Expanding Our Reach

EXPANDING OUR REACH

Annual Stewardship Report: 2019–2020 PERSPECTIVES FROM LEADERSHIP

“For six years now, The Gillian Reny Stepping Strong Center for Trauma Innovation has been a point of pride for the Brigham. I have witnessed the Reny and Epstein families show remarkable resilience in the wake of the Boston Marathon bombings and inspire the “I am proud to lead the Stepping creation of a center that is transforming trauma research.” Strong Center, including our new Betsy Nabel, MD, Brigham and Women’s Hospital President Stepping Strong Injury Prevention Program, which seeks to reduce the burden of traumatic injuries. “In 2014, the Stepping Strong We have a unique opportunity to Center honored me as the prevent injuries before they occur, inaugural recipient of the Stepping thus expanding the role of the hospital as a resource that extends far beyond our walls The mission of The Gillian Reny Stepping Strong Innovator Award. Not only and into the community.” Strong Center for Trauma Innovation is to did this funding allow my team to pursue a novel amputation Ali Salim, MD, Stepping Strong Center Medical Co-director catalyze multidisciplinary collaborations procedure that is now also being that inspire groundbreaking innovation, used in the military, but the effective prevention, and compassionate Innovator Awards have become “Too often, events take place such that civilians experience intervention to transform care for a sought-after funding source for researchers who are dedicated to transforming trauma care for patients.” injuries similar to those sustained civilians and military heroes who endure Matthew J. Carty, MD, Stepping Strong Center Director of on the battlefield, including on traumatic injuries and events. Strategy and Innovation the day of the Boston Marathon bombings. At the Stepping Strong Center, our ability to attract “As the center enters its sixth brilliant researchers from multiple year, I pause to reflect onhow institutions and think holistically about how we care far we have come with support for patients with traumatic injuries is helping us from donors like you. Stepping transform how we respond in moments when every Strong Innovator Awards have second counts.” been leveraged into larger federal Mitchel B. Harris, MD, Stepping Strong Center funding, and a small group of family Medical Co-director and friends has grown into a global community of physician-scientists, runners, and philanthropists all working together in an enduring Boston Strong spirit of collaboration to Cover: In 2018, after five ankle breaks, James McClelland underwent the Ewing Amputation to remove his right leg below the knee. The procedure was transform trauma care.” developed and performed by Matthew J. Carty, MD, a Stepping Strong Innovator Audrey Epstein Reny, Stepping Strong Center Co-founder and Award winner and the Stepping Strong Center director of strategy and innovation. Advisory Board Chair James says the procedure has given him his life back, and he has returned to his active lifestyle, including ice climbing. Photo courtesy of Marina Brock, New London, New Hampshire BWHSTEPPINGSTRONG.ORG 1 PERSPECTIVES FROM LEADERSHIP

Traumatic injuries can affect anyone, regardless of race, In 2014, the Reny and Epstein families inspired the launch ethnicity, economic status, or geographic region. Across of The Gillian Reny Stepping Strong Center for Trauma the globe, one person succumbs to injuries sustained from Innovation to address traumatic injuries and honor the trauma every three minutes. According to the Centers medical team that saved Gillian’s life in the aftermath of the THE STEPPING STRONG for Disease Control, trauma is the No. 1 cause of death Boston Marathon bombings. Since that time, and thanks for people 46 years of age and under. Injuries, including to the generous support of donors like you, the Stepping unintentional and violence-related injuries, account for 59% Strong Center has become a thriving multi-institutional, of all deaths among people 44 years of age and under. These multidisciplinary research hub. The center provides physician- account for more deaths than noncommunicable diseases scientists with critical tools and resources to advance their INNOVATOR and infectious diseases combined. Altogether, the cost from work, educates the next generation of medical leaders AWARDS traumatic injuries is nearly $7 billion a year. in treating trauma patients, and empowers community members to serve as advocates and global ambassadors. The Stepping Strong Innovator Awards inspire novel research that improves standards of care for civilian and military trauma patients. To date, the center has provided grants totaling $3.8 million to 26 research teams for groundbreaking projects in two core areas:

STEPPING STRONG CENTER FOCUS AREAS TRAUMA INNOVATION. Projects aim to address 2019 Stepping Strong Innovator Award winners clinical challenges in areas including bone, wound, and skin healing; limb transplant and reconstruction; bone and muscle In November, the center hosted the Second Annual Stepping RESEARCH EDUCATION INJURY PREVENTION COMMUNITY regeneration; advanced stem cell technology; orthopaedic Strong Trauma Research and Innovation Symposium and and plastic surgery; and bioengineering. announced the 2019 Stepping Strong Innovator Award winners. The symposium featured discussions among INJURY PREVENTION. The only way to fully eliminate past winners and Medical Executive Committee members the burden of injury is to prevent it. Innovators are pursuing on collaborative approaches to early-stage discovery, best practices in emergency preparedness, hemorrhage strategies to propel innovative ideas from lab to market, and control, and intimate partner violence. approaches for attracting venture capital. A keynote address was given by Lt. Col. Benjamin Kyle Potter, MD, director for Through Stepping The Stepping Strong The Stepping Strong True to the Boston The Stepping Strong Center’s model—bestowing seed surgery at Walter Reed National Military Medical Center. In Strong-funded education initiatives Injury Prevention Strong spirit of kindness grants of $100,000 or more to research teams that show addition to discussing his time deployed as an orthopaedic programs such as the include a Trauma Program aims to and collaboration, great promise—has a proven track record. This model has surgeon in support of Operation Enduring Freedom in Innovator Awards, Fellowship, which trains reduce traumatic members of the resulted in more than $18 million in federal funding, Afghanistan, Dr. Potter shared news of a new partnership with Research Scholars, and medical leaders in acute injuries resulting from Stepping Strong leading to better patient outcomes and the potential for Matthew J. Carty, MD, director of strategy and innovation Breakthrough Awards, and complex injury, and occurrences such community advance our commercialization. at the center, in which wounded warriors will benefit from the researchers are pursuing the Explorer Program, as older adult falls, cause by participating Stepping Strong-funded Ewing Amputation. projects to transform which expands interpersonal violence, in road races, hosting outcomes for trauma young professionals' car accidents, and fundraisers, and serving patients. knowledge of the substance use. as ambassadors. trauma field.

Learn more on Learn more on Learn more on Learn more on pages 3-6, 8-11 page 7 pages 12-13 pages 14-17

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Learn more on Learn more on Learn more on Learn more on pages 3-6, 8-11 page 7 pages 12-13 pages 14-17

2 THE GILLIAN RENY STEPPING STRONG CENTER FOR TRAUMA INNOVATION BWHSTEPPINGSTRONG.ORG 3 2019 STEPPING STRONG INNOVATOR AWARDS

In 2019, the Stepping Strong Center received a record Using Biologic Agents to Regenerate A Cell Therapy Platform for Treating A Novel Approach to Stimulating Bone number of Innovator Award applications from physician- Muscles After Traumatic Injury Skeletal Muscle Trauma Regeneration and Repairing Fractures scientists representing institutions across the country. Traumatic heterotopic Skeletal muscle has a Poor fracture healing After rigorous review, center leadership, Stepping ossification (HO)—the remarkable capacity is a major problem Strong Medical Executive Committee members, and formation of bone to regenerate due to a for patients with large Advisory Board members awarded five grants to talented in soft tissue—is a satellite stem cell that traumatic bone defects, researchers conducting novel trauma research at Brigham significant barrier to is responsible for post- but there currently are no and Women’s Hospital, Massachusetts General Hospital, patient recovery after a natal muscle growth FDA-approved therapies the Harvard Stem Cell Institute, and Dartmouth-Hitchcock musculoskeletal injury. and regeneration. to address this. Marc Medical Center. Shailesh Agarwal, Despite this, sometimes Wein, MD, PhD (left), MD (second from injuries are so severe an endocrinologist at Making the Invisible Visible: Bringing left), a plastic and that volumetric muscle Massachusetts General Intimate Partner Violence into Focus reconstructive surgeon loss (VML) occurs, the Hospital, identified a new Intimate partner violence at the Brigham, found a protein that significantly reduces HO, regenerative process is less efficient, and patients suffer oral drug that stimulates bone regeneration and promotes (IPV), defined as physical, but it is difficult and expensive to manufacture as a therapy permanent loss of movement and muscle function. Feodor fracture healing. Dr. Wein will lead a multidisciplinary team sexual, or emotional and requires patients to receive repeated injections over a Price, PhD, a research scientist at the Harvard Stem Cell of scientists with expertise in bone cell biology, skeletal violence between long period of time. To solve for this, Dr. Agarwal aims to Institute, knows that delivering satellite cells into damaged biomechanics, orthopaedic surgery, single-cell genomics, partners or former create a technology that uses a patient’s own fat tissue to muscle would help treat VML, but these cells cannot be grown and medicinal chemistry to test the effects of this drug. partners, is a prevalent express the protein. The existence of a cost-effective biologic in the lab. Dr. Price discovered a method to successfully The team will also create a new version of the drug that is public health issue. In drug would greatly improve healing for patients who suffer generate millions of cells that behave like satellite cells. targeted directly to bone for enhanced recovery with reduced the United States, one from musculoskeletal injury. These cells have the potential to regenerate muscle in trauma side effects. These studies will lay the groundwork for new in four women and patients and help restore full range of motion. therapies to improve treatment for trauma patients. one in seven men have Improving Outcomes for Patients with reported experiencing Fracture-Related Infections severe physical violence from a partner in their lifetime, Infection following and half of female homicides between 2003 and 2014 were fracture is one of linked to IPV. Radiologists like Bharti Khurana, MD, director the most prevalent of Emergency Musculoskeletal Radiology, are in a unique and challenging position to objectively identify incidents of IPV based on complications in trauma “I became a Brigham patient nearly 20 years ago and have long sought a way specific radiological findings and patterns. Dr. Khurana will patients. Adequate to give back to my amazing caregivers in the Division of Orthopaedic Trauma. develop a multidimensional alert system that analyzes a blood flow is critical I was born with a rare brittle bone condition, diagnosed as a toddler, and have patient’s signs, symptoms, imaging findings, and history; to deliver oxygen, classifies injuries for their likelihood of being a result of IPV; nutrients, and antibiotics broken more than 80 bones to date. When my husband, Greg, and I learned and automatically alerts physicians. In addition, Dr. Khurana’s to the infected bone, so about the Stepping Strong Center, we immediately connected with the center’s multidisciplinary team will generate guides for social workers an infected bone with collaborative approach to transforming trauma care and catalyzing innovative and physicians with the goal of enhancing communication poor blood flow needs to be surgically removed. Currently, between caregivers and potential IPV victims. however, there are no suitable methods for assessing bone research for patients like me. It gives us great pleasure to have the opportunity to pay it viability. I. Leah Gitajn, MD, an orthopaedic surgeon at forward by funding Dr. Wein’s Stepping Strong Innovator Award project.” Dartmouth-Hitchcock Medical Center, aims to provide Tara Ciongoli, Stepping Strong Advisory Board member physicians with a method to do so by developing a technique to optimize and measure surgical removal of infected bone for fracture-related infections. This will result in better outcomes for patients and allow them to regain mobility more rapidly.

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The Stepping Strong Center has granted Breakthrough Omid Farokhzad, MD Stepping Strong Trauma Fellowship: How did you hear about the Stepping Strong Trauma Fellowship? Awards to six previous Innovator Award winners who have Dr. Farokhzad is focused A Conversation with Yori Endo, MD made notable scientific progress, providing them with on injuries from accidents I heard Dr. Sinha present on his Stepping Strong Innovator additional financial support to advance their research to and severe trauma that Award project, and I liked how he combined his expertise the next level. In addition to Stepping Strong Breakthrough can cause large open in stem cell research with various technologies to develop a Award winners Drs. Carty, Goralnick, and Sinha, who are bone fractures and, in new scaffold for patients with muscle injuries. I believe that profiled on pages 8-11, three other Breakthrough Award more extreme cases, advances in science should positively impact patients, and recipients are having a remarkable impact on trauma large bone defects. Such in Dr. Sinha’s lab, the knowledge obtained from research is research and care. injuries are prone to directly applied to clinical issues. After joining the lab, the poor bone healing and Stepping Strong Trauma Fellowship was a very natural next Stepping Strong Center leadership works closely with high rates of infection. step because Dr. Sinha has been heavily involved in the all award winners to increase the pace and likelihood of As a result, orthopaedic Stepping Strong Center since its establishment. My fellowship success by providing strategic guidance, mentorship, trauma surgeons are often challenged to stabilize and repair reflects Dr. Sinha’s continued endeavor to improve clinical care access to the growing Stepping Strong Center network, bone injuries, while preventing infection and aiding bone for trauma patients. and assistance promoting their work. healing. Dr. Farokhzad is addressing these challenges with Yori Endo, MD (right), is the 2019–2020 Stepping Strong small, biodegradable robots called nanodrones that can Trauma Fellow under the mentorship of Stepping Strong How will your time as the Stepping Strong Trauma Fellow Reza Abdi, MD deliver antibiotics and other drugs to promote bone growth Breakthrough Award winner Indranil Sinha, MD (left). help you achieve your career goals? Dr. Abdi developed an and wound healing in a more efficient way. My goal is to lead a clinical project of my own. I have a strong innovative and life-saving interest in wound healing and skin diseases, and a newfound approach that uses skin Congratulations on being named the 2019–2020 Stepping passion for trauma research. Being the Stepping Strong allografts—tissue from a Bohdan Pomahac, MD Strong Trauma Fellow! Tell us a little bit about yourself. Trauma Fellow has given me a much clearer understanding of donor—to treat severe Dr. Pomahac developed I was born in Japan and moved to England when I was 16 the patients being impacted by my work in the lab. I have had burn patients. Rejection an ultraportable device years old. I earned my medical degree at the University of the opportunity to work with experts in the field and to grow of allografts is common, that expands the time in Cambridge, as well as my master’s degree in clinical research. as an independent researcher. It is an honor to be part of the so Dr. Abdi’s team is using which an amputated limb I have a background in biomedical science and have always Stepping Strong Center community. an immunomodulatory can be safely reattached, had a passion for conducting medical research. implantable gel that from four to six hours to suppresses allograft up to 24—a revolutionary rejection, and they are microengineering off-the-shelf, ready- development for to-use, implantable scaffolds to increase the efficacy of the wounded warriors and Stepping Strong Explorer Program allografts in burn patients. This advanced technology will allow injured medical personnel Launched in 2019, the Stepping Strong Explorer Program Julie Burland, PhD, ATC, CSCS, a for rapid closure of wounds, which in turn will help shorten faced with traumatic funds young healthcare professionals to help them develop postdoctoral research fellow at the hospital stays and improve survival rates. Dr. Abdi is planning injuries. The team is currently collaborating with engineers their knowledge, networks, and understanding of traumatic Brigham, received a Stepping Strong to apply for a National Institutes of Health grant using the data from Hydrix, a product development company, to build the injuries, to promote interest in the field, and to build Explorer Program grant to help her generated with support from the Stepping Strong Center. device and bring it to market for use in the field. community. To date, the center has awarded four Explorer attend the 2019 International Cartilage Program grants that support participation in medical, scientific, Regeneration and Joint Preservation or technical conferences and other training opportunities that Society (ICRS) Congress in Vancouver, BC. align with the Stepping Strong Center’s mission. This opportunity allowed Dr. Burland to gain further insight into the technological and research advancements for cartilage repair, regeneration, and preservation, which she hopes to apply to reducing disability after traumatic injury.

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Gillian Reny poses with Dr. Carty after he receives the Dr. Carty meets with Army veteran and Ewing Amputation inaugural Stepping Strong Innovator Award in 2014. patient Brandon Korona before he undergoes surgery.

Across town at Massachusetts General Hospital, fourth-year Jim Ewing, on more than 20 patients, including military plastic surgery resident Indranil Sinha, MD, was providing veterans injured in combat, and the first double Ewing consults for survivors who came through the emergency Amputation, with encouraging early results. Based on this department. All three physicians, playing very different roles work, Dr. Carty and his collaborators have received millions in the wake of the bombings and at very different points in of dollars in additional outside funding, including a $3 million their careers, would go on to become important members Department of Defense grant to apply the procedure to of the Stepping Strong community that was born out of that upper limbs. day’s tragedy. Eric Goralnick, MD, MS Matthew Carty, MD Indranil Sinha, MD A year later, the Stepping Strong Center was established, and Dr. Carty received the inaugural Stepping Strong Innovator On the day of the Boston Marathon bombings in 2013, Forty patients, including Gillian Reny and her family, were To date, Dr. Carty has performed the Ewing Award for a project that sought to revolutionize lower Eric Goralnick, MD, MS, an emergency medicine physician treated in the Brigham emergency department that fateful extremity amputations, a procedure that many survivors of Amputation on more than 20 patients, and former naval officer, was the Brigham’s medical director day—the most of any Boston hospital. One surgeon on the the Boston Marathon bombings have now undergone. including military veterans injured in combat, of emergency preparedness, responsible for training staff to receiving end of the triage performed by Dr. Goralnick was care for survivors of mass casualty incidents. Within minutes Matthew J. Carty, MD, director of the Lower Extremity and the first double Ewing Amputation, with “Despite remarkable advances in the technology of modern- of the two explosions at the finish line, Dr. Goralnick left Transplant Program. When the bombs went off, Dr. Carty day prosthetics, little has changed in terms of how we encouraging early results. the scene where he had been providing routine post-race was finishing up operating on the face of a young man who perform amputations for patients whose legs cannot be medical care to the Brigham marathon team and returned was involved in a motor vehicle accident a few days prior. salvaged,” says Dr. Carty. “I wanted to change that and help to the hospital by ambulance to assume his role caring for When Dr. Carty got word of the bombings, he helped deploy patients recover normal limb function.” Dr. Sinha, who was hired as a Brigham plastic surgeon after the injured. Dr. Goralnick was part of a multidisciplinary plastic surgery staff to each of the operating rooms in which completing his residency and working at the Harvard Stem team that initiated the hospital’s mass casualty incident care to survivors was administered. In conjunction with Just two years after receiving his initial funding, Dr. Carty Cell Institute, won a Stepping Strong Innovator Award in plan, resuscitated patients with life-saving medications, and members of the orthopaedic trauma, general trauma, and received a second round of Stepping Strong Center funding 2014. The award was the first grant of his career, in support triaged patients to operating rooms. vascular surgery teams, Dr. Carty and his colleagues were that enabled him to perform the first clinical representation of of his project using stem cells to regenerate injured muscle. able to provide true multidisciplinary care to 14 survivors who his work. To date, Dr. Carty has performed what is now known This work was funded by the Stepping Strong Center again needed surgery that day. as the Ewing Procedure, named in honor of his first patient, in 2017, after Dr. Sinha joined forces with fellow Innovator

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8 THE GILLIAN RENY STEPPING STRONG CENTER FOR TRAUMA INNOVATION BWHSTEPPINGSTRONG.ORG 9 Award winner Su-Ryon Shin, PhD. Drs. Sinha and Shin are Dr. Goralnick and his colleagues received a Stepping deepening their Stepping Strong Center collaboration by Strong Innovator Award the following year to support their exploring skeletal muscle regeneration following volumetric project to define best practices for preparation, mitigation, muscle loss (VML) injuries. “Approximately 500,000 trauma response, and recovery related to mass casualty incidents. patients suffer from VML injuries. We know that patients don’t Dr. Goralnick remains focused on prevention of traumatic recover well after VML because instead of the body healing injury, including his work with Stop the Bleed, a White House- and making more muscle, there is lots of scarring,” says Dr. sponsored national initiative based on military innovations Sinha. “But why? This is what the Stepping Strong grant that empowers bystanders to “be the help until help arrives” helped us answer.” by recognizing life-threatening bleeding and applying

Drs. Sinha and Shin found that signaling molecules are needed for these cells to grow, but they are absent following “The Stepping Strong Center has helped VML. Using a custom-built, handheld printer, they developed 3D-printed bio-scaffolds and successfully implanted them establish an environment in which in animal models with VML injuries. Dr. Sinha credits the collaboration can occur among people who Stepping Strong Center with allowing him to generate the otherwise would not have worked together, Brigham employees and members of the public learn about Dr. Goralnick presents on developing common standards for preliminary data necessary for additional funding. He has tourniquet application and bleeding control. disaster medicine and empowering bystanders to now received more than $5 million in federal funding for to help a population that might not otherwise respond during mass casualty incidents. this project. receive care.”

—Indranil Sinha, MD “The Stepping Strong Center's support is critical to my “The Stepping Strong Center's support is work,” says Dr. Goralnick. “It has changed the direction of my critical to my work. It has changed the career in such a positive way, to best serve our community.” direction of my career in such a positive way, Drs. Sinha and Carty feel similar gratitude to the Stepping to best serve our community.” Strong Center for including them on this journey to transform —Eric Goralnick, MD, MS trauma care. “It has been incredible to witness what a passionate pressure or tourniquets to the injured. He and his team have family can do to impact the care of others,” says Dr. Sinha. trained more than 3,000 people, including staff at stadiums, “The Stepping Strong Center has helped establish an convention centers, schools, and malls across New England. environment in which collaboration can occur among people who otherwise would not have worked together, to help a Dr. Goralnick is currently working with Massachusetts State population that might not otherwise receive care.” Rep. Shawn Dooley to advocate for the passage of the Trauma Preparedness Act, which would make it mandatory “The Stepping Strong Center was instrumental in getting to have a trauma kit in all public buildings. He has published the foundational work behind the Ewing Amputation off of in a number of peer-reviewed journals, been featured in the ground,” says Dr. Carty. “The Innovator Awards have multiple national news outlets, and serves on committees for made it possible for all of us to make incredible advances in Drs. Sinha and Shin are exploring skeletal muscle The 3D bioprinter allows surgeons to deposit materials to regeneration following muscle loss injuries. help support cellular and tissue growth directly into the defect organizations such as the American Heart Association and treatments for trauma patients. Simply put, together we are sites within weakened skeletal muscles. the American College of Emergency Physicians. Dr. Goralnick saving lives.” is now broadening his efforts to include firearm injury prevention initiatives.

10 THE GILLIAN RENY STEPPING STRONG CENTER FOR TRAUMA INNOVATION BWHSTEPPINGSTRONG.ORG 11 Award winner Su-Ryon Shin, PhD. Drs. Sinha and Shin are Dr. Goralnick and his colleagues received a Stepping deepening their Stepping Strong Center collaboration by Strong Innovator Award the following year to support their exploring skeletal muscle regeneration following volumetric project to define best practices for preparation, mitigation, muscle loss (VML) injuries. “Approximately 500,000 trauma response, and recovery related to mass casualty incidents. patients suffer from VML injuries. We know that patients don’t Dr. Goralnick remains focused on prevention of traumatic recover well after VML because instead of the body healing injury, including his work with Stop the Bleed, a White House- and making more muscle, there is lots of scarring,” says Dr. sponsored national initiative based on military innovations Sinha. “But why? This is what the Stepping Strong grant that empowers bystanders to “be the help until help arrives” helped us answer.” by recognizing life-threatening bleeding and applying

10 THE GILLIAN RENY STEPPING STRONG CENTER FOR TRAUMA INNOVATION BWHSTEPPINGSTRONG.ORG 11 STEPPING STRONG The Stepping Strong Injury INJURY PREVENTION PROGRAM Prevention Program will work to identify solutions related to the following five areas: To help launch the program, the Stepping Strong Center recently hired Molly Jarman, PhD, Adult Falls MPH, as the Injury Prevention Among older adults, falls are Program director. Dr. Jarman is the leading cause of injuries and an investigator at the Brigham’s hospital admissions for trauma. Center for Surgery and Public Falls can take a serious toll on Health and an instructor in quality of life and independence. surgery at Harvard Medical School. Her research addresses trauma surgery and emergency medical services, with a primary interest in trauma system Injury-Related Outcomes organization, access to care for underserved Patients who suffer major traumatic populations, and development of methodologies in injuries experience a 20% mortality health services research. With training in both health rate, and many survivors are left behavior and health policy, Dr. Jarman believes with permanent disability. multifaceted, interdisciplinary efforts are essential for preventing injuries. Interpersonal Violence Prevention From infants to the elderly, violence affects people in all stages comes Cheryl Lang, MPH, of life. Those who survive violence to the Stepping Strong Dr. Salim (second from left) rounds with colleagues in the Brigham Emergency Department. suffer physical, mental, and Center from Boston Children’s emotional health challenges. Hospital, where she focused on Recognizing that the only way to truly eliminate the burden of the center will officially launch the Stepping Strong Injury integrating poison prevention injury is to prevent injuries from ever occurring, the Stepping Prevention Program in June 2020, becoming one of only a strategies into community public Traffic Safety Strong Center is deeply committed to tackling this public handful of programs across the country to offer this specialized health initiatives. Ms. Lang Motor vehicle crashes, often due health issue. To date, the center has focused on key topics focus. The program will bring together patient care and received her Bachelor of Science to distracted driving, are a leading including emergency preparedness, tourniquet training, and training experts from across the Brigham and Harvard Medical and Master of Public Health degrees at Boston cause of death in the U.S. developing standards for disaster medicine. In an effort to School to provide world-class expertise in medicine, surgery, University. In her new role as the Injury Prevention make even more impact, under the direction of Ali Salim, MD, social work, psychology, and patient advocacy. Program project manager, Ms. Lang will assist in developing the program, enhancing collaboration efforts among the Brigham's existing injury Substance Use There are 19.7 million people in prevention initiatives, and establishing external the U.S. battling substance use partnerships. disorders, and more than 105,000 people die of alcohol and drug The Stepping Strong Center is taking an “upstream” approach to injury prevention overdose each year. initiatives. Upstream interventions and strategies focus on improving fundamental social and economic structures in order to decrease barriers and improve supports that allow people to achieve their full health potential. BWHSTEPPINGSTRONG.ORG 13 STEPPING STRONG The Stepping Strong Injury INJURY PREVENTION PROGRAM Prevention Program will work to identify solutions related to the following five areas: To help launch the program, the Stepping Strong Center recently hired Molly Jarman, PhD, Adult Falls MPH, as the Injury Prevention Among older adults, falls are Program director. Dr. Jarman is the leading cause of injuries and an investigator at the Brigham’s hospital admissions for trauma. Center for Surgery and Public Falls can take a serious toll on Health and an instructor in quality of life and independence. surgery at Harvard Medical School. Her research addresses trauma surgery and emergency medical services, with a primary interest in trauma system Injury-Related Outcomes organization, access to care for underserved Patients who suffer major traumatic populations, and development of methodologies in injuries experience a 20% mortality health services research. With training in both health rate, and many survivors are left behavior and health policy, Dr. Jarman believes with permanent disability. multifaceted, interdisciplinary efforts are essential for preventing injuries. Interpersonal Violence Prevention From infants to the elderly, violence affects people in all stages comes Cheryl Lang, MPH, of life. Those who survive violence to the Stepping Strong Dr. Salim (second from left) rounds with colleagues in the Brigham Emergency Department. suffer physical, mental, and Center from Boston Children’s emotional health challenges. Hospital, where she focused on Recognizing that the only way to truly eliminate the burden of the center will officially launch the Stepping Strong Injury integrating poison prevention injury is to prevent injuries from ever occurring, the Stepping Prevention Program in June 2020, becoming one of only a strategies into community public Traffic Safety Strong Center is deeply committed to tackling this public handful of programs across the country to offer this specialized health initiatives. Ms. Lang Motor vehicle crashes, often due health issue. To date, the center has focused on key topics focus. The program will bring together patient care and received her Bachelor of Science to distracted driving, are a leading including emergency preparedness, tourniquet training, and training experts from across the Brigham and Harvard Medical and Master of Public Health degrees at Boston cause of death in the U.S. developing standards for disaster medicine. In an effort to School to provide world-class expertise in medicine, surgery, University. In her new role as the Injury Prevention make even more impact, under the direction of Ali Salim, MD, social work, psychology, and patient advocacy. Program project manager, Ms. Lang will assist in developing the program, enhancing collaboration efforts among the Brigham's existing injury Substance Use There are 19.7 million people in prevention initiatives, and establishing external the U.S. battling substance use partnerships. disorders, and more than 105,000 people die of alcohol and drug The Stepping Strong Center is taking an “upstream” approach to injury prevention overdose each year. initiatives. Upstream interventions and strategies focus on improving fundamental social and economic structures in order to decrease barriers and improve supports that allow people to achieve their full health potential. BWHSTEPPINGSTRONG.ORG 13 RAISING FUNDS AND AWARENESS: STEPPING STRONG IN THE COMMUNITY 2019–2020 EVENTS

$18M+ given to the Stepping Strong Center since 2014 March 3: The New York Times publishes an article April 2: Ewing Amputation patient Tammy Jerome April 13: More than 220 runners participate April 15: 140 runners participate in the 123rd April 15: CBS Morning Show with Don Dahler on Ewing Amputation patient Morgan Stickney is honored as a “Hero Among Us” by the Boston in the B.A.A. 5K and raise $104,000 for the Boston Marathon and raise $1.5 million for highlights Stop the Bleed training with high school Celtics at TD Garden Stepping Strong Center the Stepping Strong Center students

Since 2014 1,750 runners have raised

June 26: Eataly Boston and Boston Celtics host July 25: Justin McCarty, DO (third from the August 18: 22 runners participate in the September: Members of the Stepping Strong September 2-January 15: The Stepping Strong $4M “Pizza with the Pros” to benefit the Stepping right), is honored for his service as a Stepping Falmouth Road Race and raise more than community join TextLess Live More, a student-led Center hosts the Design Museum's Bespoke to advance Strong Center Strong Trauma Fellow $19,000 for the Stepping Strong Center advocacy group dedicated to ending distracted Bodies exhibit at the Brigham driving, to demand a hands-free bill in Massachusetts trauma innovation

30,638 gifts since 2014

October 16: Stepping Strong Advisory Board October 27: Brigham patient Muji Karim, a football November 13: The Second Annual Stepping December 12: STAT reports that the Ewing February 20: We are proud to mark the sixth members meet to discuss important center player who lost both of his legs and his left hand Strong Trauma Research and Innovation Amputation is being adapted for upper extremity anniversary of The Gillian Reny Stepping Strong initiatives in a car accident, was the keynote speaker at the Symposium is hosted in the Hale Building for amputations Center for Trauma Innovation Stepping Strong trauma survivor dinner Transformative Medicine

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Since 2014 1,750 runners have raised

30,638 gifts since 2014

14 THE GILLIAN RENY STEPPING STRONG CENTER FOR TRAUMA INNOVATION BWHSTEPPINGSTRONG.ORG 15 2019 Marathon STEPPING STRONG RUNNING PROGRAM Team Stats STEP UP FOR STEPPING STRONG

143 runners 30 repeat runners

18 states 5 countries

25 BWH employees Audrey Reny Epstein, Dr. Salim, and Dr. Nabel are presented 2019 Stepping Strong Boston Marathon team with a $100,000 check from Cigna.

143 runners 30 repeat runners

18 states 5 countries

25 BWH employees Audrey Reny Epstein, Dr. Salim, and Dr. Nabel are presented 2019 Stepping Strong Boston Marathon team with a $100,000 check from Cigna.

Members of the Stepping Strong Center running program The team includes first-time runners, repeat runners, and provide the center with the necessary funds to do much of Brigham employees, all committed to training and fundraising 3,211 the critical work detailed in this report. These runners are for the center because of a personal connection to traumatic ambassadors who raise awareness and channel the Boston injury or a desire to change outcomes for patients around Strong spirit that defined the city and the running community the world. STEPUP in the wake of the 2013 Boston Marathon tragedy. In 2014, FOR STEPPING STRONG a small group of Gillian Reny’s family, friends, and caregivers In addition to the Boston Marathon, Stepping Strong runners participants created the Stepping Strong Boston Marathon team and ran participate in the Boston Athletic Association’s 5K and 10K Now in its third year, Step Up for Stepping Strong is a the race to honor her and launch fundraising for Stepping races, the Falmouth Road Race, the Nantucket Triathlon, and corporate wellness program that encourages participants to Strong Center initiatives. Six years later, the team has grown marathons across the country and around the world. stay active during a month-long, mobile app-based steps to 143 runners from 18 states and five countries. challenge. The steps challenge, which takes place in May, National Trauma Awareness Month, allows companies and individuals to raise awareness and funds for the Stepping Strong Center. 616M SAFER at the Boston Marathon: Feasibility of an Injury Prevention Program For the second year in a row, Cigna HealthCare, together with media partner WCVB, presented the Step Up for Stepping Rebecca Breslow, MD, is a primary With the support of the Stepping Strong Center, Dr. Strong Challenge and committed $100,000 to the Stepping steps care sports medicine physician at Breslow will review B.A.A. race-day medical encounter Strong Center if participants reached 300 million steps the Brigham, as well as the Stepping forms from 2017 to 2020 and analyze the data in before the end of the month. Participants from 12 different Strong running program’s official collaboration with South African colleagues. Based countries took more than 90 million steps in the first week and team doctor. This past year, the on this data and lessons learned from similar injury surpassed the 300 million steps goal by the third week. This center provided Dr. Breslow with $25,000 to focus on prevention programs, Dr. Breslow will then lead the year’s challenge was our biggest yet, with 52 local companies injury prevention for runners. Millions of people in the B.A.A. medical committee to update its medical and 3,211 individuals taking a remarkable 616 million steps, United States participate in long-distance road races practices and implement injury prevention protocols or 254,000 miles. 52 every year, and some participants experience life- for the 2020 B.A.A. road races. If proved feasible and threatening medical problems during or after a race. Dr. effective, the program will improve participant and In June, Cigna leadership presented the $100,000 check to Breslow’s goal is to prevent race-day medical problems community safety. It has the potential to impact policy Brigham President Betsy Nabel, MD, Stepping Strong Center by identifying runners who are at high risk before they and best practices for road race medical operations Medical Co-director Ali Salim, MD, and Stepping Strong run a race. A similar program was launched in South companies across the United States. Center co-founder Audrey Epstein Reny. Africa, and the country successfully lowered the rate of race-day medical problems by 29% and reduced serious BWHSTEPPINGSTRONG.ORG 17 medical problems by 64%. $5,000+ (cont.) Shaun Dewitt Andrew Vayo Juan Antonio Diaz THANK YOU Nasreen and Mark DeLaar Oleg Dulin Marcelo D. Perez Verzini Kristen Diblasi Cecily and Jason Epstein Kimberly A. and Julia Wallace Angela and Tyler Eames General Dynamics Mission Dane S. Dwyer, PhD Jon Eddy Systems Eversource $1,000+ Education First Ltd. LEADERSHIP CIRCLE $250,000+ $25,000+ General Electric Company Marjorie and Stephen Fiverson Anonymous Dwight Edwards The Hawk Foundation, Svenson and Anonymous Eileen and Paul Gilligan Lisa Fleming Marbella Acosta Kathryn A. Elbert We acknowledge the generous Nielsen Families Jessica and Shane A. Baron Erin M. Hightower Ariana Fusco ADF Community Outreach Kristin E. Ellison, MD donors who have cumulatively $100,000+ Jacqueline Bell and Aron Epstein Johnson & Johnson Sheila and Howard Galligan III Foundation Kate Enroth and Dana Schmaltz given $25,000 or more to The Jeanne M. and John Blasberg Elizabeth L. Johnson The Gershwind Family Automatic Data Processing Inc. Jennifer Epstein and Cigna HealthCare Boston Celtics Shamrock Foundation Inc. Gillian Reny Stepping Strong Robert Keach Foundation The Ayco Charitable William Keravuori Tara and Gregory Ciongoli Stephanie L. Brown Center for Trauma Innovation as Jeanette Kelly Jill C. and Paal C. Gisholt Foundation Michael Euele Deborah C. and Timothy W. Diggins Kate L. and Richard A. Doyle/Harpoon Helps of February 29, 2020. Melyssa McFayden Marie Haguel BAE Systems Flagship Motorcars Paul and Sandy Edgerley Cecily and Jason Epstein Mehrayar Morhi Ellen and Mark Hardymon Marcia and Bruce R. Balter Danae A. and John E. Foley Barbara and Michael Eisenson The Grousbeck Family Foundation $1,000,000+ G. Felda Hardymon Susan and David Fox Jennifer Epstein and William Keravuori Grousbeck Trust Morrison Mahoney LLP Steven Batchelor Brigham and Women’s Physicians Raj Hathiramani John S. Frye Nina S. and David P. Fialkow Elizabeth and Mitchel B. Harris, MD William Edward Pappendick IV Caroline R. Baumal, MD, and Organization, Department of Madeline Horn Kimberly J. Fryling-Resare Barbara and Amos Hostetter Monica and Michael Lehner and Erica Gervais Jack H. Bardy Orthopaedic Surgery The Klarman Family Foundation The M&T Charitable Foundation Robert W. Pierce Jr. Family Don Hunt The Beehive Funds2Orgs LLC Esta Gordon Epstein and Robert Epstein Anne C. Kubik, MD, and Michael A. Krupka Marathon Sports Syed Husain Alicia J. and Daniel Garvey Audrey Epstein Reny and Steven Reny Foundation Jenn Bennett The Jacobson Eric Giorgianni Jack Satter Foundation $50,000+ New England Treatment Access Bryce Remy Morgan Best Jeryl and Stephen M. Oristaglio Lynn McKenna Reny and Family Foundation Michael Bilotta Give with Liberty Anonymous $500,000+ Stephen Goodwin Porter Jr. Douglas E. Reny Kathy and Mitchell Jacobson Biogen Foundation Ashley Glendye The Bill and Joan Alfond Foundation Stephanie and John Connaughton Lynn McKenna Reny and Douglas E. Reny Maureen Johnson Alvaro Gonzalez Francis X. Claro Andrew Rodriguez Johanna Black and Betsy Banks Epstein and David R. Epstein Nancy D. and David R. Reny Jane Reny Frank and Stephen Frank Eve S. and Jonathan L. Rounds Lauren Kane Jonathon Duncan Olivia Goodson Elizabeth and L. Guy Reny Standard Duplicating Machines Corporation Heidi Lehner and Paul Milbury Sodexo Inc. Matthew Lisiecki Roberto Blasini Peter Grasso Suffolk Cares Charitable Foundation Inc. Elizabeth M. and Phil H. Loughlin Standard Duplicating Arleigh MacMaster Cristin Brown Thomas Graziani Robert W. Pierce Jr. Family Foundation Machines Corporation Sean P. Maloney Lee Buono, MD Brandon Greene Robert Stewart Sameera Mathan Betul G. Cam Julia L. Greenstein and Tufts Health Plan Inc. Marco Miranda Mitchell Cameron Paul Bleicher, MD, PhD Audrey Warner and Jo Ann Moore Nicole and Ronald Cameron Kelley Hand ANNUAL HONOR ROLL (AS OF FEBRUARY 29, 2020) Elizabeth Warner Caroline Morong Peter Carbone Michael Hanrahan Frederico Wasserman, MD Ian Murphy Marcy Gleit Carty, MD, MPH, Marianne and David Harrison Northwestern Local School Sally Havens Thank you to the individuals, $50,000+ $10,000+ The M&T Charitable Dale Wiggins and Matthew J. Carty, MD Laura Wong District Emily Casey Elizabeth Healy families, foundations, and Tara and Gregory Ciongoli Anonymous Foundation Stanley Zaslau, MD Ethan R. Parten, MBA Catherine M. Chaisson Stephen Hennessey organizations who have Betsy Banks Epstein and Boston Celtics Shamrock New England Treatment Access Douglas Pfaff Michael Chaisson John F. Herlihy given $1,000 or more David R. Epstein Foundation Inc. Jeryl and Stephen M. Oristaglio Tenly Pretyka Jeff Chandler Shawn Herlihy between March 1, 2019, The Hawk Foundation, Bright Funds Foundation Jillian Perkins $2,500+ Ruthanne Russell and Kiwon Chang Ashley Hewitt and February 29, 2020. Svenson and Kathleen M. and Charles Brizius Gillian Reny Martha Beltz Paul Crowley Angelina Cohan Diana Hoff Nielsen Families Francis X. Claro Suffolk Cares Charitable Sarah and Peter Beshar Jennifer and Jeff Sabados Mary Comer Monique M. Houlihan $100,000+ Richard D. Cummings Foundation Inc. Tanishq Bhalla Kathleen and Susan Connelly Lisa Howe Cigna Healthcare $25,000+ Paul and Sandy Edgerley Jeanne M. and John Blasberg Matthew James Scales Corning Incorporated Ben Huang Stephanie and Nina S. and David P. Fialkow $5,000+ Chelsie Boudreau Deborah C. and Nicholas J. Scales Clarissa and Kara G. Boudreau Foundation John Connaughton Timothy W. Diggins Elizabeth and Anonymous Theodore Sheehan Leslie and W. Robert Dahl Walter Hunnewell Jr. Esta Gordon Epstein and Mitchel B. Harris, MD Bank of America Doyle Brown Barbara and Michael Eisenson Abbie and J. Robert Small Patricia M. Hynes and CIBC World Markets Lisa Marie D'Amore Robert Epstein Jane Reny Frank and Stephanie Hassan Jessica and Shane A. Baron Michelle Suarez Jennifer and James H. Davis Roy L. Reardon Audrey Epstein Reny and Brian Kerzner Jacqueline Bell and Aron Epstein Corporation Stephen Frank Daniel J. Sullivan Inktothepeople.com LLC Collins Aerospace Kathleen De Riesthal Steven Reny Barbara and Amos Hostetter Heidi Lehner and Paul Milbury Roger Botelho Shryln Treadwell Dell Computer Corporation Sherry L. Iuliano, NP, and Jack Satter Foundation Elizabeth M. and John Bouchard Analise Debaie UnitedHealth Group Pamela Desautel Douglas R. Iuliano Phil H. Loughlin Cisco Foundation Adam Devlin James B. Upchurch

18 THE GILLIAN RENY STEPPING STRONG CENTER FOR TRAUMA INNOVATION BWHSTEPPINGSTRONG.ORG 19 $5,000+ (cont.) Shaun Dewitt Andrew Vayo Juan Antonio Diaz THANK YOU Nasreen and Mark DeLaar Oleg Dulin Marcelo D. Perez Verzini Kristen Diblasi Cecily and Jason Epstein Kimberly A. and Julia Wallace Angela and Tyler Eames General Dynamics Mission Dane S. Dwyer, PhD Jon Eddy Systems Eversource $1,000+ Education First Ltd. LEADERSHIP CIRCLE $250,000+ $25,000+ General Electric Company Marjorie and Stephen Fiverson Anonymous Dwight Edwards The Hawk Foundation, Svenson and Anonymous Eileen and Paul Gilligan Lisa Fleming Marbella Acosta Kathryn A. Elbert We acknowledge the generous Nielsen Families Jessica and Shane A. Baron Erin M. Hightower Ariana Fusco ADF Community Outreach Kristin E. Ellison, MD donors who have cumulatively $100,000+ Jacqueline Bell and Aron Epstein Johnson & Johnson Sheila and Howard Galligan III Foundation Kate Enroth and Dana Schmaltz given $25,000 or more to The Jeanne M. and John Blasberg Elizabeth L. Johnson The Gershwind Family Automatic Data Processing Inc. Jennifer Epstein and Cigna HealthCare Boston Celtics Shamrock Foundation Inc. Gillian Reny Stepping Strong Robert Keach Foundation The Ayco Charitable William Keravuori Tara and Gregory Ciongoli Stephanie L. Brown Center for Trauma Innovation as Jeanette Kelly Jill C. and Paal C. Gisholt Foundation Michael Euele Deborah C. and Timothy W. Diggins Kate L. and Richard A. Doyle/Harpoon Helps of February 29, 2020. Melyssa McFayden Marie Haguel BAE Systems Flagship Motorcars Paul and Sandy Edgerley Cecily and Jason Epstein Mehrayar Morhi Ellen and Mark Hardymon Marcia and Bruce R. Balter Danae A. and John E. Foley Barbara and Michael Eisenson The Grousbeck Family Foundation $1,000,000+ G. Felda Hardymon Susan and David Fox Jennifer Epstein and William Keravuori Grousbeck Trust Morrison Mahoney LLP Steven Batchelor Brigham and Women’s Physicians Raj Hathiramani John S. Frye Nina S. and David P. Fialkow Elizabeth and Mitchel B. Harris, MD William Edward Pappendick IV Caroline R. Baumal, MD, and Organization, Department of Madeline Horn Kimberly J. Fryling-Resare Barbara and Amos Hostetter Monica and Michael Lehner and Erica Gervais Jack H. Bardy Orthopaedic Surgery The Klarman Family Foundation The M&T Charitable Foundation Robert W. Pierce Jr. Family Don Hunt The Beehive Funds2Orgs LLC Esta Gordon Epstein and Robert Epstein Anne C. Kubik, MD, and Michael A. Krupka Marathon Sports Syed Husain Alicia J. and Daniel Garvey Audrey Epstein Reny and Steven Reny Foundation Jenn Bennett The Jacobson Eric Giorgianni Jack Satter Foundation $50,000+ New England Treatment Access Bryce Remy Morgan Best Jeryl and Stephen M. Oristaglio Lynn McKenna Reny and Family Foundation Michael Bilotta Give with Liberty Anonymous $500,000+ Stephen Goodwin Porter Jr. Douglas E. Reny Kathy and Mitchell Jacobson Biogen Foundation Ashley Glendye The Bill and Joan Alfond Foundation Stephanie and John Connaughton Lynn McKenna Reny and Douglas E. Reny Maureen Johnson Alvaro Gonzalez Francis X. Claro Andrew Rodriguez Johanna Black and Betsy Banks Epstein and David R. Epstein Nancy D. and David R. Reny Jane Reny Frank and Stephen Frank Eve S. and Jonathan L. Rounds Lauren Kane Jonathon Duncan Olivia Goodson Elizabeth and L. Guy Reny Standard Duplicating Machines Corporation Heidi Lehner and Paul Milbury Sodexo Inc. Matthew Lisiecki Roberto Blasini Peter Grasso Suffolk Cares Charitable Foundation Inc. Elizabeth M. and Phil H. Loughlin Standard Duplicating Arleigh MacMaster Cristin Brown Thomas Graziani Robert W. Pierce Jr. Family Foundation Machines Corporation Sean P. Maloney Lee Buono, MD Brandon Greene Robert Stewart Sameera Mathan Betul G. Cam Julia L. Greenstein and Tufts Health Plan Inc. Marco Miranda Mitchell Cameron Paul Bleicher, MD, PhD Audrey Warner and Jo Ann Moore Nicole and Ronald Cameron Kelley Hand ANNUAL HONOR ROLL (AS OF FEBRUARY 29, 2020) Elizabeth Warner Caroline Morong Peter Carbone Michael Hanrahan Frederico Wasserman, MD Ian Murphy Marcy Gleit Carty, MD, MPH, Marianne and David Harrison Northwestern Local School Sally Havens Thank you to the individuals, $50,000+ $10,000+ The M&T Charitable Dale Wiggins and Matthew J. Carty, MD Laura Wong District Emily Casey Elizabeth Healy families, foundations, and Tara and Gregory Ciongoli Anonymous Foundation Stanley Zaslau, MD Ethan R. Parten, MBA Catherine M. Chaisson Stephen Hennessey organizations who have Betsy Banks Epstein and Boston Celtics Shamrock New England Treatment Access Douglas Pfaff Michael Chaisson John F. Herlihy given $1,000 or more David R. Epstein Foundation Inc. Jeryl and Stephen M. Oristaglio Tenly Pretyka Jeff Chandler Shawn Herlihy between March 1, 2019, The Hawk Foundation, Bright Funds Foundation Jillian Perkins $2,500+ Ruthanne Russell and Kiwon Chang Ashley Hewitt and February 29, 2020. Svenson and Kathleen M. and Charles Brizius Gillian Reny Martha Beltz Paul Crowley Angelina Cohan Diana Hoff Nielsen Families Francis X. Claro Suffolk Cares Charitable Sarah and Peter Beshar Jennifer and Jeff Sabados Mary Comer Monique M. Houlihan $100,000+ Richard D. Cummings Foundation Inc. Tanishq Bhalla Kathleen and Susan Connelly Lisa Howe Cigna Healthcare $25,000+ Paul and Sandy Edgerley Jeanne M. and John Blasberg Matthew James Scales Corning Incorporated Ben Huang Stephanie and Nina S. and David P. Fialkow $5,000+ Chelsie Boudreau Deborah C. and Nicholas J. Scales Clarissa and Kara G. Boudreau Foundation John Connaughton Timothy W. Diggins Elizabeth and Anonymous Theodore Sheehan Leslie and W. Robert Dahl Walter Hunnewell Jr. Esta Gordon Epstein and Mitchel B. Harris, MD Bank of America Doyle Brown Barbara and Michael Eisenson Abbie and J. Robert Small Patricia M. Hynes and CIBC World Markets Lisa Marie D'Amore Robert Epstein Jane Reny Frank and Stephanie Hassan Jessica and Shane A. Baron Michelle Suarez Jennifer and James H. Davis Roy L. Reardon Audrey Epstein Reny and Brian Kerzner Jacqueline Bell and Aron Epstein Corporation Stephen Frank Daniel J. Sullivan Inktothepeople.com LLC Collins Aerospace Kathleen De Riesthal Steven Reny Barbara and Amos Hostetter Heidi Lehner and Paul Milbury Roger Botelho Shryln Treadwell Dell Computer Corporation Sherry L. Iuliano, NP, and Jack Satter Foundation Elizabeth M. and John Bouchard Analise Debaie UnitedHealth Group Pamela Desautel Douglas R. Iuliano Phil H. Loughlin Cisco Foundation Adam Devlin James B. Upchurch

18 THE GILLIAN RENY STEPPING STRONG CENTER FOR TRAUMA INNOVATION BWHSTEPPINGSTRONG.ORG 19 $1,000+ (cont.) Heather LeBlanc Suraja Roychowdhury, PhD, and Ann H. Sullivan Melissa Jackson Legros Aviation Services Debasish Roychowdhury, MD Christopher Sullivan Ellen S. and Robert M. Jaffe Naomi and Philip Lippincott Richley Anderson Rubin and John B. Sullivan Tammy A. and Rick Jerome Michelle Lizotte Edward Rubin Sheila Sullivan John Hancock Financial Dorothy M. and Shawn Rubin Laura R. Sweeney Services Inc. David M. Maloney Dennis Ryan, MD Kerry N. and Theodore Joubert Tristin and Martin Mannion Patricia Keiko Sakamoto and Brendan J. Swords Kaizen Management Company John Marr Sr. and William A. Witte Lynn R. and Edwin Taff Rebecca Kanninen The Marr Family Christine Saoud Angela Wen-Hui Tai, MD Benjamin Kates Patience Martin and Jennifer Sapka Ken Tanaka Stephen L. Kaufer Kenneth P. Epstein Susan and Stephen Scherr Audrey D. and Stephen Teague Jennifer W. Keddy and Linda McCabe Kira Schoenfeld, MD Judith and Michael Tembruell Stuart J. Levinson David McKenna Audrey K. and Mark S. Schuster Erica Thaler, MD Meghan C. Kelly Michael S. McKernan Carolynn and Alexander Scull Tree House Brewing Company Annemarie and Casey James McMahon Carl J. Shapiro Gail and Michael Tucci Kevin G. Kenneally Katelyn Rose Monroe Paul Siebenmorgen United Technologies Christopher Kenney Amy L. and Bradley R. Morris Silicon Valley Bank Ronit A. and Karl Velde Rex Kern, MD Allison and Bob Murray Silicon Valley Community Jane Veron and Lindsay Kershaw Steve Nash Foundation Andrew Feldstein Hugh J. Kiley Jr. Nghi Nguyen Michèle and John Simourian Justin Walsh Sungwuk Kim, MD Thomas Nicholas Suzanne Sitherwood and Suzanne Walsh Kind LLC Hope E. Pascucci Carl Bouckaert Lauren Weeks Elizabeth Knight, MD Molly Pfaff Sheryl and Ellenor Weinbel Janet Kouroubacalis Amundi Pioneer Jonathan Davis Sokoloff David Wheatley We launched the Stepping Strong Center to honor the medical teams that Daniel Laborce Herbert Plauche Andrew M. Spellman William Blair & Company saved Gillian in the aftermath of the 2013 Boston Marathon bombings and Sarah Lafreniere Relx Inc. Barbara Stedman Scotti Wood, MD to support their efforts to improve outcomes for other trauma patients. We Elizabeth Reny Ray Sterriker Serge Zborovsky Linda Lagrange had no idea if anyone would join us, but six years later, it is so humbling to Amelita Ring Jamillia Stewart Anne and Thomas E. Landers see the work of the center inspiring so many people. Physician-scientists from Steve Lanter John Rizzo Andrea and Warren Stock major academic medical institutions in Boston and beyond are collaborating Theresa Latona Joan Rodriguez The Stone Church on innovative trauma research; runners are conquering 26.2 miles on our Winslow Laverack Deborah Rooney David Stubblebine behalf; donors from across the globe are advocating for and supporting us. The Stepping Strong Center’s reach has expanded well beyond our family and Gillian’s story. James McClelland (pictured on the cover) is an amputee who is ice climbing again; Morgan Stickney is a double amputee who is swimming 2019 BOSTON MARATHON TEAM again, and; Stephen Teague is a trauma survivor who has run four Boston Christina Accardi • Marriz Agbon • Salisha Ali • Mary Ambacher • Ryan Avigne-Kennedy • Cherie Aviv • Richard A. Baum, MD • Martha Beltz • Camilla Bennett Marathons for the center. Drs. Sinha and Shin are 3D-printing muscle cells; Hana Berke • Henry Beshar • Caroline Besley • Tanishq Bhalla • Giles W. Boland, MD, FACR • Chelsie Boudreau • Jacqueline Boudreau • Alexandra Brizius Dr. Carty is revolutionizing amputation techniques; Dr. Salim is focused on Kate Brizius • Marina Burke • Rachel Burstein • Abby Cange • Alexander Canning • Ashley Carter • Emily Casey • Alison Cawlina • Mika Chesnutt preventing traumatic injuries from happening in the first place. It is more than Kaidree Christensen • Carrie Copacino • Chad Crocker • Keith Cummings • Katie Dalrymple • James Davis • Jennifer Davis • Emilie DeBaie • Mark DeLaar we could ever have imagined and has all been made possible by you. Stephen Delaney • Adam Devlin • Meghan Donahue • John (Jack) Donleavy • Samuel Eddy • Heather Edwards • Kristin E. Ellison, MD • Leyla Ewald • Alex Faura Thank you from the bottom of our hearts. Lisa Fleming • Kristen Foote • Mary Gigliotti • Ashley Glendye • Meredith Godfrey • John Greene • Lauren Grew • Daniel Gulas • Elizabeth Hale • Aaron Harms Jonathan Harrison • Valerie Hartman • Frederique Haverhals • Shea Healy • Ryan Heffrin • Erin Hightower • Katie Giuffrida Holden • Marissa Horton Jacqueline Hughes • Caroline Humphrey • Don Hunt • Aftab Husain • Sherry L. Iuliano, NP • Lindsay Jarrett • Maureen Johnson • Anne Kaplan • Meghan Kelly Elizabeth Kenneally • Shannon Vayo Kennedy • Ashton Kerzner • Brian Kerzner • Vanessa Kline • Lisa Knoppe-Reed • Amanda Krol • Ming Lai • Kyle Larrow Theresa Latona • Michelle Lizotte • Rachael Lomp • Daniel B. Loriaux, MD • Arleigh MacMaster • Nicholas Mak Esq. • Julia Marvel • Sameera Mathan Gretchen M. Mauras-Tchaprazian • Hillary Keach McConnell • Melyssa McFayden • Cathleen Grace McKeating, MD • Michael McKernan • Suzanne Mello Corinne Milbury • Lindsay Mullaney • Alyson O'Donnell • Loesje Ophuis • Christopher Ormonde • Louise Lloyd Owen • Nancy Peplau • Marcelo Perez-Verzini Jillian Perkins • Jessica Popik • Tenly Pretyka • Cindy Cortes Puentes • Melanie Rebello • Bryce Remy • Steven Reny • Meghan Rico • Lauren Riley • Jodi Roznowski Joshua Roznowski • Jack Ruske • Jennifer Sabados • Grace Santoro • Kate Santoro • Jennifer Sapka • Nicholas Scales • Theodore Sheehan • Kelly Smith Scott Stedman • Greg Stein • Brianna Sullivan • Alyssa Taubert • Stephen Teague • Katie Treadwell, MD • Ty Velde • Robin Venick • Edgard Vera • Audrey Warner Elizabeth Warner • Frederico Wasserman, MD • Erik Seiersen White • Allison Wiggins • Jessica Wiggins • Sarah Williams• Kristen Wilson • Stanley Zaslau, MD $1,000+ (cont.) Heather LeBlanc Suraja Roychowdhury, PhD, and Ann H. Sullivan Melissa Jackson Legros Aviation Services Debasish Roychowdhury, MD Christopher Sullivan Ellen S. and Robert M. Jaffe Naomi and Philip Lippincott Richley Anderson Rubin and John B. Sullivan Tammy A. and Rick Jerome Michelle Lizotte Edward Rubin Sheila Sullivan John Hancock Financial Dorothy M. and Shawn Rubin Laura R. Sweeney Services Inc. David M. Maloney Dennis Ryan, MD Kerry N. and Theodore Joubert Tristin and Martin Mannion Patricia Keiko Sakamoto and Brendan J. Swords Kaizen Management Company John Marr Sr. and William A. Witte Lynn R. and Edwin Taff Rebecca Kanninen The Marr Family Christine Saoud Angela Wen-Hui Tai, MD Benjamin Kates Patience Martin and Jennifer Sapka Ken Tanaka Stephen L. Kaufer Kenneth P. Epstein Susan and Stephen Scherr Audrey D. and Stephen Teague Jennifer W. Keddy and Linda McCabe Kira Schoenfeld, MD Judith and Michael Tembruell Stuart J. Levinson David McKenna Audrey K. and Mark S. Schuster Erica Thaler, MD Meghan C. Kelly Michael S. McKernan Carolynn and Alexander Scull Tree House Brewing Company Annemarie and Casey James McMahon Carl J. Shapiro Gail and Michael Tucci Kevin G. Kenneally Katelyn Rose Monroe Paul Siebenmorgen United Technologies Christopher Kenney Amy L. and Bradley R. Morris Silicon Valley Bank Ronit A. and Karl Velde Rex Kern, MD Allison and Bob Murray Silicon Valley Community Jane Veron and Lindsay Kershaw Steve Nash Foundation Andrew Feldstein Hugh J. Kiley Jr. Nghi Nguyen Michèle and John Simourian Justin Walsh Sungwuk Kim, MD Thomas Nicholas Suzanne Sitherwood and Suzanne Walsh Kind LLC Hope E. Pascucci Carl Bouckaert Lauren Weeks Elizabeth Knight, MD Molly Pfaff Sheryl and Ellenor Weinbel Janet Kouroubacalis Amundi Pioneer Jonathan Davis Sokoloff David Wheatley We launched the Stepping Strong Center to honor the medical teams that Daniel Laborce Herbert Plauche Andrew M. Spellman William Blair & Company saved Gillian in the aftermath of the 2013 Boston Marathon bombings and Sarah Lafreniere Relx Inc. Barbara Stedman Scotti Wood, MD to support their efforts to improve outcomes for other trauma patients. We Elizabeth Reny Ray Sterriker Serge Zborovsky Linda Lagrange had no idea if anyone would join us, but six years later, it is so humbling to Amelita Ring Jamillia Stewart Anne and Thomas E. Landers see the work of the center inspiring so many people. Physician-scientists from Steve Lanter John Rizzo Andrea and Warren Stock major academic medical institutions in Boston and beyond are collaborating Theresa Latona Joan Rodriguez The Stone Church on innovative trauma research; runners are conquering 26.2 miles on our Winslow Laverack Deborah Rooney David Stubblebine behalf; donors from across the globe are advocating for and supporting us. The Stepping Strong Center’s reach has expanded well beyond our family and Gillian’s story. James McClelland (pictured on the cover) is an amputee who is ice climbing again; Morgan Stickney is a double amputee who is swimming 2019 BOSTON MARATHON TEAM again, and; Stephen Teague is a trauma survivor who has run four Boston Christina Accardi • Marriz Agbon • Salisha Ali • Mary Ambacher • Ryan Avigne-Kennedy • Cherie Aviv • Richard A. Baum, MD • Martha Beltz • Camilla Bennett Marathons for the center. Drs. Sinha and Shin are 3D-printing muscle cells; Hana Berke • Henry Beshar • Caroline Besley • Tanishq Bhalla • Giles W. Boland, MD, FACR • Chelsie Boudreau • Jacqueline Boudreau • Alexandra Brizius Dr. Carty is revolutionizing amputation techniques; Dr. Salim is focused on Kate Brizius • Marina Burke • Rachel Burstein • Abby Cange • Alexander Canning • Ashley Carter • Emily Casey • Alison Cawlina • Mika Chesnutt preventing traumatic injuries from happening in the first place. It is more than Kaidree Christensen • Carrie Copacino • Chad Crocker • Keith Cummings • Katie Dalrymple • James Davis • Jennifer Davis • Emilie DeBaie • Mark DeLaar we could ever have imagined and has all been made possible by you. Stephen Delaney • Adam Devlin • Meghan Donahue • John (Jack) Donleavy • Samuel Eddy • Heather Edwards • Kristin E. Ellison, MD • Leyla Ewald • Alex Faura Thank you from the bottom of our hearts. Lisa Fleming • Kristen Foote • Mary Gigliotti • Ashley Glendye • Meredith Godfrey • John Greene • Lauren Grew • Daniel Gulas • Elizabeth Hale • Aaron Harms Jonathan Harrison • Valerie Hartman • Frederique Haverhals • Shea Healy • Ryan Heffrin • Erin Hightower • Katie Giuffrida Holden • Marissa Horton Jacqueline Hughes • Caroline Humphrey • Don Hunt • Aftab Husain • Sherry L. Iuliano, NP • Lindsay Jarrett • Maureen Johnson • Anne Kaplan • Meghan Kelly Elizabeth Kenneally • Shannon Vayo Kennedy • Ashton Kerzner • Brian Kerzner • Vanessa Kline • Lisa Knoppe-Reed • Amanda Krol • Ming Lai • Kyle Larrow Theresa Latona • Michelle Lizotte • Rachael Lomp • Daniel B. Loriaux, MD • Arleigh MacMaster • Nicholas Mak Esq. • Julia Marvel • Sameera Mathan Gretchen M. Mauras-Tchaprazian • Hillary Keach McConnell • Melyssa McFayden • Cathleen Grace McKeating, MD • Michael McKernan • Suzanne Mello Corinne Milbury • Lindsay Mullaney • Alyson O'Donnell • Loesje Ophuis • Christopher Ormonde • Louise Lloyd Owen • Nancy Peplau • Marcelo Perez-Verzini Jillian Perkins • Jessica Popik • Tenly Pretyka • Cindy Cortes Puentes • Melanie Rebello • Bryce Remy • Steven Reny • Meghan Rico • Lauren Riley • Jodi Roznowski Joshua Roznowski • Jack Ruske • Jennifer Sabados • Grace Santoro • Kate Santoro • Jennifer Sapka • Nicholas Scales • Theodore Sheehan • Kelly Smith Scott Stedman • Greg Stein • Brianna Sullivan • Alyssa Taubert • Stephen Teague • Katie Treadwell, MD • Ty Velde • Robin Venick • Edgard Vera • Audrey Warner Elizabeth Warner • Frederico Wasserman, MD • Erik Seiersen White • Allison Wiggins • Jessica Wiggins • Sarah Williams• Kristen Wilson • Stanley Zaslau, MD The Gillian Reny

Center for Trauma Innovation

STEPPING STRONG CENTER ADVISORY BOARD

Audrey Epstein Reny, Chair Esta Gordon Epstein Robert W. Pierce Jr. Jeffrey R. Beir Jennifer Epstein Danielle Reny Sarah P. Beir Robert Epstein Gillian Reny Paul Bleicher, MD, PhD Nina S. Fialkow Steven Reny Carl Boukaert Margaret A. Flanagan Carmichael S. Roberts, PhD Tara Ciongoli Jane Reny Frank Stanley Rosenzweig Francis X. Claro Michael A. Greeley Jonathon Rounds Timothy W. Diggins Winston Henderson Jeff Sabados Sandy Edgerley William Keravuori Suzanne Sitherwood Barbara Eisenson Elizabeth M. Loughlin Elinor Svenson Michael Eisenson Jeryl Oristaglio Hamid Tabatabaie Betsy Banks Epstein William Edward Pappendick IV Patricia Winton David R. Epstein Carroll Pierce

STEPPING STRONG CENTER MEDICAL EXECUTIVE COMMITTEE

Natalie Artzi, PhD Mitchel B. Harris, MD Olivier Pourquie, PhD Matthew J. Carty, MD Molly Jarman, PhD, MPH Ali Salim, MD Zara Cooper, MD, MSc Jeff Karp, PhD Christian Sampson, MD David Crandell, MD James Lederer, PhD Indranil Sinha, MD George Dyer, MD Yi Lu, MD, PhD Mike Weaver, MD Omid Farokhzad, MD, MBA David Mooney, MD, MPH Jack Wixted, MD Eric Goralnick, MD, MS Bohdan Pomahac, MD

STEPPING STRONG CENTER STAFF

Nish Acharya Molly Jarman, PhD, MPH Cheryl Lang, MPH Donna Woonteiler

Development Office 116 Huntington Avenue, Third Floor Boston, MA 02116