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E Unter: 7-8/2020 Eine aktuelleSARS-CoV-2 App Note Analyse und mitmehr Luna finden Reagenzien: Sie unter: 7-8/2020 be INSPIRED www.neb-online.de/Covid19 drive DISCOVERY stay GENUINE Lighting the way.™ Luna® Universal qPCR NEBs Luna-Kits für RT-qPCR nutzen eine einzigartige & RT-qPCR Produkte. „Designer” Reverse Transkriptase und bieten Ihnen unerreichte Sensitivität, Reproduzierbarkeit und qPCR-Performance. www.laborjournal.de Amplification plotplot Ihre Luna-Vorteile: 10 Input n = 8 1 μg • Einfaches Reaktions-Setup & schnelle Protokolle 0.1 μg 10 ng • Höchste Zuverlässigkeit und Reproduzierbarkeit 1 ng 1 ∆Rn 0.1 ng • Exzellente Sensitivität und Genauigkeit auf allen 10 pg Templates (egal ob AT-reich, GC-reich,…) 1 pg 0.1 pg NTC • Kompatibel mit allen gängigen qPCR-Maschinen 0.1 2 10864 161412 3836343230282624222018 40 (inkl. 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NTC = Kontrolle ohne RNA-Input.0.8 C 20.0 0.6 **RTase17.5 auch für Two-Step-Protokolle als praktisches LunaScript® RT SuperMix Kit Derivative 0.4 Informieren Sie sich noch heute und bestellen separat15.0 erhältlich! 12.5 Reporter (-Rn´) 0.2 10.0 R2 = 0.998 Sie Ihr kostenfreies Testmuster unter: One or more of these products are covered by one or more patents, trademarks and/or copyrights0.0 owned or controlled by 2 3 4 5 6 7 New England Biolabs,0.01 0.1 Inc. For 1 more 10 information, 10 10 please10 email10 us at10 [email protected] . The use of these65 70 products 75 80 85 may 90 require 95 www.neb-online.de/qPCR you to obtain additional third party intellectualQuantity property (pg) rights for certain applications. Temperature (°C) LJ_720_OC_OC.indd 2 29.06.20 10:48 Ch romat ogra HIDDEN phie HEROES. Tre IVD nnl eis MD tung Richtig trennen MD geht nur mit ROTH. www.laborjournal.de IVD IVD Trennen ist so einfach, wenn man sich auf die Produkte voll und For over 115 years, laboratory equipment from HETTICH has been used for research and ganz verlassen kann. Wir versorgen diagnostics in the fi ght against global pandemics and the development of new vaccines. Sie mit allem, was Sie für die Reliable, safe and fully compliant with all new directives – for healthy patients and a Chromatographie brauchen – innerhalb von 24 Stunden. healthy society. Today, as always, we are there for you. Jetzt bestellen: Ihr Partner für die carlroth.de Chromatographie. IVD = Conforms to In-Vitro Diagnostic Directive 98/79/EC | MD = Conforms to Medical Device Directive 93/42/EEC www.hettichlab.com Laborpraxis_Chromatografie_210x297.indd 2 24.02.2020 10:35:59 LJ_720_IC_IC.indd 2 29.06.20 13:09 EDITORIAL Liebe Leserinnen und Leser, eigentlich wollen wir nicht mehr über Coro- Beispiel. Letzteres kann natürlich an der Fuß- Achtsamkeit, Reflektion, über den Teller- na schreiben. Aber das Virus steht nicht nur ball-Dürre liegen. Das schnelle Stadionbier rand hinausschauen, sich abseits der ausge- im Verdacht, unsere Neuronen – auch die im oder der Sixpack zur Sportschau sind offen- tretenen Pfade bewegen, mal etwas länger Gehirn – zu befallen und dort allerlei Ausfäl- sichtlich dem (hoffentlich) langsameren und nachdenken – dafür steht hingegen jedes Jahr le auszulösen, etwa Atmung, Geschmacks- bewussteren Genuss von Wein gewichen. Hier unser Essay-Heft, dessen neueste Ausgabe und Geruchssinn. Nein, es befällt sogar un- ein Umsatzrückgang, dort ein Umsatzplus. Sie gerade in den Händen halten. Ihre Kolle- ser Denken, Fühlen und Verhalten. Die Regale der Supermärkte sind inzwi- ginnen und Kollegen, Forscher und Forsche- So gestand uns neulich ein Mitarbeiter, schen wieder gefüllt. Aber wenn etwas fehlt, rinnen, haben diese Ausgabe mit Inhalt und ihm hätte das wochenlange Zuhausebleiben dann sind es die feineren Sachen. Die gute Leben gefüllt. Ganz ohne das Thema Corona und im Homeoffice – manchmal war‘s wohl italienische Nudel oder der Sushi-Reis. Dre- ging das natürlich nicht. Es ist eben in unse- eher ein Couchoffice – nichts ausgemacht. Im hen die Deutschen jetzt schon Sushis? Makis ren Köpfen. Jetzt brauchen Sie nur noch ein Gegenteil. Er glaube, dass die Ruhe und die rollen statt Schnitzel klopfen? Nigiris basteln bisschen Ruhe und Muße zum Lesen. gewohnte, von ihm als schön empfundene statt Seelachs frittieren? Umgebung eher seinem Gemüt entspreche. Werden wir also durch Corona Jedenfalls eher als das permanente Herum- wirklich achtsamer, reflektierter, rennen und das ewige Geplapper seiner Kol- langsamer? (Den Kalauer mit der Co- legen. Und dann kamen abends auch noch rona-App lassen wir jetzt mal weg.) immerzu Freunde und Bekannte zu Besuch. Leider hindert uns unsere Neu- Jetzt dagegen kämen zu Hause als Vortei- gier oft daran, die angebotene Ru- le die Nähe zum Kühlschrank sowie der bes- he auch wirklich anzunehmen. Rast- sere Kaffee hinzu. Und etwas leiser und ein los zappen wir durch die Fernseh- wenig verlegen gestand er noch: „Im eige- programme oder durch das Inter- nen Bett ist das Mittagsschläfchen natürlich net, immer auf der Suche nach den auch besser als auf dem Bürostuhl“. neuesten Zahlen. Und immer sind‘s Abstand als Chance. die falschen. „Was interessiert mich, Oder als Herausforderung: Böse Zun- wie viele Infizierte wir schon hat- gen behaupten, die Abstandsregeln hätten ten. Wir schaffen ja doch keine Her- Montage: LJ Pixabay/Sponchia; Foto: vor allem im Nordosten der Republik zu gro- denimmunität. Ich will wissen, wie ßem Unbehagen geführt. Aber nachdem die viele aktuell infiziert sind.“ Mal gucken, was Wir geben allerdings zu, dass wir beim 1,5-Meter-Regel abgeschafft wurde, können das RKI sagt. Und Johns Hopkins. Und der Produzieren dieses Heftes kaum Ruhe und sie dort wieder auf die gewohnten 4 Meter Drosten. Und der Kekulé. Und der Streeck. Muße hatten. Trotz, oder eigentlich gerade lockern. Und, und, und. wegen Corona. Viele Autoren mussten For- Wird uns Physical Distancing zur Gewohn- Je mehr Informationen wir abrufen, des- schung und Lehre auf digital umstellen und heit? Auch über Corona hinaus? „Ich kann to mehr bekommen wir. Getriggert wird das kamen so in Zeitnot, und die hat sich dann auf dieses dauernde Geknutsche – Busserl hier, nämlich durch Einschaltquoten und Klickzah- uns übertragen. Auch unsere Redaktionsbe- Küss chen da! – sowieso nicht ab“, bestätigt len oder Follower. Und seitdem die Zustän- sprechungen wurden zum Zeitfresser, muss- uns Praktikant P. Und der kommt nicht aus digkeit für die Epidemie von der Bundes- ten doch immer erstmal die aktuellen Coro- Schwerin. Als gelernter Mikrobiologe gibt er regierung an die Länder gegangen ist, hat na-Fakten diskutiert werden, bevor wir zum sowieso nie Händchen. Er weiß, was da so al- sich die Informationsflut annähernd versech- Organisatorischen übergehen konnten. Und les dran klebt. zehnfacht, weil jedes Land sein eigenes Süpp- das alles mit Maske, und immer juckt die Na- Möglicherweise hat Corona so manchen chen kocht: Sachsen-Anhalt lockert, Nord- se darunter. von einigen sozialen Zwängen befreit. Phy- rhein-Westfalen macht wieder zu – und was Es war keine reine Freude. Es wird Zeit sische Nähe, Shopping und Biertrinken zum macht eigentlich Hamburg? für den Impfstoff. 7-8/2020 | 3 LJ_720_Editorial.indd 3 29.06.20 13:32 INHALT Forscher-Essays: Nachdenken Eine Spezialausgabe mit Essays von Akteuren aus den Lebenswissenschaften und der Biotech-Industrie. ESSAY ESSAY ESSAY SONSTIGES 6 Im Nebel ungesicherten 30 Make Experimentation 56 On the Dark Side 33 Impressum Wissens / Great Again! / of Science / 82 Comic: Die „Lab-Files“ Wilhelm Krull Tobias Straub Christoph Enz von Chris Schlag 10 Translationale Forschung 34 Dark Knowledge ans 60 Von Lipid Rafts zur in Pandemiezeiten / Licht holen / Lipidomik / Andreas Meyer- Jonathan Jeschke, Isabelle Kai Simons Lindenberg Bartram, Tina Heger, 64 Mit dem Rucksacklabor Sophie Lokatis und SERVICE 14 Wissenschaft in in den Dschungel – Klement Tockner Corona-Zeiten – transportable PCR- und Hindernis oder Hilfe? / 38 Von Pandemien lernen, Sequenziergeräte 74 Kongresse Gerd Antes um die Wissenschaft zu revolutionieren genomi- 77 Fortbildungen verbessern / sche Feldstudien / 18 Scholastik 21 – Über Peter Grabitz und Stefan Prost 81 Stellenmarkt gutes Argumentieren Benjamin Carlisle zum Thema grüne 66 Open Source, selbstge- Gentechnik / 42 Verlorene Sterne und baute Laborgeräte und Karl Schmid erfundene Zielscheiben / die Maker-Szene in den Bettina Bert Biowissenschaften / 22 Warum Präzisionswerk- Daniel F. Gilbert zeug, wenn wir doch 46 „Ehre, wem Ehre den Presslufthammer gebührt“ – Ist der „Dr. 70 Flüssigbiopsie: Ein neuer haben? / h. c.“ noch zeitgemäß? / Hoffnungsträger in der Theresa Schredelseker Christoph Plieth Krebsdiagnostik / Natalie Reimers und 26 Selbstzensur und 50 Die Nordwestpassage / Klaus Pantel Produktivitätswahn in Claus Kremoser der akademischen 54 „Wenn ich‘s nicht Wissenschaft / ausprobiere, weiß Johannes Jäger ich‘s ja nicht“ / Hella Kohlhof www.facebook.de/ laborjournal @Lab_Journal www.laborjournal.de 4 | 7-8/2020 LJ_720_Inhaltsverzeichnis.indd 4 29.06.20 12:53 TRUST YOUR RESULTS 1 2 3 4 6 5 10 7 8 9 Images made using using our IHC-validated recombinant monoclonal antibodies. Examine tumor immunology targets with data driven antibodies. Stay at the forefront of immuno-oncology research with our comprehensive portfolio of IHC-validated antibodies against key translational targets. 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