Assessment of Outcomes in Septic and Severe Patients with Early Critical Care Intervention

A Case Comparison Study

Kenmore Mercy Hospital, Buffalo, NY

Matthew Missert DO Gopichand Pendurti MBBS Thomas Brewer DO Background & Rationale

 Severe sepsis and are characterized by a systemic inflammatory state secondary to an infectious cause with evidence of end-organ damage or hemodynamic instability

 In the United States there are an estimated 215,000 deaths annually as a result of severe sepsis and septic shock

 In the past, despite heroic measures septic shock and severe sepsis have carried a staggering mortality rate of 40 to 50 percent

Surviving Sepsis Campaign: http://www.survivingsepsis.org. 2012. Background & Rationale

 Newer methods of treatment such as those described by Rivers et. al. (Early Goal-directed Therapy) have demonstrated a 28-day reduction in mortality from 49.2 to 33.3 percent

 Comparable results have been observed with similar protocols placing emphasis on urgency and appropriateness of treatment

Shapiro N, Howell MD, Talmor D. Implementation and Outcomes of the Multiple Urgent Sepsis Therapies (MUST) Protocol. Critical Care . 2006. 34(4), 1025-32. Background & Rationale

Rivers E, Nguyen B, Havstad S, et al. Early Goal-directed Therapy in the Treatment of Severe Sepsis and Septic Shock. New England Journal of Medicine. 2001; 345(19), 1368-1377. Background & Rationale

 The Society of Critical Care Medicine in conjunction with the European Society of have established recommendations for the management of severe sepsis and septic shock

 The Surviving Sepsis Campaign was established to standardize the classification, diagnosis and treatment protocols

 The latest recommendations were released in 2008

Surviving Sepsis Campaign: http://www.survivingsepsis.org. 2012. Background & Rationale

 In summary, the Surviving Sepsis Campaign bundle recommends the following be completed within the first 6 hours of diagnosis:

1. ICU admission

2. Measurement of serum lactate within the first hour

3. Fluid resuscitation to achieve a CVP of ≥ 8 mmHg (≥ 12 mmHg in mechanically ventilated patients)

4. Maintenance of MAP ≥ 65 with the use of vasopressors if needed

5. Obtain blood cultures prior to the administration of

6. Administer broad spectrum antibiotics within the first 3 hours of ED admission and within the first 1 hour of non-ED admission

7. Achieve a central venous oxygen saturation (ScvO2) > 70% OR a mixed central venous oxygen saturation M(SvO2) > 65%

Surviving Sepsis Campaign: http://www.survivingsepsis.org. 2012. Background & Rationale

 On January 1st, 2011 Kenmore Mercy Hospital implemented a modified sepsis bundle adapted from the University of Rochester Medical Center and Strong Memorial Hospital in concordance with the Surviving Sepsis Campaign

 The modified sepsis bundle includes recommendations to have the ICU team notified and involved in patient care as soon as a patient with severe sepsis or septic shock has been identified in the

 It was postulated that there would be an improvement in morbidity and length of stay in this select patient population at Kenmore Mercy Hospital after the implementation of 24-hour critical care coverage and the use of the modified sepsis bundle Design

 A case-comparison retrospective analysis

 Comparison of patients admitted with a diagnosis of severe sepsis and/or septic shock prior to and following the implementation of the protocol with 24 in-house critical care coverage

 Institutional review board approval Design

 Inclusion criteria – The fulfillment of SIRS (systemic inflammatory response syndrome), AND – Identifiable source of infection, AND – A systolic blood pressure no greater than 90 mmHg on arrival or after a crystalloid-fluid challenge, OR – Blood lactate concentration ≥ 19.8 mg/dL (4 mmol/L), OR – Evidence of acute end-

Rivers E, Nguyen B, Havstad S, et al. Early Goal-directed Therapy in the Treatment of Severe Sepsis and Septic Shock. New England Journal of Medicine. 2001; 345(19), 1368-1377. Design

 Exclusion criteria – age < 18 years – pregnancy – acute cerebral vascular accident (as a primary diagnosis) – acute coronary syndrome (as a primary diagnosis) – status asthmaticus – cardiac dysrhythmia (as a primary diagnosis) – contraindication to central venous catheterization – active gastrointestinal hemorrhage (as a primary diagnosis) – seizure on arrival – drug overdose – Do Not Resuscitate (DNR) order on arrival or within the first 72 hours of admission

Rivers E, Nguyen B, Havstad S, et al. Early Goal-directed Therapy in the Treatment of Severe Sepsis and Septic Shock. New England Journal of Medicine. 2001; 345(19), 1368-1377. Design Methods

 Independent sample t-test analysis

 Utilizing IBM Statistical Package for the Social Sciences (SPSS) software

 Help from a statistically inclined colleague! Outcome Measures

 Primary – Absolute APACHE-II at 72 hours – Net reduction in APACHE-II at 72 hours

 Secondary – Hospital Length of Stay (days) – ICU Length of Stay (days) – Emergency Department Length of Stay (hours) – Volume infused in the first 6 and 12 hours – Volume infused over the first 24 hours – MAP at 24 hours

APACHE-II Score

Knaus WA, Draper EA, Wagner DP, Zimmerman JE. 1985. "APACHE II: a severity of disease classification system". Critical Care Medicine 13 (10): 818–29.

Results

Without Protocol (N=95) With Protocol (N=53)

Age (years) 68.2 65.1

Weight on Arrival (kg) 78.4 85.6

Temperature on Arrival (˚C) 37.6 37.9

Heart Rate on Arrival (bpm) 106 106

24 Hour Input (liters) 6.05 8.42

24 Hour Ouput (liters) 2.11 2.34

MAP at 24 Hours 82 84.7

Percentage Receiving Central Line 49.4% 98.1%

*Mortality 25.3% (24/95) 20.7% (11/53)

*Underpowered to detect mortality Results

Without Protocol With Protocol (N=95) (N=53) p Value

APACHE-II at Arrival 17.5 21.5 <0.00001

Absolute APACHE-II at 72 Hours 15.7 14.9 0.419

Net Reduction in APACHE at 72 1.8 6.5 <0.00001 Hours

ED Length of Stay (Hours) 4.51 3.51 0.002

ICU Length of Stay (Days) 7.2 6.1 0.296

Hospital Length of Stay (Days) 13.6 10.7 0.046

Input in first 6 Hours (liters) 1.62 2.23 0.002

Input in first 12 Hours (liters) 3.13 5.15 <0.00001 Results

Without Protocol With Protocol (N=95) (N=53) p Value

APACHE-II at Arrival 17.5 21.5 <0.00001

Absolute APACHE-II at 72 Hours 15.7 14.9 0.419

Net Reduction in APACHE at 72 1.8 6.5 <0.00001 Hours

ED Length of Stay (Hours) 4.51 3.51 0.002

ICU Length of Stay (Days) 7.2 6.1 0.296

Hospital Length of Stay (Days) 13.6 10.7 0.046

Input in First 6 Hours (liters) 1.62 2.23 0.002

Input in First 12 Hours (liters) 3.13 5.15 <0.00001 Results

Comparison in the Net Reduction of the APACHE-II Score at 72 Hours (p < 0.00001)

With Protcol (N=53) 6.5

Without Protocol (N=95) 1.8

0 1 2 3 4 5 6 7

APACHE-II Point Reduction Results

Comparison in ED Length of Stay (p = 0.002)

5

4 4.51 3 3.51 Hours 2

1

0 Without Protocol (N=95) With Protcol (N=53) Results

Comparison in Hospital Length of Stay (p = 0.046)

14

12 13.6

10 10.7 Hospital Days 8 6

4 2

0 Without Protocol (N=95) With Protcol (N=53) Results

Mean p Value

Age (Years) Mortality (N=35) 76.4 <0.001 No Mortality (N=113) 63.4

APACHE-II at 72 Mortality (N=35) 20.4 <0.001 No Mortality (N=113) 13.8

ED Length of Stay (Hours) Mortality (N=35) 4.2 0.98 No Mortality (N=113) 4.1

ICU Length of Stay (Days) Mortality (N=35) 8.9 0.11 No Mortality (N=113) 6.2

Hospital Length of Stay (Days) Mortality (N=35) 14.9 0.19 No Mortality (N=113) 11.9 Results

Mean p Value

Age (Years) Mortality (N=35) 76.4 <0.001 No Mortality (N=113) 63.4

APACHE-II at 72 Mortality (N=35) 20.4 <0.001 No Mortality (N=113) 13.8

ED Length of Stay (Hours) Mortality (N=35) 4.2 0.98 No Mortality (N=113) 4.1

ICU Length of Stay (Days) Mortality (N=35) 8.9 0.11 No Mortality (N=113) 6.2

Hospital Length of Stay (Days) Mortality (N=35) 14.9 0.19 No Mortality (N=113) 11.9 Time (Hours) 0 6 12 18 24

Temperature ˚C

No Protocol (N=95) 37.5 37.3 37.5 37.5 37.5

Protocol (N=53) 37.9 37.4 37.6 37.7 37.5

Heart Rate (bpm)

No Protocol (N=95) 106 98 97 94 95

Protocol (N=53) 106 96 93 91 93

Input (liters)

No Protocol (N=95) 0.00 1.67 3.13 4.70 6.05

Protocol (N=53) 0.00 2.23 5.15 6.96 8.42

Output (liters)

No Protocol (N=95) 0.00 0.42 1.01 1.56 2.10

Protocol (N=53) 0.00 0.36 0.96 1.60 2.34

MAP

No Protocol (N=95) 79.0 76.9 76.0 76.4 78.2

Protocol (N=53) 75.0 73.6 75.6 74.1 78.8 Time (Hours) 0 6 12 18 24

Temperature ˚C

No Protocol (N=95) 37.5 37.3 37.5 37.5 37.5

Protocol (N=53) 37.9 37.4 37.6 37.7 37.5

Heart Rate (bpm)

No Protocol (N=95) 106 98 97 94 95

Protocol (N=53) 106 96 93 91 93

Input (liters)

No Protocol (N=95) 0.00 1.67 3.13 4.70 6.05

Protocol (N=53) 0.00 2.23 5.15 6.96 8.42

Output (liters)

No Protocol (N=95) 0.00 0.42 1.01 1.56 2.10

Protocol (N=53) 0.00 0.36 0.96 1.60 2.34

MAP

No Protocol (N=95) 79.0 76.9 76.0 76.4 78.2

Protocol (N=53) 75.0 73.6 75.6 74.1 78.8 Conclusions

 The patients in the protocol arm had a significantly higher APACHE-II on arrival (21.5 vs 17.5, p<0.00001)

 There was a significant difference in the net reduction in the APACHE-II score at 72 hours in the protocol arm (6.5 vs 1.8, p<0.00001) but no significant difference in the absolute APACHE-II score at 72 hours (14.9 vs 15.7, p=0.419)

Conclusions

 The use of a sepsis bundle and protocol significantly reduced the emergency department length of stay by 60 minutes (p=0.002)

 The use of a sepsis bundle and protocol significantly reduced the hospital length of stay by 2.9 days (p=0.046)

 The fluid input for the first 6 & 12 hours was significantly greater in the protocol vs the no protocol arms (p=0.002 & p<0.00001, respectivley) Discussion and Considerations

•19 of the 78 charts identified (24 percent) after the implementation of the sepsis bundle failed to follow the protocol

•These are missed opportunities to improve the patient’s APACHE-II and significantly reduce their ED & Hospital lengths of stay Discussion and Considerations

 The data included out layers in both arms that may have actually skewed the results in favor non- significance

 However, these were still included in the analysis in order to preserve the integrity of the data

 Despite the out layers, hospital and emergency department length of stay were still found to be significantly reduced Discussion and Considerations

 Underpowered to detect mortality between the two arms

 Analysis of the entire population reflects what we already know: – The higher the APACHE-II, the greater the mortality (20.4 vs. 13.8, p<0.001) – The older the patient, the greater the mortality (76.4 vs 63.4, p<0.001)

 APACHE-II has only been validated as a predictor of mortality at admission and not as a dynamic predictor of mortality. However, APACHE-II is routinely used in the literature as a severity of illness index in a dynamic fashion (see Rivers et al) Discussion and Considerations

 Statistical considerations – p-Value of < 0.00001 is not always a good thing

– As in the case of the net reduction of the APACHE-II and APACHE-II at arrival having p<0.00001

– Can either mean the data is truly highly significant or there is the presence of a Type-I (alpha) error . e.g. Falsely rejecting the null hypothesis

Discussion and Considerations

 Can the principles learned from early goal directed therapy be executed in a small community based hospital and have meaningful outcomes? –YES !!!!!!!!!!!!!!!! Questions References

1. Schmidt GA, Mandel J, Parsons, PE, et al. Management of Severe Sepsis and Septic Shock in Adults. UpToDate®. February 3, 2010.

2. Shapiro N, Howell MD, Talmor D. Implementation and Outcomes of the Multiple Urgent Sepsis Therapies (MUST) Protocol. Critical Care Medicine. 2006. 34(4), 1025-32.

3. Dellinger RP, Levy, MM, Carlet JM, et. al. Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock: 2008. Critical Care Medicine. 2008.

4. The Surviving Sepsis Campaign: http://www.survivingsepsis.org. 2012.

5. Rivers E, Nguyen B, Havstad S, et al. Early Goal-directed Therapy in the Treatment of Severe Sepsis and Septic Shock. New England Journal of Medicine. 2001; 345(19), 1368-1377.

6. Knaus WA, Draper EA, Wagner DP, Zimmerman JE. 1985. "APACHE II: a severity of disease classification system". Critical Care Medicine 13 (10): 818–29.

7. Bryan-Brown CW, Dracup K. Procrastination is the Thief of Time: Surviving Guidelines. American Journal of Critical Care. 2004; 14(4), 287-289.

8. Talmore D, Greenberg D, Howell M et al. The Cost and Cost-effectiveness of an Integrated Sepsis Treatment Protocol. Critical Care Medicine. 2008; 36(4), 1168-1174.