Detail Expenditures by Sponsor Federal Name FY04 Expenditures National Cancer Institute 37,657,271.58 Heart,Lung & Blood 36,598,255.95 NIMH 27,996,752.16 Gen Med Sciences 27,396,844.18 Child Health & Hum Dev 27,094,951.12 Allergy & Infect Dis 22,974,536.45 NSF 22,491,966.99 Department of Education 22,092,520.94 AID 18,132,198.51 Diab & Dig Kid Dis 16,391,741.95 Ctr for Disease Cntrl (CDC) 14,342,287.82 National Center for Res Resr 10,974,299.16 Envir Health Sciences 9,718,945.61 Neuro/Disorder/Strok 9,425,134.97 EPA 8,252,644.45 National Institute Dntl & Crani 7,231,676.14 Alcohol Abuse & Alco 6,410,943.85 National Institute Nursing Res 5,180,742.47 National Institute Drug Abuse 4,950,725.37 Arth Musculosk Skin 3,928,512.33 National Institute Biomed Imag 3,717,437.09 Bureau of Health Prof 3,381,842.62 NASA 2,859,647.59 Health Resour Ser Admi (HRSA) 2,820,908.52 SBA 2,473,842.30 Fogarty Internat Center 2,452,873.44 National Institute on Aging 2,403,798.32 US Army Med Res 2,251,058.09 Department of Energy 2,192,409.70 US Department Transportation 2,174,996.91 Deaf&Other Cmnca Dis 2,045,222.90 Office of Naval Research 1,871,758.62 Agcy Hth Care Research 1,561,952.45 Maternal & Chld Health 1,394,120.99 National Institute Dental Res 1,358,816.75 National Eye Institute 1,273,119.53 National Center Com & Alt Me 1,171,914.53 Agcy Healthcare Res Qu 932,958.57 Women's Health Initiat 909,921.28 National Library of Med 794,130.01 National Center on Child Abu 761,335.37 Office Rural Hth Policy 754,994.20 Child Care Bureau 731,849.20 National Center Human Genome 680,518.08 National Center Minor Health 674,859.34 National Human Genome Res 667,800.29 USAF-Office of Sci Res 645,719.44 US Department Agriculture 621,531.08 US Army Research Office 569,236.57 Admin on Dev Dis 561,274.96 HRSA Div of Medicine 544,198.16 Head Start Bureau 534,255.06 Div of Medicine-Bhp 491,313.95 Children's Bureau 359,736.10 US Department Commerce 342,530.21 US Department Defense 325,418.45

1 of 22 OSR FY04 Annual Report Appendix 4 Detail Expenditures by Sponsor Name FY04 Expenditures Federal (continued) Indian Health Servic 225,084.75 US Department Interior 187,233.22 Medicare Paymnt Advi 172,537.62 NEH 148,292.17 National Center Research Resour 122,589.56 Corp for National Service 121,431.75 Uniformed Serv Univ 115,420.75 Naval Air Warfare 114,799.00 Office of Secretary 107,729.01 US Department of State 106,232.39 Hiv/Aids Bureau 81,236.73 National Institute Gen Med Sc 79,826.20 FDA 78,171.70 National Archives 74,443.02 NEA 63,794.94 Department of Hud 61,262.79 Department of Veterans Aff 58,969.05 Center Medicre & Medicd 58,968.35 Institute Museum Services 57,160.95 Institute Museum & Librar 53,040.47 National Security Agncy 35,415.38 National Acad of Science 35,149.28 Sub Abuse/Mentl Health 34,585.65 US Geological Su/Doi 34,202.26 Naval Health Research Center 34,120.96 National Park Service 29,175.70 US Department of Justice 25,989.01 US Peace Corps 19,232.59 Institute Envir Health Sci 18,233.51 FEMA 14,502.78 National Hist Publicatio 8,432.60 US Department of The Army 5,158.15 US Department Army - Darpa 925.30 Div Acquisition Mgmt 311.14 US Air Force -1,479.05 Federal Subtotal 390,934,432.35 Indirect Federal 6671P Foundation 35,029.42 Academyhealth 129,003.63 Alan Penn & Assoc 55,035.26 Albany Med College 16,790.87 Albert Einstein Coll 10,335.41 Amer Coll Radiology 573,423.52 Amer College Ob-Gyn -2,119.08 American Cancer Society 7,675.00 American Egg Board 67,072.01 Argonne National Labs 3,276.30 Arizona State University 566.68 Artecel Sciences, In -15.30 Assc Amer Medical 270,566.61 Assc Teachrs Prev Md 349,564.94 Assoc Amer Med Colle 36,856.49 Assoc Liaison Office 2,837.91 Assoc Sch Pub Health 3,986,567.23 Atlanta Research Edu Foundation 63,320.53

2 of 22 OSR FY04 Annual Report Appendix 4 Detail Expenditures by Sponsor Name FY04 Expenditures Indirect Federal (continued) Awwa Research Foundation 626,333.30 Axio Research Corp 34,657.08 B Thompson Ins Plant 108,208.07 Barnes-Jewish Hosp 10,503.62 Battellle, Inc 60,136.46 Baylor Col Med 4,782.86 Bellomo-Mcgee, Inc 13,138.99 Bioreliance Corp 16,603.64 Boston University 292,135.87 Brandies University 6,171.32 Brown University 229,896.32 Calgb/University Chicago 5,209.64 California Institute Tech 264,203.28 Cancervax 36,118.79 Center Line Prod 137,820.61 Ch2M Hill 118,897.77 Chatham Research 147,742.85 Children's Hosp Phil 39,977.67 Children's Hosp/Bost 45,695.36 Chldren Hosp Oakland 31,552.76 Chldrns Hosp Reg Med 26,293.43 Chldrns Hosp Research Center 27,945.88 Clemson University 103,522.03 Coda, Inc 100,322.54 Columbia Hosp/Chmcd 762.93 Columbia University 28,609.24 Courtesy Assoc 51,446.43 Darpharma, Inc 11,300.53 Dartmouth College 261,985.47 DC Department Hmn Ser-Oecd 144,330.31 Debby Cryer & Assoc 20,397.11 Duke Clinical Research 20,057.55 Duke University 4,219,041.76 Duke University Med Center 1,596,282.26 Dynamac Corporation -5,202.04 E Glaser Ped Aids Foundation 60,901.02 E H Pechan & Assoc 50,879.52 Eastern Virginia Med Sch 34,620.98 Emory University 137,554.60 Encelle, Inc 6,950.28 Engenderhealth, Inc 38,573.51 Environmental Export -37.01 Family Health Intnl 200,670.04 Family Violence & Ra 38,624.80 Flying Bridge Techno 104,527.98 Foundation Children's Oncol 4,008.41 Geo-Centers, Inc 168,939.98 Georgia Institute of Tech 240,719.98 Georgia State University 79,033.52 Gynecologic Oncology 87,669.46 Harvard University 77,050.04 Health Sys Res, Inc 93,697.12 Health Sys Research Inc 84,368.36 Henry Ford Health Sys 27,398.36 Hosp Joint Diseases 29,583.57 Hosp Special Surgery 74,349.87

3 of 22 OSR FY04 Annual Report Appendix 4 Detail Expenditures by Sponsor Name FY04 Expenditures Indirect Federal (continued) IBM Business Consult 10,313.90 Icf Consulting 147,797.98 Icf Inc 25,910.98 Indiana University 152,328.65 Inotek Corporation 4,393.06 Institute Ecosystem Studi 49,620.09 Intellitools Inc 8,279.19 Intrahealth 20,834.94 Iowa State University 123,845.37 IT Corporation 52,269.00 Jackson State University 349,257.20 Jaeb Center for Health Re 23,636.84 Jhpiego Corp 1,026.28 Johns Hopkins University 3,843,066.30 Joint Oceangphc Institute 2,052.26 Kaiser Foundation Res Institute 9,598.00 Karolinska Institute 63,646.82 Kenan Institute Asia 268,267.42 Lambada Technologies 37,464.51 Lehigh University -4.88 MA Institute of Technology 173,967.88 Madison Tech Internl 8,070.00 Management Sciences -7,687.65 Marine Biological La 21,913.39 Marshfield Clinic Foundation 11,425.04 Maryland Med Res Institute 8,261.17 Mclean Hospital 1,416.34 Mcnc 602,499.33 Med Unv of Sc 139,081.89 Medical College Ohio 40,764.62 Mfm Group, Inc 13,723.55 Michigan St University 135,221.03 Mi-Corporation 8,287.33 Miriam Hospital 10,912.50 Mississippi State Un 14,224.39 Mt Sinai Sch of Med 151,844.62 Naccho 3,737.11 National Acad of Science 337,177.66 National Assoc St Ems 56,592.76 National Brd Profes Teach 136,469.17 National Chldhd Cncr Foundation 45,694.29 National Init Chld Healthcr 52,043.16 National Jewish Med Research 143,273.68 National Rnl Enrg Lab/Mri 221,417.50 National Safety Council 40,710.34 Natural Pharmacia In 10,318.39 Neighbrhd Reinv Corp 38.29 New Eng Med Center Hos 16,180.90 New England Med Hosp 28,808.77 New Hanover Reg Med 180.68 New Mexico Tech 3,506.63 New York University 23,343.64 Northern Calif Institute 55.48 Northwestern University 62,043.46 Nova Southeast University 189,961.04 NPI Inc 2,081.67

4 of 22 OSR FY04 Annual Report Appendix 4 Detail Expenditures by Sponsor Name FY04 Expenditures Indirect Federal (continued) Nsabp Foundation 79,489.75 Oak Ridge Institute Scien 112,858.80 Ohio State U Res Foundation 46,833.40 Oregon Health Sciences 53,464.37 Other -592.29 Pacific Institute Research 66,712.55 Pan Lutheran Ministr 233,380.46 Pathfinder Internatl 161,514.78 Penn State University 18,961.53 Planned Parenthood 54,860.95 Policy Resrch Assoc 249,241.70 Princeton University 893,887.01 Rand Corporation,Inc 47,311.30 Research Foundation of Suny 785,165.57 Rhode Island Hospitl 564,197.50 Rice University 21,781.06 RTI 1,705,121.14 Rutgers 119,410.34 Salk Insitute 5,445.67 Science Appli Int'L 65,156.04 Scientific Sys Co 30,000.00 Scripps Research Institute 80,261.67 Seta Corporation 57,992.55 Shaw University 122,799.54 Sloan-Kettering Institute 78,489.20 Smithsonian Astrophy 11,392.79 Social & Scientific 1,386,077.16 Southcentral Foundation -0.27 Space Telescope Sci 12,384.85 Sprinkle Consulting 4,552.30 SRI International 197,741.80 St Louis University 400,561.57 State & Terr Injury 71,146.07 State of Alabama/Dph 37.58 Syracuse University 18,170.42 Tanglewood Research Inc 176,176.20 Texas A&M Research Foundation 1,443.62 The Noah Group, Llc -9,598.60 Thomas Jefferson Uni 41,222.73 Transanalytics 599.38 TRC Garrow Associate 9,476.67 Triangle Labs, Inc 182,760.66 Tulane University 92,776.20 University Calif- Lawrence Liver 57,822.23 University Corp Atmospheric R -32.62 University Med & Dentstry NJ 32,303.93 UNC-General Admin 62,272.08 Universidad Metropol 8,388.35 University Ala-Tuscaloosa 17,380.91 University Calif-Berkeley 144,068.61 University Calif-Davis 1,395.28 University Calif-Irvine 8,976.39 University Calif-San Franc 36,253.04 University Calif-Santa Cru 12.25 University Cincinnati -793.70

5 of 22 OSR FY04 Annual Report Appendix 4 Detail Expenditures by Sponsor Name FY04 Expenditures Indirect Federal (continued) University Colorado Health 63,215.11 University Conn Health Center 34,222.82 University Louisiana @ Laf 7,118.97 University Mass/Amherst 20,127.52 University Md Col Pk Foundation 17,643.72 University Md-Baltimore 19,226.06 University Miss Med Center 306,813.17 University New Hampshire 77,657.46 University of Alabama 118,872.95 University of Alabama-Birm 86,453.55 University of Arizona -6,150.28 University of Arkansas 7,999.33 University of Bath 2,329.35 University of California 365,900.82 University of Chicago 3,512.90 University of Colorado 37,091.16 University of Connecticut 15,736.51 University of Florida 19,978.73 University of Hawaii 136,814.85 University of Houston 34,513.85 University of Ill-Champaig 52,623.24 University of Ill-Chicago 14,968.50 University of Ill-Urbana C 173.25 University of Iowa 33,705.84 University of Kansas 58,842.85 University of Louisville 11,882.65 University of Maryland 367,503.64 University of Memphis 122,940.83 University of Miami 42,455.87 University of Michigan 313,010.41 University of Minnesota 296,877.71 University of Mississippi 57,509.57 University of Missouri -1,546.18 University of Mo Columbia 2,487.48 University of NM Albuquerq -105.77 University of Notre Dame -7,681.37 University of Pennsylvania 409,970.55 University of Pitt 8,251.47 University of Rhode Island 246,606.41 University of So Florida 284,173.65 University of Tennessee 10,858.69 University of Texas-Austin 182,004.90 University of Utah 183,259.12 University of Virginia 544,965.20 University of Wash-Seattle 328,669.13 University Southern Califo 240,082.31 University Tennessee/Knoxv 41,166.14 University Texas Health Sci Center 176,650.21 University Texas Med Branc 15,587.47 University Wisconsin 113,126.18 University Wisconsin-Milwa -1.21 URS Corp 90,875.57 UT Southwest Med Center 235,435.37 UT-Battelle/Ornl 117,540.28 Vanderbilt U Med C 223,013.80

6 of 22 OSR FY04 Annual Report Appendix 4 Detail Expenditures by Sponsor Name FY04 Expenditures Indirect Federal (continued) Vanderbilt University 14,880.74 Wake Co Pub Sch Syst 32,648.17 Wake Forest University Hlt Sci 25,811.12 Wake Forest University Sch Med 793,026.98 Wash University-St Louis 91,883.49 Washington St University 48,422.87 Washington University -67.41 West Virginia University 84,592.71 Westat 593,685.75 Western Michigan Un 58,079.29 Wits Health Consorti 51,664.88 Woods Hole Ocea Institute 102,032.10 Yale University 144,977.79 Yale-Griffin Prev 92,751.95 Indirect Federal Subtotal 40,923,982.68 Industry 3M Company 1,694.18 3M Espe 5,202.05 3M Pharmaceuticals 5,305.49 Aai International 25,495.87 Abbott Laboratories 187,457.37 Abgenix, Inc -292.79 Abt Associates 448.82 Acambis, Inc 3,000.00 Acer/Excel 1,251.55 Acorda Therapeutics 32,199.15 Actelion Pharmaceuti 25,480.28 Activbiotics, Inc 35,533.30 Adeza Biomedical 4,316.16 Adolor Corporation 7,465.92 Advanced Tissue Sci -59.13 Advectus Life Scienc -57,076.12 Alexion Pharmaceutic 41,122.49 Alkermes, Inc 143,087.73 Allergan Sales, Inc 81,542.30 Allos Therapeutics 8,019.39 Alza Corporation 2,490.57 Amer Coll of Surgeon 1,569.87 Amer Foundation Aids Res 1,244.94 Amgen, Inc 1,272,615.57 Ampc, Inc -5,226.81 Amylin Pharmaceutica 23,543.48 Antigenics Inc 5,777.95 Applied Nanotechnolo 94,339.82 Arginox Pharmaceutic 1,044.35 Arjo, Inc. 28,621.58 Aronex Pharmaceutica -15,679.37 Asahi Kasei Corp 142.85 Astarix Institute, Inc -87,500.00 Astra Tech, Inc 58,485.97 Astrazenecca, LP 1,313,800.51 Aventis Behring Llc 15,957.05 Aventis Pharmaceutic 254,606.61 Baron Adv Meteor Sys 70,411.73 BASF 2,409.46 Baxter Healthcare 16,745.98

7 of 22 OSR FY04 Annual Report Appendix 4 Detail Expenditures by Sponsor Name FY04 Expenditures Industry (continued) Bayer Corporation 45,384.44 Bayer Healthcare LLC 128,271.23 Becton Dickinson -8,235.15 Berlex Laboratories 39,417.20 Berlex, Inc 7,939.19 Biomachines Inc 21,896.57 Biomarin/Genzyme Llc 34,824.43 Biomeasure Inc 51,356.86 Biomerieux, Inc 53,789.44 Biomimetic Pharmaceu 4,136.09 Biopure Corporation 103,075.54 Bioreliance Corp 4,561.72 Biostratum Inc 6,868.51 Biotransplant, Inc 87.66 Biotronik 10,152.67 Black & Veatch 78,621.75 Boehringer Ingelheim 97,784.27 Boston Healthcare Asso 544.45 Boston Scientific 6,642.09 Bracco Diagnostics, 68,451.39 Bracco/Soc Cardiac 12,334.22 Brigham Women's Hosp 43,924.90 Bristol-Myers Squibb 613,819.84 Brown & Caldwell -268.81 Burroughs Wellcome C 7,341.30 Camp Dresser & Mckee 44,403.69 Cardiovascular Clini 14,422.21 Carolina Ballet 1,384.28 Carollo Engineers 66,631.64 Catalyst Pharm Research 10,977.25 Celgene 24,814.54 Cell Genesys, Inc 108,410.37 Cell Therapeutics 1,341.28 Cellpro, Inc 68.87 Centocor, Inc 93,529.38 Cerebrus Limited 12,565.56 Ch2M Hill 38,482.99 Children's Hosp/Pitt -4,250.08 Chiron Corporation -1,671.11 Chiron Therapeutics 17,528.89 Ciba-Geigy Corp -284.90 Circe Biomedical,Inc -5,951.26 Clin Micro Sensors 412,805.73 Clinical Cardiovascu -305.63 Clinical Trial Mgm'T 76,132.92 Clintrials Network 13,538.53 Coaltn Nat Can/Alpha 1,333.69 Cognis Corporation 13,730.96 Colgate-Palmolive Co 1,574.49 Concentric Medical 9,233.97 Conopco/Lipton -3,279.71 Constella Clinical 34,247.09 Convatec 16,013.76 Cook Biotech Inc 12,552.97 Cook Inc 1,253.22 Corgentech, Inc 23,719.88

8 of 22 OSR FY04 Annual Report Appendix 4 Detail Expenditures by Sponsor Name FY04 Expenditures Industry (continued) Corixa Corp 384.02 Covalent, Inc 69.60 Covance Periapproval 53,068.11 Cv Therapeutics Inc 7,418.00 Cydex, Inc 75,994.49 Daiichi Pharma Holdi 650.01 Dentalview, Inc 1,016.69 Dentsply (Caulk Div) 15,646.99 Dentsply Professiona 28,656.39 Dermagraft Joint Ven 8,590.00 Dexcom 1,339.99 Digene Corporation 20,004.72 Dj Ortho 58,065.65 Drug Abuse Sciences, -7,300.54 Dupont Pharmaceutica 42,483.88 E H Pechan & Assoc 3,518.13 E I Dupont De Nemour 331,653.61 Elan Pharmaceuticals 108,015.60 Electro-Optical Sci -759.27 Eli Lily 403,320.59 Enamelon Research 288.83 Enanta Pharmaceutica 1,563.10 Epigenesis Pharmaceu -2,283.78 Ercole Biotech Inc 347,748.56 Escalon Medical Corp -16,203.00 Espe Dental-Medizin 8,523.85 Ethicon Inc 16,881.64 Fastaff Nursing Corp 1,153.99 Ferx, Inc 138,511.02 Fischer Imaging Corp -5,308.00 Forest Laboratories 29,846.01 Forest Pharmaceutica 1,043.40 Freddie Mac Corp 1,076.84 Fujisawa Healthcare 23,183.05 Gene Logic, Inc 130,072.65 Genecom 5,348.60 Genetech, Inc 177,888.20 Genetics Institute 17,588.17 Genta, Inc 3,708.52 Gentronics, Inc 1,216.72 Genzyme Corp 14,774.58 Gilead Sciences, Inc 49,455.79 Glaxo-Wellcome, Inc 1,748,138.29 Governance Institute 6,261.77 Guidant 12,391.94 Guilford Pharmaceuti 10,412.20 Haemonetics Corp 54,692.79 Health Benchmarks 6,793.81 Health Decisions,Inc 3,121.08 Healthecon Health Serv -3,279.34 Hemocellular Dev Cor 39,391.88 Hemosol, Inc 47,737.16 Hesperion USA, Inc 147.19 Hewlett-Packard 1,250.00 Health Rept Srvcs, Inc -362.48 Hoechst Celanese Cor 9,205.49

9 of 22 OSR FY04 Annual Report Appendix 4 Detail Expenditures by Sponsor Name FY04 Expenditures Industry (continued) Hoffmann-La Roche 82,506.12 Human Genome Science -3,503.01 Ibah, Inc 11,365.38 Ibm Corporation 861.46 Icon Clinical Resear 65,709.88 Idec Pharmaceuticals 49,536.44 Ilst North America 648.46 Immtech Internat'L 127,913.83 Immunex Corp 6,381.35 Incara Pharmaceutica 1,348.82 Ingenix Pharmaceutic -3,896.82 Innapharma, Inc -1,676.20 Inspire Pharmaceutic 142,108.50 Intermune Inc 13,057.50 Intrabiotics Pharmac 37,001.33 Inveresk Research NC 33,468.00 Isis Pharmaceuticals 61.91 Ivoclar Vivadent 8,302.74 Janssen Pharmaceutic 77,031.53 Janssen Research Foundation 74,092.49 Johnson&Johnson 54,564.64 Kaplan Companies, In -19,387.39 Karobio, USA 3,740.13 Keryx Biopharmaceuti 11,730.91 Kimeragen, Inc -15,625.35 King Pharamceuticals 17,126.16 Kos Pharmaceuticals 25,845.89 Kuraray America Inc 573.41 Lilly Research Labs 621,026.05 Logisticare Solution 39,427.69 Luminex Corp -852.63 Lupus Clin Trials 32,935.22 M&M Mars, Inc 2,964.41 Macrochem Corporatio 3,603.96 Maxim Pharmaceutical 7,316.74 Mcneil Consumer Spec 79,555.04 Mds Pharma Services 10,823.93 Med & Tech Res Assoc 61,682.80 Medco Research, Inc 1,092.27 Medical City Dallas 104.44 Medimmune, Inc 21,458.11 Mednova (USA) Inc 22,094.79 Medtronic Ave, Inc 3,611.13 Medtronic, Inc 13,344.94 Merck & Co, Inc 285,209.38 Metrigenix Inc 13,846.29 Mgi Pharma Inc 34,889.56 Millennium Pharmaceu 516,809.84 Monsanto Company 11,150.43 Montgomery Watson Ha 40,019.20 Myogen, Inc 15,052.64 N.V. Organon 57,678.40 NC Advanced Energy 411.52 Neurogesx 2,292.42 Nexmed, Inc 3,335.21 Nexstar Pharmaceutic 9,481.54

10 of 22 OSR FY04 Annual Report Appendix 4 Detail Expenditures by Sponsor Name FY04 Expenditures Industry (continued) Nike, Inc -210.96 Nitromed, Inc -42,370.40 Nobex Corp 48,461.32 Novartis Pharm Corp 702,190.98 Novo Nordisk Pharm 65,547.92 Oculex Pharmaceutica 8,472.97 Omnicare Clinical 46,009.14 Onyx Pharmaceuticals -2,279.65 Orapharma, Inc 215,780.57 Oread, Inc 13.56 Organon, Inc 81,860.22 Oriel Therapeutics 1,617.97 Ortho Biotech Produc 6,596.19 Ortho Diagnostic Sys 31,736.00 Osiris Therapeutics, -6,203.79 Otsuka Maryland Res 38,893.98 Outcome Sciences 1,256.49 Oxford Biomedica 112,955.58 Oy Contral Pharma 8,270.61 Pan Pacific Pharmace 1,991.64 Panacos Pharmaceutic 228,819.18 Paradigm Genetics In 260.35 Paragon Biomedical 1,012.14 Parexel Internat Cor 40,477.24 Parion Sciences, Inc 15,468.07 Paul&Louise Johnson 39.75 Pfizer, Inc 1,211,015.87 Pharm Res Assoc, Inc 1,428.50 Pharmaceutical Res A 16,247.17 Pharmacia & Upjohn 1,038.70 Pharmacyclics, Inc 4,500.00 Pharmanet, Inc 11,464.70 Pharmaresearch Corp 61,024.46 Philip Morris USA 70,697.33 Philips Oral Health 84,095.57 Phoenix Int Life Sci 15,854.41 Pozen, Inc -1,166.45 PPD Devleopment, Inc 133,599.40 PPD Pharmaco 2,959.43 Proctor & Gamble Co 201,264.85 Proctor & Gamble Pha 116,190.84 Prologue Research -114.19 Protein Design Labs 1,099.85 Protein Tech Intnatl 16,346.23 Proxima Therapeutics 1,333.52 Qualyst, Inc 12,175.58 Quintiles Pacific 4,211.49 Quintiles, Inc 215,178.53 Renal Research Institute 211.13 Repligen Corp 2,006.50 Research Foundation of Suny 4,250.55 Ribapharm Inc 42,224.74 Roche Laboratories 22,510.56 Roche Molecular Sys 97,001.64 Roche Pharmaceutical 19,411.67 Salix Pharmaceutical 4,500.00

11 of 22 OSR FY04 Annual Report Appendix 4 Detail Expenditures by Sponsor Name FY04 Expenditures Industry (continued) Sandoz Nutrition Cor 3,730.00 Sanofi Phar/Prologue 24,183.43 Sanofi Winthrop, Inc -177.88 Sanofi-Synthelabo 1,242.27 Sc Liver Research 832.50 Schering Corporation 1,361.84 Schering-Plough Res 11,474.94 Scios Inc 15,353.29 Scirex Corporation 36,305.49 Sensus Corp 4.65 Sepracor, Inc 14,662.89 Shire Pharmaceutical 1,779.36 Shorebank Advisory S 2,676.40 Siemens Medical Sys 2,175.14 Signal Pharmaceutica 40,252.86 Smith & Nephew -1,509.08 Smithkline Beecham 2,332.42 Social & Scientific 59,618.49 St Jude Medical 1,654.74 St Jude Medical Crmd 10,838.50 Sucampo Pharmaceutic 64,304.49 Sunstar, Inc 106,525.91 Suntory Pharm 9,930.71 Supergen, Inc 13,154.49 Syngenta Biotechnolo -485.88 Syreon Corporation 18,971.64 Tap Pharmaceutical 1,214.52 The Boeing Company 52,958.13 The Cleveland Clinic 18,830.19 The Lipsome Co., Inc 15,546.27 The Med Co 53,458.26 Theradex 46,960.71 Thrombogenics, Ltd 6,000.00 Tibotec Pharmaceutic 975.63 Tokuyama Dental Corp 24,098.39 Transkaryotic Therap 667,212.07 Triangle Pharmaceuti 2,862.12 Trimeris, Inc 20.20 Ucb Pharma, Inc 7,832.59 Unilever Research 130,486.68 United Therapeutics 60,765.11 US Oncology Research 2,829.00 Vasogen Inc 3,280.31 Vasomedical, Inc 41,546.77 Verizon, Inc. 23,800.95 Vernalis Research Ltd 5,947.00 Vertex Pharmaceutica 117,918.93 Vesta Therapeutics 291,810.43 Vitagen Inc -10,821.79 W L Gore & Assoc Inc 7,362.05 Warner Lambert Co 9,955.33 Waters Tech Corp 159,299.34 Watson Laboratories 11,383.40 Wyeth Pharmaceutical 71,511.80 Wyeth Research 31,694.46 Wyeth-Ayerst Researc 27,486.20

12 of 22 OSR FY04 Annual Report Appendix 4 Detail Expenditures by Sponsor Name FY04 Expenditures Industry (continued) Xtl Biopharm Ltd 2,145.09 Zars Inc 3,000.00 Zeneca Pharmaceutica 15,899.56 Zimmer, Co -30,994.62 Zonic Labs, Inc -7,656.23 Industry Subtotal 19,106,386.11 State Acct Cancelled 3/04 12.70 Appalachian ASU -809.09 Div Emergency Mgmt 8,411.57 East Carolina University 139,833.64 Env,Health,Natu Resour 41,294.38 Forsyth County Pub Health -13,246.10 Gov's Advocacy Counc 14,352.55 Mountain Ahec 69,963.82 NC A & T University 39,879.34 NC Adm off of Courts 29,257.46 NC Arts Council 16,858.67 NC Asthma Board 27,500.00 NC Central - NCCU 16,843.20 NC Clean Water Mgm'T 15,978.23 NC Council Dev Disab 68,392.97 NC Crme Cntl Pub Saf 5,848.00 NC Department Commerce 475,582.05 NC Department Correction 614,818.25 NC Department Cultural Res -3,496.91 NC Department Insurance 23,317.05 NC Department Juvnle Jstic 49,288.41 NC Department of Admin 65,354.46 NC Department Public Instr 36,338.91 NC Department State Trans 1,030,986.53 NC Department Transportati 20,432.80 NC Dev Dis Cncl 178,308.87 NC Employment Securi 54,881.84 NC Env, Nat Resour -31,737.52 NC Governor's Safety 444,072.47 NC Health & Well Trust 1,292,217.87 NC Office Juvnle Jstice 85,030.53 NC St Bar Plan-Iolta 319,028.64 NC State Bd Ed 14,956.57 NC State University (NCSU) 121,687.84 NCDHHS 253,098.98 NCDHHS/Dag 173,263.61 NCDHHS/Dcd 353,459.73 NCDHHS/Deie 2,847,344.98 NCDHHS/Dfs 34,778.60 NCDHHS/Dfs/Oems 99,680.85 NCDHHS/Dma 962,723.39 NCDHHS/Dph 1,934,071.82 NCDHHS/Dph/Wch 2,990,941.79 NCDHHS/Dps/Wch 2,004,886.36 NCDHHS/Dss 80.00 NCDHHS/Ltc 4,298,375.23 NCDHHS/Mh/Dd/Sas 428,023.94 NCDHHS/Mhdd/J U Hosp 1,061,455.68 NCDHR/Dag 729,302.69

13 of 22 OSR FY04 Annual Report Appendix 4 Detail Expenditures by Sponsor Name FY04 Expenditures State (continued) NCDHR/Mh/Dd/Sas 730.58 NCSU/Itre 568,255.50 NCSU-Sea Grant-Fed 24,725.88 NCSU-Wrri 257,810.79 Office of Governor 265,519.65 UNC Hospitals 806,778.84 UNC-Charlotte 210,980.81 UNC-General Admin 7,476.11 UNC-Greensboro 1,754,200.50 UNC-Office of President 97,400.68 UNC-Wilmington 58,777.82 Wake County Department Hlt -279.67 State Subtotal 27,495,305.14 Other A W Mellon Foundation 1,116,334.36 A W Mellon Interest 173,484.67 Access Care, Inc 41,767.44 Accp Research Institute 7,802.52 Accutane Supprt/Liam 7,009.99 Advantage West 22,328.59 Alcohol Bev Med Research 6,551.70 Alfred P Sloan Foundation 152,258.79 Alternatives Research & 13,625.69 Alumni Annual Giving 7,271.29 Alzheimer's Assn 189,403.33 American Acad Pediatrics 2,493.04 American Assn Dental Research 2,100.00 American Assn Oral/Oral & 285,140.43 American Assn Retired Pers 72,181.59 American Assn Stdy Liver 49,678.91 American Assoc Adv Science 1,198.26 American Coll of Surgeons 21.61 American Orth Soc Sprts Md 69,833.65 American Physical Therapy 5,447.49 American Society Blood & Marro -118.54 American Society Ther Rad & On 51.25 American Acad Nursing 105,003.40 American Acad Otolaryngo 2,612.82 American Assn Cancer Research 35,406.46 American Assn Coll Pharm 1,974.29 American Chem Society 17,183.63 American Chemistry Counc 526,811.65 American Coll Clin Pharm -1,966.09 American Coll Gastroente 51,472.31 American College Ob-Gyn -60.75 American Digestive Health 670.71 American Dntl Assc Health 715.25 American Foundation Aids Research 6,302.20 American Fed Aging Research 121,838.17 American Gastroent Assoc 25,214.64 American Institute Cancer Research 7,587.14 American Liver Foundation 9.10 American Lung Assn 131,710.75 American Lung Assn of NC 7.19 American Nurses 4,675.64 American Psych Institute Research 390.00

14 of 22 OSR FY04 Annual Report Appendix 4 Detail Expenditures by Sponsor Name FY04 Expenditures Other (continued) American Society Clin Oncolo 24,362.74 American Society for Pharm 6,250.00 American Society Hematology 1,412.32 American Cancer Society 1,512,640.93 American Chem Society 207,747.13 American Heart Assoc 1,558,428.50 Annie E Casey Foundation 204,286.64 Appalachian Reg Comm 47,652.47 Arizona State University 8,889.00 Arthritis Foundation 245,193.77 Asrt Ed & Research Foundation 2,511.04 Assc Amer Medical -3,356.39 Assc Dir Geriatric 81,198.73 Assc Dress & Sauces -4,124.00 Assn Intern'L Cancer 92,095.02 Assoc Sch Pub Health 80,632.40 Astrazeneca Uk Lmtd 138,174.48 Atlantic Philanthrop 36,698.67 Aventis Pasteur-Fran 52,892.48 Awwa Research Foundation 119,898.43 B & M Gates Foundation 1,205,438.78 Baron Adv Meteor Sys 14,160.69 Beckman Foundation 85,329.19 Beckman Interest Acc 1,807.29 Bespak Europe Ltd -1,807.84 Blakemore Foundation 14,981.42 Boardman Family Foundation 1,999.12 Brigham Women's Hosp 44.76 Brookdale Foundation 61,529.92 Brookings Institute 42,960.33 Burroughs Welcome F 430,242.74 C & H Dreyfus Foundation 11,242.76 C Reeve Paralysis Foundation 29,347.25 Cabarrus County Plan 10,920.11 Calf Healthcare Found 11,000.00 Calgb Foundation 26,021.20 Calif Air Research Bd -40,367.93 Camille/Henry Dreyfu 9,690.01 Cancer Research Foundation Amer 46,518.92 Cancer Research Institute 27,636.39 Cap Cure 305.00 Carolina Ballet 3,916.61 Carolina Health Care 6,683.96 Carolinas Center Hospic 42,147.56 Carteret County -2.29 Carteret County Econ 18,058.47 CDC Foundation 101,148.99 Celltech 95,462.73 Cf Foundation Therapeudics 1,080.00 Chapel Hill 12,927.51 Chatham Cnty Partner 87,178.62 Chatham Hospital Inc 427.73 Children's Hosp/Denv -174.52 Children's Hospital 41,570.51 Chldrns Hosp Reg Med 179,078.37 Citizens League Oppo -2,137.79

15 of 22 OSR FY04 Annual Report Appendix 4 Detail Expenditures by Sponsor Name FY04 Expenditures Other (continued) City College of NY 11,798.94 City of Durham, NC 56,606.80 City of Hickory, NC -9,545.00 Cncl Intn'L Exchange 29,685.34 Coastal Horizons Center 18,977.64 Columbia University 5,894.14 Commonwealth Fund 309,947.17 Commonwealth of Virginia 7,411.27 Compton Foundation, Inc 18,761.24 Corp for Public Broa 525,799.23 Council Intnl Exchge 38,423.06 Crohn's & Colitis Fn 268,453.98 Center Envir, Fisheries 75,000.00 Center Health Care Strtgy -1,230.85 Center Health Manage Research 74,088.38 Center Housing Policy -164.86 Center Responsible Lend 101,352.91 Cumberland Comm Foundation 2,843.38 Cystic Fib Therapeut 1,726,541.27 Cystic Fibrosis Foundation 1,812,311.53 D W Reynolds Foundation 229,581.19 David-Lucile Packard 165,248.55 DC Department Hmn Ser-Oecd 119,631.68 Dermatology Foundation 4,741.26 Doris Duke Charitabl 249,749.36 Dudley Observato Foundation 10,000.00 Duke Clinical Research 101,138.31 Duke Endowment 1,070,751.36 Duke Institute on Care 5,283.40 Duke University Med Center 28,860.47 Duke University 88,769.87 Durham Housing Auth 5,824.45 E Glaser Ped Aids Foundation 340,183.44 E M Kauffman Foundation 4,511.24 E&E Broad Foundation 52,352.39 Eastern Virginia Med Sch 181,120.10 Electric Pow Research Institute 70,595.19 Eli-Edythe Broad Foundation 137,422.21 Ellison Med Foundation 289,053.13 Elsa U Pardee Foundation 16,437.74 Emergency Med Foundation 1,807.27 Emory University 34,967.79 Endocrine Fellows Foundation 2,750.36 Environm Defense Fun 3,328.25 Environmental Defens 2,612.30 European Commission 108,428.51 Ewing Marion Kauffma 44,583.22 Family Health Intnl -9.61 Fannie Mae Foundation 91,994.90 Foundation Adv Health Prog 93,121.29 Foundation Child Developmen 597,069.51 Foundation Clinical Research 15.95 Foundation Digest Health/Nutr 10,403.98 Foundation Fighting Blindne 16,835.33 Foundation for Child Dev 11,244.48 Foundation for Inf Med Dec 24,342.04

16 of 22 OSR FY04 Annual Report Appendix 4 Detail Expenditures by Sponsor Name FY04 Expenditures Other (continued) Foundation for The Carolina 2,160.00 Foundation Music-Based Lear 65,804.98 Foundation Physical Therapy 53,735.67 Foundation Suicide Prevent 42,967.62 Fetzer Institute 19,810.83 Florida Game & Fresh 1,225.96 Florida Institute of Tech 18,236.11 Ford Foundation 1,766,471.68 Foundation of Hope 22,404.15 Francis Families Foundation 37,799.26 Fraxa Research Foundation 34,848.52 Fresenius Kabi Deuts 81,178.17 Fritz Thyssen Foundation 4,970.92 Fujisawa Healthcare 4,646.27 G J Richardson Trust 4,875.90 Gen Motors Canc Research 97,983.61 Genentech Foundation Growth 24,769.09 George Washington University 790.74 Gerontological Socie 11,203.44 Gladys K Delmas Foundation 1,553.39 Glaxosmithkline Foundation 455,792.31 Glaxosmithlkine Institutet 58,754.41 Glaxo-Well Interest 5,482.13 Golden Leaf Foundation 146,147.73 Governor's Institutet Alco 1,460.71 Greenwall Foundation 104,855.79 H & M Rothschld Foundation 20,000.00 H J Kaiser Fam Foundation 1,263.23 Hamilton Health Scienc 2,931.95 Harvard University 63,229.61 Hcr Manor Care Foundation 20,000.00 Heartwise -3,534.30 Helene Fuld Health Trs 10,744.42 Hemophilia of Georgi 14,660.22 Henry Luce Foundation, Inc 67,881.89 Heraeus Kulzer Gmbh 4,065.78 Hereditary Dise Foundation 47,972.57 Hewlett Foundation 105,406.34 Hewlett Foundation Interest 1,993.82 Health Research and Educ Tr 19,160.16 Home Safety Council 83,727.91 Howard Hughes Intrst 10,833.34 Howard Hughes Med In 632,247.45 Human Frontier Sc Pg 47,210.92 Hunters Hope Foundation 124,075.09 Income Acct 581,743.53 Institute for Hwy Saf 32,092.32 Institute Advmt Comm Phar 38,084.32 Institute for Stdy Aging 96,255.36 Institute Healthcare Impr -115.15 Inter Foundation Music Research 24,354.08 Inter Unec 23,139.18 International Vaccine Inst 228,378.15 International Aids Vaccine 85,976.46 JD French Foundation-Alzhei 3,516.00 Jessie Ball Dupont 78,726.75

17 of 22 OSR FY04 Annual Report Appendix 4 Detail Expenditures by Sponsor Name FY04 Expenditures Other (continued) John A Hartford Foundation 18,197.01 John E Fetzer Institute 12,035.82 John Rex Endowment 25.70 John Templeton Foundation 0.03 Johns Hopkins University 94,916.47 Joyce Foundation 20,000.00 JS & JL Knight Foundation 215,679.21 Juvenile Diabetes Foundation 441,946.53 K B Reynolds C Trust 200,650.25 Kauffman Center 0.29 Kauffman Foundation 49,752.50 Kellogg Foundation 260,164.73 Kentucky Hist Society 21.75 Kerr Tar Reg Coun Go 32,664.54 Kidney Foundation Canada -81.44 La Ct Prop 10 Commis 744,350.06 Law Sch Adm Svcs Inc 44,033.17 Lawson Wilkins Pedia 30,327.69 League Amer Bicyclst 17,130.74 Leukemia & Lymphoma 65,038.68 Leukemia Research Foundation -6,255.73 Leukemia Society of Amer 100,755.94 Life Sci Research Foundation 34,720.36 Lilly Endowment, Inc 626,925.20 Louisiana Department Health 101,652.61 Lucille Markey Ch Tr 53,078.86 Lupus Research Institute 52,246.53 M L Richardson Fund 2,645.98 Macarthur Foundation Intrst 62.45 Macarthur Foundation 1.57 Maine Med Assess Foundation 3,820.35 Maine Sci & Tech Foundation 29,712.13 Mamea Imaging Ab -1,338.22 Manpower Demo R Corp 10,366.55 March of Dimes 316,671.44 Marion Stedman Covin 7,589.11 Mayo Clinic Rocheste 133,516.71 Mayo Foundation -171.76 Mccormick Trbune Foundation 63,830.15 MCNC 9,982.72 Med for Malaria Vent 132,585.50 Merck Co Foundation 15,355.28 Metlife Foundation 8,934.33 Mid Cape Fear River 5,934.85 Milheim Foundation 10,800.51 Multi Wrk Team/Fgid 21,375.57 Muscular Dystrophy 199,536.24 N Calif Cancer Center 65,279.75 Naccho 33,546.77 Nami/Stanley Foundation 87,577.93 Narsad 84,153.28 Nasdaq Educ Foundation Inc 24,610.00 Nasdaq Stck Mkt Edu 10,661.49 National Athletic Trainer 502.57 National Conf State Legis 28,446.74 National Council on Aging 23,237.47

18 of 22 OSR FY04 Annual Report Appendix 4 Detail Expenditures by Sponsor Name FY04 Expenditures Other (continued) National Center Addctn & Sub -3,966.69 National Fragile X Foundation 28,555.20 National Init Chld Healthcr 696,818.41 National Mult Scleros Society 213,840.98 Nathan Cummings Foundation 11,449.58 National Acad Record Art 12,133.19 National Alliance Autism 28,882.97 National Blood Foundation -169.12 National Epifellows Foundation 790.85 National Foundation Ectodermal 12,035.81 National Fnd Cdc & Preve 87,234.53 National Geographic Society 1,792.00 National Hemophilia Foundation 101,415.88 National Kidney Foundation of N 5,144.18 National Park Foundation 40,288.12 Natureserve 18,640.32 NC Acdmy Fam Physici 75,878.21 NC Adcmy Fam Physici 61,398.08 NC Biotech Center 373,088.32 NC Chld Yng Adlt Crf -5.73 NC Chldrn's & Adult 25,500.06 NC Health & Well Trust 552.96 NC Healthy Start Foundation -120.78 NC Humanities Cncl 9,454.86 NC Indian Economic 7,128.61 NC Lions Foundation, Inc -1,995.00 NC Parternship Child 53,225.10 NC Partnership Child 1,022.89 NC Rural Economic De -156.65 NC Southeast 4,826.83 NC Tech Dvlpmnt Auth -5,952.38 Nevada Department Employ 56,426.66 New York Comm Trust 27,025.48 Nocsae 14,172.98 Northwestern University 22,852.98 Nova Southeast University 11,516.11 New York Acad of Medicine -3,211.87 Office of Population 8,119.00 Oncology Nurs Society Foundation 2,918.04 Online Computer Libr 919.34 Optiva Corp Interest 5,676.51 Orange Cnty Art Com 1,000.00 Orange Co Partnershi 78,403.77 Orange County, NC 10,000.00 Orange,Person,Chatha 516,904.79 Oregon Community Foundation -233.21 Oregon Health Sciences 44,552.19 Ortho Diag Sy Intrst -4,390.00 Pacific Institute Research -5,022.49 Padi Foundation -907.86 Park Foundation 7,787.95 Partners Out-School 1,377.31 Pharm Research & Manuf 100,771.36 Policy Research Asso 45,315.99 Pop Srvc Int'L 8,999.67 Pop Srvc Int'L India 2,980.56

19 of 22 OSR FY04 Annual Report Appendix 4 Detail Expenditures by Sponsor Name FY04 Expenditures Other (continued) Potts Memorial Foundation 32,558.10 Preeclampsia Foundation 549.54 Prevnt Chld Abuse NC -48.72 Price Foundation Ltd 65,299.04 Prince William Sound 23,707.37 Princeton University 57,526.17 Prostate Cancer Foundation 91,162.24 Public Wrks & Govt 53,593.55 Racial Justce Collab 2,601.95 Research Corporation 22,416.51 Research Foundation of Suny 23,701.25 Retirement Research Foundation 127,638.50 Robert Wood Johnson 5,393,501.85 Rockefeller Foundation 105,435.65 Rockefller Brthrs Foundation 14,561.91 Ronald Mcdonald Hous 84,436.80 Roswell Park Canc In 14,050.99 Research Trngle Reg Par 34,298.03 RTI 368,887.20 Russell Sage Foundation 67,883.34 Rutgers 1,153,371.09 Rwj Interest Account 181,005.23 S G Komen Breast Can 61,192.99 S G Komen-NC Affilia 3,063.16 S Waxman Cancer Rsrc 79,820.31 Samuel H Kress Foundation 28,876.37 Sandler Prog Asthma 229,263.79 Sanfilippo Research Foundation 46,783.18 Schwarz Biosciences 88,347.44 Searle Schrl Pgm 79,145.13 Searle Schrl Pgm-Cct -280.91 Sidney Kimmel Foundation 182,216.06 Sigma-Tau Industrie 11,158.46 Smith Richardson Foundation 140,684.26 Society Gen Internal Med -377.63 Society Brst Imaging 11,964.51 Society Toxicology 29,510.76 Southrn Cali Coastal 86,724.26 Southrn Medical Asso -196.25 Special Library Assn 522.25 Spencer Foundation 254,572.96 Spinal Cord Research Foundation 52,351.32 St Johns River Water 38,025.94 Stanford University 17,134.57 State & Terr Injury 5,000.00 State of Florida 29,983.06 State of New Jersey 3,241.32 Strength Blck Family 23,674.51 Tech Assist Collab 5.30 Temple University 32,559.98 Texas A&M Research Foundation 43,856.82 The 3D Research Foundation -412.17 The Acld Foundation 0.01 The Ejlb Foundation 44,737.70 The Freeman Foundation 138,137.24 The Grable Foundation 37,418.97

20 of 22 OSR FY04 Annual Report Appendix 4 Detail Expenditures by Sponsor Name FY04 Expenditures Other (continued) The Leakey Foundation 308.30 The Lustgarten Foundation P 30,472.32 The Wenner-Gren Foundation 16,230.04 Theatre Comm Grp Inc 6,480.35 Tinker Foundation 3,968.03 Triangle Comm Foundation 4,898.24 Triological Society 39,224.92 UNC 4,115.05 United Cerebral Pals 66,656.26 United Nations Pop F 3,667.48 United Negro College 64,171.11 United Tribes Techn 519.24 University Calif/Pew Intrs -514.99 University Calif-Berkeley 47,814.89 University Calif-San Franc 29,896.25 University Liverpool 727.50 University Mass/Amherst 10,603.89 University of Alabama-Birm 18,107.28 University of California 127,854.49 University of Chicago 57,057.48 University of Florida 47,380.84 University of Maryland 13,681.62 University of Michigan 297,791.48 University of Minnesota -0.51 University of Notre Dame 4,139.48 University of Oxford 11,007.74 University of Tennessee 28,163.22 University of Texas-Austin 111,133.59 University of Toronto 45,125.14 University of Utah 9,859.47 University of Vermont 48.52 University of Waikato 15,744.31 University Utrecht -2,503.67 University Western Ontario 68,449.61 Unocal Foundation 154,895.09 US Civilian Research & -45.19 USA Track & Field 6,940.29 US-Israel Binatl Sci 10,406.95 Virginia Polytechnic Institute 54,119.19 Veterans Med Research Foundation 7,449.25 Vhl Family Alliance 1,036.00 W M Keck Foundation Intrst 219.96 W T Grant Foundation 283,929.34 Wabash Center 13,972.55 Wake Forest University Health Sci 8,256.60 Wake Forest University Sch Med 15,365.88 Wake Forest University 33,026.94 Wallace Genetic Foundation 2,497.42 Warner Dannh Test Tr 41,432.71 Water Environ Research -846.67 West Virginia University Res Cor 33,786.50 West Virginia University 50,152.70 Whitaker Foundation 155,906.68 Whitehall Interest A 247.69

21 of 22 OSR FY04 Annual Report Appendix 4 Detail Expenditures by Sponsor Name FY04 Expenditures Other (continued) Winston-Salem Foundation 58,249.34 Woodrow Wilson Foundation 37,241.67 Yale University 6,450.34 Z Smith Reynolds Foundation 792,566.29 *Other Subtotal 45,095,204.33 Total Expenditues 523,555,310.61 *Plus Expenses removed 99,513.04 FY04 Total Expenditures 523,654,823.65

22 of 22 OSR FY04 Annual Report Appendix 4