AMIC®) for Cartilage Repair in the Knee

Home , Cartilage, Chondrocyte, Microfracture surgery

Literature Highlight

The Orthopaedic Journal of Sports Medicine, 7(9). DOI: 10.1177/2325967119868212 Collagen-Covered Autologous Chondrocyte Implantation (ACI-C) versus Autologous Matrix-Induced Chondrogenesis (AMIC®) for Cartilage Repair in the Knee

Vegard Fossum, Ann Kristin Hansen, Tom Wilsgaard, Gunnar Knutsen > First randomized controlled clinical study (Level 2) comparing clinical outcomes between ACI-C and AMIC® Chondro-Gide® for the treatment of chondral or osteochondral defects in the knee > At 2 years, both treatment methods resulted in a similar significant improvement in clinical outcomes while no significant superio- rity of either ACI-C or AMIC® was observed.

Start At 1 year follow-up At 2 years follow-up > Patients with 1 or 2 chondral or osteochondral lesions of > No treatment failures and no patients > Failure was defined as any deterioration in KOOS the distal femur and/or patella were randomly assigned were lost-to follow-up during the 2-year follow-up (= clinical failure) to undergo either AMIC® or ACI-C treatment or patients needing a new resurfacing procedure > Symptomatic defects > 2cm2 was an inclusion criterion. of the index lesion or a total knee replacement (= "hard failure") > All patients had 1-6 prior surgeries in the index knee and 50% had a prior microfracture procedure

21 ACI-C 21 ACI-C 21 ACI-C 0 > Mean age: 37.2 (19-55) years > 17 patients with 1 defect, 4 with 2 defects > Mean defect size: 4.9 (1.2-21.5) cm2 > 33% females 41 > 24% of the cases with Kellgren-Lawrence (K-L) grade ≥2

20 AMIC 20 AMIC 17 AMIC > Mean age: 38.3 (24-55) years > 16 patients with 1 defect, 4 with 2 defects 2 > Mean defect size: 5.2 (2-12.3) cm2 > 60% females > 40% of the cases with K-L grade ≥2 1 "lost to follow-up"

Significant Improvement of Knee Function (KOOS/Lysholm) and Pain VAS Score > Both cartilage repair methods resulted in significant improvement of average KOOS and Lysholm scores as well as a significant reduction in pain VAS at 1- and 2-year follow-up, when compared to baseline values. > Despite a larger mean defect size and more patients with K-L grade ≥ 2 in the AMIC® group, at 1 and 2 years, this group showed a higher mean improvement in all clinical scores compared to the ACI-C group (see graphs below).

Mean total KOOS Score Mean Lysholm Score Mean Pain (VAS) Score

. . . . . . . . . . . . . . . . . . ACIC AMIC ACIC AMIC ACIC AMIC

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