Brain (2001), 124, 1020–1032 The role of the striatum and hippocampus in planning A PET activation study in Parkinson’s disease Alain Dagher,1,4 Adrian M. Owen,3 Henning Boecker1 and David J. Brooks1,2 1MRC Clinical Sciences Centre, Imperial College School of Correspondence to: Alain Dagher, MD, Montreal Medicine, Hammersmith Hospital, 2Institute of Neurology, Neurological Institute, 3801 University Street, Montreal, London, 3MRC Cognition and Brain Sciences Unit, Que´bec, Canada H3A 2B4 Cambridge, UK and 4McConnell Brain Imaging Centre, E-mail:
[email protected] Montreal Neurological Institute, McGill University, Montre´al, Que´bec, Canada Summary Previous work has identified the prefrontal cortex (PFC) in the control group, this was not evident in the and striatum as participating in the planning and Parkinson’s disease patients. This suggests that normal selection of movements. We compared the brain normal frontal lobe activation can occur in Parkinson’s activation patterns during planning in Parkinson’s disease despite abnormal processing within the basal 15 disease patients and age-matched controls using H2 O- ganglia. Moreover, right hippocampus activity was PET and the Tower of London (TOL) task. In this suppressed in the controls and enhanced in the study, our mildly affected Parkinson’s disease group Parkinson’s disease patients. This could represent a performed as well as the control group but showed a shift to the declarative memory system in Parkinson’s different pattern of neuronal activation. In the two disease during performance of the TOL task, possibly groups, overlapping areas of the PFC were activated resulting from insufficient working memory capacity but, whereas the right caudate nucleus was activated within the frontostriatal system.