DOCSLIB.ORG

2011/2012 NNI Newsletter

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
2011/2012 NNI Newsletter Nanoscience and Nanotechnology Institute at The University of Iowa FALL 2011 FROM THE DIRECTOR Welcome to the 2011 newsletter from the or example, ties and research miology, Radioactive Nanoparticle earlier this year, needs for nanomate- (Radon) Exposure and Lung Cancer Nanoscience and Thomas Peters, rial interactions with January, 2011: Amanda Haes, Associate Pro- environmental and Assistant Professor of Chemistry, Nanotechnology fessor of Occupa- biological systems Designing Nanomaterials for Bio- Vicki H. Grassian Institute at UI (NNI@ tional and Environ- from a chemical, mo- medical Applications, Immunology mental Health, was Director of NNI@UI lecular perspective. & Molecular Cellular Biology UI). It has been an invited to Moscow The workshop identi- Graduate Programs, UI Depart- in February, 2011 for the Science fied a number of grand challenges, ment of Internal Medicine exciting year for UI and Technology Working Group knowledge gaps, methodology January, 2011: Thomas Peters, Meeting (STWG) of the US-Russia gaps, and research needs where Airborne Monitoring to Distinguish students, staff and Bilateral Presidential Commission. molecular-based approaches could Engineered Nanomaterials from Through an interagency selection provide significant insights into Incidental Particles faculty engaged in process under the National Nano- the effect of nanomaterials on Nanoscience and Nanotech- technology Initiative, Dr. Peters environmental health and safety. nology researchers continue to nanoscience and was chosen to lead a topical area The workshop report can be found be very successful in acquiring of the Environmental Health and at http://nsfenv-nano.chem.wisc. funding for collaborative efforts nanotechnology Safety (EHS) session: Protocol and edu. in cutting edge research. Jerald research and methods development, including Besides outside engagement, a Schnoor, Allen S. Henry Chair in dosimetry and measurement tools, number of interesting seminars in Engineering, Department of Civil education. methods for identification of nano- nanoscience and nanotechnology and Environmental Engineering materials in the biological medium were given on the UI campus in & Co-Director of the Center for and in the environment and methods the last year, including: Global and Regional Environ- for assessment of their hazard levels. September, 2010: Balaji Nara- mental Research, was awarded a In June, I had the opportunity simhan, Professor of Chemical $200,000 subcontract with Rice to co-chair with Robert Hamers, and Biological Engineering, Iowa University’s EPA/NSF STAR- Distinguished University Professor State University, Nanovaccine Plat- funded grant: “Engineered Nano- from University of Wisconsin- forms for Biodefense Pathogens materials and Plant Interactions: Madison, a National Science October, 2010: Maureen Don- Uptake, Transformations, and Foundation-funded workshop in ovan, Professor of Pharmaceutics Effects”. Dr. Schnoor and Anne Arlington, VA. The workshop and Translational Therapeutics, Schwarzkopf Alexander, Civil was titled “Nanomaterials and UI College of Pharmacy, Size and and Environmental Engineering, the Environment: The Chemistry Surface Characteristics Influencing are examining the uptake, toxic- and Materials Perspective”. The Nanoparticle Uptake and Transport ity and metabolism by plants to a 35 participants of the workshop, through the Olfactory Mucosa variety of nanoparticles including including UI professors Tori March, 2011: R. William Field, cerium oxides, iron oxides, silver Forbes and Sarah Mason, met Professor of Occupational and oxides, quantum dots and nC60. to discuss challenges, opportuni- Environmental Health, and Epide- (Continued next page) Sarah Larsen, Professor of Jessop, Associate Professor, De- structures that are being devel- Chemistry, and co-Director partment of Chemical & Biochem- oped for biomedical, environmen- Nanotoxicology of NNI@UI, along with Allan ical Engineering; Vicki Grassian, tal, and energy applications. Guymon, Professor of Chemical Professor of Chemistry, Chemical Five NNI@UI Core Faculty Research Cluster at & Biochemical Engineering, re- & Biochemical Engineering, and members have received one-year ceived a $360,000 NSF Research Occupational & Environmental pilot grant awards ranging up to the University of Iowa Experiences for Undergraduates Health; and Randy Nessler, Cen- $50,000 each through the Insti- (REU) grant, funding an REU tral Microscopy Research Facility. tute for Clinical and Translational program for the summers of In January 2011, the Depart- Science (ICTS). ICTS pilot grants he toxicology of man- 2011, 2012, and 2013. This fol- ment of Chemistry in the College are awarded annually to junior ufactured nanomateri- lows a very successful 3-year REU of Liberal Arts and Sciences re- investigators and established als is a burgeoning program Dr. Larsen directed in ceived a $198,500 grant from the scientists to enable preliminary science. Since 2008, 2008-2010. See page 3 for more Roy J. Carver Charitable Trust and and proof-of-concept studies and a Nanotoxicology information and highlights of the $40,000 in matching funds from encourage the expansion of clini- Initiative under the 2011 REU program. the UI Office of the Vice President cal and translational research into co-directorship of Drs. Peter S. In November, 2010, the Roy J. for Research for the purchase of new areas. Pilot grant award win- Carver Charitable Trust awarded a state-of-the-art Bruker D8 Ad- ners include the following: Alias- Thorne and Vicki H. Grassian a $175,000 grant to the UI for the vance X-ray diffractometer. This ger Salem, Associate Professor of has developed with members acquisition of a dispersive Raman instrument will provide critical Pharmaceutics; Amanda Haes, from the Colleges of Public spectrophotometer with confocal information on the atomic struc- Assistant Professor of Chemistry; Health, Medicine, Pharmacy, microscope. Maureen Donovan, ture of a wide-range of cutting- Amnon Kohen, Ph.D., Professor Engineering, and Liberal Arts Professor of Pharmaceutical Sci- edge solid-state materials being of Chemistry; Kevin Rice, Profes- and Sciences. This initiative has ences and Experimental Thera- investigated in research labora- sor of Medicinal & Natural Prod- been successful and combines the peutics, is the PI on the grant. tories across campus. These new ucts Chemistry and Pharmaceu- expertise of investigators from The Co-PI’s are Jennifer Fiegel, diffraction capabilities will greatly tics; and Leonard MacGillivray, NNI@UI with those from the Assistant Professor of Pharmaceu- aid in the study of powders and Professor of Chemistry. Environmental Health Sciences tical Sciences and Experimental films such as pharmaceutical drug Research Center (EHSRC). Therapeutics, and Chemical & compositions, poorly crystalline Biochemical Engineering; Julie nanoscale particles, and polymeric Manufactured nanomaterials are found in cosmetics, coatings, consumer electronics, household products, and building materials, and are used in environmental FACULTY C. Allan Guymon remediation. Because of this Chemical & Biochemical Engineering they present a potential risk for PROFILE College of Engineering, University of Iowa human exposure, and thus pro- vide an impetus for studying their health implications. The primary goal of nanotoxicology research ith the on combining the promising fields Professor Guymon has been a is to better understand the health increased of nanotechnology and photopo- research mentor with the NNI@ effects of these very small par- opportunities lymerization in understanding the UI REU program since the first ticles from several different per- that nanotech- role of order on polymerization group of undergraduate research- spectives, including toxicity and kinetics in and of self-assembled ers arrived on campus in May, nology has pro- novel methods for drug delivery. vided in polymeric systems, and conversely the 2008. He joined Professor Sarah Nanotoxicology investigators materials, understanding the role impact of the polymerization on Larsen as co-director this past of order in polymer systems and ultimate nanostructure and prop- summer. Participants benefit not study manufactured nanomateri- the consequent effect of this order erties. Further work has focused only from his technical expertise, als, nanomaterials for drug deliv- on ultimate properties is critical on developing new chemistries but also his love of soccer (devel- ery and incidental nanoparticles. in development of organic nano- and methodologies to expand the oped by coaching 3 children in the The latter are nanoparticles or structured systems. Additionally, scope of photopolymerization by sport) through a series of friendly ultrafine particles that arise photopolymerization, i.e. polymer- alleviating current limitations soccer matches at Hubbard Park. from high temperature processes ization processes initiated by light, through molecular design. Critical The final event this past summer including combustion and weld- is one of the most rapidly expand- in this work is investigating and was a visit to the Amana Colonies ing as well as from gas to particle ing and transformative technolo- characterizing the system before, in which the students were able conversion processes that are during, and after polymerization to compare the intricacies of hand gies for materials production. prevalent in both urban and Dr. Allan Guymon, Professor, to allow optimization and develop- crafted technology with the nano- rural environments.
Load more

Recommended publications
  • Dosimetry of Brachytherapy Using Radioactive Nanoparticles: in Silico
    ESCOLA DE ENGENHARIA DEPARTAMENTO DE ENGENHARIA NUCLEAR PROGRAMA DE PÓS-GRADUAÇÃO EM CIÊNCIAS E TÉCNICAS NUCLEARES UNIVERSIDADE FEDERAL DE MINAS GERAIS Baljeet Seniwal Dosimetry of Brachytherapy using Radioactive Nanoparticles: In silico Belo Horizonte May 2021 BALJEET SENIWAL Dosimetry of Brachytherapy using Radioactive Nanoparticles: In silico Thesis presented to the Postgraduate Course in Nuclear Sciences and Techniques at the School of Engineering of the Federal University of Minas Gerais, as a partial requirement to obtain the title of Doctor in Nuclear Sciences and Techniques Concentration area: Radiation Sciences Promoter: Prof. Telma C. F. Fonseca, PhD Co-Promoter: Prof. Jan Schuemann, PhD Line of Research: Applications of Radiation to Biomed- ical Sciences Belo Horizonte 2021 Seniwal, Baljeet. S477d Dosimetry of brachytherapy using radioactive nanoparticles [recurso eletrônico] : in silico / Baljeet Seniwal. - 2021. 1 recurso online (xxiv, 143 f. : il., color.) : pdf. Orientadora: Telma C. F. Fonseca. Coorientador: Jan Schuemann. Tese (doutorado) - Universidade Federal de Minas Gerais, Escola de Engenharia. Anexos: f. 112-143. Bibliografia: f. 104-111. Exigências do sistema: Adobe Acrobat Reader. 1. Engenharia nuclear - Teses. 2. Braquiterapia - Teses. 3. Método de Monte Carlo - Teses. I. Fonseca, Telma Cristina Ferreira. II. Schuemann, Jan. III. Universidade Federal de Minas Gerais. Escola de Engenharia. IV. Título. CDU: 621.039(043) Ficha catalográfica elaborada pelo bibliotecário Reginaldo Cesar Vital dos Santos CRB/6 2165 Biblioteca Prof. Mário Werneck, Escola de Engenharia da UFMG To my Family and my Supervisor Acknowledgements I am indebted to many people who helped me through this journey of Ph.D. research. Without their help, this work would never see light.
    [Show full text]
  • | Ana Maria Titat De La Timurni
    |ANA MARIATITAT DEUS009974870B2 LA TIMURNI (12 ) United States Patent (10 ) Patent No. : US 9 , 974 ,870 B2 Achilefu et al. (45 ) Date of Patent: May 22, 2018 ( 54 ) COMPOSITIONS AND METHODS FOR 6 , 106 , 866 A 8 / 2000 Ranney TREATMENT AND IMAGING USING 6 ,127 ,339 A 10 / 2000 Hatanaka et al . 2006 / 0019876 A1 1 / 2006 Faulk NANOPARTICLES 2007 /0218049 AL 9 /2007 Chen et al. 2007 /0292353 A1 12 / 2007 Levy et al . (71 ) Applicant: Washington University, St. Louis , MO 2009 /0202650 A18 / 2009 Hwu et al . (US ) 2009 /0220430 A1 * 9 /2009 Rajopadhye . .. A61K 47 /48338 424 / 9 . 6 2010 /0209479 Al 8 / 2010 Carroll et al. (72 ) Inventors : Samuel Achilefu , St. Louis , MO (US ) ; 2012 /0101427 Al 4 /2012 Farmer et al . Kvar Black , St. Louis , MO (US ) 2012 /0220870 A18 /2012 Gambhir et al . 2012 /0282185 AL 11/ 2012 Dobson et al . ( 73 ) Assignee : WASHINGTON UNIVERSITY , St . 2013 / 0017266 A11 / 2013 Ogino et al. Louis , MO (US ) 2013 /0137916 Al 5 / 2013 Goer 2017 /0007724 A11 /2017 Achilefu et al. ( * ) Notice : Subject to any disclaimer , the term of this patent is extended or adjusted under 35 FOREIGN PATENT DOCUMENTS U . S . C . 154 ( b ) by 0 days. days . WO 2015183346 A2 12 / 2015 ( 21 ) Appl. No. : 14 /734 , 761 OTHER PUBLICATIONS ( 22 ) Filed : Jun . 9 , 2015 Shi et al , Journal of the American Chemical Society , 2012, vol. 134 , pp . 17972 - 17981. * (65 ) Prior Publication Data Zhang et al ., “ Actiavtable Molecular Systems Using Homologous US 2015 / 0352234 A1 Dec. 10 , 2015 Near - Infrared Fluorescent Probes for Monitoring Enzyme Activities in Vitro , in Cellulo , and in Vivo ," Molecular Pharmaceutics, Aug.
    [Show full text]
  • Radiometric Methods for Measuring and Modeling Multiphase Systems
    Radiometric Methods for Measuring and Modeling Multiphase Systems Report of the 3rd RCM of the CRP F2.20.60, April 11-15, 2016 The originating Section of this publication in the IAEA was: Industrial Applications and Chemistry Section International Atomic Energy Agency Wagramer Strasse 5 P.O. Box 100 A-1400 Vienna, Austria FOREWORD The third Research Coordination Meeting (RCM) of the Coordinated Research Project (CRP) on Radiometric Methods for Measuring and Modeling Multiphase Systems towards Industrial Processes was held at the International Atomic Energy Agency (IAEA) Head Quarters, Vienna, Austria from 11-15 April 2016. The Chief Scientific Investigators of all research contracts and agreements under the CRP participated in the meeting. Four research agreement holders from Norway, France, Poland and Korea provided assistance to the other RCM participants with their expertise and know-how. The twelve research contract holders from Brazil, Cuba, China, Ghana, Malaysia, Morocco, Pakistan, Poland, Tunisia, Vietnam, India and Peru are with recognized experience in radiotracer and nucleonic measurement systems technologies. Multiphase flow systems are widely used in industrial and environmental processes, and widespread throughout chemical processing, mineral processing, oil production, wastewater treatment, sediment and solids transport, and many others. Optimized design and scale-up of these multiphase flow systems are important in ensuring enhanced performance, economic viability and environmental acceptability. The third RCM is organized to make a final review of the activities performed and progress achieved by all the participants of CRP, to draft and adopt the final meeting report and to finalise the CRP document to be published as a Radiation Technology Series.
    [Show full text]
  • Radionuclide Therapy Using 131I-Labeled Anti-Epidermal Growth
    J Cancer Res Clin Oncol (2016) 142:619–632 DOI 10.1007/s00432-015-2067-2 ORIGINAL ARTICLE – CANCER RESEARCH Radionuclide therapy using 131I‑labeled anti‑epidermal growth factor receptor‑targeted nanoparticles suppresses cancer cell growth caused by EGFR overexpression Wei Li1 · Zhongyun Liu2 · Chengxia Li1 · Ning Li1 · Lei Fang3 · Jin Chang3 · Jian Tan1 Received: 7 July 2015 / Accepted: 23 October 2015 / Published online: 16 November 2015 © Springer-Verlag Berlin Heidelberg 2015 Abstract Results The EGFR-targeted nanoparticle EGFR–BSA– Introduction Anti-epidermal growth factor receptor PCL and the non-targeted nanoparticle BSA–PCL were con- (EGFR)-targeted nanoparticles can be used to deliver a structed; the effective diameters were approximately 100 nm. therapeutic and imaging agent to EGFR-overexpressing The results from flow cytometry and confocal microscopy tumor cells. 131I-labeled anti-EGFR nanoparticles derived revealed significant uptake of EGFR–BSA–PCL in EGFR- from cetuximab were used as a tumor-targeting vehicle in overexpressing tumor cells. Compared with EGFR–BSA– radionuclide therapy. PCL, BSA–PCL could also bind to cells, but tumor cell Methods This paper describes the construction of the retention was minimal and weak. In MTT assays, the EGFR- anti-EGFR nanoparticle EGFR–BSA–PCL. This nanopar- targeted radioactive nanoparticle 131I–EGFR–BSA–PCL ticle was characterized for EGFR-targeted binding and cel- showed greater cytotoxicity and targeted cell killing than the lular uptake in EGFR-overexpressing cancer cells by using non-targeted nanoparticle 131I–BSA–PCL. The radioiodine flow cytometry and confocal microscopy. Anti-EGFR and uptake of both 131I-labeled nanoparticles, 131I–EGFR–BSA– non-targeted nanoparticles were labeled with 131I using the PCL and 131I–BSA–PCL, was rapid and reached maximal chloramine-T method.
    [Show full text]
  • Industrial Radiotracer Technology for Process Optimizations in Chemical Industries – a Review
    View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by Pertanika Journal of Scholarly Research Reviews (PJSRR - Universiti Putra Malaysia,... PJSRR (2016) 2(3): 20-46 eISSN: 2462-2028 © Universiti Putra Malaysia Press Pertanika Journal of Scholarly Research Reviews http://www.pjsrr.upm.edu.my/ Industrial Radiotracer Technology for Process Optimizations in Chemical Industries – A Review Mohd Amirul Syafiq MOHD YUNOSa,b*, Siti Aslina HUSSAINb, Hamdan MOHAMED YUSOFFb, Jaafar ABDULLAHa aMalaysian Nuclear Agency, Bangi, 43000 Kajang, Selangor, Malaysia bFaculty of Engineering, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia [email protected]*, [email protected], [email protected], [email protected] Abstract - Radioisotope techniques are constantly and extensively used all over the world as a method to identify process systems malfunctions in various industries without requiring the shut down of the processing plant thus leading to high economical benefits to the plant owner. Different aspects of industrial radiotracer technology for troubleshooting, process control and optimization are evaluated through an exhaustive literature survey. The review covers the advantages of radiotracers, most commonly used radiotracers in industry for specific studies, applications of radiotracer techniques in various chemical industries, the design of radiotracer technology experiments, radiation detection and data acquisition in radiotracer technology as well as radiological safety aspects. Two industrial radiotracer techniques of residence time distribution (RTD) measurements and radioactive particle tracking (RPT) are discussed. The design of radiotracer technology experiments are also divided into two categories - radioactive particle tracking applications and residence time distribution applications. Keyword: Industrial radiotracer, Industrial process, Process optimization, Residence time distribution, Radioactive particle tracking.
    [Show full text]
  • Radioimmunotherapy with Radioactive Nanoparticles: Biological Doses and Treatment Efficiency for Vascularized Tumors with Or Without a Central Hypoxic Area ͒ V
    Radioimmunotherapy with radioactive nanoparticles: Biological doses and treatment efficiency for vascularized tumors with or without a central hypoxic area ͒ V. Bouchata and V. E. Nuttens Research Center in Physics of Matter and Radiation (PMR), Laboratoire d’Analyses par Réactions Nucléaires (LARN), University of Namur (FUNDP), Rue de Bruxelles 61, B-5000 Namur, Belgium C. Michiels Unité de Recherche en Biologie Cellulaire (URBC), University of Namur (FUNDP), Rue de Bruxelles 61, B-5000 Namur, Belgium B. Masereel Department of Pharmacy (DP), University of Namur (FUNDP), Rue de Bruxelles 61, B-5000 Namur, Belgium O. Feron Unité de Pharmacothérapie (FATH), Université Catholique de Louvain (UCL), Avenue Mounier 53, B-1200 Brussels, Belgium B. Gallez Laboratoire de Resonance Magnétique Biomédicale (CMFA), Université Catholique de Louvain (UCL), Avenue Mounier 73, B-1200 Brussels, Belgium T. Vander Borght Center for Molecular Imaging and Experimental Radiotherapy (IRME), Université Catholique de Louvain (UCL), Dr. G. Therasse 1, B-5530 Yvoir, Belgium S. Lucas Research Center in Physics of Matter and Radiation (PMR), Laboratoire d’Analyses par Réactions Nucléaires (LARN), University of Namur (FUNDP), Rue de Bruxelles 61, B-5000 Namur, Belgium ͑Received 7 September 2009; revised 23 February 2010; accepted for publication 1 March 2010; published 29 March 2010͒ Purpose: Radioactive atoms attached to monoclonal antibodies are used in radioimmunotherapy to treat cancer while limiting radiation to healthy tissues. One limitation of this method is that only one radioactive atom is linked to each antibody and the deposited dose is often insufficient to eradicate solid and radioresistant tumors. In a previous study, simulations with the Monte Carlo N-Particle eXtended code showed that physical doses up to 50 Gy can be delivered inside tumors by replacing the single radionuclide by a radioactive nanoparticle of 5 nm diameter containing hundreds of radioactive atoms.
    [Show full text]
  • The Toxicity of Thorium Oxide Nanoparticles Conjugated With
    International Journal of Medical Laboratory 2014;1(1):36-45. Original Article Toxicity of Thorium Oxide Nanoparticles Conjugated with Folic acid and Antibody on the Blood Mononuclear Cells from Patients with Chronic Lymphocytic Leukemia and Normal Persons Seyedhossein Hekmatimoghaddam1M.D., Ali Jebali1*Ph.D. 1 Department of Laboratory Sciences, School of Paramedicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. A B S T R A C T Article history Background and Aims: The aim of this study was to synthesize antibody-conjugated Received 27 Oct 2014 radioactive(thorium oxide) nanoparticles (ACRNPs) and folic acid-conjugated Accepted 30 Nov 2014 Available online 17 Dec radioactive nanoparticles (FACRNPs). 2014 Materials and Methods: After synthesis of nanoparticles, blood samples from CLL Keywords Chronic Lymphocytic patients and normal subjects were obtained, and their mononuclear cells were isolated Cytotoxicity Detection by Ficoll method. To evaluate cytotoxicity, serial concentrations of ACRNPs and Nanoparticle FACRNPs were separately added to cancerous and normal mononuclear cells, Thorium oxide incubated for 12 hours at 37 ºC, and then different assays including MTT, MTS, cell metabolic, and ATP assay were carried out. On the other hand, the mononuclear cells were captured by anti-CD20 antibody in the polystyrene tube, and then ACRNPs and FACRNPs were separately added to them. After washing, the radioactivity (counts per minute (CPM)) of each tube was read. Downloaded from ijml.ssu.ac.ir at 10:27 IRST on Monday October 11th 2021 Results: The images obtained from electron microscopy showed that both ACRNPs and FACRNPs were spherical with the same size (near 50 nm). This study obviously demonstrated a direct relationship between CPM and concentration of ACRNPs and FACRNPs in both cancerous and normal samples.
    [Show full text]
  • Netic Resonance Imaging
    CANADIAN MEDICAL PHYSICS NEWSLETTER Le BULLETIN CANADIEN InterACTIONS de PHYSIQUE MÉDICALE Detection of Lung Remodelling following Radiation Therapy using Hyperpolarized 3He Mag- netic Resonance Imaging PUBLICATIONS MAIL AGREEMENT NO. 40049361 RETURN UNDELIVERABLE CANADIAN ADDRESSES TO: COMP/CCPM Office PO Box 72024 Kanato North RPO OTTAWA, ON K2K 2P4 CANADA A publication of the Canadian Organization of Medical Physicists and the Canadian College of Physicists in Medicine http://www.medphys.ca ISSN 1488-6839 56 (3) juillet/July 2010 PTW AD ALREADY UP- LOADED 70 56(3) juillet/July Canadian Medical Physics Newsletter / Le bulletin canadien de physique médicale InterACTIONS Volume 56, Number 3– juillet/July 2010 73 Message from the COMP President— Peter McGhee 74 Message from the CCPM President— Dave Wilkins 75 Message from the Executive Director— Nancy Barrett 76 CNSC Feedback Forum— Submission of Annual Compliance Reports Kavita Murthy, Director 77 Feature Article: Detection of Lung Remodelling following Radiation Therapy using Hyperpolarized 3He Magnetic Resonance Imaging L. Mathew, S. Gaede, A. Wheatley, R. Etemad-Rezai, G. Rodrigues and G. Parraga 79 Coeff6 – A Tool for Radiation Physics — Jack Cunningham 80 Book Review: Clinical Dosimetry Measurements in Radiotherapy—Alasdair Syme 85 Report of the 2009 Harold E. Johns Travel Award Visit Hyperpolarized Gas Magnetic Resonance Lung Imaging at the Robarts Research In- stitute in London, Ontario — Dr. Atiyah Yahya 88 Laptops for Kenya — Marija Popovic 89 NSERC opening up for Medical Physics — David W O Rogers and William Whelan 91 Interesting Things Medical Physicists Do: Swords into Ploughshares?! — Alex Vitkin 93 Easy Particle Propagation — Jonas Lippuner 94 Editor’s Note — Idris Elbakri Cover Image Hyperpolarized helium-3 magnetic resonance imaging (MRI) methods are being developed in a handful of respiratory and MR centres to provide a quantitative method for the measurement of lung function and tissue microstructure by exploiting the diffusion properties of 3He.
    [Show full text]
  • For Personal Use Only
    26 May 2011 The Manager Company Announcements Office Australian Securities Exchange Limited 20 Bridge Street Sydney NSW 2000 Managing Directors Report Good morning ladies and gentlemen. As your Managing Director I warmly welcome you to Cyclopharm’s 2011 Annual General Meeting located here on the beautiful campus of Macquarie University, both the home of Macquarie University Hospital and The Australian School of Advanced Medicine. This is our first AGM located in New South Wales. In having the meeting here your board believed it was an ideal opportunity to show you the fruits of our labor. Across the street is located a couple of other firsts as well. Located on Basement 2 is our first cyclotron facility, CycloPet, and on the ground floor you can find our first medical imaging joint venture, Macquarie Medical Imaging. Following the formal meeting today, I welcome you all to join me on a tour of the facilities that your continued support has made possible. I am certain you will be impressed with what you see. Since 1986, our company has been saving lives every day. Your company was founded and continues to leverage off the global success of Technegas; however, the company’s transformation that we delivered in 2010 through diversification can best be summarised by stating that we are no longer a one product company. In addition to Technegas, we are now involved in the radiopharmaceutical production of isotopes used in Positron Emission Tomography or PET. The third development in our diversification evolution is our involvement in the Joint Venture MMI, a comprehensive imaging practice that also includes interventional radiology.
    [Show full text]
  • (12) Patent Application Publication (10) Pub. No.: US 2005/0013775 A1 Kotov (43) Pub
    US 2005OO13775A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2005/0013775 A1 Kotov (43) Pub. Date: Jan. 20, 2005 (54) BIOCONJUGATES OF NANOPARTICLES AS (60) Provisional application No. 60/208,631, filed on Jun. RADIOPHARMACEUTICALS 1, 2000. (76) Inventor: Nicholas A. Kotov, Superior, MI (US) Publication Classification Correspondence Address: (51) Int. Cl. ................................................. A61K 51/00 FELLERS SNDER BLANKENSHIP (52) U.S. Cl. ............................................................. 424/1.11 BALEY & TIPPENS THE KENNEDY BUILDING (57) ABSTRACT 321 SOUTH BOSTON SUTE 800 Abioconjugate including a nanoparticle covalently linked to TULSA, OK 74103-3318 (US) a biological vector molecule. The nanoparticle is a generally radioactive metal ion and most typically a metal Sulfide or (21) Appl. No.: 10/774,332 metal oxide. The biological vector molecule is typically a monoclonal antibody or fragment of a monoclonal antibody (22) Filed: Feb. 6, 2004 or a peptide having a known affinity to cancer cells. One or more additional, different biological moieties may be covalently linked to the nanoparticle in addition to the Related U.S. Application Data biological vector molecule to enhance its activity. The bioconjugate of the present invention has utility as an (63) Continuation-in-part of application No. 09/871,166, effective radiopharmaceutical to deliver a radiolabel in filed on May 31, 2001, now Pat. No. 6,689,338. tumor treatment. Patent Application Publication Jan. 20, 2005 Sheet 1 of 3 US 2005/0013775 A1 us 5 S s5 '. 9 5 O - G on I Q O (N r O S 2. N \ y 6 - Patent Application Publication Jan. 20, 2005 Sheet 2 of 3 US 2005/0013775 A1 Lys-NH2 Fig.
    [Show full text]
  • Meeting Report (Pdf)
    Radiometric Methods for Measuring and Modeling Multiphase Systems Report of the 1 st RCM of the CRP F2.20.60, October 15-19, 2012 The originating Section of this publication in the IAEA was: Radioisotopes Products and Radiation Technology Section International Atomic Energy Agency Wagramer Strasse 5 P.O. Box 100 A-1400 Vienna, Austria FOREWORD The first Research Coordination Meeting (RCM) of the Coordinated Research Project (CRP) on Radiometric Methods for Measuring and Modeling Multiphase Systems towards Industrial Processes was held at the headquarters of the International Atomic Energy Agency (IAEA) in Vienna on 15-19 October 2012. The Chief Scientific Investigators of all research contracts and agreements under the CRP participated in the meeting. Six research agreement holders from Norway, France, Poland, Germany, USA and Korea provided assistance to the other RCM participants with their expertise and know-how. The twelve research contract holders from Brazil, Cuba, China, Ghana, Malaysia, Morocco, Pakistan, Poland, Tunisia, Vietnam, India and Peru are with recognized experience in radiotracer and nucleonic measurement systems technologies. Multiphase flow systems are widely used in industrial and environmental processes, and widespread throughout chemical processing, mineral processing, oil production, wastewater treatment, sediment and solids transport, and many others. Optimized design and scale-up of these multiphase flow systems are important in ensuring enhanced performance, economic viability and environmental acceptability. The fluid-dynamic properties of such systems are not yet well understood, which makes the prediction of important process parameters such as flow rate, phase distributions, flow pattern, velocity and turbulent parameters a challenging task. It is therefore necessary to measure them to facilitate the process control and optimization to achieve efficient management of industrial processes.
    [Show full text]
  • Download Author Version (PDF)
    Chemical Society Reviews Near Infrared light responsive nanomaterials in cancer therapeutics Journal: Chemical Society Reviews Manuscript ID: CS-REV-01-2014-000011.R1 Article Type: Review Article Date Submitted by the Author: 07-Mar-2014 Complete List of Authors: Shanmugam, Vijayakumar; National Cheng Kung University, Department of Chemistry Selvakumar, Subramanian; National Cheng Kung University, Department of Chemistry Yeh, Chen-Sheng; National Cheng Kung University, Department of Chemistry Page 1 of 36 Chemical Society Reviews Journal Name ARTICLE Near-infrared light-responsive nanomaterials in cancer therapeutics Vijayakumar Shanmugam ‡ S. Selvakumar ‡ and Chen-Sheng Yeh* Noninvasive techniques, such as breath tests (urea breath test), blood pressure measurements using a sphygmomanometer, and electrocardiography, were employed by a physician to perform classical diagnosis. The use of state-of-the-art noninvasive therapies at the organ level in modern medicine has gradually become possible. However, cancer treatment demands for spatially and temporally controlled noninvasive therapy at the cell level because nonspecific toxicity often causes complicated side effects. To increase survival in cancer patients further, combination therapy and combination drugs are explored which demand for high specificity to avoid combined drug side effects. We believe that high specificity could be obtained by implementing near-infrared (NIR) light-assisted nanoparticles in photothermal therapy, chemotherapy-, and photodynamic therapy. To refine this therapy and subsequently achieve high efficiency, novel nanomaterials have been designed and modified either to enhance the uptake and drug delivery to the cancer site, or control treatment to administer therapy efficiently. These modifications and developments have been demonstrated to achieve special and temporal control when conducting an in vivo xenograft, because the NIR light effectively penetrated the biological tissue.
    [Show full text]