Airlanggins A-B, Two New Isoprenylated Benzofuran-3-Ones from the Stem Bark of Calophyllum Soulattri

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Airlanggins A-B, Two New Isoprenylated Benzofuran-3-Ones from the Stem Bark of Calophyllum Soulattri

NATURAL PRODUCT RESEARCH, 2017 https://doi.org/10.1080/14786419.2017.1380027 Airlanggins A-B, two new isoprenylated benzofuran-3-ones from the stem bark of Calophyllum soulattri Mulyadi Tanjunga, Fida Rachmadiartib, Anindita Prameswaria, Villa Ultha Wustha Agyania, Ratih Dewi Saputria, Tjitjik Srie Tjahjandariea and Yana Maolana Syahc aFaculty of Science and Technology, Department of Chemistry, Natural Products Chemistry Research Group, Organic Chemistry Division, Universitas Airlangga, Surabaya, Indonesia; bFaculty of Science, Department of Biology, Universitas Negeri Surabaya, Surabaya, Indonesia; cNatural Products Chemistry Research Group, Organic Chemistry Division, ITB, Bandung, Indonesia ABSTRACT ARTICLE HISTORY Two new isoprenylated benzofuran 3-ones, airlanggin A (1) Received 12 August 2017 and B (2) along with two known xanthones, ananixanthone (3) Accepted 1 September 2017 and trapezifolixanthone (4) were isolated from the stem bark of KEYWORDS Calophyllum soulattri. Structures of all the compounds were elucidated Airlanggins A and B; using extensive spectroscopic methods, including UV, IR, HRESIMS, 1D isoprenylated benzofuran- and 2D NMR. Compounds 1–4 were evaluated for their cytotoxicity 3-one; Calophyllum soulattri; against P-388 cells, showing that compound 3 was the most active P-388 cell with IC50 0.68 μg/mL and compound 1 showed moderate activity with IC50 5.80 μg/mL. Downloaded by [210.57.215.234] at 02:00 27 September 2017 1. Introduction Calophyllum soulattri locally known ‘bintangor’ belongs to the Clusiaceae family. Calophyllum is widely distributed in Asia, Australia, Africa and Polynesia. In Indonesia, the aqueous decoc- tion of stem bark or leaves of this plant has been used to treat inflammation and rheumatism (Heyne 1987) (Figure 1). The Calophyllum genus has been known to produce a variety of CONTACT Mulyadi Tanjung [email protected] Supplemental data for this article can be accessed at https://doi.org/10.1080/14786419.2017.1380027. © 2017 Informa UK Limited, trading as Taylor & Francis Group.

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(Calophyllum Soulattri) (CLUSIACEAE) (ISOLA
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