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6Th Symposium on Medical Radioisotopes BOOK OF ABSTRACTS SCK•CEN/22527775 SCK•CEN BA-0092 6th Symposium on Medical Radioisotopes Challenges in production and transport and applications in the presence of HRH Princess Astrid Lamot Conference and Heritage Centre Mechelen | May 11, 2017 SCK•CEN Boeretang 200 BE-2400 MOL Belgium http://www.sckcen.be 6th Symposium on Medical Radioisotopes page 2 of 58 SCK•CEN/22527775 ISC: Public BOOK OF ABSTRACTS SCK•CEN BA-0092 Scientific and organising committee Prof. em. Yvan Bruynseraede | KU Leuven* Pietro Caputo | SCK•CEN Rudy Couwenbergh | ISI* Prof. Filip De Vos | UGent Prof. em. Frank Deconinck | SCK•CEN, VUB and Chair* Prof. em. Michel Giot | UCL* Prof. Serge Goldman | ULB Serge Goossens | ISI and EITA* Prof. Tony Lahoutte | VUB Prof. Renaud Lhommel | UCL Prof. Stéphane Lucas | Unamur Prof. André Luxen | Ulg Bernard Ponsard | SCK•CEN and AIPES* Prof. Jean-Michel Vanderhofstadt | ULg and IRE/IRE EliT Prof. Koen Van Laere | KU Leuven Prof. Eric van Walle | SCK•CEN and KU Leuven Kristel Vermeersch | EITA* Prof. Leonie Wyffels | UAntwerpen Inge van Aert | SCK•CEN* *member of the organising committee © SCK•CEN Studiecentrum voor Kernenergie Centre d’Etude de l’Energie Nucléaire Boeretang 200 BE-2400 MOL Belgium http://www.sckcen.be COPYRIGHT RULES All property rights and copyright are reserved to SCK•CEN. In case of a contractual arrangement with SCK•CEN, the use of this information by a Third Party, or for any purpose other than for which it is intended on the basis of the contract, is not authorized. With respect to any unauthorized use, SCK•CEN makes no representation or warranty, expressed or implied, and assumes no liability as to the completeness, accuracy or usefulness of the information contained in this document, or that its use may not infringe privately owned rights. 6th Symposium on Medical Radioisotopes page 3 of 58 SCK•CEN/22527775 ISC: Public 6th Symposium on Medical Radioisotopes page 4 of 58 SCK•CEN/22527775 ISC: Public Contents Introduction .............................................................................................................................................................................. 7 Programme ................................................................................................................................................................................ 8 Abstracts and biographies ................................................................................................................................................ 11 The new BR2 reactor - perspectives for radioisotope production The MYRRHA accelerator - perspectives for radioisotope production World status on reactor and cyclotron radioisotope production Good Distribution Practice: challenges and implementation Security issues during transport and delivery Urban mobility and Good Distribution Practice Safety and security: general vision by FANC & the upcoming transport regulations Central vs. distributed radiopharmacies The Ge/Ga generator: first evaluation Safety/security issues in the hospital Theranostics Which radionuclide for solid tumour treatment? Degenerative neurological diseases Posters ....................................................................................................................................................................................... 41 Hybrid gold nanoparticles coated with organic polymers and antibodies as platform for cancer theranostics: Cytotoxicity assessment 213Bismuth-labeled nanobodies as a new treatment approach in Targeted Alpha Therapy Producing 225Ac at CERN-MEDICIS via combined Resonant Laser Ionization and Mass Separation Cyclotron produced terbium radionuclides for theranostic applications Analysis of Laser Resonance Ionization of Lutetium for the MEDICIS project Separation of radium and actinium from historical Th-229 sources for production of radioisotopes for targeted alpha immunotherapy A type B container for the transport of isotopes for medical purpose: design’s strategies and shielding characterization CERN-MEDICIS: A new facility for the production of innovative medical radioisotopes Visual reading of amyloid-PET in MCI challenged: should we consider alternative methods? Large scale production of 11C for PET-aided hadron therapy Purification of medical 153Sm using radiation-resistant ionic liquids 6th Symposium on Medical Radioisotopes page 5 of 58 SCK•CEN/22527775 ISC: Public 6th Symposium on Medical Radioisotopes page 6 of 58 SCK•CEN/22527775 ISC: Public Introduction Dear participants, Welcome to the 6th edition of the Symposium on Medical Radioisotopes. The very first edition of the symposium was organised in 2007 by SCK•CEN in Mol, Belgium. Since, very successful editions were organised at SCK•CEN, at the Royal Military Academy and at the Palace of the Academies. The organisation of the symposium is an initiative by the European Isotope Transport Association (EITA), Isotopes Services International (ISI) and the Belgian Nuclear Research Centre SCK•CEN. It brings together international researchers, suppliers, service providers and users who take an active interest in the benefits of radioisotopes for healthcare. This 6th edition strives to: Promote the exchange of information about the perspectives of the world production of medical radioisotopes during the next decade; Stimulate the discussion on challenges related to the distribution processes including safety, security, transparency and prompt delivery; Present breakthroughs of research in radiopharmacy, medical imaging and nuclear medicine; Describe new Belgian industrial and research initiatives. The quality of the invited talks and posters by researchers in the field guarantees that this 6th edition of the Symposium will once again reflect the interest of all stakeholders for a sustainable and timely access to radioisotopes for research, diagnosis and therapy. On behalf of the Organising and Scientific Committee, I thank all authors, chairs and participants for their valuable contributions and presence. Also, very sincere thanks to our generous sponsors for supporting the organisation of this symposium. Prof. em. Frank Deconinck Chair of the Organising Committee 6th Symposium on Medical Radioisotopes page 7 of 58 SCK•CEN/22527775 ISC: Public Programme 08:15 – 09:00 Registration and welcome coffee 09:15 – 09:30 Opening Formal opening | Frank Deconinck, Conference Chair Introductory address | Bart Somers, Mayor of Mechelen 09:30 – 10:30 Session 1: Radioisotope production | Chair: Jean-Michel Vanderhofstadt 1: The new BR2 reactor - perspectives for radioisotope production | Bernard Ponsard (SCK•CEN and AIPES) 2: The MYRRHA accelerator - perspectives for radioisotope production | Lucia Popescu (SCK•CEN) 3: World status on reactor and cyclotron radioisotope production | Richard Zimmermann (MEDraysintell) 10:30 – 11:00 Coffee break and poster session 11:00 – 12:00 Session 2: Radioisotope Transport and Good Distribution Practice | Chair: Yvan Bruynseraede 4: Good Distribution Practice: challenges and implementation | Rob Dekkers (GE Healthcare and AIPES) 5: Security issues during transport and delivery | Yvan De Mesmaeker (ECSA) 6: Urban mobility and Good Distribution Practice | Milena Janjevic (ULB) 12:00 – 12:30 Special highlight by the Federal Agency for Nuclear Control | Chair: Michel Giot 7: Safety and security: general vision by FANC | Rony Dresselaers, Director Security & Transport (FANC) 8: The upcoming transport regulations | Rony Dresselaers, Director Security & Transport (FANC) 12:30 – 14:00 Lunch and poster session 6th Symposium on Medical Radioisotopes page 8 of 58 SCK•CEN/22527775 ISC: Public 14:00 – 15:00 Session 3: Radiopharmaceuticals | Chair: Filip De Vos 9: Central vs. distributed radiopharmacies | Vicky Caveliers (UZBrussel, VUB) 10: The Ge/Ga generator: first evaluation | Philippe van Put (IRE-ELiT) 11: Safety/security issues in the hospital | Myriam Monsieurs (UGent) 15:00 – 16:00 Session 4: Medical Radioisotope Applications | Chair: Serge Goldman 12: Theranostics | Patrick Flamen (Bordet Institute) 13: Which radionuclide for solid tumour treatment? | Stéphane Lucas (UNamur) 14: Degenerative neurological diseases | Rik Vandenberghe (KU Leuven) 16:00 – 16:15 Poster prize ceremony Serge Goossens | CEO ISI & President EITA 16:15 – 16:30 Conclusions and closure Kristoff Muylle | President EANM 16:30 – 17:00 Reception 6th Symposium on Medical Radioisotopes page 9 of 58 SCK•CEN/22527775 ISC: Public 6th Symposium on Medical Radioisotopes page 10 of 58 SCK•CEN/22527775 ISC: Public Frank Deconinck Professor Emeritus Conference Chair Frank Deconinck obtained his PhD in Medical Physics from the Vrije Universiteit Brussel (VUB). He was research associate at the University of California (UCSF) and research collaborator at Brookhaven National Laboratory. He is professor emeritus of medical physics at VUB. In the nuclear field, he is honorary chairman of the board of governors of the Belgian Nuclear Research Centre (SCK•CEN), vice-president of Belgonucléaire NV, member of the French Commission Nationale d'Evaluation (CNE), president of the Belgian Hadron Therapy Centre foundation and honorary president of the European Nuclear Society. He coordinates Rad4Med.be, the Belgian network for radiation applications in healthcare. In the socio-cultural field he organised, together with Mrs. Deconinck-De Ries, the exhibition “Tactile Graphic Art”, selected by UNESCO for the U.N. World decade for cultural development. Exhibitions were held in Belgium, Paris (UNESCO), Köln, Taejou, Osaka,
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