Furuncles, Carbuncles and Erysipelas of Head. Etiology, Pathogeny
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Coexistence of Antibodies to Tick-Borne
Mem Inst Oswaldo Cruz, Rio de Janeiro, Vol. 98(3): 311-318, April 2003 311 Coexistence of Antibodies to Tick-borne Agents of Babesiosis and Lyme Borreliosis in Patients from Cotia County, State of São Paulo, Brazil Natalino Hajime Yoshinari/+, Milena Garcia Abrão, Virginia Lúcia Nazário Bonoldi, Cleber Oliveira Soares*, Claudio Roberto Madruga*, Alessandra Scofield**, Carlos Luis Massard**, Adivaldo Henrique da Fonseca** Laboratório de Investigação em Reumatologia (LIM-17), Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, Av. Dr. Arnaldo 455, 3º andar, 01246-903 São Paulo, SP, Brasil *Embrapa Gado de Corte, Campo Grande, MS, Brasil **Universidade Federal Rural do Rio de Janeiro, Seropédica, RJ, Brasil This paper reports a case of coinfection caused by pathogens of Lyme disease and babesiosis in brothers. This was the first case of borreliosis in Brazil, acquired in Cotia County, State of São Paulo, Brazil. Both children had tick bite history, presented erythema migrans, fever, arthralgia, mialgia, and developed positive serology (ELISA and Western-blotting) directed to Borrelia burgdorferi G 39/40 and Babesia bovis antigens, mainly of IgM class antibodies, suggestive of acute disease. Also, high frequencies of antibodies to B. bovis was observed in a group of 59 Brazilian patients with Lyme borreliosis (25.4%), when compared with that obtained in a normal control group (10.2%) (chi-square = 5.6; p < 0.05). Interestingly, both children presented the highest titers for IgM antibodies directed to both infective diseases, among all patients with Lyme borreliosis. Key words: lyme borreliosis - lyme disease - spirochetosis - borreliosis - babesiosis - coinfection - tick-borne disease - Brazil Babesiosis is a tick-borne disease distributed world- The first case of babesiosis in a healthy person, with wide, caused by hemoprotozoans of the genus Babesia, intact spleen, was reported in 1969 in a woman from Nan- which infects wild and domestic animals, promoting eco- tucket Island (Massachusetts, USA)(Wester et al. -
WO 2014/134709 Al 12 September 2014 (12.09.2014) P O P C T
(12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2014/134709 Al 12 September 2014 (12.09.2014) P O P C T (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every A61K 31/05 (2006.01) A61P 31/02 (2006.01) kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, (21) International Application Number: BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, PCT/CA20 14/000 174 DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, (22) International Filing Date: HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, 4 March 2014 (04.03.2014) KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, (25) Filing Language: English OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, (26) Publication Language: English SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, (30) Priority Data: ZW. 13/790,91 1 8 March 2013 (08.03.2013) US (84) Designated States (unless otherwise indicated, for every (71) Applicant: LABORATOIRE M2 [CA/CA]; 4005-A, rue kind of regional protection available): ARIPO (BW, GH, de la Garlock, Sherbrooke, Quebec J1L 1W9 (CA). GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, (72) Inventors: LEMIRE, Gaetan; 6505, rue de la fougere, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, Sherbrooke, Quebec JIN 3W3 (CA). -
Bacterial Infections Diseases Picture Cause Basic Lesion
page: 117 Chapter 6: alphabetical Bacterial infections diseases picture cause basic lesion search contents print last screen viewed back next Bacterial infections diseases Impetigo page: 118 6.1 Impetigo alphabetical Bullous impetigo Bullae with cloudy contents, often surrounded by an erythematous halo. These bullae rupture easily picture and are rapidly replaced by extensive crusty patches. Bullous impetigo is classically caused by Staphylococcus aureus. cause basic lesion Basic Lesions: Bullae; Crusts Causes: Infection search contents print last screen viewed back next Bacterial infections diseases Impetigo page: 119 alphabetical Non-bullous impetigo Erythematous patches covered by a yellowish crust. Lesions are most frequently around the mouth. picture Lesions around the nose are very characteristic and require prolonged treatment. ß-Haemolytic streptococcus is cause most frequently found in this type of impetigo. basic lesion Basic Lesions: Erythematous Macule; Crusts Causes: Infection search contents print last screen viewed back next Bacterial infections diseases Ecthyma page: 120 6.2 Ecthyma alphabetical Slow and gradually deepening ulceration surmounted by a thick crust. The usual site of ecthyma are the legs. After healing there is a permanent scar. The pathogen is picture often a streptococcus. Ecthyma is very common in tropical countries. cause basic lesion Basic Lesions: Crusts; Ulcers Causes: Infection search contents print last screen viewed back next Bacterial infections diseases Folliculitis page: 121 6.3 Folliculitis -
Abscesses Are a Serious Problem for People Who Shoot Drugs
Where to Get Your Abscess Seen Abscesses are a serious problem for people who shoot drugs. But what the hell are they and where can you go for care? What are abscesses? Abscesses are pockets of bacteria and pus underneath you skin and occasionally in your muscle. Your body creates a wall around the bacteria in order to keep the bacteria from infecting your whole body. Another name for an abscess is a “soft tissues infection”. What are bacteria? Bacteria are microscopic organisms. Bacteria are everywhere in our environment and a few kinds cause infections and disease. The main bacteria that cause abscesses are: staphylococcus (staff-lo-coc-us) aureus (or-e-us). How can you tell when you have an abscess? Because they are pockets of infection abscesses cause swollen lumps under the skin which are often red (or in darker skinned people darker than the surrounding skin) warm to the touch and painful (often VERY painful). What is the worst thing that can happen? The worst thing that can happen with abscesses is that they can burst under your skin and cause a general infection of your whole body or blood. An all over bacterial infection can kill you. Another super bad thing that can happen is a endocarditis, which is an infection of the lining of your heart, and “septic embolism”, which means that a lump of the contaminates in your abscess get loose in your body and lodge in your lungs or brain. Why do abscesses happen? Abscesses are caused when bad bacteria come in to contact with healthy flesh. -
Cellulitis (You Say, Sell-You-Ly-Tis)
Cellulitis (you say, sell-you-ly-tis) Any area of skin can become infected with cellulitis if the skin is broken, for example from a sore, insect bite, boil, rash, cut, burn or graze. Cellulitis can also infect the flesh under the skin if it is damaged or bruised or if there is poor circulation. Signs your child has cellulitis: The skin will look red, and feel warm and painful to touch. There may be pus or fluid leaking from the skin. The skin may start swelling. The red area keeps growing. Gently mark the edge of the infected red area How is with a pen to see if the red area grows bigger. cellulitis spread? Red lines may appear in the skin spreading out from the centre of the infection. Bad bacteria (germs) gets into broken skin such as a cut or insect bite. What to do Wash your hands before and Cellulitis is a serious infection that needs to after touching the infected area. be treated with antibiotics. Keep your child’s nails short and Go to the doctor if the infected area is clean. painful or bigger than a 10 cent piece. Don’t let your child share Go to the doctor immediately if cellulitis is bath water, towels, sheets and near an eye as this can be very serious. clothes. Make sure your child takes the antibiotics Make sure your child rests every day until they are finished, even if and eats plenty of fruit and the infection seems to have cleared up. The vegetables and drinks plenty of antibiotics need to keep killing the infection water. -
Pseudomonas Skin Infection Clinical Features, Epidemiology, and Management
Am J Clin Dermatol 2011; 12 (3): 157-169 THERAPY IN PRACTICE 1175-0561/11/0003-0157/$49.95/0 ª 2011 Adis Data Information BV. All rights reserved. Pseudomonas Skin Infection Clinical Features, Epidemiology, and Management Douglas C. Wu,1 Wilson W. Chan,2 Andrei I. Metelitsa,1 Loretta Fiorillo1 and Andrew N. Lin1 1 Division of Dermatology, University of Alberta, Edmonton, Alberta, Canada 2 Department of Laboratory Medicine, Medical Microbiology, University of Alberta, Edmonton, Alberta, Canada Contents Abstract........................................................................................................... 158 1. Introduction . 158 1.1 Microbiology . 158 1.2 Pathogenesis . 158 1.3 Epidemiology: The Rise of Pseudomonas aeruginosa ............................................................. 158 2. Cutaneous Manifestations of P. aeruginosa Infection. 159 2.1 Primary P. aeruginosa Infections of the Skin . 159 2.1.1 Green Nail Syndrome. 159 2.1.2 Interdigital Infections . 159 2.1.3 Folliculitis . 159 2.1.4 Infections of the Ear . 160 2.2 P. aeruginosa Bacteremia . 160 2.2.1 Subcutaneous Nodules as a Sign of P. aeruginosa Bacteremia . 161 2.2.2 Ecthyma Gangrenosum . 161 2.2.3 Severe Skin and Soft Tissue Infection (SSTI): Gangrenous Cellulitis and Necrotizing Fasciitis. 161 2.2.4 Burn Wounds . 162 2.2.5 AIDS................................................................................................. 162 2.3 Other Cutaneous Manifestations . 162 3. Antimicrobial Therapy: General Principles . 163 3.1 The Development of Antibacterial Resistance . 163 3.2 Anti-Pseudomonal Agents . 163 3.3 Monotherapy versus Combination Therapy . 164 4. Antimicrobial Therapy: Specific Syndromes . 164 4.1 Primary P. aeruginosa Infections of the Skin . 164 4.1.1 Green Nail Syndrome. 164 4.1.2 Interdigital Infections . 165 4.1.3 Folliculitis . -
Skin Disease and Disorders
Sports Dermatology Robert Kiningham, MD, FACSM Department of Family Medicine University of Michigan Health System Disclosures/Conflicts of Interest ◼ None Goals and Objectives ◼ Review skin infections common in athletes ◼ Establish a logical treatment approach to skin infections ◼ Discuss ways to decrease the risk of athlete’s acquiring and spreading skin infections ◼ Discuss disqualification and return-to-play criteria for athletes with skin infections ◼ Recognize and treat non-infectious skin conditions in athletes Skin Infections in Athletes ◼ Bacterial ◼ Herpetic ◼ Fungal Skin Infections in Athletes ◼ Very common – most common cause of practice-loss time in wrestlers ◼ Athletes are susceptible because: – Prone to skin breakdown (abrasions, cuts) – Warm, moist environment – Close contacts Cases 1 -3 ◼ 21 year old male football player with 4 day h/o left axillary pain and tenderness. Two days ago he noticed a tender “bump” that is getting bigger and more tender. ◼ 16 year old football player with 3 day h/o mildly tender lesions on chin. Started as a single lesion, but now has “spread”. Over the past day the lesions have developed a dark yellowish crust. ◼ 19 year old wrestler with a 3 day h/o lesions on right side of face. Noticed “tingling” 4 days ago, small fluid filled lesions then appeared that have now started to crust over. Skin Infections Bacterial Skin Infections ◼ Cellulitis ◼ Erysipelas ◼ Impetigo ◼ Furunculosis ◼ Folliculitis ◼ Paronychea Cellulitis Cellulitis ◼ Diffuse infection of connective tissue with severe inflammation of dermal and subcutaneous layers of the skin – Triad of erythema, edema, and warmth in the absence of underlying foci ◼ S. aureus or S. pyogenes Erysipelas Erysipelas ◼ Superficial infection of the dermis ◼ Distinguished from cellulitis by the intracutaneous edema that produces palpable margins of the skin. -
Factsheet Boils and Impetigo
FACTSHEET BOILS AND IMPETIGO WHAT IS A BOIL? HOW CAN YOU STOP THE SPREAD OF BOILS A boil is an infection of the skin, usually caused by AND IMPETIGO? Staphylococcus bacteria. Boils are tender, swollen sores, Wash your hands which are full of pus. The tenderness usually goes away, Hand washing is the most important way to prevent the once the boil bursts and the pus and fluid drain. spread of boils and impetigo. Wash all parts of your hands (including between the fingers and under fingernails) WHAT IS IMPETIGO? vigorously with soap and running water for 10-15 seconds. Impetigo is an infection of the skin caused by either Rinse well and dry your hands (with a paper towel if you Staphylococcus or Streptococcus bacteria. The symptoms can). Wash your hands: of impetigo are either small blisters or flat, honey-coloured crusty sores, on the skin. Impetigo is sometimes called • before and after touching or dressing an infected area ‘school sores’. or wound; • after going to the toilet; HOW ARE BOILS AND IMPETIGO TREATED? • after blowing your nose; If you have the symptoms of boils or impetigo: • before handling or eating food; • see your doctor for advice on the treatment of both; • before handling newborn babies; • if sores are small or few, local antiseptic cream and hot • after touching or handling unwashed clothing or linen; compresses may help; • after handling animals or animal waste. • your doctor may prescribe you antibiotic tablets or Cover boils and impetigo ointment. It is important to take the full course of antibiotics. If you don’t, the sores may come back. -
Laboratory Diagnosis of Gonococcal Infections * ALICE REYN, M.D.'
Bull. Org. mond. Sante 1 1965, 32, 449-469 Bull. Wld Hlth Org. Laboratory Diagnosis of Gonococcal Infections * ALICE REYN, M.D.' CONTENTS Page Pagp INTRODUCTION . ............... 449 DRUG SENsiTIVITY DETERMINAnON .... 462 COLLECTION AND HANDLING OF SPECIMENS MEDIA AND REAGENTS General remarks .... ........... 450 Preparation of broth . 462 Method of transportation . ........ 451 Chocolate ascitic-fluid-agar . ....... 463 HYL medium ..... ......... 464 BACTERIOLOGICAL EXAMINATION Fermentation media .... ...... 464 . Microscopy and Gram-staining technique . 452 1. Danish fermentation medium .... 464 2. HAP medium ...... 465 Culture and isolation . ....... 453 Stuart's medium with solid agar ..... 465 Control strains . ......... 456 .... .. 466 Fermentation tests .... ......... 457 Oxidase reagent ........ .... Diagnostic criteria .... ......... 458 Polymyxin B .......... 466 . Reporting of results ... ......... 458 Nystatin ..... ............ 466 Reagents to be used in the Gram-staining technique 466 SEROLOGICAL EXAMINATION ANNEX. Reviewers ...... 467 General remarks .... ........... 459 Gonococcus complement-fixation reaction . 460 REFERENCES .................. 467 INTRODUCTION The genus Neisseria comprises Gram-negative, organisms have been described more thoroughly than aerobic or facultatively anaerobic cocci, usually but the other members of the group, such as N. catar- not invariably arranged in pairs. The size is about rhalis, N. flavescens, N. sicca and N. flava (sub- 0.8,u by 0.6,u. They often grow poorly on ordinary species I-III). The classification of the Neisseria is media and they are frequently pathogenic. Few far from being complete and a taxonomic study of carbohydrates are fermented, indole is not produced this group is needed. and nitrates are not reduced. With a few exceptions, are N. gonorrhoeae (gonococcus) is the etiological catalase and oxidase abundantly produced; some agent of " gonorrhoea ", whereas N. -
Pediatric Cutaneous Bacterial Infections Dr
PEDIATRIC CUTANEOUS BACTERIAL INFECTIONS DR. PEARL C. KWONG MD PHD BOARD CERTIFIED PEDIATRIC DERMATOLOGIST JACKSONVILLE, FLORIDA DISCLOSURE • No relevant relationships PRETEST QUESTIONS • In Staph scalded skin syndrome: • A. The staph bacteria can be isolated from the nares , conjunctiva or the perianal area • B. The patients always have associated multiple system involvement including GI hepatic MSK renal and CNS • C. common in adults and adolescents • D. can also be caused by Pseudomonas aeruginosa • E. None of the above PRETEST QUESTIONS • Scarlet fever • A. should be treated with penicillins • B. should be treated with sulfa drugs • C. can lead to toxic shock syndrome • D. can be associated with pharyngitis or circumoral pallor • E. Both A and D are correct PRETEST QUESTIONS • Strep can be treated with the following antibiotics • A. Penicillin • B. First generation cephalosporin • C. clindamycin • D. Septra • E. A B or C • F. A and D only PRETEST QUESTIONS • MRSA • A. is only acquired via hospital • B. can be acquired in the community • C. is more aggressive than OSSA • D. needs treatment with first generation cephalosporin • E. A and C • F. B and C CUTANEOUS BACTERIAL PATHOGENS • Staphylococcus aureus: OSSA and MRSA • Gp A Streptococcus GABHS • Pseudomonas aeruginosa CUTANEOUS BACTERIAL INFECTIONS • Folliculitis • Non bullous Impetigo/Bullous Impetigo • Furuncle/Carbuncle/Abscess • Cellulitis • Acute Paronychia • Dactylitis • Erysipelas • Impetiginization of dermatoses BACTERIAL INFECTION • Important to diagnose early • Almost always -
Building Blocks of Clinical Practice Helping Athletic Trainers Build a Strong Foundation
Building Blocks of Clinical Practice Helping Athletic Trainers Build a Strong Foundation Issue #2: Bacterial Infections of the Skin Folliculitis Carbuncles Definition: Definition: • Inflammation of a hair follicle • A complication of folliculitis, a carbuncle is several • Can progress down hair follicle or into multiple furuncles that have merged.merged follicles and result in a furuncle or carbuncle • Carbuncles are readily transmitted by skin-to-skin contact. Often, the direct cause of a carbuncle cannot Causes: be determined.determined • Bacterial or viral infection, chemical irritation • Secondary to skin injury, which introduces bacteria to Causes: the area • Most carbuncles are caused by the bacteria • Shaving hairy areas may facilitate infection staphylococcus aureus. The infection is contagious and • Occlusion of hair-bearing areas may facilitate growth may spread to other areas of the body or other people.people of microbes • Friction Symptoms: • Hyperhidrosis • A carbuncle is a swollen lump or mass under the skin which may be the size of a pea or as larlargege as a golf ball.ball Symptoms: • The carbuncle may be red and irritated and might hurt • Areas are usually non-tender or slightly tender when you touch it.it • Area may itch • Pain gets worse as it fills with pus and dead tissue.tissue • Erythematous perifollicular papules or pustules may • Other signs and symptoms include itching at the site of develop infection, skin inflammation around the wound, general • Grouped lesions ill feeling, fever, or fatigue. Pain improves -
Dermatology in the ER
DRUG ERUPTIONS and OTHER DISORDERS Lloyd J. Cleaver D.O. , F.A.O.C.D, F.A.A.D. Professor of Dermatology ATSU-Kirksville College of Osteopathic Medicine INTERNAL MEDICINE BOARD REVIEW COURSE I Disclosures No Relevant Financial Relationships DRUG ERUPTIONS Drug Reactions 3 things you need to know 1. Type of drug reaction 2. Statistics What drugs are most likely to cause that type of reaction? 3. Timing How long after the drug was started did the reaction begin? Clinical Pearls Drug eruptions are extremely common Tend to be generalized/symmetric Maculopapular/morbilliform are most common Best Intervention: Stop the Drug! Do not dose reduce Completely remove the exposure How to spot the culprit? Drug started within days to a week prior to rash Can be difficult and take time Tip: can generally exclude all drugs started after onset of rash Drug eruptions can continue for 1-2 weeks after stopping culprit drug LITT’s drug eruption database Drug Eruptions Skin is one of the most common targets for drug reactions Antibiotics and anticonvulsants are most common 1-5% of patients 2% of all drug eruptions are “serious” TEN, DRESS More common in adult females and boys < 3 y/o Not all drugs cause eruptions at same rate: Aminopenicillins: 1.2-8% of exposures TMP-SMX: 2.8-3.7% NSAIDs: 1 in 200 Lamotrigine: 10% Drug Eruptions Three basic rules 1. Stop any unnecessary medications 2. Ask about non-prescription medications Eye drops, suppositories, implants, injections, patches, vitamin and health supplements, friend’s medications