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Specialists in Small Molecule Drug Development
Specialists in Small Molecule Drug Development Dr Stephen Parker, Chairman Dr Tim Mitchell, CEO & Co-Founder Dr John Reader, CSO & Co-Founder Final Results for the Year Ending 30 June 2019 October 2019 www.sareum.co.uk Disclaimer The information contained in this document (“Presentation”) is directed at (i) members or creditors of a corporate body within the meaning of Article 43 of the Financial Services and Markets Act 2000 (Financial Promotions) Order 2005, as amended ("Order"), (ii) persons who have professional experience in matters relating to investments falling within Article 19(5) of the Order, or (iii) those persons to whom it can otherwise be distributed without contravention of article 21 of the Financial Services and Markets Act 2000 (“FISMA”) or to whom it can lawfully be distributed. This Presentation has been prepared by Sareum Holdings PLC (“Company”) and provided to you for information purposes only. This Presentation is not an invitation or inducement to engage in an investment activity for the purposes of FISMA. This Presentation has not been approved by an Authorised Person (as defined in s31 FISMA), as would be required for financial promotions under s21 FISMA and, for the avoidance of doubt, is not a financial promotion for the purposes of FISMA. If, contrary to the above, this Presentation is deemed to be a financial promotion for the purposes of FISMA, the Company relies on the exemptions set out in Articles 19, 43, 59 and 69 of the Order, which exempts companies admitted to trading on relevant markets making certain communications. Please note that any indication of past performance should not be relied upon as a guide to future performance. -
Helmdon's War Memorial Project, 2016
Helmdon’s War Memorial The Men Behind the Names WEA Helmdon Branch November 2016 | The Men Behind the Names Contents Preface History of the War Memorial Index of Service Records (WWI unless stated otherwise) Edmund John Ayres George Victor Creed Charles Frederick Finch Arthur Oliver Franklin John Thomas Grant Alfred Humphrey Sidney Lines William Merrison William Harold Seckington Charles Arthur John Southam James Tugwood Harry Turnham William Edwin Turnham Frederick John Watson Frank Branson Watts Francis John Winmill Alfred George Humphrey (WWII) The Helmdon Roll of Honour & other Helmdon connections - William John Major - Edward Stanley Strachan Acknowledgements Appendix Memorial Dedication Service Preface Helmdon’s War Memorial - The Men Behind the Names In 2014, the 100th Anniversary of the start of the 1914 -1918 Great War, a group of Helmdon residents decided to research and publish personal details of those servicemen whose names appear on the Helmdon War Memorial. Such was their enthusiasm that the work has expanded into looking at other aspects, notably the Roll of Honour of Old Boys of Helmdon School Who Served in the First World War. First published in 2014, this 2016 update includes newly discovered facts and stories. The most relevant, up-to-date information available has been put together and can be printed off as a booklet. It is to be hoped that it will not only add to the history of Helmdon but that it will go some way to honour the great sacrifice made by those village servicemen. The authors apologise that some entries do not contain as much detail as others; available records are not always fruitful. -
Public Session
PUBLIC SESSION MINUTES OF ORAL EVIDENCE taken before HIGH SPEED RAIL COMMITTEE On the HIGH SPEED RAIL (LONDON – WEST MIDLANDS) BILL Tuesday, 24 February 2015 (Morning) In Committee Room 5 PRESENT: Mr Robert Syms (Chair) Sir Peter Bottomley Mr Henry Bellingham Ian Mearns Mr Michael Thornton _____________ IN ATTENDANCE: Mr Timothy Mould QC, Lead Counsel, Department for Transport Witnesses: Mr Simon Marinker, Radstone Residents Group Mr Murray Brown Mr Simon Harris Mr A. M. and Mrs R. J. Herring Mr Robert and Sally Drummond-Hay Mr Tim Smart, International Director for High Speed Rail, CH2M Hill _____________ IN PUBLIC SESSION INDEX Subject Page Radstone Residents Group Parochial Church Council for Helmdon with Stuchbury and Radstone Introduction from Mr Mould 3 Submissions from Mr Marinker 4 Mr Smart, examined by Mr Mould 17 Mr Smart, cross-examined by Mr Marinker 23 Murray Brown Submissions from Mr Brown 26 Submissions from Mr Harris 27 Submissions from Mr Mould 34 Simon Marinker Submissions from Mr Marinker 40 Mr and Mrs A Herring Submissions from Mrs Herring 44 Response from Mr Mould 49 Further submissions from Mrs Herring 53 Robert and Sally Drummond-Hay Submissions from Mr and Mrs Drummond-Hay 57 Submissions from Mr Mould 71 Closing submissions from Mr Drummond-Hay 73 Hugh Smith Submissions from Mr Smith 77 Submissions from Mr Mould 80 2 (At 9.20) 1. CHAIR: Order, order. Welcome, good morning everybody to the HS2 Select Committee. It is nice to see such a large audience of interested people. Radstone Residents Group Parochial Church Council for Helmdon with Stuchbury and Radstone 2. -
Drug Discovery Chemistry
Save up to $200! Final Agenda Register by February 23 COVER CHI’s 13th Annual CONFERENCE AT-A-GLANCE PLENARY KEYNOTES SHORT COURSES Drug Discovery AGENDA Plenary April 3-4 Conferences »» Protein-Protein Interactions Keynotes »» Inflammation»&»Autoimmune» Inhibitors Chemistry »» Kinase»Inhibitor»Chemistry Optimizing Small Molecules for Tomorrow's Therapeutics »» GPCR-Targeted Drug Design »» Fragment-Based»Drug» Activity-Based April 2-6, 2018 | San Diego, CA | Hilton San Diego Bayfront Discovery Proteomics: April 4-5 Conferences Protein and »» Ubiquitin»Proteasome»System» Ligand Discovery Inhibitors on a Global Scale CONFERENCE PROGRAMS »» Small»Molecules»for»Cancer» Benjamin F. Cravatt, Immunotherapy PhD, Professor and APRIL 3-4 APRIL 4-5 APRIL 6 Co-Chair, Department »» Macrocyclics»&»Constrained» of Molecular Peptides Medicine, The Protein-Protein Ubiquitin Proteasome Biophysical Approaches »» Targeting»Complex» Scripps Research Membrane»Proteins Institute Interactions System Inhibitors for Drug Discovery April 6 Symposia »» Biophysical»Approaches»for» Lead Optimization Inflammation & Small Molecules for Drug»Discovery for Drug Metabolism Autoimmune Inhibitors Cancer Immunotherapy »» Lead»Optimization»for»Drug» & Safety Metabolism»&»Safety » Targeting Ras » Blood-Brain»Penetrant» Kinase Inhibitor Macrocyclics & Blood-Brain Inhibitors and MYC for the Treatment of Chemistry Constrained Peptides Penetrant Inhibitors HOTEL & TRAVEL Cancer Stephen Fesik, SPONSORSHIP PhD, Professor GCPR-Targeted Targeting Complex Plus Short Courses & EXHIBIT -
2019 Analyst Day
2019 Analyst Day March 12, 2019 NASDAQ: LGND 2 Safe Harbor Statement The following presentation contains forward-looking statements by Ligand and its partners that involve risks and uncertainties and reflect Ligand's and it’s partners’ judgment as of the date of this presentation. Words such as “plans,” “believes,” “expects,” “projects,” “could,” “anticipates,” and “will,” and similar expressions, are intended to identify forward-looking statements. These forward-looking statements include, without limitation, financial projections, expectations regarding research and development programs, potential uses of capital, including any potential dividend or share repurchase program, and the timing of the initiation or compilation of preclinical studies and clinical trials by Ligand and its partners. Actual events or results may differ from Ligand’s expectations due to risks and uncertainties inherit in Ligand’s business, including: Ligand has wide discretion on its use of capital and may choose not to engage in any share repurchases, declare any dividends or pursue acquisitions or internal develop programs; Ligand and its partners may not be able to timely or successfully advance any product(s) in its internal or partnered pipeline;, drug development program benefits may not be realized; Ligand will achieve its guidance in 2019 or thereafter; third party research summarized herein may not be correct or complete; Kyprolis®, EVOMELA® and Zulresso™ may not perform as expected, Ligand relies on collaborative partners for milestone and royalty payments, -
Form 8-K Ligand Pharmaceuticals
UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 ______________ FORM 8-K ______________ CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 11, 2020 LIGAND PHARMACEUTICALS INCORPORATED (Exact Name of Registrant as Specified in Its Charter) Delaware 001-33093 77-0160744 (State or other jurisdiction of (Commission File Number) (I.R.S. Employer incorporation or organization) Identification No.) 3911 Sorrento Valley Boulevard, Suite 110 San Diego CA 92121 (Address of principal executive offices) (Zip Code) (858) 550-7500 (Registrant’s Telephone Number, Including Area Code) N/A (Former Name or Former Address, if Changed Since Last Report) Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions: ☐ Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425) ☐ Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12) ☐ Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b)) ☐ Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c)) Securities registered pursuant to Section 12(b) of the Act: Title of each class Trading Symbol(s) Name of each exchange on which registered Common Stock, par value $0.001 per share LGND The Nasdaq Global Market Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933(§230.405 of this chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 (§240.12b-2 of this chapter). -
Planning Support Statement
PLANNING SUPPORT STATEMENT New 2FE Primary School At Radstone Fields Developed, Brackley, Northamptonshire For Northamptonshire County Council (c/o Lend Lease) Prepared by Peter Haddon and Partners Architects July 2014 • First Issue 23/07/2014 • Second Issue 10/09/2014 • Third Issue 18/11/2014 • Fourth Issue 10/01/2014 150110sp4073 A2 Planning Support Statement Radstone Fields Page 1 of 24 Contents 1 – Introduction 2 – Site Context 3 – Planning history 4 – Proposed Development 5 – Planning Policy 6 – Assessment of the Proposed Development 7 – Section 106 Agreement 8 – Mechanical Plant 9 – Conclusion 150110sp4073 A2 Planning Support Statement Radstone Fields Page 2 of 24 1. Introduction 1.1 This statement has been prepared by pHp Architects in support of a detailed planning application as the Agent of Northamptonshire County Council (NCC) (the ‘Applicant’) for the development of a 2 Form Entry Primary School and associated facilities on the Radstone Fields housing development. As the time of this report being issued a more accurate site address has not been created. 1.2 The site consists of land within the Radstone Fields housing development and will be a key building within the estate where outline planning consent has already been given for a primary school of this size. An earlier outline consent (application S/2010/0995/MAO) gave approval for existing trees, hedges and other key details to be managed or removed from site prior to the full application for the school being submitted. Construction of the housing development is currently in progress around the outside of the proposed site. 1.3 The development of the site will deliver approximately 45 (new) jobs for teaching and support staff, including cleaners, caterers and admin staff. -
South Northamptonshire Housing and Homelessness Strategy 2015-18
South Northamptonshire Housing and Homelessness Strategy 2015-18 1 | P a g e Portfolio Holder Introduction It is an ideal time for South Northamptonshire to re-affirm its lead role in directing and defining housing development and service delivery. While our role focuses on affordable housing; private sector housing and homelessness prevention we are also providing direction on new market development and securing our partnerships with registered providers and private sector landlords. We share a challenging environment with our partners where we must instil the confidence to be brave in the development and delivery of new products and service models when public sector resources are shrinking and there is limited central investment. This means making the most of our assets by developing new partnerships across boundaries, with the voluntary sector and in the communities where we work and deliver more integrated working. We are working in a local housing market which is meeting demand but not always need and where competition for land and funding often leads to our registered provider partners being priced out by market developers. There is unmet need for accommodation that is more expensive to deliver and more difficult for our partners to manage and unmet mental health support and community safety issues in our communities. We recognise it is not about competition between services and providers it is about presenting a single joined up service and meaning it. Thresholds for support services are going up making them more difficult to access and there is uncertainty over how the Community Wellbeing Hubs will operate and help. -
Dashboard for the Parish of Helmdon: St Mary Magdelene W Stuchbury & Radstone: in the Deanery of BRACKLEY Parish Census and Deprivation Summary 2
Dashboard for the parish of Helmdon: St Mary Magdelene w Stuchbury & Radstone: in the Deanery of BRACKLEY Parish census and deprivation summary 2. Worshipping Community, 2014-19 Parish population (2018): 943 1. Attendance summary, 2010-19 Parish Diocese National 500 % aged 0-17 23% 23% 21% 9 160 % aged 18-44 29% 36% 37% 8 400 140 % aged 45-64 32% 26% 25% 7 120 % aged 65 & over 16% 15% 16% 6 300 100 5 % Christian 67% 60% 59% 80 4 % non-Christian religion 1% 6% 9% 200 60 3 40 2 Parish deprivation rank (IMD, 2019): 10424 Number of people Number of people 100 Number of people 20 1 (1=most deprived parish in the Church of England, 12,382=least deprived) 0 0 0 For more detailed census & deprivation info: see http://arcg.is/1RaS4CS 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 Christmas Easter age 0-17 age 18-69 https://www.churchofengland.org/researchandstats Average week, October Usual Sunday age 70+ age unspecified Joiners Leavers and http://www2.cuf.org.uk/poverty-england/poverty-map Worshipping Community Number of churches in parish (2020): 2 Parish code: 280018 3. Usual Sunday attendance, 2010-19 4. Average weekly attendance, October, 2010-19 5. Percentage children, 2010-19 Services for schools 70 100 60% identified from 2013 90 60 50% 80 40% 50 70 30% 40 60 50 20% 30 Percentage 40 10% 30 20 0% Number of people Number of people 20 10 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 10 0 0 Usual Sunday (aged <16) 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 Average week, October, excluding school services (aged < 16) Adults Children Adults Children Adults, School Children, School Worshipping community (aged < 18) 6. -
Milner Symposium 2020
THERAPEUTICS SYMPOSIUM 2020 GLOBAL THERAPEUTIC ALLIANCE OVERVIEW A SERIES OF ONLINE EVENTS STARTING ON JUNE 12TH ALLIANCE GLOBAL THERAPEUTIC ALLIANCE The Milner Therapeutics Institute encompasses both a research institute and a global outreach programme for collaboration. GLOBAL THERAPEUTIC ALLIANCE Research in the Milner Therapeutics Institute is funded by: Our outreach programme is through the Global Therapeutic Alliance, which aims to build a global research community working together across academia and industry, with Cambridge providing a hub of expertise. The Milner Therapeutics Consortium is central to this aim (p4), and the Alliance has been expanded with the Affiliated Company p8( ) and Affiliated Institutions scheme p37( ) to bring complementary expertise and resources to the community, and provide opportunity to extend collaborative links within and beyond Cambridge. The Affiliated Venture Partnersprogramme, operational since October 2017, provides mentoring and potential funding opportunities for the Milner Therapeutics Institute and its Global Therapeutic Alliance, and especially for our in-house company accelerator Start Codon. 3 CONSORTIUM ASTEX PHARMACEUTICALS MILNER THERAPEUTICS CONSORTIUM The Milner Therapeutics Astex is a leader in innovative drug discovery and Consortium is an academic- development, committed to the fight against cancer and industry partnership, active since diseases of the central nervous system. Astex is developing June 2015. This is underpinned a proprietary pipeline of novel therapies and has multiple -
Memory in Early Modern England
Part II Special Subject C Memory in Early Modern England Prof. Alex Walsham ([email protected]) Overview Without memory, we could not write History. But memory itself has a history. This Special Subject investigates one segment of that history in the context of sixteenth- and seventeenth- century England. By contrast with medievalists and modernists, early modernists have been slow to investigate how the arts of remembering and forgetting were implicated in and affected by the profound religious, political, intellectual, cultural, and social upheavals of the period. However, there is now a growing surge of exciting and stimulating research on this topic. Its relevance and centrality to key historiographical debates and its capacity to shed fresh light on classic questions regarding one of the most tumultuous eras in English history are increasingly being recognised. Set against the backdrop of the profound ruptures of the Reformation, Civil Wars, and the constitutional revolution of 1688, this Paper seeks to explore how individuals and communities understood and practised memory alongside the ways in which it was exploited and harnessed, divided and fractured, by the unsettling developments through which contemporaries lived and in which they actively participated. It assesses the role played by amnesia and oblivion, nostalgia and commemoration, in facilitating change and in negotiating the legacies it left. Students will be exposed to a wide range of primary sources – from chronicles, diaries, histories, memoirs and compilations of folklore to legal depositions, pictures, maps, buildings, funeral monuments and material objects – that afford insight into the culture and transmutations of early modern memory. Sessions in the Michaelmas Term will explore contemporary perceptions and practices of memory. -
South Northamptonshire Accommodation Guide
www.southnorthants.gov.uk South Northamptonshire Accommodation Guide Quality Assurance and Star Ratings Index Several of the venues featured in this guide have Hotels 6 a star rating – the official mark of quality awarded to accommodation by VisitEngland and the AA. Inns with Bed and These two organisations assess accommodation Breakfast Bedrooms 9 to the same criteria and award one to five stars. What the stars mean … Bed and Breakfast H Accommodation 12 Simple, practical, no frills Self-Catering H H This guide has been produced by South Northamptonshire Council (SNC) as one of a number of initiatives to Well presented and well run encourage tourism in the district, with the active participation of the businesses mentioned. Every care has been Accommodation 18 taken by SNC to ensure that all the information contained in this document is accurate and up-to-date at the time H H H of printing and that all relevant establishments have been included. No responsibility or liability can be taken by the Good level of quality and comfort Council for any errors or omissions, or for any inconvenience caused after the guide has gone to press. Camping & Please send comments, corrections, or recommendations for other businesses that might be suitable to include Caravanning Sites 20 H H H H in a future edition of this guide to: [email protected], or to Strategic Planning and the Economy, Excellent standard throughout South Northamptonshire Council, Springfields, Towcester, Northamptonshire NN12 6AE. Map 22 January 2015/All rights reserved. H H H H H South Northamptonshire Council reserves all editorial rights.