progress

Photography: Jeff Becker Dublin

10 2011 progress report DONOR PERSPECTIVE Joe & Ali Torre

Prostate cancer can be managed. It’s treatable and you can often survive it… but if you can prevent it from ever happening, that’s all the better. PCF is working on all fronts. That is why we are proud to support the Foundation’s work and that of their talented researchers.

View a video with Ali Torre at:

Photography: Bliese Paul www.pcf.org/2011progress SPECIAL INTERVIEW DONOR PERSPECTIVE Steve Burd David & Judy Fleischer Chairman, Safeway A DECADE OF SAFEWAY SUPPORT There Is No Such Thing as Small Change

For more than 10 years, Safeway customers have been given an opportunity to make donations in support of PCF-sponsored research. The fundraising campaign occurs each June at stores across the U.S. and in Canada. Whether rounding up to the nearest dollar or donating several dollars, Safeway shoppers have collectively given new meaning to the phrase, “There Is No Such Thing as Small Change.”

Not only has the annual Safeway campaign raised $800,000. Last year, during that same period, we important funding for game-changing research, it raised more than $10 million. The numbers are has raised awareness for prostate cancer among both a testimony to the system we have put in Safeway customers and employees nationally. The place to raise funds and to the generosity of our following is a discussion with Steve Burd, Chairman, customers. We’ve created a unique model that President and Chief Executive Officer of Safeway. allows us to leverage the considerable foot traffic that gets generated in a grocery store, and doesn’t Q. Why did Safeway choose to become involved burden the donor. Most of our in-store donations in raising money to support cancer research? are relatively small.

How did Safeway choose to partner with A. We got involved because we saw an Q. the Prostate Cancer Foundation? opportunity to make a difference with diseases that impact a significantly large part of our customer and employee populations. Prostate A. The organization is widely regarded as the Images AP Credit: Image cancer affects 1 in 6 American men. Breast leading private funder of prostate cancer research. cancer affects 1 in 8 women. By supporting both It is highly respected in the cancer research causes, we believe we are making an impact on community and viewed as a catalyst for accelerating the science of finding a cure, saving lives and contributing to our nation’s overall health. ...we are making an impact on the science of finding a cure, Q. Since the annual campaign for Prostate Cancer began, Safeway customers and the saving lives and contributing Safeway Foundation have raised more than to our nation’s overall health. $75 million to support research for a prostate cancer cure. Does this surprise you? the science of cancer research closer to a cure. Since we started our fundraising the prostate A. Not really. Over the years we’ve engaged our cancer death rate has been reduced 40 percent customers on charitable activities, and are always from what was once projected, and nearly 200,000 impressed with their generosity. In the first year American men are alive today because of advances of our June prostate cancer campaign, we raised in treatments. That is encouraging. Continued on page 16 14 2011 progress report The organization has a growing presence in the DONOR PERSPECTIVE We’ve created a unique model social media world. I’m told they had more than David & Judy Fleischer that allows us to leverage the 5 million “Friends” on Facebook—which is an impressive number in that space. considerable foot traffic that gets generated in a grocery store, and doesn’t burden the donor. Q. Safeway is known for its progressive employee health programs. Is there a parallel between those and some of the work of PCF? Q. Is PCF different from similar organizations? A. PCF’s research correlating diet and exercise A. We are careful about only funding charitable with disease prevention tracks with the work organizations that operate efficiently. PCF has we have been doing at Safeway. We provide our developed a reputation for their entrepreneurial employees with a range of incentives to improve approach to doing things. They keep overhead their overall health while reducing their out-of- costs low and there is a sense of urgency to pocket healthcare costs. PCF research provided everything PCF does. I serve on their Board, so I early input for our understanding of lifestyle understand how funds and its connection to are allocated and the cancer prevention. organization’s focus on science. PCF’s CEO, Q. Do you believe Jonathan Simons, MD that together we and his team hold their are making funding recipients to a high standard and progress against insist that sponsored prostate cancer? work and resulting data are shared broadly We most certainly with other funded A. believe we are institutions doing making progress. As similar work. I indicated earlier, mortality rates have Q. Until recently, declined dramatically prostate cancer has in the time we’ve long remained in been connected to the cause. Men are the shadows. Is that living longer, more changing? productive lives. At Safeway, we look forward to building on our partnership going forward so we A. We think we’ve had a hand in bringing the can overtreat less and cure more. disease out into the open. However, Mike Milken The Prostate Cancer Foundation and Michael Milken have placed prostate cancer ‘on the map’ and his PCF team deserve the real credit for PCF research provided early input in bringing dramatically increased attention to this major killer as well as broad knowledge to creating a public dialog about the disease. He has men, enabling more to effectively fight prostate cancer. At the same time, the PCF approach surrounded himself with a gifted team of scientists for our understanding of lifestyle and to aggressively raising seed money and creatively stimulating research has ‘changed the who also happen to be exceptional communicators. its connection to cancer prevention. PCF has also done a great job creating awareness game’ in how rapidly research can be completed, shared and advanced. As a direct result, and getting messages out to mass audiences the best researchers are now being attracted to the field of prostate cancer and new drugs View a video on Safeway’s campaigns at: through the sports and entertainment industries. are coming out of the laboratory at a record pace, revolutionizing the fight against this once

www.pcf.org/2011progress Photography: Frank DeChirico ignored disease. We are pleased to be able to support such an extraordinary organization.

16 2011 progress report SPECIAL INTERVIEW DONOR PERSPECTIVE Adam Garone David & Judy Fleischer CEO & Co-Founder, Movember MOVEMBER’S UNIQUE DNA Changing the Face of Men’s Health—One Mo at a Time

Movember first took root in 2003, when a group of men in Australia decided to have some fun by bringing the Mo (Aussie slang for moustache) back for 30 days. They chose the month formerly known as November and enlisted 30 men to grow moustaches. They not only had a great time doing it, they were amazed by the conversations generated by the growth of a simple moustache.

Movember’s four co-founders—Adam Garone, Travis Garone, Luke Slattery and Justin Coghlan— Q. How did a small local program grow into an recognized that the Mo could be the “hairy ribbon” to international cultural phenomenon? raise awareness and funds for prostate cancer and other health issues affecting men. Thus, a movement In 2007, the movement went global, with official was born. We asked Adam Garone, CEO and co- A. founder of Movember, to reflect on the success and Movember campaigns introduced beyond Australia future of the global movement. in New Zealand, Spain, UK, Ireland, Canada, and the U.S. Today, official Movember campaigns are held in 14 countries. In each country, we partner Q. Looking back on that initial discussion with the very best men’s health organizations, and about bringing back the Mo, did you have any we’ve enjoyed a long-standing relationship with the idea what you were starting? Prostate Cancer Foundation in the U.S.

More than $10 million has gone to research A. The initial discussion about bringing back the programs supported by PCF. Globally, since 2004, Mo was between my brother, Travis, and friend Luke, more than 1.9 million participants have raised $281 who pondered why the moustache had never made million to change the face of men’s health. a fashionable comeback. As part of the original 30 Mo-growers, we initially grew for fun, but quickly realized that the moustache was an incredible ...we initially grew for fun, but quickly conversation starter. For the entire month, from realized that the moustache was an bosses to girlfriends and strangers, everyone had an opinion about our Mos. incredible conversation starter.

In 2004, Movember became an official charity and 450 Mo Bros and Mo Sistas raised $54,000 for the Q. How does the Mo raise awareness and Prostate Cancer Foundation of Australia. It was raise funds? the largest donation they had received up until that time. As a result we truly appreciated the power of the moustache to raise awareness and funds for A. Movember participation begins by registering at men’s health issues. We realized there was a lack of Movember.com. On their own or as part of a team, resources and charitable endeavors focused on men’s men grow and women support a moustache for the 30 days of Movember. Much like the commitment health. Inspired by the women around us, and all they Adam Garone (standing), had done for breast cancer, we knew we had to strive to do a charity run or walk, Movember participants Photography: Bliese Paul with Movember colleague, commit to changing their appearance by growing a Donny Killian, in front of to bring the same kind of awareness to the health Movember U.S.headquarters issues affecting men, such as prostate cancer. in Venice, CA Continued on page 20 18 2011 progress report A. In countries where Movember runs official 2011 Donor roll We partner with the very best campaigns, we look to partner with charities that men’s health organizations, and are aligned with Movember’s vision to have an The support of our generous donors makes all that we do at PCF possible. This honor we’ve enjoyed a long-standing everlasting impact on the face of men’s health. roll acknowledges actual gifts of $1,000 or more, exclusive of pledges, made to PCF relationship with the Prostate We choose our men’s health partners based on during calendar year 2011. We thank you, our friends and supporters, for making 2011 PCF’s best year yet. Cancer Foundation in the U.S. their corporate governance policies, cost ratios, leadership within the area, and most importantly, their achievements funding world-class programs Brian and Patricia Reynolds Beth Kobliner Shaw and David Johnson & Johnson Services, moustache. Along the way, they get their family, and research. $5,000,000+ friends, and colleagues to donate to their Mo- The Safeway Foundation The Ruppel Family Trust E. Shaw Inc. Ted and Dani Virtue William P. and Dorian S. growing efforts. Team building and managing Once our U.S. partner assessment was complete, M. Shanken, Chairman-M. $1,000,000 - $4,999,999 Shanken Communications, Kimbra and Mark Walter Jordan-William P. and Dorian your personal campaign is handled easily on the it was abundantly clear that PCF was the right The Charles Evans Foundation Inc. Stanley and Barbara Zax S. Jordan Foundation, Inc. Movember website, where fit. As the leading national Edward P. Evans Foundation Silicon Valley Community Richard and Deborah Justice each participant has their own prostate cancer charitable $50,000 - $99,999 David H. and Julia Koch Foundation Mr. Joseph C. Kastner organization, PCF is funding personalized fundraising page. Movember Foundation Varian Medical Systems Anonymous Kovler Family Foundation and accelerating prostate Foundation Ron and Judy Baron The Honorable Earle I. and During Movember, each The News Corporation cancer research globally. Foundation J. Eustace Wolfington Robert K. Barth Carol Mack Mo Bro becomes a walking Pier Luigi Tolaini Dwight Wubbenhorst Living Reina and Emilio Bassini Jeffrey A. Marcus billboard for men’s health. Trust Blavatnik Family Foundation Charles N. Mathewson Globally in 2011, our Q. How would you $500,000 - $999,999 Estate of Irene Pamela Foundation $100,000 - $149,999 participants had over 800,000 characterize Movember’s Anonymous Bridenbecker Robert A. Meister, Todd A. Joseph and Annette Allen Meister, Keith A. Meister face-to-face conversations partnership with PCF? The San Francisco Foundation The Brin Wojcicki Foundation Becker Family Fund at about Movember, with a The Brookdale Foundation Shmuel Meitar $250,000 - $499,999 Baltimore Community Group Merkin Family Foundation reach of over 65 million. Foundation A. We are very proud of the Anonymous Joe & Trina Cayre Foundation MidOcean Partners Mo Bros and Mo Sistas The Bill and Ann Bresnan research programs we’ve American Apparel & Footwear Robert D. Collins Fund Lowell Milken Family actively communicated our Foundation, Inc. helped PCF fund. We are Association Mr. and Mrs. Stephen A. Cooper Foundation men’s health messaging, Cablevision Systems honored to have had a hand Exosome Diagnostics, Inc. Dendreon Corporation Millennium Pharmaceuticals, Corporation totaling nearly four billion in helping scientists discover Foundation 14 Bonnie Pfeifer Evans Inc. Mr. Joe Clark conversations via social the 27+ types of prostate Milken Family Foundation Ralph and Cynthia Finerman B. Scott Minerd Peter and Laurie Grauer The Neubauer Family media, in person, phone calls, cancer and in sequencing Sanofi-Aventis Mr. and Mrs. Albert Fuss The Katz Foundation Foundation emails, texts, and blogs. Larry and Joyce Stupski- Gen-Probe Incorporated the prostate cancer genome, Kern Family Fund Stupski Family Fund Pamela and Robert B. Goergen Polaris edging us closer to a world The Cynthia and George Golfers Against Cancer Progenics Pharmaceuticals, where no man should die Mitchell Foundation Inc. Q. How do women $150,000 - $249,999 George & Reva Graziadio Joel M. Pashcow participate in Movember? from prostate cancer. Susan and Jim Blair Foundation The Republic of Tea William A. Richardson Bristol-Myers Squibb Company The Rodin Family Trust Movember’s vision is to have Guggenheim Partners Stephen J. and Chantal Sam Herzberg Marc J. and Carolyn Rowan A. While not Mo-growers, women are a very an everlasting impact on the state of men’s health Cloobeck, Diamond Resorts important part of the success of the Movember by funding programs focused on awareness and International campaign. Sixty percent of our donors and many education, survivorship, and research. PCF has The Steven A. and Alexandra M. The journey of caring for my beloved husband with Prostate Movember team captains are women. As women provided invaluable insights and results for research. Cohen Foundation, Inc. Cancer was a challenge I did not face alone. With support of the often act as the “Chief Medical Officer” of their The Neil and Sandra DeFeo Prostate Cancer Foundation, we had the most up-to-date research Family Foundation households, they have an integral part in engaging Sixty percent of our donors and many information, treatment options and medical support. My husband men to participate in the campaign, as well as The Durden Foundation, Inc. Movember team captains are women. R. Christian B. Evensen fought courageously, with absolute belief, that donating to PCF helping to spread awareness and education about David and Judith Fleischer would lengthen his life and save the lives of countless men in the men’s health causes. Richard S. and Karen LeFrak future. With great conviction, the Durden Foundation continues it’s Together, I believe we will end death and suffering as a Charitable Foundation support of PCF with funding for cutting-edge research. Though result of prostate cancer. Q. When Movember began in the U.S., how Major League Baseball my husband lost his battle, he wanted other men to be victorious Charites, Inc. did it decide to select the Prostate Cancer Medical Research Agencies of through the successful work being accomplished daily. Foundation as its men’s health partner? View a video about Movember at: America — Mrs. Earl Durden www.pcf.org/2011progress Tony Ressler and Jami Gertz

20 2011 progress report 2011 progress report 21 Mrs. Juliane Ruppel Robert Levin Terry & Jane Semel Charitable Joy and Jerry Monkarsh Family James H. Coleman Mr. and Mrs. Michael P. Berger & Montague, PC Little Falls Lions Club Larry W. Ruvo Mr. Jimmy J. Liataud Foundation Foundation Community Foundation of Muldowney Mr. Alex M. Bernstein Mr. and Mrs. Les Little The Mortimer D. Sackler Mr. Peter Maslen Richard and Phyllis Sharlin William and Nona Morgan Greater Memphis Marc and Jane Nathanson Boucher Charitable Foundation Dr. Brant Luebbe Foundation, Inc. Jerome Meislin Mr. Jeffrey M. Steinberg Motorola Foundation Confidence Foundation Reverend Christie Cozad Mr. James Boyd Eric and Rose Lyght Mrs. Sandra M. Salka Melvin Simon & Associates, Sternlicht Family Foundation Mrs. Dagmar Mulac Mr. and Mrs. Thomas J. Neuger and Mr. Win J. Neuger Ms. Linda Brodigan Stewart Manheim Ellen and Richard V. Sandler Inc. M & B Sugarman Family Trust My Father Cigars, Inc. Coughlin Obermayer Rebmann Maxwell Mr. Brian S. Brown Manowitz and Drillings Family John and Jana Scarpa–The George and Sandra Norcross Team Winter NASDAQ Philadelphia Stock Mr. and Mrs. Alan Dahl & Hippel LLP The Capital Group Companies Foundation John F. Scarpa Foundation Mr. Rocky Patel William H. Tilley Exchange (PHLX) Foundation Governor Gray Davis Odd Fellows of Massachusetts Charitable Foundation Harold M. Messmer, Jr. SEI Giving Fund Mr. and Mrs. Joseph Pretlow Varhegyi Foundation National Philanthropic Trust DGS Management & Consulting Others First Ms. Nicole Cashman Eustace and Susanne Mita Mark Shenkman Mr. Irwin Rausch The Walsh Family Foundation- Tony and Laura Nethercutt Drexel University, College of Palermo Ravich Family Wade F.B. Thompson Cliff and Debbie Robbins and Mr. Brian Walsh New York Yankees Foundation Medicine Foundation Charitable Foundation the Robbins Family Mr. and Mrs. Henry L. Nordhoff Drummond Community Bank Myles C. Pollin and Kaitlin PCF’s track record for promptly and $10,000 - $14,999 Trinh Mr. John H. Tyson-Tyson Family Foundation Mr. Walter C. Parkins Mr. and Mrs. Bruce N. Duff efficiently advancing patient-based prostate Foundation Anonymous (2) Deborah and Richard Previdi RP Cigar Lounge, LLC Nelson and Claudia Peltz David and Marsha Ederer cancer research is unparalleled. The Wagner Family Foundation Mr. and Mrs. Jason Safriet Judd Apatow Daryl & Steven Roth The Estee Lauder Companies, Muhit and Anna Rahman Douglas Wood The Mara and Ricky Sandler Arby’s Foundation Inc. Michael and Debbi Fields Rose — Neal Rodin Foundation Victor and Lia Assad Schwartz, Kales Accountancy Freeport-McMoRan Foundation St. Albans Congregational $25,000 - $49,999 J. Gary and O.J. Shansby Mr. and Mrs. Seth Bernstein Corp. Fuente Family Foundation, Inc. Church Clayman Family Foundation Nintendo of America, Inc. Anonymous Foundation Mr. Ron Biscardi Mickey Shapiro Charitable D. Wayne and Anne Gittinger Saks Incorporated Connecticut Baseball David P. Nolan Foundation The G. Chris Andersen Family Howard Shore Mr. Jay R. Bloom Trust Goldman Sachs Gives Mr. Nicholas Sandler Charitable Foundation The Norwood Company – Jack Foundation Herb Simon Family Fund Mr. and Mrs. Ivor Braka Smithburg Family Foundation Tamar and Eric Goldstein Ms. Tracy Sandler David and Courtney Corleto Farrell, Principal The Cecile and Fred Bartman The Stanley & Arna Smith C. Fuente Holdings, Inc. The Snider Foundation John P. Gould and Kathleen A. The Douglas and Jill Schatz Corporate Office Properties Oakland Black Firefighters Foundation Foundation Mr. and Ms. Robert B. Tatuaje Cigars, Inc. Carpenter Family Trust Trust Association Ambassador Frank and Kathy Joseph and Diane Steinberg Campbell Bruce E. and Robbi S. Toll Laurence Graff Stephen and Suzy Shechtman Mr. and Mrs. Don Cusick Mr. Robert A. Olstein Baxter 1992 Charitable Trust Anthony and Jamie Carr Foundation Mr. Richard J. Green The Shidler Family Foundation Mr. and Mrs. Eric K. Davidson The Ostler Group Bloomberg L.P. Stride Everyday S. Ward and Roxanne The Robert & Jane Toll The Marion and Louis David E. and Jacqueline Simon Baroness Philippine de Mr. and Mrs. Gary F. Papa Arthur Byrnes Bob and Nikki Sudack Casscells, III Foundation Grossman Foundation Charitable Foundation Rothschild Charles Maxfield Parrish and Chicago White Sox United Way of Greater Los Catholic Community Mr. Donald J. Toumey Thomas R. Hagadone and Pam The Sloan Foundation Mr. and Mrs. Alan K. Docter Gloria F. Parrish Foundation The Copses Family Foundation Angeles Foundation The U.S. Charitable Gift Trust Miller David M. Solomon Mr. Steven Einhorn Mr. John D. Payne Dalio Family Foundation, Inc. The C. George Van Kampen Robert and Beverly Cohen University of Pennsylvania David S. Howe and Charlene The Staggs Family Foundation The Epstein Family Foundation Drs. Richard and Margaret Mr. and Mrs. Bruce D. Deifik Foundation Family Foundation Armond Waxman Wang The John R. & Inge P. Stafford Eugene and Sallyann Fama Pepe Bethany and Niko Elmaleh Dennis and Phyllis Washington Crane Foundation Mr. and Mrs. Eric Zinterhofer Integrated Health Campus Foundation Dr. Jeffrey P. Feingold Mr. David A. Plastino Don Engel Foundation Credit Suisse Securities (USA) Jones Lang LaSalle Americas Mr. Glen Stimson Stanley M. Feingold William L. Price Robert S. Evans Gregory and Mindy White LLC $5,000 - $9,999 Wayne D. Jorgenson Gary Stoneburner First National Bank in Sioux William, Constance, and Susan Christopher J. Eykyn Gilles DeVoe and Rob Simon Anonymous Ms. Pam Kehaly Mr. David H. Storper Falls Purdy Charitable Fund Faith, Love, Hope, Win $15,000 - $24,999 Lee and Daniele Einsidler Anthem Blue Cross KMR Lifestyle Services, LLC Mr. and Mrs. Maurice J. Stouse Firstrust Bank Redbird District Projects, Inc. Foundation A Charity Challenge Frank M. Ewing Foundation Ann Appleman and Andrew Emerson and Peggy Knowles Mr. Meir Teper Alex Fisher Mr. Bruce Riedl William B. Finneran Mr. Adam Cohn Mr. Eric C. Fast Thomas-Gadzik Loida N. Lewis Jesse I. Treu Mr. Edmund Garno, Jr. James S. Riepe Family Keith Frankel Mr. and Mrs. I Michael Coslov Grizzard Communication Group Bank of America Foundation Mr. and Mrs. Eric Luse UBS Employee Giving Program Ms. Karen Goforth Foundation Ryan Freedman, Corigin Exelixis, Inc. Haarlow Family Charitable Bay Area Beverage Company Mr. and Mrs. Paul Madura Unified Grocers William and Vicki Hamilton Richard A. Rigg Holdings John and Kiendl Gordon Foundation Mr. Bradley D. Belt Ms. Cynthia B. Mandell United Advantage Signs, Inc. Mr. and Mrs. Clay W. Hamlin, III The H. English & Ermine Cater Mr. and Mrs. Tim Gannon Hastings Capital Group, LLC Kerry and Kelly Hagen The Frances & Benjamin Maple Leaf Estates The VF Foundation Mr. and Ms. Joseph B. Robinson Foundation Mr. and Mrs. Michael Gelband The Helping Hands Sales, Inc. Mr. Bryan Hancock Benenson Foundation Homeowners Corporation Will Weinstein Haulenbeek Mr. and Mrs. William S. Rustico Bennett and Meg Goodman Mr. and Mrs. Thomas F. Herche The Iacocca Foundation William Bikoff Mr. Gary Maxwell Mr. Lee Weiss Heritage Wealth Counselors, Jill and Ronald Sargent Stephen Gordon Heritage Operating, LP Glenn R. Jones Braden Partners LLP William McDaniel Charitable The Wistar Institute LLC Mr. and Mrs. Jeffrey Schantz John & Amy Griffin Foundation, Jefferson University Robert A. Kotick Mr. and Mrs. Todd J. Brading Foundation, Inc. Hub International Northeast Mr. and Mrs. James W. Inc. Kissick Family Foundation Thomas H. Lee and Ann Mr. and Mrs. David C. Brown, George A. Mealey $2,500 - $4,999 Limited Schlotzhauer Griffon Corporation Margaritaville Holdings, LLC Tenenbaum Jr. Mr. and Mrs. Carl Meyer Anonymous (2) Mr. Michael Hunt Sellers Publishing, Inc. Mr. and Mrs. Thomas J. Hughes MediUSA Mr. Joel Levine Mr. Chad T. Brownstein The Michael Companies, Inc. 21st Century Oncology Mr. Anthony M. Hunter Mr. Martin Shafiroff Jerry Katell, Katell Sandra and Lawrence Post Lyonross Capital Management Ms. Aviva Carmy and Mr. Harry Mr. Paul J. Milbury Accusplit, Inc. The Kandell Fund The George F. and Myra Productions, LLC Family Foundation LLC Horowitz Thomas E. and Pamela M. Alliance Partners HSP Mr. David Kelsey Shaskan Foundation Jerry King Allan V. Rose Dorothy Phillips Michaud Cars Fighting Cancer Mischell Family Foundation American Medical Sytems, Inc. Mr. Stephen B. Klein Mr. and Mrs. Timothy Shortoff Stephanie and Ron Kramer Mr. Andrew Rosenburgh Charitable Trust Gary Charlesworth Jay and Elaine Moorin, Arete Foundation Kathleen and Kirk Knous Sarah Spencer Foundation Dalia & Larry Leeds, The Leeds Mr. Kern W. Schumacher Gregory and EJ Milken Allen and Jill Chozen ProQuest Investments Mr. Zachary Aters KSB Dental Starkey Sports Consulting, LLC Family Foundation Miller’s Field Mr. Stephen A. Cohen Morgan, Lewis & Bockius, LLP Mr. James Berg Mr. Gerald P. Lee T. F. Trust

22 2011 progress report 2011 progress report 23 Tenenbaum & Saas, P.C. Ms. Teri Barrett and Mr. Edwin Mr. and Mrs. Craig Caffarelli Mr. and Mrs. Kirk Cruikshank Mr. Bernard Friedman Mr. Bobby Hodges Dr. and Mrs. Stephen H. Levine The Meredith Corporation The Tides at Charleston HOA R. Freudenburg Mr. Kenneth Cahn Cumming Foundation Fuller Family Foundation Dr. and Mrs. Stuart Holden Leon Levy Foundation Foundation Matching Gifts Towersource, Inc. Mr. Herbert B. Baskin Mr. Arthur J. Calace Mr. and Mrs. William Curry G4S Secure Solutions (USA) Kenneth B. Holdsman Family Barbara and Stan Levy Program USA Volleyball Michael J. Batza, Jr. Mr. and Mrs. Gary Calandra Mr. Anthony D’Alessandro III Inc. Fund Mr. Jainfei Li Louis and Patricia Meshon United Way of Orange County Beach Investment Counsel, Inc. Ms. Lisa Caplan Mr. Joseph L. D’Amico Mr. and Mrs. Erik Gabell William E. & Audrine Honey Peter D. Linneman, Ph.D. Mr. and Mrs. Leslie D. United Way Silicon Valley Mr. Thomas Beach Mr. and Mrs. Sidney L. Carey Rich and Linda A. Danter Garrison Family Trust Foundation Robert E. Linton Michelson Mr. John A. Urquhart Mr. Robert L. Beardslee Ronald G. Carley Mr. James A. Davidson GE Foundation Lynne and Harold Honickman Litigation Adjusters, Inc. Midrex Technologies, Inc. Wool Labs, LLC Fred Bedard Ms. Corinna Carlson Mr. Bruce B. Dayton Mr. and Mrs. Ritchie L. Geisel Mr. and Mrs. Larry Horn Mr. Neil Little Mrs. Allison Mignone Helen A. Wright Elliott H. Berger Mr. and Mrs. Edward R. Karen L. Degerberg and Mr. and Mrs. Stanley Geist Ernest H. Hui Family Ms. Debra Livengood Mr. David Miller David and Pamela Berkman Carlson Andrew L. Sandler Mr. Warren Gerow Foundation The Livingston Family Mr. James I. Miller $1,000 - $2,499 Mr. and Mrs. Barry Berlin Carlyle Fraser Employees Deka Athletics, Inc. Dr. Theodore L. Gerstl Mr. Maxwell M. Hunter Foundation Mr. Jay L. Miller Anonymous (12) Mr. and Mrs. William Benefit Fund Devcon Security Services Corp Mr. Jason G. Ghassemi IEC – Fort Worth Tarrant Lord Family Foundation Sherman R. Miller and Mary M. Mr. Alden A. Abraham Berlinghof Carolina Urology Partners Mr. B. Dever Gibson Family Foundation County Chapter Mr. and Mrs. John R. Lord, Sr. Sullivan Mrs. Marion Achtentuch Douglas Berry PLLC Mr. and Mrs. William C. Dever Mr. Christopher C. Gibson Mr. and Mrs. Chris Iero Mr. and Ms. Arthur E. Lottes, Theodore N. Miller Addison Reserve Best Buy Co., Inc. Mr. Greg T. Carter Mr. Steele Dewey Mr. Wayne Giebler Independence Blue Cross Jr. Mr. Adam T. Milstein Mr. Stanley M. Adler Mr. and Mrs. Fred B. Bialek Dr. and Mrs. William C. Carter, Mr. Tyler Dickson and Mrs. Mr. David Gill Infiniti of Pleasanton Douglas and Nancy Lowe Molzie-Q, LLC The Alden Foundation Bibleway Baptist Church of III Roseann Stewart The Honorable and Mrs. J/K South Insurance, Inc. Mr. and Mrs. Larry Luck Monaghan Corp, Inc. Mr. and Mrs. Stanford Christ Mr. J. T. Childs, Jr. Mr. and Mrs. Gary Dicovitsky Rudolph W. Giuliani Herb W. Jacobs Robert Luka Estate The Mitchell & Hilarie Morgan Alexander Mr. and Mrs. Jack M. Bilson, Jr. Choate Rosemary Hall Ms. Kristen M. Dietrick and Ms. Give With Liberty Mr. Stephen L. Jacobs Robert G. Lusk Trust Family Foundation Mr. William Alspaugh Eliot and Susan Black-Ira N. David and Suzanne Chonette Esther Dietrick The Ed and Sue Glass Ms. Julie Jaeger Gordon Maahs Morgan Stanley Smith Barney Alta Data Technologies, LLC Langsan & Lillian Langsan Christian Brothers Academy Mr. E. J. Dixon Charitable Fund Mr. Tim G. Jaeger Fredric Mack GIFT, Inc. American College of Philanthropic Fund HTL Ms. Christine Christian Mrs. Mary H. Dobson The Glickenhaus Foundation Daryl L. Jesperson Mr. and Mrs. Harry D. Madonna Mr. James Murphy Healthcare Executives Blackstreet Capital Circle of Hope Bracelets Mr. and Mrs. Joseph Doyle Mr. Brian Glowatz Jewish Community Federation Mr. and Mrs. Jonathan Maldon Mr. and Mrs. Paul R. Murphy The Amgen Foundation Management, LLC CIT Group Mr. Philip Drury James Godsey, Ph.D. and Endowment Fund Mandelbaum Foundation Mr. Nelson Naranjo Mr. and Mrs. Robert M. Each Mr. Myles Goldfein Mr. Matthew Junge and Ms. Laurence and Karen Mrs. Mildred Neely Dr. Shafiq Ebrahim Leonard & Jerry Greenbaum Carol Junge Mandelbaum Mr. Alonzo A. Neese, Jr. It is comforting as a donor to know that gifts to PCF are supporting Mr. John D. Edwards Family Foundation Dr. Larry Kaiser Mr. Paul A. Manese Renato Negrin unbiased awards granted through competitive, peer reviews that Mr. and Mrs. James W. Mr. and Mrs. Herb Greenman Mr. Francis Katzka Mangen Family Charitable Blake Lee Neubauer aim to broaden and change the current landscape of prostate Eggenberger Mr. Reg Greenslade Mr. and Mrs. William D. Foundation Mr. Michael R. Neumann Kaufman L. Mark Newman Family cancer diagnostics, prognostics and treatment for so many men and El Paso Corporation Mr. Art Greif Philip and Marcia Marcus Mr. Jack P. Ellman Mr. Randall M. Griffin The Estate of Stan Katz Stephen J. Marcus Foundation their families. Elmwood Country Club Mr. and Mrs. Dan L. Griffith Mr. Robert Keith Mr. Douglas G. Martin Mr. Reginald B. Newman II — William & Nona Morgan Mr. Robert L. Ernst Mr. Murry Gunty Mrs. Rose M. Klein Mr. Charles W. Martindale Mr. Mark Nickson Mr. Clifford F. Evans Mr. and Mrs. Max Gutierrez Mr. and Mrs. Larry L. Klopp Ms. Brenda Martinez Chuck Nicolette, M.D. Mr. and Mrs. Chandler H. H2L2, Architects-Planners LLC Mr. and Mrs. Michael J. Klosk Mr. Eugene Mascolo Mr. Franz Niedermair Mr. Marquard J. Anderson, Jr. Mr. Richard Bogomolny Citi Business Services Everett Mr. Lee P. Hackett Rose & Louis Klosk Fund Andrew Mathias Mr. and Mrs. Richard A. Nortz Mrs. Sarah Anderson Mr. and Mrs. Kenneth H. Boone Mrs. Esther G. Clairmore, TTEE Mr. and Mrs. John O. Ewald Mr. Matthew R. Hagey Harold and Shirley Kobliner Mr. and Mrs. Philip L. Maxey Mr. and Mrs. John Norwood Anreder & Company Mr. Edward Borovatz Mr. and Mrs. James T. Clarke Ms. Bayla K. Falber Mr. and Mrs. Charles E. Ms. Ann Koch Mr. Lawrence McCarthy Jonathan R. Novak ARRIS Group, Inc. Charitable Lead Annuity Trust Coastal Physicians & Mr. and Mrs. Joel Fernelius Haldeman, Jr. Roger and Lorraine Kotch Mr. and Mrs. Michael J. Oakland Alameda County Emeryville Firefighters AT&T United Way Employee ULWT of Gladys Borrus Surgeons, PC Mr. Joseph T. Ferrara Harbourside Custom Home, Ms. Cynthia H. Koulax McCaslin Charity Fund Giving Campaign Ms. Emmie Lou Boston Ms. Ashley Cofone Fifth Third Bank Inc. Mr. John R. Krause Mr. Charles C. McCroskey The Oakland Athletics Aureon Laboratories, Inc. Mr. and Mrs. Richard Bowden Jerry and Adrianne Cohen Ms. Jeri Finard Mr. Eric Harrah Mr. and Mrs. Frank Kulze Mr. and Mrs. Patrick McGrath Community Fund Mr. Gene Axelrod Boyds, L.P. Karen B. Cohen Foundation Inc Ms. Karen Finerman Hayden Real Estate Dr. Kevin Kumashiro Mr. and Mrs. David McHenry Dr. James E. O’Brien Mr. James D. Bagwell Mr. and Mrs. Curt Boylls William S. Comanor, Ph.D. First Descents Investments, LLC L.I. Midweek Baseball League Mr. and Mrs. Robert McInnes Mr. and Mrs. Stephen T. O’Brien Mr. Calvin Bak Braman & Associates, Inc. Comcast Spectacor Foundation FIS Jerry and Marilyn Hayden LA-CO Industries, Inc. Laureston and Barbara Ocean Partners USA, Inc. Mr. Mark R. Baker Mr. David Brenay Conair Corporation and Mr. and Mrs. Howard M. Mr. William Healy, Jr. Mr. and Mrs. David E. Laing McLellan Mr. and Mrs. Kevin J. O’Grady Ms. Carrie Ballester Mr. and Mrs. Steve Brody Subsidiaries Fischer Mr. James Heerwagen Mr. and Mrs. Patrick J. Landers McMillan & Associates, LLC Mr. Ronald Olson Mr. Jack Balos Mr. Pierre Brondeau Mr. Cody Connell Mr. and Mrs. James C. Fish, Jr. Mr. Jay Hemenway Martin and Sheila Lasky Mr. and Mrs. Harry McMillan Mr. Richard Omata Barack, Ferrazzano, Stanley Brosman, M.D. Constellation Energy Group Mr. John Fisher Dr. William E. Hendrix Steve Lawrence and Eydie Mr. and Mrs. Donald A. Mr. Daniel O’Toole Kirschbaum & Nagelberg, Ms. Cynthia Brown Employee Fund Ms. Sandra Fitzgerald Mr. William Henry Gorme McMullen, Jr. LLP Mr. and Mrs. David P. Brownell Mr. Mark Cooper Mr. and Mrs. Thomas Fitzmyers The Hill Family Charitable Mr. James Ledbetter Mr. William B. McNamara Ottawa Boys Mr. Peter Barna Mr. and Mrs. Timothy W. Mr. and Mrs. James W. Corbin, Mr. Patrick Folger Foundation Mr. Eugene B. Lefevre Meals On Wheels Pasadena Padres Oncology-Cindy Matters Fund Mr. and Mrs. Dean B. Barnes Buckley Jr. Mr. William Frankel Himmelstein Family Mr. W. Bruce Lehmkuhl Medical & Dental Staff of Terre John Paffenbarger Mr. and Mrs. James W. Barrett Mr. and Mrs. Bernard J. Burke Coventry Health Care, Inc. Mr. Joseph S. Franzia Foundation Mr. J. Michael Lekson Haute Regional Hospital Mr. Frank Pagnotta The Caesar Foundation Mr. Philip L. Coyne Mr. Barry S. Friedberg Dr. and Mrs. Michael Hirsig Mr. Steven Leonard

24 2011 progress report 2011 progress report 25 Mr. and Mrs. Russell E. Palmer Mr. Gregory A. Romney Mr. Gerald Sussman Ms. Nancy C. Wilson Mr. Christopher Gibson Mr. Robert Tebo Men’s Senior Baseball Leagues C.A.R.E. (Cancer Alzheimer’s Mr. and Mrs. Anthony Panzica Mr. and Mrs. Robert Rooke Mr. and Mrs. Robert Swartz Matthew and Elizabeth Winkler Ms. Becca Goldman Mr. Steve Teichow Newton Running Company Research Event) Charles A. Partain Rosner Law Group Mr. and Mrs. Richard Szilasi Andrew Wise Mr. Jeffrey Gust Ms. Bridgid Thomas Northland College Men’s Cahokia Fire Department at Mario and Alma Pastega Family Ms. Charlotte H. Ross Mr. David Tallo Wolf Development Services, Mr. David Guy Ms. Sara Towne Hockey Prairies Golf Course Foundation Rubenstein Partners Dr. and Mrs. Robert L. Tar, LLC Mr. Mark Hammond Mr. Peter Tsatsaronis Pennies for Pete Calabasas Country Club Rafael Pastor Mr. Ronald Rubin D.D.S. Mr. and Mrs. George Wolfe Mr. Frank Hanes Ms. Michelle Ungar Play For Blue (Arnie’s Army and We Spark) Thomas J. Patrician Mr. and Mrs. Robert A. Rudnick Fredricka Taubitz and Dennis Ms. Laura J. Wolfe Ms. Dana Hefter Mr. Tiger Vo Quinnipiac University Men’s Canoe Brook Country Club The Peninsula Club Mr. and Mrs. Ron Rufener M. Griffin Mary and David Wolff Mr. Nicholas Hellman Mr. Sean Walter Hockey Team Carolina Trace Country Club (Annual Stag Day) Mr. and Mrs. Henry Perera Mr. Chris J. Rufer Thrivent Financial Employee Mr. Andrew Wolfington Mr. Brian Hester Mr. AJ Weiss Robert W. Baird & Co. Cherokee Country Club (Stan Mr. Barry Perlman Mr. Eugene C. Rumsey Giving Campaign Mr. Gerald Wolkoff Mr. Christian Isakson Ms. Lindsay Weiss Incorporated’s Denim Day Camp Golf Tourney) Mr. Richard J. Wright Mr. Patrick Jarvis Mr. Brandon Wood Scituate Beach Association The Club at Admiral’s Cove WXVU The Spot 89.1 FM Mr. Michael Jaskulsky Team Winter Concordia Men’s Golf Club Supporting PCF research was an easy decision. They drive cutting- Mr. Talen Yerger Mr. Colin Kambak Special Partnerships UNC School of Medicine Class of 2014 Cotton Creek Men’s Golf Mr. and Mrs. Harry P. Young Mr. Emerson Knowles and Hosted Events edge research and their ability to build global collaboration delivers Western Maine Baseball Association, Inc. at Craft Zarett Rehab & Fitness Ms. Kathleen Lawler Special partnerships or results for millions of men, like our long-time friend who is affected by Umpire Association (WMBUA) Farms Golf Resort Mr. Gerald P. Lee hosted events that raised “Blues Go Blue” Country Club of Beloit (Donny’s this disease and in whose honor we made our donation. Champions for a Cause Mr. James Leo $1,000 or more Wycliffe Country Club Men’s Revenge) Athletes for a Cure Mr. Jason Leyrer — Tony & Laura Nethercutt 6th Annual Tom Dawes “We’d Golf Association Country Club of Roswell participants who raised Mr. Ryan Limor Be Fools Not To” Function Battle at Dublin Ranch $1,000 or more Mr. Nicholas Loran 7th Annual Faith Love Hope Arnie’s Army Battles El Conquistador Stephen G. Tolchin Mr. Brant Luebbe Win Foundation Golf Phillies Charities, Inc. Edward B. Rust, Jr. Ms. Jessica Adams Prostate Cancer Golf Battle at Estero Country Club Mr. Pascal F. Tone Tournament Piolin Productions Mr. and Mrs. Gerard M. Ruvo Mr. Ian Adamson Mr. Seth-David Maack Tournaments at the Vines 9th Annual Philadelphia Mr. Michael Piotrowski Mr. Robert Ryall Track Shack Fitness Club, Inc. Ms. Jennifer Ahn Mr. Richard Maisel Forest Glen Golf and Country Prostate Cancer Fundraiser, Arnie’s Army Golf Mr. Andrew Plasman Salem Dugout Club Richard and Nancy Trefzger Mr. Oscar Alvarez Mr. Todd Malcolm Club (Golf for US – Men’s PC Hosted by Neal Rodin and Tournaments that raised Mr. Gary G. Pollock Ms. Mary Ann Saleski Tropicana Royale – WestCorp Mr. Patrick Amsbry Mr. Hendrik Marais Tournament) Clay Hamlin $1,000 or more Polycom Mr. and Mrs. David A. Salzman Management Group Mr. Zachary Aters Mr. H.C. Martensen Golfer’s Club at Fort 91X Blue September Addison Reserve Tournament Mr. Edward Potkay The San Diego Foundation Truist Mr. Bill Barnett Mr. Christopher Maulsby McPherson Fundraiser Aliso Creek Inn and Golf PPD Development, LP R.C. and Helen Sandler Bypass Mr. Chris Unger Mr. Michael Barron Mr. Gary Maxwell Golfing Fore The Cure Alpha Omicron Pi Course (2nd Annual W.R. Price Coin San Diego Trust United HealthCare Services, Mr. Ryan Bassham Mr. Andrew Maxwell Golfview Golf & Racquet Club Artidote Manese Memorial Golf Princeton Area Community Alan L. Saroff, M.D. Inc. Ms. Talia Bensinger-Colton Mr. Britt McCormick Grandfather Golf & Country AV Men’s Senior Baseball Tournament) Foundation, Inc. Mr. and Mrs. Michael J. Scharf US Trust Bank of America Mr. Chris Biggerstaff Mr. Kean Mihata Club League Alta Mesa Golf Club Charity ProCure Proton Therapy Mr. Randolph A. Schwartz United Way of New York City Ms. Jennifer Bocker Mr. Malcolm Mulroney Greenbriar-Whittingham Golf ACC Men’s Golf League Tournament Center Mr. and Mrs. Ray C. Shiflett University of Utah Mr. John Broich Mr. Chris Oliphant Association Be Bold, Be Bald Arnie’s Army Golf Tournament Prudential Foundation Dr. Joel Shoolin Mr. Zachary Valade Mr. Mark Bunger Ms. Megan O’Neill Greenbriar Woodland Golf Club The Charles Evans PCF Pro- (Arkansas) Matching Gifts Valiance Partners, Inc. Mr. Scott Burrow Ms. Kristine Palmero (Greenbriar Golf Association) Ms. Dru E. Short Am Tennis Tour Artesia Country Club Mr. Sridev Raghavan Mr. Franklin Vargo Ms. Christine Christian Mr. Bhavesh Patel Hawthorn Woods Ladies 9-Hole Mr. and Mrs. Robert G. Siegel Coon Rapids-Bayard Aspetuck Valley Country Club Mr. and Mrs. James Rankin Villanova University Mr. Chris Paterson Group Silk City Striders, Inc. Mr. Jordan Citron Crusaders “Kick Cancer” Battle at BallenIsles Country Marc and Sheri Rapaport Mr. and Mrs. John F. Volk Heron’s Glen Country Club Mr. Gary Singer Mr. Thomas Collignon Mr. Levi Pickett football game Club Warren Rasmussen Vorsheck Family Foundation Battle at Hershey’s Mill Golf Mr. F. Joseph Sirdevan Mr. Flavio Costa Ms. Katherine Pothier Chesapeake Men’s Senior Battle at Bella Vista Mr. Douglas M. Reid Mr. and Mrs. Roger A. Club Slosburg Family Charitable Ms. Clarissa Cruz Mr. Peter Reinhard Baseball League The Beech Mountain Club (Pink Mr. Robert Reiland Waesche, Jr. High Meadow Ranch Golf Club Trust Ms. Tanya Dandeneau Mr. George Reinhardt Derric’s Day at Thunder Hill & Blue) Ms. Kathleen Lister and Mr. Mr. James Walker Highland Meadows Golf Club Mr. and Mrs. Joe Smith Mr. Timothy Day Mr. Peter Ripmaster Raceway Bella Vista Country Club (AR) Jeffrey A. Reinhold Mr. and Mrs. Geoffrey (Rally for A Cure-Arnie’s Ms. Regina O. Sommer Mr. Andre Deckrow Mr. Darren Ritch Detroit MSBL Bent Tree Country Club Richard and Marget Reneberg Walworth Army) Ms. Denise Sova Mr. Greg DeFrancisco Mr. Michael Rowan Doherty Men’s Soccer Program Blue Ridge Trail Pink & Blue Jeffrey J. Rhodes Family Mrs. Louise H. Warren The Members of Highland Specialists In Urology Mr. Lex Depp Mr. Robert Sabo Friends of Eastern Bag and Tournament Foundation The Warrior – Jodi L. DeCrenza Woods Golf & Country Club Irwin and Lorri Spiegel Mr. Jonathan Dingle Ms. Cristine Santa Croce Paper Group Battle at Boca Woods Mr. Brian C. Ricker Waste Management HLT Texas Shootout Mr. Norman M. Spieler Mr. Larry Distler Mr. David Schatz Friends of James Reyburn Boobs & Balls Against Cancer Mr. John Ripoli WCMC-FM, Inc. Battle at Iron Lakes Country Mr. Todd Spriggs Mr. Greg Dougherty Mr. Christopher Schwyter Golfers Against Cancer Golf, Inc. Leandro P. Rizzuto Mr. and Mrs. Warren Weiner Club Mr. and Mrs. Gilbert L. Steward Mr. Jordan Emmerson Mr. Roger Seiken International Stunt Association Broken Sound Golf Club Drs. W. Scott and Karen T. Michael and Jill Weinstein Jonathan’s Landing Golf Club Mr. and Mrs. Blake Y. Stock Mr. Ed Esposito Mr. Shaune Shelby (ISA) 3rd Annual Charity Brown’s Run Country Club Robertson Mr. and Mrs. Stephen H. KBK Charity Golf Tournament Storm Smart Building System, Ms. Dawn Estelle Mr. F. Joseph Sirdevan Paintball Tournament Bruce Alan Hupfer Memorial Ms. Tiffany E. Rodriguez Weitzer Lago Vista Men’s Golf Inc. Mr. Brad Foster Mr. Adam Slevin Kilted to Kick Cancer Burlington Country Club Mr. and Mrs. Joseph W. Rogers Wells Fargo Community Association Mr. Peter Studner Mr. Alberto Garcia Mr. John Stinnett Let’s Hit a Grand Slam for the (Arnie’s Army & Rally for the Ms. Katherine Rogers Support Campaign Lake Spivey Golf Club Sunnyland Bulgur Wheat, Inc. Ms. Michelle Gauvin Mr. Greg Streiff Cure of PC Cure) Mr. Harry J. Wild Legends Men’s Golf Association Roll Global Susquehanna Bank Mediven Socks for Men

26 2011 progress report 2011 progress report 27 Lobster Classic Sawgrass Country Club (Irish Thomas Goliash Stan Camp Lords Valley Country Club Open) Phillip Goodman Paul DuPont A SURVIVOR’S APPEAL FOR SUPPORT Maple Leaf Country Club Silverado (Napa Swing for a Phil Guy Doug Ellison McCanless Golf Club Cure) Gerald L. Hanes R. Christian B. Evensen Battle at the Meadow Club Stan Camp Golf Outing James Hirsig Ralph Finerman Meadowlark Country Club (7th Steamboat Golf Club Parker Holt D. Govberg Dear Friends, Robert Hagey Annual Turf & Surf Golf Sterling National Country Club John O. Hustad Dr. Gavin Helton Tournament) (Eastern Bag & Paper) William L. Jaeger Ten years ago, at age 49, Minebrook Golf Course (Shakey Stonebriar Country Club Gilbert Jeffries I was diagnosed with Jakes Golf Outing) (Annual Community Benefit Thomas Junge advanced metastatic Golf Classic) I support PCF Mt. Kisco Country Club (Senior Stanley Katz Strand Country Club (Hairy prostate cancer throughout Championship and Super Charles F. “Chip” King because they Senior Championship) Knuckles Tournament) my body. On the day I was Paul King continually advance North Ranch (Westlake Village Sugarloaf Country Club (Jay Apostoles Achilles “Paul” important lines given my news, I was Sunrise Rotary) Moody Memorial) Kotseos certain I had but two to Northgate Ladies Golf Sunny Hill Resort of translational Nicholaos Georgios three years left in my life. Association (Toni Jones Terravita Golf Club research for the Koutzoulis Memorial Tournament) Texas Propane Gas I was wrong. I am now in my Edward J. Krebs direct benefit of Old Course of Loveland Association–Pros4Care fifth remission. William Judson “Jud” Laws prostate cancer (Edward Jones Putts for Tournament Gregory Alan Mack patients. They Prostate) Vasari Country Club (Vasari Despite the aggressiveness Anthony Armand Malizia, Jr., Battle at Old York Road Golf & Tennis Tournament for also encourage M.D. of my prostate cancer, I was Palatine Hills Golf Association Cancer) innovative and often Gordon Martin able to help my wife raise (PHGA Prostate Cancer Drive) Wycliffe Golf & Country Club risky projects that John Paul Mosca three young children to Palm Beach Polo & Country (Wycliffe Country Club Men’s could not be funded Golf Association) Dennis Nelson become fine teenagers, join Club elsewhere. These Palm-Aire Country Club at Zylka’s Red Bull Bar & Grill Gregory J. Nelson the Army Reserve (perhaps Earnest Preston Page approaches will lead research that—stewarded effectively by PCF— Sarasota Golf Tournament making me the only metastatic cancer patient Paupack Hills Golf and Country Anthony Pappalardo to improved patient delivers results and much needed advances in to ever do so) and serve in Iraq. Later, I Club In Memory Funds Eugene J. Potkay treatments and treatment science for patients like me and became Assistant U.S. Secretary of Defense Pebblecreek Men’s Golf Funds that contributed $1,000 James Robert Reyburn better outcomes. millions of others around the world. Association (Battle at Eagle’s or more James H. Scheper for Health Affairs. I have also started two Nest at Pebble Creek) John Seliskar — R. Christian B. Evensen companies that employ thousands of people. In Memory of: Money is research and research is the key to Pelican Point Golf & Country Herbert Achtentuch Gary J. Serfilippi In short, despite the challenges presented by Club Joseph “Jack” Armul Edward Peter Shortoff cures for a disease that affects so many men, Gene Hill advanced prostate cancer, I am leading a The Peninsula Club Men’s Golf Kevin J. Sullivan their families and friends. Antonio Sistos Arredondo Ken Lahners longer and more productive life—something I Association (Three Kings and Anthony Tomlon Claud Ballester Michael Milken a Queen Golf Tournament) Jack Walker didn’t think was possible years ago. Jack Barnes James B. Nebel With sincerest appreciation for your Battle at Persimmon Woods Richard Warren William W. Batoff Carl Orlando Pink & Blue at Balcones I’ve been blessed to reap many of the benefits continued support, Florence Blate Harold J. Wild Chris Paterson Country Club Arnold Brundage George E. Wojack Bruno Perillo made possible by research and clinical trials Putting for Prostates Arthur Bernard Celie Dwight Wubbenhorst Brian Rigo supported by the Prostate Cancer Foundation Quail West Golf Club Alan B. Chandler Bob Robinson and to have been treated all this time by Dr. Rancho Bernardo Golf Club In Honor Funds James “Jim” D. Clairmore Ron Rooke Hon. S. Ward “Trip” Casscells, MD (COL, USAR) Rarity Bay Golf Club Christopher Logothetis, a brilliant PCF- Thomas A. Dawes Funds that contributed $1,000 Tom Rosazza John E. Tyson Distinguished Professor of Medicine and Rio Verde 18-Hole WGA-Rio or more sponsored scientist at MD Anderson Cancer Derric DesMarteau Peter Scardino, M.D. Public Health, University of Texas at Houston Verde Country Club Dr. Howard Soule Center. It is because of this combination that Gilbert Dieteman In Honor of: Riverwood Golf Club Richard L. Starkey Jess Dietrick Bob and Deanne Adler’s I am alive today and able to make a very (Riverwood Men’s Club) Anniversary Larry Stupski Harry Falber personal appeal to you for your continued View a 30-minute documentary on Trip’s Roffin Country Club Chris Mark Allen Barbara and Stanley Zax’s 50th Michael Farley support of the work of PCF. San Carlos Golf Course Phillip and Arlene Barnes Wedding Anniversary remarkable journey through prostate cancer Elbert “Tootie” Fernandez (Halftime Lounge and Sports Randy and Debbie Barnes Dan Zenka diagnosis and treatment at: Bar Fights Cancer) Dan Fogelberg As a member of the PCF Board of Directors, I Ron and Mary Anne Barnes www.pcf.org/2011progress Sandbulte Memorial Golf William Fritsche H. Joseph Barthold can assure you that 79 percent of every dollar Tournament Hal Gaba The wedding of Mary-Alice that comes into PCF is deployed rapidly to Thomas N. Garrett Brady and Robert Miller Represents annual donations as of December 31, 2011. support game-changing programs. It is

28 2011 progress report 2011 progress report 29 Prostate Cancer Foundation SUPPORTING CURES CONSOLIDATED Statement of Financial Position

Continuing our momentum in finding better treatments and cures for prostate cancer Temporarily 2011 2010 requires the support of our more than 170,000 donors from across the globe. It enables December 31 Unrestricted Restricted Total Total PCF to identify the most promising research ideas and attract brilliant individuals and teams of junior and senior scientists to PCF’s research enterprise, moving discovery forward and ensuring continued progress. ASSETS Cash and Cash Equivalents $ 30,768,686 $ 800,000 $ 31,568,686 $ 17,501,144 Investments - - - 12,555,258 To support this urgent need, the Prostate Cancer Donations Pledges Receivable (Net) 13,442,463 5,150,000 18,592,463 15,442,076 Foundation offers individuals and charitable Prepaid Expenses and Other Assets 192,221 - 192,221 121,975 foundations various options for becoming involved Please mail your check to: and supporting crucial research. We welcome gifts Property and Equipment (Net) 643,867 - 643,867 593,827 of cash, securities, non-cash assets and gifts by will Prostate Cancer Foundation 1250 Fourth Street or living trust. We also welcome contributions made Total Assets $ 45,047,237 $ 5,950,000 $ 50,997,237 $ 46,214,280 in memory or in honor of friends or loved ones. Santa Monica, CA 90401 To make an online contribution, please visit our website: LIABILITIES AND NET ASSETS Challenge Awards www.pcf.org Liabilities ($1,000,000 and above for 2-4 year programs) If you prefer, you can make a donation by phone by calling Accounts Payable $ 280,776 $ - $ 280,776 $ 217,575 toll-free (800) 757-CURE (2873). PCF supports transformational prostate cancer research Accrued Liabilities 1,166,584 - 1,166,584 632,827 to accelerate progress toward reducing death and Grants Payable 19,001,183 - 19,001,183 15,063,044 suffering due to advanced prostate cancer. Teams may be Memorial or Tribute Gifts assembled from one or several institutions and should include at least three investigators capable of providing • Honor the memory of a loved one or celebrate the Total Liabilities 20,448,543 - 20,448,543 15,913,446 unique scientific expertise to solve a significant problem accomplishments of a friend or family member in prostate cancer research. These awards cover direct by helping others Net Assets costs of the research. • Make a memorial or tribute gift and PCF Unrestricted 24,598,694 - 24,598,694 23,860,990 will send an acknowledgement card to the family Creativity Awards or honoree Temporarily Restricted - 5,950,000 5,950,000 6,439,844 ($300,000 for 2 year programs) • PCF can also set up an ‘in memory of’ webpage to Total Net Assets 24,598,694 5,950,000 30,548,694 30,300,834 PCF supports innovative and daring research with Creativity honor your loved one Awards. Paid over a two-year period, these awards, totaling $300,000, support exceptionally novel projects with great Monthly Giving Total Liabilities and Net Assets $ 45,047,237 $ 5,950,000 $ 50,997,237 $ 46,214,280 potential to produce breakthroughs for detecting and treating prostate cancer. They are complementary and • Set up recurring donations for a convenient and integrated with other PCF award programs. manageable gift process that fits your monthly budget

Young Investigator Awards Other Gift Suggestions ($225,000 for 3-year career investment) • Assets or property including appreciated stock and real estate PCF provides these three-year awards, totaling $225,000, to keep the field of prostate cancer research vibrant with • Bequest – remember PCF in your will new ideas. The awards, matched by recipients’ institutions, offer career and project support for young but proven –– Name PCF as the primary or contingent beneficiary for your individual retirement account or a life insurance policy investigators (typically 35 years old or younger) who are committing their lives to a cure for prostate cancer. For more information, visit: www.pcf.org/donate

PCF has received a Four Star rating facebook.com/PCF.org from Charity Navigator, the highest honor attained by fewer than 25 percent of U.S. public charities. @PCFnews

30 2011 progress report 2011 progress report 31 Prostate Cancer Foundation Prostate Cancer Foundation CONSOLIDATED Statement of Activities CONSOLIDATED Statement of Cash Flows

Temporarily 2011 2010 December 31 2011 2010 December 31 Unrestricted Restricted Total Total CASH FLOWS FROM OPERATING ACTIVITIES: Revenue and Public Support Change in Net Assets $ 247,860 $ 7,753,173 Grants and Contributions $ 41,162,099 $ 1,950,000 $ 43,112,099 $ 40,219,226 Adjustments to Reconcile Change in Net Assets Interest and Dividends 322,190 - 322,190 214,678 to Net Cash Provided by (Used in) Operating Activities: Realized Loss on Investments (349,600) - (349,600) - Uncollectable Pledges Receivable 575,000 - Net Assets Released from Realized Loss on Investments 349,600 - Purpose Restrictions 2,439,844 (2,439,844) - - Depreciation and Amortization 239,332 134,750 (Increase) Decrease in: Pledges Receivable (3,725,387) (7,021,050) Total Revenue and Prepaid Expenses and Other Assets (70,246) 57,095 public Support 43,574,533 (489,844) 43,084,689 40,433,904 Increase (Decrease) in: Accounts Payable 63,201 86,961 Expenses Accrued Liabilities 533,757 (250,199) Program Services 33,841,169 - 33,841,169 24,749,774 Grants Payable 3,938,139 (1,290,334) Supporting Services: Management and General 3,217,658 - 3,217,658 3,261,488 Net Cash Provided by (Used in) Operating Activities 2,151,256 (529,604) Fundraising 5,778,002 - 5,778,002 4,669,469 CASH FLOWS FROM INVESTING ACTIVITIES: Purchase of Property and Equipment (289,372) (536,785) Total Expenses 42,836,829 - 42,836,829 32,680,731 Proceeds on Sale of Investments 12,205,658 - Purchase of Investments - (11,728,612) Reinvested Interest and Dividends - (214,678) Change in Net Assets 737,704 (489,844) 247,860 7,753,173

Net Cash Provided by (Used in) Investing Activities 11,916,286 (12,480,075) Net Assets – Beginning of Year 23,860,990 6,439,844 30,300,834 22,547,661 Net Increase (Decrease) in Cash and Cash Equivalents 14,067,542 (13,009,679) Net Assets – End of Year $ 24,598,694 $ 5,950,000 $ 30,548,694 $ 30,300,834 Cash and Cash Equivalents – Beginning of Year 17,501,144 30,510,823

Cash and Cash Equivalents – End of Year $ 31,568,686 $ 17,501,144

32 2011 progress report 2011 progress report 33 Prostate Cancer Foundation Report of Independent Auditors pcf supporting partners PCF is grateful for the support of our corporate partners. These organizations’ contributions and campaigns are enabling PCF to move closer to our goal of realizing a world without prostate cancer.

To the Board of Directors Prostate Cancer Foundation

We have audited the accompanying consolidated statement of financial position of the Prostate Cancer Foundation (the Foundation) as of December 31, 2011, and the related consolidated statements of activities, functional expenses and cash flows for the year then ended. These consolidated financial statements are the responsibility of the Foundation’s management. Our responsibility is to express an opinion on these consolidated financial statements based on our audit. The prior year summarized comparative information has TM been derived from the December 31, 2010 financial statements of the Foundation and in our report dated April 11, 2011, we expressed an unqualified opinion on those financial statements.

We conducted our audit in accordance with auditing standards generally accepted in the United States of

America. Those standards require that we plan and perform the audit to obtain reasonable assurance about TM whether the consolidated financial statements are free of material misstatement. An audit includes examining, on a test basis, evidence supporting the amounts and disclosures in the consolidated financial statements. An audit also includes assessing the accounting principles used and significant estimates made by management, Signature & Premier TAKE AIM Partners as well as evaluating the overall consolidated financial statement presentation. We believe that our audit provides a reasonable basis for our opinion.

In our opinion, the consolidated financial statements referred to above present fairly, in all material respects, the consolidated financial position of the Foundation as of December 31, 2011, and the changes in its net assets and its cash flows for the year then ended in conformity with accounting principles generally accepted in the Biotechnology & Pharmaceutical Partners United States of America.

Green Hasson & Janks LLP Green Hasson Janks

April 24, 2012 Los Angeles, California

TM

34 2011 progress report 2011 progress report 35 BOARD OF DIRECTORS & LEADERSHIP TEAM

Board of Directors Leadership Team

Michael Milken Arthur H. Kern Jeff C. Tarr Jonathan W. Simons, MD Founder and Chairman Investor Chairman President and Prostate Cancer Foundation Junction Advisors, Inc. Chief Executive Officer David H. Koch David H. Koch Chair Emilio Bassini Executive Vice President Paul Villanti Managing Principal Koch Industries, Inc. Executive Director Ralph Finerman Bassini & Company Global Program Investments Chief Financial Officer, Richard S. LeFrak Movember Treasurer and Secretary J. Darius Bikoff Chairman, President and Founder Chief Executive Officer Stanley R. Zax Howard R. Soule, PhD The Observatory US, Inc. LeFrak Organization Chairman and President Chief Science Officer and Zenith National Insurance Corp. Executive Vice President James C. Blair The Honorable Earle I. Mack General Partner Senior Partner Stuart Holden, MD Domain Associates, LLC Mack Company Medical Director

Steven A. Burd Jeffrey A. Marcus Gary Dicovitsky Chairman, President and Managing Director Executive Vice President We Are Not Letting Up Chief Executive Officer Crestview Partners Development Safeway, Inc. Shmuel Meitar Jan Haber The Honorable Director Vice President S. Ward Casscells, MD Aurec Group Events, Donor Relations While many men affected by prostate cancer are John E. Tyson Distinguished living longer, more productive lives as a result of Professor of Medicine and Public EJ Milken Helen Hsieh Health, and Vice President for Co-Founder Senior Vice President the advances we have made in the fight against this External Affairs and Public Policy Milken Institute Young Finance and Administration University of Texas Health Science Leaders Circle disease, too many are still dying. And, too many are Center at Houston Dave Perron Lori Milken Vice President being overtreated. The Prostate Cancer Foundation— Neil P. DeFeo Vice President Baseball and Sports Enterprises our Board of Directors, leadership team and staff— Chairman Prostate Cancer Foundation Sun Products Corporation Jan Wolterstorff remain committed to finding and supporting the most Henry L. Nordhoff Vice President David A. Ederer Vice Chairman Movember Initiatives innovative researchers around the world, building Chairman The Shipston Group Ederer Investment Company Dan Zenka, APR global collaboration and engaging with effective Lynda Resnick Senior Vice President partners to accelerate discovery. Through this R. Christian B. Evensen Vice Chairman Communications Managing Partner Roll Global, LLC commitment, we will, sooner than later, arrive at a Flintridge Capital Investments, LLC Richard V. Sandler day when all men can receive the precision medicine Vice President Peter T. Grauer Maron & Sandler they require for their level of prostate cancer and we Chairman Executive Vice President can overtreat less and cure more. Bloomberg, LP Milken Family Foundation The Reverend Rosey Grier J. Gary Shansby

Image credit: istock photography Milken Family Foundation Chairman Partida Tequila, LLC Stuart Holden, MD Director, Louis Warschaw Lawrence J. Stupski Prostate Cancer Center Chairman Cedars-Sinai Medical Center Stupski Foundation Cover background image credit: © thesupe87 / www.fotosearch.com Stock Photography 1250 Fourth Street, Santa Monica, CA 90401 | 800.757.CURE (2873) | www.pcf.org