BOTTLE-LOCKERTM: Overcap Closure System

DRUG SUBSTANCE SECURITY: BioFlex Solutions introduces it’s high purity closure system for drug substance storage bottles. Easily protect drug substance and create a tamper proof cover on a bottle, container, or carboy used in BioPharmaceutical production. The simple, easy-to-use lockout cover snaps in place in seconds, adding another level of protection to your final product.

AVOIDING ISSUES WITH BOTTLES: Maintaining drug product substance safety throughout production is critical to a process. Current storage bottles are convenient to use, but their simple screw top design can easily be opened or tampered. Common bottle failures occur at the bottle cap tubing system. The Bottle Locker will easily protect the tubing closure while eliminating the potential for accidentally exposing the bottle contents to the environment.

APPLICATIONS: >> Freeze Thaw >> Drug Product Protection >> Viral Containment >> Product Transportation >> Cell and Gene Therapy

BioFlex Solutions, LLC | 119 Fredon-Springdale Road - Newton, NJ 07860 www.BFlex.CO | [email protected] | 973-383-1232 1 NEXT LEVEL PRODUCT PROTECTION:

The Bottle LockerTM Closure System was designed to act as a tamper evident system for active ingredient that aligns with similar industry regulations currently required by law on final product.

FEATURES: ELIMINATE > Fits Industry standard bottles THE RISK > 100mL to 20 Liters ASSOCIATED > Patent Pending design WITH SHIPPING > Tamper Evident and Tamper Proof BOTTLES WITH > Easy to validate COMMON SCREW CAPS. ORDERING INSTRUCTIONS

Media Bottle, BioTainer, 1 Select Bottle Type Carboy

2 Confirm Closure Thread 38-430, 48 mm, GL 45

Standard cap, cap with 3 Determine Closure Height tubing insert

Material of construction, 4 Any Custom Requirements lockout

BioFlex Solutions, LLC | 119 Fredon-Springdale Road - Newton, NJ 07860 www.BFlex.CO | [email protected] | 973-383-1232 2