The War in Afghanistan: War As a Labortory for Trauma Research

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The War in Afghanistan: War As a Labortory for Trauma Research THE WAR IN AFGHANISTAN | NEWSFOCUS From soldier to subject. Researchers are collecting data from casualties like this one in Afghanistan. Downloaded from http://science.sciencemag.org/ personnel, they come with exhaustive data relating to preinjury health and postinjury on October 16, 2017 War as a Laboratory outcome. Many of the insights gained from battlefi eld studies have found their way into For Trauma Research civilian emergency medicine. But war is also the most chaotic and stressful environment The military is sending scientists onto the battlefi eld to fi nd ways to improve imaginable for doing science. “Someone has emergency medicine, but the research faces a practical and ethical minefi eld to take down all this data,” Osborne says. “I saw this poor girl trying to turn this blood- KANDAHAR AIRFIELD, AFGHANISTAN— question.” What saved him was a series of smeared page, trying to get data off of it. … Easing back into a borrowed chair in a tiny extremely rapid interventions, including new That’s the reality. Until you’ve lived that, you trailer office here on the base, Cmdr. Lisa techniques for applying tourniquets, drugs, don’t realize how diffi cult it is.” Osborne should be enjoying a moment of and blood products. Those insights came Adding to the diffi culty, controversy has calm. But all she can talk about is work. “I saw from medical research conducted in Iraq and dogged JC2RT projects, including charges a guy show up here in trauma. You wouldn’t Afghanistan, orchestrated through a U.S. mili- by journalists that researchers rushed experi- believe the condition he was in,” she says, tary program called the Joint Combat Casu- mental treatments onto the battlefi eld without recalling the victim of an improvised explo- alty Research Team (JC2RT). As its deputy proper ethical review or suffi cient safety test- sive device (IED). The extent of the injuries director, Osborne runs the show. ing, needlessly risking the lives of soldiers. was shocking, even to the hardened medics In many ways, war is the perfect labora- Science investigated these issues with the help working here in Afghanistan. “He was miss- tory for trauma medicine research. On any of two bioethicists and several sources from ing both legs and his whole backside. But he given day, dozens or even hundreds of casu- both civilian and military trauma medicine. was alive, breathing on his own.” alties arrive by helicopter to military hospi- For most people, a scene like that would tals across Afghanistan. IEDs are the num- Exploring the golden hour fill them with nothing but horror. But for ber one risk, often combining burns, deep From the moment a bullet or piece of shrap- Osborne, a U.S. Navy anesthesiologist and lacerations from shrapnel, and brain trauma nel hits the body, the clock is ticking. Trauma medical researcher, it was a reminder of from blast waves. Injuries like these are too medics call it the “golden hour,” the small hard-earned progress. “Years ago, that kind rare to study in peacetime. And because window of time in which the patient’s life CREDIT: AP CREDIT: of patient would be dead,” she says. “No all the patients in these studies are military can be saved. Death can come in a mat- www.sciencemag.org SCIENCE VOL 331 11 MARCH 2011 1261 Published by AAAS NEWSFOCUS ter of minutes, hours, or days, but the most components—plasma containing platelets crucial interventions must be made imme- and clotting factors—added sparingly later. diately. War has been “an amazing learning “What we realized,” says Osborne, “is that environment,” says Osborne, with each con- if you wait on those clotting factors, then fl ict pushing trauma medicine forward. New you’re always behind. You can keep putting motorized ambulances in World War I saved in red blood cells and they just keep pouring wounded soldiers by getting them from the right out [of the wounds].” The transfusion front lines to the hospitals quickly. World protocol for severe injuries has now been War II saw the fi rst large-scale use of anti- revamped based on JC2RT research. For biotics. Medics in the Korean War pioneered injuries that require massive transfusions, repair and grafting techniques for vascular the equivalent of whole blood is now given surgery. In the Vietnam War, portable radi- immediately, including a full complement of ology equipment and ventilators were tested clotting factors. The researchers found that it in the fi eld. reduced mortality rates in these patients from With the wars in Afghanistan and Iraq, 65% to 17%. combat medicine has faced a new prob- Another dramatic change from JC2RT lem. “The diffi culty for the current genera- research is how “damage control” surgery is tion is getting approval for research,” says performed. “We found that it’s critical that we Col. Martin Bricknell, a senior doctor in the Whole blood. These empty transfusion bags from not close some injuries when they come in Downloaded from U.K. Royal Army Medical Corps who hosted a single patient in Afghanistan show the 1-to-1 here,” Osborne says, “because the outcomes this reporter’s visit to military facilities in ratio of blood products now used. are massive infections and sepsis.” Instead, Kandahar (see p. 1256). “It is considerably blood vessels are tied off and the wound is left more rigorous than it used to be, and there- Once a research project passes this pre- open, sometimes for several days, vigorously fore the lag between good idea to outcomes is screening, it must be approved by an inde- cleaning it with saline. “We used to close that much greater.” JC2RT was created in 2006 to pendent U.S. Army institutional review board wound 7 years ago,” she says. http://science.sciencemag.org/ streamline that process. (IRB) based at Fort Detrick, Maryland. That Other problems have yet to be solved. “We’re a team of eight,” says Osborne, review process is identical to those at any One of the most urgent is compartment syn- a petite, blonde 42-year-old in the middle research institution, Osborne says, sourc- drome, the accumulation of fl uid between of her 6-month tour of duty in Afghanistan. ing outside experts as needed. Osborne and tissue layers that can result in amputation When she is not at war, Osborne is the direc- her colleagues identify issues likely to cause or even death if the pressure cuts off blood tor of anesthesiology research at the Uni- problems with reviewers, giving researchers to organs. One JC2RT project is testing formed Services University of the Health a chance to address them early “so that when whether the pressure in an injured limb can Sciences in Bethesda, Maryland. “Most of [the proposal] goes to IRB it has a chance,” be diagnosed earlier by detecting a drop in us have Ph.D.s,” she says, “but we’re not data Osborne says. At least one of the investigators oxygen in the tissue. Another unsolved prob- collectors.” Instead, JC2RT is a gatekeeper must be present to undertake the study in the lem explored by JC2RT projects is how to on October 16, 2017 and overseer. Ideas for projects are put for- fi eld. “Most of these folks, they’re only here diagnose brain trauma, for example, using ward by researchers from all branches of the for a short amount of time. If their stuff gets ultrasound to measure the blood pressure of U.S. military, often with university-based held up in IRB for 6 months, they miss the vessels within the eye. scientifi c partners. As the proposals roll in, boat. We try to prevent that from happening. Because of the streamlined process, Osborne says, “I’m the one who has to give But it does happen.” insights from those projects will move quickly people the bad news that their research proj- To date, about 100 projects have made it onto the battlefi eld. In medical research, says ect isn’t going to work.” through this gauntlet and into the fi eld, so far Osborne, “you normally have a 10-year pipe- A typical problem is feasibility. “The producing dozens of peer-reviewed research line” between the fi rst experiment and a new people who are writing these [proposals] papers (see table on p. 1263). All of them take treatment for patients. “For us, it can be half are just coming into theater,” Osborne says. advantage of data from the U.S. military’s a year,” she says. “They don’t realize that there’s no way they’re Joint Theater Trauma Registry (JTTR), a The speedy turnaround has doubtless going to be able to do it.” As an example, she continuously updated record of trauma cases saved lives. But at the same time, it has describes a project that would have required in Iraq and Afghanistan. JTTR currently con- invited intense scrutiny. infrared photography of injured soldiers’ tains the case histories of 40,000 patients, limbs. “You often have a whole sea of people including medical observations, treatments, Serious charges working on the patient. You can’t tell them, and outcomes in minute detail. Most of the Wartime medical research has a troubled his- ‘Okay, everybody step back. I’m going to research has yielded incremental improve- tory. The most notorious examples are the snap some photos.’ ” ments to existing treatments. But some have experiments performed on prisoners by Ger- Another fatal fl aw is the use of experi- overturned paradigms of trauma care, says man and Japanese doctors during World War mental medical devices. “It’s a deal-breaker,” Osborne. One example is blood transfusion.
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