ICRS2017 Symposium Final Programme
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TH 27 ANNUAL SYMPOSIUM OF THE INTERNATIONAL CANNABINOID RESEARCH SOCIETY MONTRÉAL, QC CANADA JUNE 22 - 27, 2017 TH 27 ANNUAL SYMPOSIUM OF THE INTERNATIONAL CANNABINOID RESEARCH SOCIETY MONTRÉAL JUNE 22 – 27, 2017 Symposium Programming by Cortical Systematics LLC Copyright © 2017 International Cannabinoid Research Society Research Triangle Park, NC USA ISBN: 978-0-9892885-6-9 These abstracts may be cited in the scientific literature as follows: Author(s), Abstract Title (2017) 27th Annual Symposium on the Cannabinoids, International Cannabinoid Research Society, Research Triangle Park, NC, USA, Page #. Funding for this conference was made possible in part by grant 2R13DA016280 from the National Institute on Drug Abuse. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government. ICRS Sponsors Government Sponsors National Institute on Drug Abuse Non- Profit Organization Sponsors Monique and George Braude Memorial Foundation Kang Tsou Memorial Fund 2017 Symposium on the Cannabinoids Conference Coordinators Matt Hill, Ph.D. Cecilia Hillard, Ph.D. Jason Schechter, Ph.D. Programme Committee Mary Abood, Ph.D. Steve Alexander, Ph.D. Ziva Cooper, Ph.D. Meg Haney, Ph.D. Cece Hillard, Ph.D. Andrea Hohmann, Ph.D. Aron Lichtman, Ph.D. Mauro Maccarrone, Ph.D. Ian MacGregor, Ph.D. Jayme McReynolds, Ph.D. Maria Morena, Ph.D. Pal Pacher, M.D., Ph.D. Sachin Patel, M.D., Ph.D. Roger Pertwee, MA, D.Phil., D.Sc. Haley Vecchiarelli, Ph.D. Mark Ware, MBBS, MRCP Committee on Awards Steve Kinsey, Ph.D., Chair Aron Lichtman, Ph.D. Sachin Patel, M.D., Ph.D. Keith Sharkey, Ph.D. Student Prizes Committee Chair Steve Alexander, Ph.D. Mechoulam Award Committee Mary Abood, Ph.D. Francis Barth, Ph.D. Benjamin Cravatt, Ph.D. Vincenzo Di Marzo, Ph.D. Cecilia Hillard, Ph.D. Allyn Howlett, Ph.D. John Huffman, Ph.D. George Kunos, M.D., Ph.D. Gerard Le Fur, Ph.D. Aron Lichtman, Ph.D. Beat Lutz, Ph.D. Ken Mackie, M.D. Mauro Maccarrone, Ph.D. Alex Makriyannis, Ph.D. Roger Pertwee, D.Phil, D.Sc. Raj Razdan, Ph.D. Patti Reggio, Ph.D. Murielle Rinaldi- Carmona, Ph.D. 2017 ICRS Board of Directors Executive Director Cecilia Hillard, Ph.D. President Matt Hill, Ph.D. President- Elect Heather Bradshaw, Ph.D. Past President Michelle Glass, Ph.D. Secretary Sachin Patel, M.D., Ph.D. Treasurer Steve Kinsey, Ph.D. International Secretary Roger Pertwee, M.a., D.Phil, D.Sc. Student Representative Natalia Małek, M.Sc. Grant PI Jenny Wiley, Ph.D. Managing Director Jason Schechter, Ph.D. nd Registration: June 22 , 2017 (16.00 – 18.00) Le Centre Sheraton, Montréal, QC, Canada Welcome Reception: 18.30 – 20.00 4th Floor Lobby Day 1 Friday, June 23rd 7.00 Breakfast Welcome and Opening Remarks 8.30 Salle De Bal Centre & Est Oral Session 1. Inflammation and Autoimmunity CHAIRS: MELANIE KELLY AND STEVE KINSEY Jenny L. Wilkerson, DIACYLGLYCEROL LIPASE BETA KNOCKOUT MICE DISPLAY 8.45 Benjamin F. Cravatt 1 PROTECTION FROM EXPERIMENTAL and Aron H. Lichtman AUTOIMMUNE ENCEPHALOMYELITIS NEUROPROTECTION VIA CANNABINOID RECEPTOR Ian Burkovskiy, Juan 2 ACTIVATION AS MEANS 9.00 Zhou, Melanie E. Kelly 2 TO PREVENT CNS INJURY- and Christian Lehmann INDUCED IMMUNODEFICIENCY SYNDROME IN MICE Richard Porter, Anna-Maria Szcesniak, INVESTIGATING NOVEL SELECTIVE James Toguri, Simon CANNABINOID 2 RECEPTOR Gebremeskel, Brent 9.15 AGONISTS AS POTENTIAL 3 Johnston, Christian THERAPEUTIC DRUGS FOR THE Lehmann, Uwe Grether, TREATMENT OF UVEITIS Christoph Ullmer and Melanie Kelly Natalia Murataeva, A ROLE FOR CANNABINOID Sally Miller, Cecilia 9.30 CB2 RECEPTORS IN CORNEAL 4 Hillard, Julian Romero WOUND HEALING and Alex Straiker Resat Cinar, Bernadette R. Gochuico, IDENTIFYING CANNABINOID CB1 Malliga Iyer, Tadafumi RECEPTOR AS A THERAPEUTIC Yokoyama, Joshua K. TARGET FOR IDIOPATHIC 9.45 5 Park, Nathan J. Coffey, PULMONARY FIBROSIS AND A Tony Jourdan, DUAL-TARGETING PARTNER FOR William A. Gahl IMPROVING ANTI-FIBROTIC EFFICACY and George Kunos URB597 AND JZL184 PROTECTS Daniel Couch, Jon Lund 10.00 THE HUMAN COLON AGAINST 6 and Saoirse O'Sullivan INFLAMMATION VIA CB1 Haley A. Vecchiarelli, Maria Morena, Kaitlyn Tan, Catherine DYNAMIC REGULATION OF THE M. Keenan, Martin 10.15 CENTRAL ENDOCANNABINOID 7 Sticht, Kira Leitl, SYSTEM INDUCED BY COLITIS Winnie Ho, Min Qiao, Keith A. Sharkey and Matthew N. Hill 10.30 Coffee Break Oral Session 2. Drug Development and Medicinal Chemistry CHAIRS: MARY ABOOD AND MARIO VAN DER STELT Annelot C.M. van Esbroeck, Antonius P.A. Janssen, Armand B. Cognetta, Daisuke Ogasawara, Guy Shpak, Mark van der Kroeg, Vasudev Kantae, Marc P. Baggelaar, Femke M.S. de Vrij, Hui Deng, Marco Allarà, Filomena ACTIVITY-BASED Fezza, Zhanmin Lin, Tom van der PROTEIN PROFILING REVEALS Wel, Marjolein Soethoudt, Elliot 11.00 D. Mock, Hans den Dulk, Ilse L. OFF-TARGET PROTEINS OF THE 8 Baak, Bogdan I. Florea, Giel FATTY ACID AMIDE HYDROLASE Hendriks, Luciano De Petrocellis, INHIBITOR BIA 10-2474 Herman S. Overkleeft, Thomas Hankemeier, Chris I. De Zeeuw, Vincenzo Di Marzo, Mauro Maccarrone, Benjamin F. Cravatt, Steven A. Kushner and Mario van der Stelt Richard C. Kevin, POTENTIALLY TOXIC THERMOLYTIC Alexander L. Kovach, 11.15 DEGRADANTS OF CARBOXAMIDE 9 Iain S. McGregor SYNTHETIC CANNABINOIDS and Brian F. Thomas Alessia Ligresti, SURPRISING MECHANISM David Woodward, OF FAAH INHIBITION 11.30 Jose Martos, Sabatino 10 BY NEWLY DESIGNED Maione, Gennaro Marino MULTI-TARGET ANALGESICS and Vincenzo Di Marzo Sergiy Tyukhtenko, Girija Rajarshi, Xiaoyu Ma, Ioannis THE DISCOVERY OF Karageorgos, Nikolai ALLOSTERIC SITES OF HUMAN Zvonok, Elyssia S. 11.45 MONOACYLGLYCEROL LIPASE 11 Gallagher, Hongwei FOR IDENTIFICATION OF NOVEL Huang, Kiran Vemuri, PHARMACEUTICALS Jeffrey W. Hudgens, Spiro Pavlopoulos and Alexandros Makriyannis 12.00 Lunch Poster Session 1 13.00 - 15.00 P1 Salle De Bal Ouest Young Investigator Award Presentation CARDIOVASCULAR EFFECTS OF CANNABIDIOL 15.00 Saoirse O’Sullivan Associate Professor, Faculty of Medicine and Health Sciences University of Nottingham United Kingdom Oral Session 3. Endocannabinoids, Related Lipids and Cannabinoid Receptors CHAIRS: HEATHER BRADSHAW AND RUTH ROSS Diane L. Lynch, CRYSTAL PACKING ISSUES IN 15.30 Dow P. Hurst and 12 THE CB1 CRYSTAL STRUCTURES Patricia H. Reggio Attila Oláh, Majid A. Alam, CB1 REGULATES Gréta Kis, Zoltán Hegyi, MITOCHONDRIAL FUNCTIONS 15.45 Johannes Lerchner, OF HUMAN EPIDERMAL 13 Silvia Vidali, Andreas KERATINOCYTES IN SITU Zimmer, Tamás Bíró AND IN VITRO and Ralf Paus Amey Dhopeshwarkar, 1-ARACHIDONOYLGLYCEROL Zachary Osborne, 16.00 SIGNALING AT CANNABINOID 14 Alex Straiker CB1 RECEPTORS and Ken Mackie Emma Leishman, REGION AND DEVELOPMENT- Michelle Murphy, DEPENDENT EFFECTS OF CP 55,940 16.15 15 Ken Mackie ON THE WIDER ENDOCANNABINOID and Heather B Bradshaw LIPIDOME IN THE MOUSE BRAIN Jennifer Bialecki, Alexander W. Lohman, PANNEXIN-1 TRANSPORTS Nicholas L. Weilinger, ANANDAMIDE RESULTING 16.30 16 Haley A. Vecchiarelli, IN MODULATION OF GABA Matthew N. Hill TRANSMISSION and Roger J. Thompson 16.45 Coffee Break Linda Console-Bram, Sandra M Ciuciu, MODULATION OF THE ENDOGENOUS Pingwei Zhao, 17.15 CANNABINOID SYSTEM BY NAGLY 17 Robert E. Zipkin, VIA GPR18 AND GPR55 Eugen Brailiou and Mary E. Abood Gregory Carbonetti, TRANSPORT OF MAGL-PRODUCED Xiaoxue Peng, LIPIDS BY FABP5 LEADS TO 17.30 Tessa Wilpshaar, 18 INCREASED PROSTATE Simon D’Oelsnitz, CANCER AGGRESSION and Martin Kaczocha Fabiana Piscitelli, Giulia Donvito, Pretal Muldoon, Asti Jackson, Rosa Maria Vitale, Enrico D'Aniello, Catia Giordano, Bogna M. Ignatowska- OLEOYLGLYCINE IS PRODUCED Jankowska, Mohammed BY BRAIN TRAUMA AS A 17.45 A. Mustafa, Gavin N. 19 NOVEL AND MULTI-TARGET Petrie, Linda Parker, Reem Smoum, ENDOGENOUS LIPID SIGNAL Sabatino Maione, Aron H. Lichtman, M. Imad Damaj, Vincenzo Di Marzo and Raphael Mechoulam Presidential Plenary Speaker ACCOMPLICES TO MURDER: ENDOCANNABINOIDS DIRECT MICROGLIA TO KILL NEWBORN NEURONS 18.00 Margaret McCarthy, Ph.D. Professor and Chair DepartMent of PharMacology School of Medicine University of Maryland United States Notes: Day 2 Saturday, June 24th 7.00 Breakfast Oral Session 4. Pain CHAIRS: ANDREA HOHMANN AND ARON LICHTMAN Alex Hanson, ENDOCANNABINOID-MEDIATED 8.30 Emily Kabeiseman HABITUATION PERSISTENTLY 20 and Brian Burrell REDUCES NOCICEPTIVE SIGNALING Matthew Elmes, Joseph Sweeney, Olivia Joseph, TOWARDS A NEW CLASS Gregory Carbonetti, OF ANTINOCICEPTIVE DRUG: Simon Tong, Su Yan, DEVELOPMENT OF FATTY 8.45 Kongzhen Hu, 21 ACID BINDING PROTEIN Hao-Chi Hsu, Huilin Li, INHIBITORS TO ALTER THE Robert Rizzo, ENDOCANNABINOID TONE Iwao Ojima, Martin Kaczocha and Dale Deutsch INFLAMMATORY PAIN CHANGES Adrianne R. Wilson- THE EXPRESSION AND FUNCTION 9.00 Poe, Chris Trousdale 22 OF CB1 RECEPTORS IN THE and Jose Morón PERIAQUEDUCTAL GRAY Caitlin Nealon, Angela Henderson-Redmond, AGONIST-SPECIFIC MECHANISMS 9.15 Rebecca LaFleur, OF CANNABINOID TOLERANCE IN 23 Matt Yuill DESENSITIZATION RESISTANT MICE and Daniel Morgan Rebecca M. Craft, CANNABIDIOL MODULATION 9.30 Nicholas Z. Greene OF ANTINOCICEPTIVE 24 and Jenny L. Wiley TOLERANCE TO THC BRAIN PERMEANT AND IMPERMEANT INHIBITORS OF FATTY-ACID AMIDE HYDROLASE SUPPRESS THE Richard A. Slivicki and DEVELOPMENT AND MAINTENANCE 9.45 25 Andrea G. Hohmann OF PACLITAXEL-INDUCED NEUROPATHIC PAIN AND SYNERGIZE WITH THE OPIOID ANALGESIC MORPHINE Zachary A. Curry, MONOACYLGLYCEROL