Supplementary Table 2: Differentially Expressed Tumor Genes Between African-American and European-American Patients

Supplementary Table 2: Differentially expressed tumor genes between African-American and European-American patients

Fold Gene Symbol Gene Title GenBank ID Affy ID Change P value FDR (%) ADI1 acireductone dioxygenase 1 NM_018269 217761_at 0.71 1.20E-04 0 AMFR autocrine motility factor receptor NM_001144 202203_s_at 1.9 2.38E-05 0 APOLD1 apolipoprotein L domain containing 1 NM_030817 221031_s_at 1.56 4.36E-04 0 C1orf38 chromosome 1 open reading frame 38 AB035482 210785_s_at 1.58 4.48E-04 0 C1orf38 chromosome 1 open reading frame 38 NM_004848 207571_x_at 1.51 7.06E-04 0 C8orf4 chromosome 8 open reading frame 4 NM_020130 218541_s_at 1.71 8.49E-06 0 CCR7 chemokine (C-C motif) receptor 7 NM_001838 206337_at 1.66 1.03E-03 0 CD2 CD2 molecule NM_001767 205831_at 1.49 6.17E-03 0 CD28 CD28 molecule NM_006139 206545_at 1.38 8.11E-03 0 CRYBB2 crystallin, beta B2 NM_000496 206777_s_at 3.02 1.30E-11 0 CTNNB1 catenin, beta 1, 88kDa NM_001904 201533_at 1.25 4.11E-07 0 DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 NM_013238 218435_at 1.64 3.78E-04 0 EIF2AK1 eukaryotic translation initiation factor 2-alpha kinase 1 AW007368 217735_s_at 0.76 3.27E-05 0 FLJ20035 hypothetical protein FLJ20035 NM_017631 218986_s_at 1.42 1.88E-04 0 GZMA granzyme A NM_006144 205488_at 1.63 6.47E-04 0 HERC2P2 hect domain and RLD 2 pseudogene 2 AB002391 217317_s_at 0.79 5.79E-05 0 HLA-B major histocompatibility complex, class I, B L07950 211911_x_at 1.34 3.19E-04 0 HLA-C major histocompatibility complex, class I, C U62824 211799_x_at 1.41 7.73E-05 0 HLA-DPB1 major histocompatibility complex, class II, DP beta 1 NM_002121 201137_s_at 1.44 5.96E-05 0 HLA-E major histocompatibility complex, class I, E X56841 200904_at 1.38 3.05E-04 0 LGALS8 lectin, galactoside-binding, soluble, 8 (galectin 8) AF074000 208936_x_at 0.71 2.36E-05 0 LGALS8 lectin, galactoside-binding, soluble, 8 (galectin 8) AF342815 208934_s_at 0.7 2.15E-04 0 LGALS8 lectin, galactoside-binding, soluble, 8 (galectin 8) AF342816 210732_s_at 0.58 2.14E-04 0 LOC283970 hypothetical protein LOC283970 AI925734 221992_at 1.53 4.38E-05 0 LOC474170 c114 SLIT-like testicular protein NM_014834 206088_at 0.71 2.13E-04 0 MAP3K15 Mitogen-activated protein kinase kinase kinase 15 BF739979 200979_at 1.2 1.64E-05 0 matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, MMP9 92kDa type IV collagenase) NM_004994 203936_s_at 1.86 3.27E-04 0 NKG7 natural killer cell group 7 sequence NM_005601 213915_at 1.46 5.64E-04 0 P2RY14 purinergic receptor P2Y, G-protein coupled, 14 NM_014879 206637_at 1.45 5.27E-04 0 PCGF3 polycomb group ring finger 3 NM_006315 204564_at 0.79 2.18E-05 0 PSCDBP protein L06633 209606_at 1.87 9.43E-04 0 PSPHL phosphoserine phosphatase-like NM_003832 205048_s_at 4.64 1.00E-11 0 RABIF RAB interacting factor NM_002871 204478_s_at 0.8 3.13E-05 0

Fold change for annotated probesets with European-American patients as the reference Supplementary Table 2: Differentially expressed tumor genes between African-American and European-American patients

RASA4 RAS p21 protein activator 4 AB011110 212706_at 1.5 2.01E-04 0 SF1 splicing factor 1 D26121 210172_at 2.17 9.22E-04 0 STAT1 signal transducer and activator of transcription 1, 91kDa BC002704 209969_s_at 1.71 5.51E-04 0 STAT1 signal transducer and activator of transcription 1, 91kDa M97935_3 M97935_3_at 1.38 3.10E-04 0 ZNF654 zinc finger protein 654 NM_018293 219239_s_at 0.7 8.31E-05 0 CCL5 chemokine (C-C motif) ligand 5 M21121 1405_i_at 1.61 1.36E-03 2 CD3D CD3d molecule, delta (CD3-TCR complex) NM_000732 213539_at 1.39 9.99E-04 2 CD8A CD8a molecule AW006735 205758_at 1.41 1.12E-03 2 HLA-C major histocompatibility complex, class I, C M12679 214459_x_at 1.2 4.34E-04 2 IFITM1 interferon induced transmembrane protein 1 (9-27) AA749101 214022_s_at 1.4 1.00E-03 2 PRF1 perforin 1 AI445650 214617_at 1.28 7.58E-04 2 RASA4 RAS p21 protein activator 4 NM_006989 208534_s_at 1.29 8.65E-04 2 SOS1 son of sevenless homolog 1 (Drosophila) L13857 212777_at 1.36 1.30E-03 2

TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) NM_000593 202307_s_at 1.39 8.35E-04 2 TRBV19 T cell receptor beta variable 19 M15564 210915_x_at 1.64 1.02E-03 2 EIF1AX eukaryotic translation initiation factor 1A, X-linked BG149698 201017_at 0.79 2.96E-04 2 LGALS8 lectin, galactoside-binding, soluble, 8 (galectin 8) L78132 208935_s_at 0.72 4.49E-04 2 LOC440434 hypothetical protein FLJ11822 AW340850 214107_x_at 0.8 2.59E-04 2 PRO1843 hypothetical protein PRO1843 NM_018507 219599_at 0.75 3.24E-04 2 TBC1D3I TBC1 domain family, member 3I AK021884 215090_x_at 0.8 2.77E-04 2 ADRA2C adrenergic, alpha-2C-, receptor AI264306 206128_at 1.38 1.93E-03 3 BTN3A1 butyrophilin, subfamily 3, member A1 U90552 209770_at 1.29 1.40E-03 3 CD1E CD1e molecule AA309511 215784_at 1.49 1.81E-03 3 CD83 CD83 molecule NM_004233 204440_at 1.39 1.47E-03 3 COTL1 coactosin-like 1 (Dictyostelium) NM_021615 221059_s_at 1.29 1.20E-03 3

EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa NM_001415 205321_at 0.65 1.31E-03 3 HLA-E major histocompatibility complex, class I, E M31183 217456_x_at 1.21 7.86E-04 3 IGH immunoglobulin heavy locus M87789 211430_s_at 1.78 2.46E-03 3 PEX14 peroxisomal biogenesis factor 14 AB017546 33760_at 1.24 1.08E-03 3 SMA3 /// SMA5 SMA3 /// SMA5 X83301 215043_s_at 0.61 8.53E-04 3 STAT1 signal transducer and activator of transcription 1, 91kDa NM_007315 200887_s_at 1.35 1.62E-03 3

TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) NM_000544 204770_at 1.31 1.07E-03 3 TXNDC13 thioredoxin domain containing 13 AL544094 201580_s_at 1.21 8.67E-04 3

BRDG1 BCR downstream signaling 1 NM_012108 220059_at 2.06 3.79E-03 3 CCL5 chemokine (C-C motif) ligand 5 NM_002985 204655_at 1.51 2.72E-03 3 CD1C CD1c molecule NM_001765 205987_at 1.3 1.79E-03 3 HLA-DQB1 major histocompatibility complex, class II, DQ beta 1 M17955 209823_x_at 1.48 2.48E-03 3 HLA-DQB1 major histocompatibility complex, class II, DQ beta 1 M32577 211656_x_at 1.31 2.13E-03 3 IFITM1 interferon induced transmembrane protein 1 (9-27) NM_003641 201601_x_at 1.35 2.03E-03 3 IL7R interleukin 7 receptor NM_002185 205798_at 1.61 2.88E-03 3 INDO indoleamine-pyrrole 2,3 dioxygenase M34455 210029_at 1.64 3.03E-03 3 ITK IL2-inducible T-cell kinase D13720 211339_s_at 1.76 2.77E-03 3 LOC153561 hypothetical protein LOC153561 X75940 214850_at 0.71 1.24E-03 3 LOC652745 similar to Ig kappa chain V-I region Walker precursor AJ408433 216401_x_at 2.12 3.50E-03 3 LSP1 lymphocyte-specific protein 1 NM_002339 203523_at 1.24 1.57E-03 3 LYZ lysozyme (renal amyloidosis) AV711904 213975_s_at 1.61 2.47E-03 3 MTMR2 myotubularin related protein 2 AK027038 203211_s_at 0.77 6.01E-04 3 MXRA7 matrix-remodelling associated 7 BF968134 212509_s_at 1.28 2.08E-03 3 STAT1 signal transducer and activator of transcription 1, 91kDa M97935_MB M97935_MB_at 1.51 2.38E-03 3 TRBV19 T cell receptor beta variable 19 AL559122 213193_x_at 1.57 2.37E-03 3 C5AR1 complement component 5a receptor 1 NM_001736 220088_at 1.37 2.87E-03 4 CD52 CD52 molecule N90866 34210_at 1.7 3.78E-03 4 HLA-E major histocompatibility complex, class I, E NM_005516 200905_x_at 1.27 2.09E-03 4 MARK1 MAP/microtubule affinity-regulating kinase 1 NM_018650 221047_s_at 0.8 5.47E-04 4 proteasome (prosome, macropain) subunit, beta type, 9 (large PSMB9 multifunctional peptidase 2) NM_002800 204279_at 1.44 3.27E-03 4

RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated) NM_015376 205801_s_at 1.27 2.27E-03 4 VPS53 vacuolar protein sorting 53 (S. cerevisiae) NM_018289 219794_at 0.81 5.10E-04 4 type 1 tumor necrosis factor receptor shedding aminopeptidase ARTS-1 regulator AF183569 209788_s_at 1.32 3.81E-03 5 BCL2A1 BCL2-related protein A1 NM_004049 205681_at 1.43 4.21E-03 5 CCDC109B coiled-coil domain containing 109B NM_017918 218802_at 1.29 3.04E-03 5 CPZ carboxypeptidase Z BC006393 211062_s_at 1.26 3.39E-03 5 CXCR4 chemokine (C-X-C motif) receptor 4 AJ224869 217028_at 1.72 4.49E-03 5 EVI2A ecotropic viral integration site 2A NM_014210 204774_at 1.48 3.88E-03 5 HLA-DQB1 major histocompatibility complex, class II, DQ beta 1 AI583173 212998_x_at 1.39 4.36E-03 5 HLA-DRB1 major histocompatibility complex, class II, DR beta 1 AJ297586 215193_x_at 1.3 3.91E-03 5 HLA-DRB1 major histocompatibility complex, class II, DR beta 1 U65585 209312_x_at 1.3 3.70E-03 5

HLA-F major histocompatibility complex, class I, F NM_018950 204806_x_at 1.29 3.58E-03 5 HLA-G HLA-G histocompatibility antigen, class I, G M90684 211529_x_at 1.22 2.34E-03 5 ICAM2 intercellular adhesion molecule 2 NM_000873 204683_at 1.2 2.36E-03 5 IFI27 interferon, alpha-inducible protein 27 NM_005532 202411_at 1.34 4.38E-03 5 IFI44L interferon-induced protein 44-like NM_006820 204439_at 1.63 4.67E-03 5 IGHM immunoglobulin heavy constant mu BC001872 209374_s_at 2.37 4.91E-03 5 IGKC immunoglobulin kappa constant L14458 211644_x_at 1.88 4.82E-03 5 IGKC Immunoglobulin kappa constant BG485135 214669_x_at 1.67 5.16E-03 5 IGL immunoglobulin lambda locus X57812 214677_x_at 1.81 4.63E-03 5 IGL immunoglobulin lambda locus AA680302 215121_x_at 1.74 4.81E-03 5 IGL immunoglobulin lambda locus AV698647 215379_x_at 1.67 5.67E-03 5 IGL Immunoglobulin lambda locus M87790 209138_x_at 1.82 5.35E-03 5 IRF1 interferon regulatory factor 1 NM_002198 202531_at 1.38 4.59E-03 5 ISG15 ISG15 ubiquitin-like modifier NM_005101 205483_s_at 1.6 4.41E-03 5 LOC400410 similar to cervical cancer suppressor-1 AL109714 217104_at 0.72 1.34E-03 5 LOC651629 similar to Ig kappa chain V-I region Walker precursor AW404894 215176_x_at 1.91 6.10E-03 5 PLGLB2 plasminogen-like B2 BC005379 205871_at 0.66 1.33E-03 5 PTPRC protein tyrosine phosphatase, receptor type, C NM_002838 207238_s_at 1.6 4.87E-03 5 STAT1 signal transducer and activator of transcription 1, 91kDa M97935_MA M97935_MA_at 1.45 4.33E-03 5 TRBV21-1 T cell receptor beta variable 21-1 AF043179 211796_s_at 1.58 4.13E-03 5 WASPIP Wiskott-Aldrich syndrome protein interacting protein AI005043 202663_at 1.33 4.06E-03 5 3.8-1 MHC class I mRNA fragment 3.8-1 AI346483 214186_s_at 1.21 3.61E-03 5 ADAMDEC1 ADAM-like, decysin 1 NM_014479 206134_at 1.81 7.57E-03 5

ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 AK023795 222162_s_at 1.48 7.10E-03 5 ADRB1 adrenergic, beta-1-, receptor NM_000684 208214_at 0.63 1.89E-03 5 APOL6 apolipoprotein L, 6 NM_030641 219716_at 1.2 3.58E-03 5 ARL17P1 ADP-ribosylation factor-like 17 pseudogene 1 AF119889 210718_s_at 0.67 1.77E-03 5 C1QA complement component 1, q subcomponent, A chain NM_015991 218232_at 1.37 5.47E-03 5 C1QB complement component 1, q subcomponent, B chain NM_000491 202953_at 1.43 4.98E-03 5 CD48 CD48 molecule NM_001778 204118_at 1.44 7.26E-03 5 CORO1A coronin, actin binding protein, 1A U34690 209083_at 1.4 6.63E-03 5 CREM cAMP responsive element modulator D14826 209967_s_at 1.43 7.22E-03 5 CTSC cathepsin C NM_001814 201487_at 1.35 6.48E-03 5 CXCR4 chemokine (C-X-C motif) receptor 4 AF348491 211919_s_at 1.66 8.18E-03 5 CXCR4 chemokine (C-X-C motif) receptor 4 L01639 209201_x_at 1.65 4.77E-03 5

DUSP2 dual specificity phosphatase 2 NM_004418 204794_at 1.53 6.81E-03 5 Epstein-Barr virus induced gene 2 (lymphocyte-specific G EBI2 protein-coupled receptor) NM_004951 205419_at 1.56 6.65E-03 5 GMFG glia maturation factor, gamma NM_004877 204220_at 1.32 4.68E-03 5 GPR171 G protein-coupled receptor 171 NM_013308 207651_at 1.49 5.69E-03 5 HERC5 hect domain and RLD 5 NM_016323 219863_at 1.21 3.55E-03 5 HLA-B major histocompatibility complex, class I, B L42024 209140_x_at 1.2 3.24E-03 5 IFIT3 interferon-induced protein with tetratricopeptide repeats 3 NM_001549 204747_at 1.25 5.03E-03 5 immunoglobulin J polypeptide, linker protein for IGJ immunoglobulin alpha and mu polypeptides AV733266 212592_at 2.02 6.63E-03 5 IGKC immunoglobulin kappa constant BC005332 221651_x_at 1.59 5.93E-03 5 IGKC immunoglobulin kappa constant M63438 221671_x_at 1.6 5.72E-03 5 IGKV1D-13 immunoglobulin kappa variable 1D-13 AW408194 216207_x_at 1.73 6.68E-03 5 IGLJ3 immunoglobulin lambda joining 3 AB014341 211881_x_at 1.45 7.66E-03 5 IL10RA interleukin 10 receptor, alpha NM_001558 204912_at 1.38 6.05E-03 5 interleukin 2 receptor, gamma (severe combined IL2RG immunodeficiency) NM_000206 204116_at 1.32 4.92E-03 5 IRF8 interferon regulatory factor 8 AI073984 204057_at 1.3 5.80E-03 5 LOC339562 similar to Ig kappa chain V-I region Walker precursor M20812 217480_x_at 1.64 6.35E-03 5 LOC96610 Hypothetical protein similar to KIAA0187 gene product X79782 217179_x_at 1.57 8.45E-03 5 NARS2 asparaginyl-tRNA synthetase 2 (mitochondrial) NM_024678 219217_at 0.81 1.40E-03 5 PARP12 poly (ADP-ribose) polymerase family, member 12 NM_022750 218543_s_at 1.21 3.11E-03 5 PEX14 peroxisomal biogenesis factor 14 NM_004565 203503_s_at 1.2 3.34E-03 5 PI15 peptidase inhibitor 15 NM_015886 207938_at 1.63 6.73E-03 5 PTGDS prostaglandin D2 synthase 21kDa (brain) NM_000954 212187_x_at 1.3 6.99E-03 5 RASA4 RAS p21 protein activator 4 AI738591 212707_s_at 1.24 3.85E-03 5

RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated) NM_005739 205590_at 1.45 7.12E-03 5 SMA3 SMA3 NM_006780 206565_x_at 0.7 1.79E-03 5 TFEC transcription factor EC NM_012252 206715_at 1.34 6.83E-03 5 TNFRSF7 tumor necrosis factor receptor superfamily, member 7 NM_001242 206150_at 1.38 7.19E-03 5 ZNF37B zinc finger protein 37B AK026980 215358_x_at 0.76 1.45E-03 5 SEPT6 septin 6 AY034177 212413_at 1.21 6.58E-03 6 APOL1 apolipoprotein L, 1 AF323540 209546_s_at 1.28 7.04E-03 6 CD53 CD53 molecule NM_000560 203416_at 1.34 9.22E-03 6 CROCC ciliary rootlet coiled-coil, rootletin BC006312 211038_s_at 1.27 7.21E-03 6

ENOSF1 enolase superfamily member 1 AF305057 213645_at 0.79 2.10E-03 6 FAIM3 Fas apoptotic inhibitory molecule 3 AI084226 221601_s_at 1.55 0.01 6 HCLS1 hematopoietic cell-specific Lyn substrate 1 NM_005335 202957_at 1.39 7.91E-03 6 HLA-B major histocompatibility complex, class I, B D83043 208729_x_at 1.23 5.34E-03 6 HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 BG397856 212671_s_at 1.48 9.08E-03 6 HLA-DQB1 major histocompatibility complex, class II, DQ beta 1 AW276186 212999_x_at 1.48 9.58E-03 6 HLA-DQB1 major histocompatibility complex, class II, DQ beta 1 M17565 211654_x_at 1.32 8.13E-03 6 HLA-F major histocompatibility complex, class I, F BE138825 221978_at 1.36 7.37E-03 6 HLA-F major histocompatibility complex, class I, F AW514210 221875_x_at 1.25 6.60E-03 6 IFI16 interferon, gamma-inducible protein 16 NM_005531 206332_s_at 1.25 7.57E-03 6 IFITM3 interferon induced transmembrane protein 3 (1-8U) BF338947 212203_x_at 1.22 5.99E-03 6 IGHM immunoglobulin heavy constant mu X17115 212827_at 2.48 0.01 6 immunoglobulin kappa constant /// immunoglobulin kappa IGKC /// IGKV1-5 variable 1-5 BG536224 214836_x_at 1.58 9.52E-03 6 IGLV2-14 immunoglobulin lambda variable 2-14 AJ249377 217148_x_at 1.96 9.89E-03 6 ISG20 interferon stimulated exonuclease gene 20kDa NM_002201 204698_at 1.33 8.15E-03 6 proteasome (prosome, macropain) subunit, beta type, 8 (large PSMB8 multifunctional peptidase 7) U17496 209040_s_at 1.29 6.92E-03 6 PTGDS prostaglandin D2 synthase 21kDa (brain) M61900 211663_x_at 1.3 7.23E-03 6 PTGDS prostaglandin D2 synthase 21kDa (brain) BC005939 211748_x_at 1.29 7.60E-03 6 PTPRC protein tyrosine phosphatase, receptor type, C Y00062 212588_at 1.58 9.17E-03 6 ras-related C3 botulinum toxin substrate 2 (rho family, small RAC2 GTP binding protein Rac2) BE138888 213603_s_at 1.4 7.65E-03 6 RAMP3 receptor (calcitonin) activity modifying protein 3 NM_005856 205326_at 1.23 6.93E-03 6

SAMSN1 SAM domain, SH3 domain and nuclear localisation signals, 1 NM_022136 220330_s_at 1.6 9.90E-03 6 SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9 BC002538 209723_at 1.36 7.27E-03 6 SLA Src-like-adaptor NM_006748 203761_at 1.36 9.55E-03 6 SLFN12 schlafen family member 12 NM_018042 219885_at 1.24 7.58E-03 6 STK17B serine/threonine kinase 17b (apoptosis-inducing) NM_004226 205214_at 1.31 7.19E-03 6 TRA T cell receptor alpha locus M15565 210972_x_at 1.42 8.84E-03 6 CREM cAMP responsive element modulator NM_001881 207630_s_at 1.41 0.01 7 CXCL11 chemokine (C-X-C motif) ligand 11 AF030514 210163_at 2.34 0.01 7 ECHDC3 enoyl Coenzyme A hydratase domain containing 3 NM_024693 219298_at 1.24 9.14E-03 7 HLA-DRB1 major histocompatibility complex, class II, DR beta 1 NM_002125 204670_x_at 1.27 8.78E-03 7 IFI44 interferon-induced protein 44 NM_006417 214453_s_at 1.4 9.86E-03 7

IFI6 interferon, alpha-inducible protein 6 NM_022873 204415_at 1.62 0.01 7 IFITM2 interferon induced transmembrane protein 2 (1-8D) NM_006435 201315_x_at 1.23 8.75E-03 7 LOC644450 hypothetical protein LOC644450 AI050036 222347_at 0.68 2.69E-03 7

OBSCN Obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF AI344415 222324_at 0.65 2.61E-03 7 PLEKHQ1 pleckstrin homology domain containing, Q member 1 NM_025201 204436_at 1.21 7.59E-03 7 PRG1 proteoglycan 1, secretory granule NM_002727 201859_at 1.32 9.74E-03 7 PTPN22 protein tyrosine phosphatase, non-receptor type 22 NM_015967 206060_s_at 1.26 9.83E-03 7 THBD thrombomodulin NM_000361 203888_at 1.31 9.35E-03 7 ZNF606 zinc finger protein 606 NM_025027 219635_at 0.82 1.73E-03 7 SEPT6 septin 6 AY034177 212414_s_at 1.24 0.01 8 CD37 CD37 molecule NM_001774 204192_at 1.44 0.01 8 claudin 5 (transmembrane protein deleted in velocardiofacial CLDN5 syndrome) NM_003277 204482_at 1.53 0.01 8 CLIC2 chloride intracellular channel 2 AI768628 213415_at 1.21 0.01 8 CSF2RB colony stimulating factor 2 receptor, beta AV756141 205159_at 1.42 0.01 8 CTA-246H3.1 similar to omega protein AL022324 215946_x_at 1.54 0.01 8 EDNRA endothelin receptor type A NM_001957 204464_s_at 1.28 0.01 8 FLJ20152 hypothetical protein FLJ20152 AI816291 218510_x_at 0.72 2.75E-03 8 HLA-A major histocompatibility complex, class I, A M80469 217436_x_at 1.23 0.01 8 HLA-DRA major histocompatibility complex, class II, DR alpha M60334 208894_at 1.31 0.01 8 HLA-DRA major histocompatibility complex, class II, DR alpha M60333 210982_s_at 1.31 0.01 8 immunoglobulin heavy constant alpha 1 /// immunoglobulin IGHA1 /// IGHA2 heavy constant alpha 2 (A2m marker) S55735 217022_s_at 1.74 0.01 8 IGLJ3 immunoglobulin lambda joining 3 AB001733 211798_x_at 1.47 0.01 8 IL20RA interleukin 20 receptor, alpha NM_014432 219115_s_at 0.74 3.75E-03 8 LCK lymphocyte-specific protein tyrosine kinase NM_005356 204891_s_at 1.36 0.01 8 myxovirus (influenza virus) resistance 1, interferon-inducible MX1 protein p78 (mouse) NM_002462 202086_at 1.34 0.01 8 OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa NM_016817 204972_at 1.41 0.01 8 PDK4 pyruvate dehydrogenase kinase, isozyme 4 NM_002612 205960_at 1.71 0.01 8 PLTP phospholipid transfer protein NM_006227 202075_s_at 1.33 0.01 8 RNASE1 ribonuclease, RNase A family, 1 (pancreatic) NM_002933 201785_at 1.3 0.01 8 TSGA10 testis specific, 10 NM_025244 220623_s_at 0.69 2.75E-03 8 ZAP70 zeta-chain (TCR) associated protein kinase 70kDa AI817942 214032_at 1.21 9.38E-03 8 BIRC4BP XIAP associated factor-1 NM_017523 206133_at 1.26 0.01 9 BTN3A2 butyrophilin, subfamily 3, member A2 AI991252 212613_at 1.32 0.01 9

C1orf54 chromosome 1 open reading frame 54 NM_024579 219506_at 1.23 0.01 9 CCL19 chemokine (C-C motif) ligand 19 U88321 210072_at 1.63 0.01 9 CCL4 chemokine (C-C motif) ligand 4 NM_002984 204103_at 1.58 0.01 9 CCR5 chemokine (C-C motif) receptor 5 NM_000579 206991_s_at 1.23 0.01 9 CLEC4A C-type lectin domain family 4, member A NM_016184 219947_at 1.24 0.01 9 DOCK10 dedicator of cytokinesis 10 NM_017718 219279_at 1.37 0.01 9 elongation of very long chain fatty acids (FEN1/Elo2, ELOVL2 SUR4/Elo3, yeast)-like 2 BF508639 213712_at 1.46 0.01 9 FBN2 fibrillin 2 (congenital contractural arachnodactyly) NM_001999 203184_at 1.37 0.01 9 GLTP glycolipid transfer protein NM_016433 219267_at 0.77 2.90E-03 9 GNG11 guanine nucleotide binding protein (G protein), gamma 11 NM_004126 204115_at 1.24 0.01 9 ICAM2 intercellular adhesion molecule 2 AA126728 213620_s_at 1.23 0.01 9 IGHA1 immunoglobulin heavy constant alpha 1 AB035175 216510_x_at 1.62 0.01 9 IGHG1 Immunoglobulin heavy constant gamma 1 (G1m marker) AW519168 215118_s_at 1.78 0.02 9 IGL@ Immunoglobulin lambda locus D84143 216984_x_at 1.79 0.01 9 IL16 interleukin 16 (lymphocyte chemoattractant factor) NM_004513 209827_s_at 1.27 0.01 9 IRS2 insulin receptor substrate 2 BF700086 209184_s_at 1.27 0.01 9 ISG20 interferon stimulated exonuclease gene 20kDa U88964 33304_at 1.28 0.01 9 integrin, alpha L (antigen CD11A (p180), lymphocyte function- ITGAL associated antigen 1; alpha polypeptide) AC002310 213475_s_at 1.21 0.01 9 OLFML2A olfactomedin-like 2A AL050002 213075_at 1.29 0.01 9 PLEK pleckstrin NM_002664 203471_s_at 1.32 0.01 9 RGS16 regulator of G-protein signalling 16 BF304996 209324_s_at 1.42 0.01 9 SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin) NM_003357 205725_at 2 0.02 9 THBD thrombomodulin NM_000361 203887_s_at 1.4 0.01 9 TP53TG3 TP53TG3 protein NM_015369 220167_s_at 0.8 2.35E-03 9 UCP2 uncoupling protein 2 (mitochondrial, proton carrier) U94592 208998_at 1.22 0.01 9 WASPIP Wiskott-Aldrich syndrome protein interacting protein AW058622 202664_at 1.31 0.01 9 ARHGAP25 Rho GTPase activating protein 25 D29642 38149_at 1.2 0.01 10 CD86 CD86 molecule L25259 210895_s_at 1.35 0.01 10 CD97 CD97 molecule NM_001784 202910_s_at 1.22 0.01 10 DNASE1L3 deoxyribonuclease I-like 3 NM_004944 205554_s_at 1.25 0.01 10 HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 NM_006042 219985_at 1.24 0.01 10 LAPTM5 lysosomal associated multispanning membrane protein 5 NM_006762 201721_s_at 1.32 0.01 10 lymphocyte cytosolic protein 2 (SH2 domain containing LCP2 leukocyte protein of 76kDa) AI123251 205269_at 1.37 0.01 10

leukocyte immunoglobulin-like receptor, subfamily B (with TM LILRB2 and ITIM domains), member 2 AF004231 210146_x_at 1.2 0.01 10 MAP4K1 mitogen-activated protein kinase kinase kinase kinase 1 AA744529 214339_s_at 1.26 0.01 10 MAPK8 mitogen-activated protein kinase 8 U35004 210671_x_at 0.82 2.41E-03 10 MS4A1 membrane-spanning 4-domains, subfamily A, member 1 BC002807 210356_x_at 1.84 0.02 10 MTMR2 myotubularin related protein 2 NM_016156 203212_s_at 0.8 2.87E-03 10 NID1 nidogen 1 BF940043 202007_at 1.27 0.01 10 PLGLA1 plasminogen-like A1 N58120 214415_at 0.79 3.48E-03 10 PMS2 PMS2 postmeiotic segregation increased 2 NM_024521 221206_at 0.82 2.96E-03 10 PRG1 proteoglycan 1, secretory granule J03223 201858_s_at 1.4 0.01 10 PTPRC protein tyrosine phosphatase, receptor type, C AI809341 212587_s_at 1.44 0.01 10 RGS1 regulator of G-protein signalling 1 S59049 216834_at 1.29 0.01 10 RHOD ras homolog gene family, member D BC001338 209885_at 0.81 3.40E-03 10 SELP selectin P (granule membrane protein 140kDa, antigen CD62) NM_003005 206049_at 1.29 0.01 10 SLAMF1 signaling lymphocytic activation molecule member 1 NM_003037 206181_at 1.23 0.01 10 SOCS1 suppressor of cytokine signaling 1 AB005043 210001_s_at 1.28 0.01 10 UBE2L6 ubiquitin-conjugating enzyme E2L 6 NM_004223 201649_at 1.26 0.01 10 ADAM28 ADAM metallopeptidase domain 28 NM_014265 205997_at 1.61 0.02 11 ARHGAP15 Rho GTPase activating protein 15 NM_018460 218870_at 1.25 0.02 11 ARL4C ADP-ribosylation factor-like 4C BG435404 202207_at 1.23 0.02 11 BTN3A2 butyrophilin, subfamily 3, member A2 BC002832 209846_s_at 1.3 0.02 11 CD207 CD207 molecule, langerin NM_015717 220428_at 1.27 0.02 11 CDC7 CDC7 cell division cycle 7 (S. cerevisiae) NM_003503 204510_at 1.28 0.02 11 CKMT1B creatine kinase, mitochondrial 1B NM_020990 202712_s_at 0.66 5.83E-03 11 CPM carboxypeptidase M NM_001874 206100_at 2.16 0.02 11 CREM cAMP responsive element modulator U44836 214508_x_at 1.34 0.02 11 GPM6A glycoprotein M6A BF939489 209469_at 1.63 0.02 11 HLA-DQB1 major histocompatibility complex, class II, DQ beta 1 M16276 209480_at 1.5 0.02 11 IGHD immunoglobulin heavy constant delta AJ275469 214973_x_at 1.55 0.02 11 integrin, beta 2 (complement component 3 receptor 3 and 4 ITGB2 subunit) NM_000211 202803_s_at 1.32 0.01 11 MGC2463 hypothetical protein LOC79037 NM_024070 219812_at 1.24 0.02 11 MS4A1 membrane-spanning 4-domains, subfamily A, member 1 X12530 217418_x_at 1.79 0.02 11 NACHT, leucine rich repeat and PYD (pyrin domain) containing NALP1 1 NM_021730 218380_at 1.3 0.02 11 RUNX3 runt-related transcription factor 3 AA541630 204198_s_at 1.34 0.02 11

TRA T cell receptor alpha locus M12423 209671_x_at 1.23 0.01 11 VSIG4 V-set and immunoglobulin domain containing 4 NM_007268 204787_at 1.27 0.01 11 apolipoprotein B mRNA editing enzyme, catalytic polypeptide- APOBEC3G like 3G NM_021822 204205_at 1.27 0.02 13 APOE apolipoprotein E NM_000041 203382_s_at 1.47 0.02 13 CD69 CD69 molecule L07555 209795_at 1.5 0.02 13 cytidine monophosphate-N-acetylneuraminic acid hydroxylase CMAH (CMP-N-acetylneuraminate monooxygenase) AF074480 210571_s_at 1.26 0.02 13 CTSS cathepsin S BC002642 202901_x_at 1.27 0.02 13 DKFZP761N09121 hypothetical protein DKFZp761N09121 BF435376 213486_at 0.8 7.05E-03 13 EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha BC002513 201143_s_at 0.82 6.68E-03 13 EVI2B ecotropic viral integration site 2B BC005926 211742_s_at 1.42 0.02 13 FLI1 Friend leukemia virus integration 1 NM_002017 204236_at 1.27 0.02 13 GPRC5B G protein-coupled receptor, family C, group 5, member B NM_016235 203632_s_at 1.23 0.02 13 GSTM3 glutathione S-transferase M3 (brain) AL527430 202554_s_at 1.27 0.02 13 GZMK granzyme K (granzyme 3; tryptase II) NM_002104 206666_at 1.68 0.03 13 IFIT1 interferon-induced protein with tetratricopeptide repeats 1 NM_001548 203153_at 1.33 0.02 13 IFNG interferon, gamma M29383 210354_at 1.24 0.02 13 IL1R2 interleukin 1 receptor, type II NM_004633 205403_at 1.23 0.02 13 IRS2 insulin receptor substrate 2 AF073310 209185_s_at 1.21 0.02 13 ISGF3G interferon-stimulated transcription factor 3, gamma 48kDa NM_006084 203882_at 1.22 0.02 13 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 ITGA4 receptor) BG532690 213416_at 1.4 0.02 13 LAPTM5 lysosomal associated multispanning membrane protein 5 AI589086 201720_s_at 1.35 0.02 13 MMP19 matrix metallopeptidase 19 U38321 204575_s_at 1.59 0.03 13 MRC1 mannose receptor, C type 1 NM_002438 204438_at 1.31 0.02 13 MX2 myxovirus (influenza virus) resistance 2 (mouse) NM_002463 204994_at 1.25 0.02 13 NR4A3 nuclear receptor subfamily 4, group A, member 3 U12767 209959_at 1.54 0.02 13 PLCL1 phospholipase C-like 1 NM_006226 205934_at 1.29 0.02 13 RNASE6 ribonuclease, RNase A family, k6 NM_005615 213566_at 1.25 0.02 13 SERF1A small EDRK-rich factor 1A (telomeric) NM_022978 219982_s_at 0.79 6.20E-03 13 SERHL serine hydrolase-like AL450314 214243_s_at 1.46 0.03 13 STYXL1 serine/threonine/tyrosine interacting-like 1 NM_016086 218321_x_at 0.83 5.66E-03 13 SYT11 synaptotagmin XI BC004291 209198_s_at 1.27 0.02 13 TMEM111 Transmembrane protein 111 AU147317 215250_at 0.81 4.86E-03 13 TRAT1 T cell receptor associated transmembrane adaptor 1 AJ240085 217147_s_at 1.29 0.02 13 WISP1 WNT1 inducible signaling pathway protein 1 NM_003882 206796_at 1.2 0.02 13

WNT2B wingless-type MMTV integration site family, member 2B NM_024494 206458_s_at 1.52 0.03 13 CBR4 carbonyl reductase 4 AL049442 213626_at 0.79 6.52E-03 14 CCL8 chemokine (C-C motif) ligand 8 AI984980 214038_at 1.45 0.03 14 CHRDL1 chordin-like 1 AL049176 209763_at 1.2 0.02 14 CNN1 calponin 1, basic, smooth muscle NM_001299 203951_at 1.21 0.03 14 DKFZP686A01247 hypothetical protein AK027231 212325_at 0.82 6.78E-03 14 DPYSL4 dihydropyrimidinase-like 4 NM_006426 205493_s_at 1.22 0.03 14 EFTUD1 elongation factor Tu GTP binding domain containing 1 NM_024580 218973_at 0.81 5.85E-03 14 FBN1 fibrillin 1 NM_000138 202766_s_at 1.24 0.03 14 FGL2 fibrinogen-like 2 NM_006682 204834_at 1.23 0.02 14 FLJ20152 hypothetical protein FLJ20152 NM_019000 218532_s_at 0.74 7.67E-03 14 FLJ31568 hypothetical protein FLJ31568 AW975050 222274_at 0.59 0.01 14 FYB FYN binding protein (FYB-120/130) AF198052 211795_s_at 1.27 0.02 14 HERC6 hect domain and RLD 6 NM_017912 219352_at 1.23 0.02 14 HSPB8 heat shock 22kDa protein 8 AF133207 221667_s_at 1.2 0.03 14 ITGB3BP integrin beta 3 binding protein (beta3-endonexin) NM_014288 205176_s_at 0.78 7.61E-03 14 KIAA1462 KIAA1462 AL050154 213316_at 1.21 0.02 14 LAMP3 lysosomal-associated membrane protein 3 NM_014398 205569_at 1.26 0.02 14 LOC221362 hypothetical protein LOC221362 AL577024 213248_at 1.22 0.03 14 MTMR2 myotubularin related protein 2 U58033 214649_s_at 0.81 5.56E-03 14 NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase) NM_000662 214440_at 1.46 0.03 14 NCKAP1L NCK-associated protein 1-like BC001604 209734_at 1.2 0.02 14 NR4A2 nuclear receptor subfamily 4, group A, member 2 S77154 216248_s_at 1.22 0.03 14 PCLO piccolo (presynaptic cytomatrix protein) AB011131 213558_at 0.82 5.06E-03 14 POU2AF1 POU domain, class 2, associating factor 1 NM_006235 205267_at 1.59 0.03 14 PRIM2A primase, polypeptide 2A, 58kDa NM_000947 205628_at 1.32 0.03 14 PTPN7 protein tyrosine phosphatase, non-receptor type 7 NM_002832 204852_s_at 1.2 0.02 14 RGS1 regulator of G-protein signalling 1 NM_002922 202988_s_at 1.31 0.03 14 RGS16 regulator of G-protein signalling 16 U94829 209325_s_at 1.26 0.02 14 RTN1 reticulon 1 BC000314 210222_s_at 0.61 9.08E-03 14 SCCPDH saccharopine dehydrogenase (putative) AL572542 201825_s_at 0.82 6.70E-03 14 SECTM1 secreted and transmembrane 1 BF939675 213716_s_at 1.2 0.02 14 SELE selectin E (endothelial adhesion molecule 1) NM_000450 206211_at 1.58 0.03 14 SLC29A2 solute carrier family 29 (nucleoside transporters), member 2 AF034102 204717_s_at 0.8 6.20E-03 14 VANGL1 vang-like 1 (van gogh, Drosophila) NM_024062 219330_at 0.81 6.26E-03 14 ZNF443 zinc finger protein 443 NM_005815 205928_at 0.83 7.65E-03 14

ZNF467 zinc finger protein 467 BE549732 214746_s_at 0.68 7.52E-03 14 ANPEP alanyl (membrane) aminopeptidase NM_001150 202888_s_at 1.57 0.04 16 C14orf78 chromosome 14 open reading frame 78 AI935123 212992_at 1.3 0.04 16 C17orf81 chromosome 17 open reading frame 81 NM_015362 219260_s_at 0.75 0.01 16 C20orf39 chromosome 20 open reading frame 39 NM_024893 219310_at 1.21 0.03 16 C3orf64 chromosome 3 open reading frame 64 AK023140 221935_s_at 1.22 0.03 16 C8orf70 chromosome 8 open reading frame 70 NM_016010 205308_at 0.81 8.31E-03 16 CCND1 cyclin D1 BC000076 208711_s_at 1.2 0.03 16 CDH2 cadherin 2, type 1, N-cadherin (neuronal) M34064 203440_at 1.72 0.04 16 CEBPD CCAAT/enhancer binding protein (C/EBP), delta AV655640 213006_at 1.38 0.04 16 CEBPD CCAAT/enhancer binding protein (C/EBP), delta NM_005195 203973_s_at 1.22 0.03 16 CECR1 cat eye syndrome chromosome region, candidate 1 NM_017424 219505_at 1.24 0.03 16 CUGBP2 CUG triplet repeat, RNA binding protein 2 U69546 202157_s_at 1.2 0.03 16 CXCL9 chemokine (C-X-C motif) ligand 9 NM_002416 203915_at 1.87 0.04 16 ECGF1 endothelial cell growth factor 1 (platelet-derived) NM_001953 204858_s_at 1.2 0.03 16 elongation of very long chain fatty acids (FEN1/Elo2, ELOVL2 SUR4/Elo3, yeast)-like 2 NM_017770 220029_at 1.36 0.04 16 ETS2 v-ets erythroblastosis virus E26 oncogene homolog 2 AL575509 201328_at 1.27 0.03 16 ETS2 v-ets erythroblastosis virus E26 oncogene homolog 2 NM_005239 201329_s_at 1.22 0.03 16 GIMAP6 GTPase, IMAP family member 6 NM_024711 219777_at 1.22 0.03 16 GLIPR1 GLI pathogenesis-related 1 (glioma) NM_006851 204222_s_at 1.24 0.03 16 GPM6A glycoprotein M6A D49958 209470_s_at 1.5 0.04 16 GPR64 G protein-coupled receptor 64 NM_005756 206002_at 1.67 0.04 16 GPR65 G protein-coupled receptor 65 NM_003608 214467_at 1.26 0.03 16 HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 X00452 213831_at 1.57 0.04 16 IGHA1 immunoglobulin heavy constant alpha 1 U92706 216557_x_at 1.38 0.03 16 IL15 interleukin 15 NM_000585 205992_s_at 1.23 0.03 16 INHBB inhibin, beta B (activin AB beta polypeptide) NM_002193 205258_at 0.81 9.77E-03 16 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 ITGA4 receptor) NM_000885 205884_at 1.23 0.03 16 LY96 lymphocyte antigen 96 NM_015364 206584_at 1.28 0.03 16 microtubule associated monoxygenase, calponin and LIM domain MICAL1 containing 1 NM_022765 218376_s_at 1.21 0.03 16 MYB v-myb myeloblastosis viral oncogene homolog (avian) NM_005375 204798_at 1.38 0.03 16 NFIL3 nuclear factor, interleukin 3 regulated NM_005384 203574_at 1.29 0.03 16 NR4A3 nuclear receptor subfamily 4, group A, member 3 NM_006981 207978_s_at 1.57 0.04 16

OPTN optineurin AV757675 202073_at 1.21 0.03 16 PDLIM3 PDZ and LIM domain 3 BC001017 210170_at 1.4 0.03 16 PDZRN4 PDZ domain containing RING finger 4 NM_013377 220595_at 1.25 0.03 16 PECAM1 platelet/endothelial cell adhesion molecule (CD31) AA702701 208981_at 1.21 0.03 16 PIM2 pim-2 oncogene NM_006875 204269_at 1.22 0.03 16 peroxisome proliferative activated receptor, gamma, coactivator PPARGC1A 1, alpha NM_013261 219195_at 1.33 0.03 16 RSAD2 radical S-adenosyl methionine domain containing 2 AI337069 213797_at 1.22 0.03 16 SFTPA2 surfactant, pulmonary-associated protein A2 NM_006926 218835_at 2.38 0.04 16 solute carrier family 7 (cationic amino acid transporter, y+ SLC7A5 system), member 5 AB018009 201195_s_at 1.34 0.03 16 SOX17 SRY (sex determining region Y)-box 17 NM_022454 219993_at 1.36 0.04 16 SOX5 SRY (sex determining region Y)-box 5 AL049337 215768_at 1.31 0.03 16

TLE4 transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila) NM_007005 204872_at 1.21 0.03 16 ADCY7 adenylate cyclase 7 NM_001114 203741_s_at 1.24 0.04 17 CLU clusterin M25915 208792_s_at 1.28 0.04 17 CLU clusterin M25915 208791_at 1.26 0.04 17 COL21A1 collagen, type XXI, alpha 1 NM_030820 208096_s_at 1.2 0.04 17 CTSS cathepsin S NM_004079 202902_s_at 1.29 0.04 17 Fc fragment of IgE, high affinity I, receptor for; gamma FCER1G polypeptide NM_004106 204232_at 1.24 0.04 17 FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32) M31933 210889_s_at 1.27 0.04 17 FYN FYN oncogene related to SRC, FGR, YES S74774 216033_s_at 1.2 0.03 17 GADD45G growth arrest and DNA-damage-inducible, gamma NM_006705 204121_at 1.31 0.04 17 GBP1 guanylate binding protein 1 NM_002053 202270_at 1.37 0.04 17 GLRX glutaredoxin (thioltransferase) NM_002064 206662_at 1.27 0.03 17 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 HMGCS2 (mitochondrial) NM_005518 204607_at 1.44 0.04 17 HYMAI hydatidiform mole associated and imprinted AF241534 215513_at 1.3 0.04 17 ITIH5 inter-alpha (globulin) inhibitor H5 NM_030569 219064_at 1.25 0.04 17 MS4A4A membrane-spanning 4-domains, subfamily A, member 4 NM_024021 219607_s_at 1.49 0.04 17 MYBL1 v-myb myeloblastosis viral oncogene homolog-like 1 AW592266 213906_at 1.35 0.04 17 PDE3B phosphodiesterase 3B, cGMP-inhibited NM_000922 208591_s_at 0.79 0.01 17 PLAC8 placenta-specific 8 NM_016619 219014_at 1.27 0.04 17 RABEP1 rabaptin, RAB GTPase binding effector protein 1 AF098638 214552_s_at 0.77 0.01 17

RTN1 reticulon 1 NM_021136 203485_at 0.6 0.01 17 SELL selectin L (lymphocyte adhesion molecule 1) NM_000655 204563_at 1.45 0.04 17 STOM stomatin M81635 201061_s_at 1.21 0.04 17 TCEAL2 transcription elongation factor A (SII)-like 2 AF063606 211276_at 1.37 0.04 17 TMEM35 transmembrane protein 35 NM_021637 219685_at 1.23 0.04 17 TRAC T cell receptor alpha constant M12959 209670_at 1.24 0.04 17 TYMS Thymidylate synthetase BG281679 217690_at 0.8 0.01 17 SEPT11 Septin 11 NM_018243 214293_at 1.2 0.04 20 ALOX5AP arachidonate 5-lipoxygenase-activating protein NM_001629 204174_at 1.25 0.04 20 BCL11B B-cell CLL/lymphoma 11B (zinc finger protein) NM_022898 219528_s_at 1.2 0.04 20 C1qRP/CD93 CD93 antigen NM_012072 202878_s_at 1.21 0.04 20 DKFZP434P211 POM121-like protein NM_014549 206819_at 1.2 0.04 20 DLC1 deleted in liver cancer 1 AF026219 210762_s_at 1.23 0.04 20 GPATC2 G patch domain containing 2 NM_018040 219078_at 0.81 0.01 20 GPR18 G protein-coupled receptor 18 AF261135 210279_at 1.21 0.04 20 NFASC neurofascin homolog (chicken) AA995925 213438_at 1.2 0.04 20 RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) AK022494 212932_at 0.81 0.01 20 RIS1 Ras-induced senescence 1 BF062629 213338_at 1.23 0.04 20 RPL37A ribosomal protein L37a AU155515 213459_at 0.82 0.01 20 SLC35E2 solute carrier family 35, member E2 BE885244 215169_at 0.83 0.01 20 CUGBP1 CUG triplet repeat, RNA binding protein 1 NM_006560 204113_at 0.78 0.01 22 FMO2 flavin containing monooxygenase 2 BC005894 211726_s_at 0.69 0.02 22 KIAA0265 KIAA0265 protein AI808625 209254_at 0.83 0.01 22 OCLN occludin U53823 209925_at 0.74 0.01 22 USP6 ubiquitin specific peptidase 6 (Tre-2 oncogene) NM_004505 206405_x_at 0.82 0.01 22 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative ENPP4 function) AW194947 204160_s_at 0.81 0.01 24 GTF2F1 general transcription factor IIF, polypeptide 1, 74kDa AW190445 202354_s_at 0.8 0.02 24 PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha NM_006823 204612_at 0.78 0.01 24 SRD5A2L steroid 5 alpha-reductase 2-like NM_024592 218800_at 0.81 0.01 24 BIRC1 baculoviral IAP repeat-containing 1 NM_004536 204861_s_at 0.81 0.03 26 BIRC1 baculoviral IAP repeat-containing 1 AI817801 204860_s_at 0.71 0.03 26 ChGn chondroitin beta1,4 N-acetylgalactosaminyltransferase NM_018371 219049_at 0.77 0.03 26 DHFR dihydrofolate reductase AI144299 48808_at 0.82 0.02 26 HS3ST2 heparan sulfate (glucosamine) 3-O-sulfotransferase 2 NM_006043 219697_at 0.78 0.02 26 MEST mesoderm specific transcript homolog (mouse) NM_002402 202016_at 0.78 0.03 26 PTK7 PTK7 protein tyrosine kinase 7 NM_002821 207011_s_at 0.79 0.02 26

phosphorylase, glycogen; liver (Hers disease, glycogen storage PYGL disease type VI) NM_002863 202990_at 0.74 0.02 26 RBM3 RNA binding motif (RNP1, RRM) protein 3 BF437591 222026_at 0.8 0.02 26

TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) NM_005077 203222_s_at 0.81 0.02 26 TRIM2 tripartite motif-containing 2 AA149745 202341_s_at 0.79 0.03 26 TRIM2 tripartite motif-containing 2 BC005016 215945_s_at 0.79 0.03 26 ZNF322B zinc finger protein 322B NM_024639 219376_at 0.82 0.02 26 CDR2L cerebellar degeneration-related protein 2-like AI422335 213230_at 0.78 0.03 30 CHKA choline kinase alpha AI991328 204233_s_at 0.77 0.04 30 ELOVL family member 6, elongation of long chain fatty acids ELOVL6 (FEN1/Elo2, SUR4/Elo3-like, yeast) BC001305 210868_s_at 0.7 0.03 30 FLJ22795 hypothetical protein FLJ22795 NM_025084 220602_s_at 0.79 0.03 30 FRK fyn-related kinase NM_002031 207178_s_at 0.82 0.03 30 LOC286434 hypothetical protein LOC286434 AK000470 222196_at 0.6 0.03 30 NBR2 neighbor of BRCA1 gene 2 BC000924 210435_at 0.83 0.02 30 NQO1 NAD(P)H dehydrogenase, quinone 1 AI039874 201467_s_at 0.76 0.03 30 PIK3CA phosphoinositide-3-kinase, catalytic, alpha polypeptide NM_006218 204369_at 0.82 0.02 30 PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 AI754404 202619_s_at 0.76 0.04 30 PRKCBP1 protein kinase C binding protein 1 BC001004 209049_s_at 0.82 0.03 30 PRKG2 protein kinase, cGMP-dependent, type II NM_006259 207505_at 0.75 0.03 30 RABEP1 rabaptin, RAB GTPase binding effector protein 1 NM_004703 203223_at 0.83 0.02 30 SLC39A4 solute carrier family 39 (zinc transporter), member 4 NM_017767 219215_s_at 0.82 0.04 30 ZNF278 zinc finger protein 278 AF254088 210581_x_at 0.81 0.03 30 ZNHIT4 zinc finger, HIT type 4 AI862454 65133_i_at 0.78 0.04 30

Fold change for annotated probesets with European-American patients as the reference