SUPPLEMENTARY TABLE S1. List of 19 MM cell lines used in this study. No Cell line Source 1 NCI-H28 ATCC 2 NCI-H2452 ATCC 3 NCI-H2052 ATCC 4 MSTO-211H ATCC 5 ACC-MESO-1 RBCCB 6 ACC-MESO-4 RBCCB 7 HMMME RBCCB 8 ONE58 ECACC 9 NO36 ECACC 10 LO68 ECACC 11 Mero-14 ECACC 12 Mero-25 ECACC 13 Mero-41 ECACC 14 Mero-48a ECACC 15 Mero-82 ECACC 16 Mero-83 ECACC 17 Mero-84 ECACC 18 Mero-95 ECACC 19 NCI-H226 ATCC Abbreviations: ATCC, American Type Culture Collection (Manassas,VA); RBCCB, RIKEN BioResource Center Cell Bank (Tsukuba, Japan); ECACC, European Collection of Cell Cultures (Salisbury, UK). SUPPLEMENTARY TABLE S2. Clinicopathological characteristics of 23 MM cases subjected to targeted exon sequ Asbestos Pathological Sample Tumor / normal Gender Age Smoking Surgery exposure type CT-1T Tumor and normal F 40 no yes B panpleuropneumonectomy CT-2T Tumor and normal M 51 yes no E panpleuropneumonectomy CT-3T Tumor and normal M 50 yes no B panpleuropneumonectomy CT-4T Tumor and normal M 56 yes no E panpleuropneumonectomy CT-5T Tumor and normal M 67 yes no E panpleuropneumonectomy CT-6T Tumor and normal M 60 yes yes B panpleuropneumonectomy CT-7T Tumor and normal M 48 yes no E panpleuropneumonectomy CT-9T Tumor and normal M 46 no no B panpleuropneumonectomy CT-10T Tumor and normal M 54 yes yes E panpleuropneumonectomy CT-11T Tumor and normal M 61 yes yes B panpleuropneumonectomy CT-12T Tumor and normal M 50 yes no E panpleuropneumonectomy CT-13T Tumor and normal F 56 no no E panpleuropneumonectomy CT-14T Tumor and normal M 62 yes yes E panpleuropneumonectomy CT-15T Tumor and normal M 66 no yes B panpleuropneumonectomy CT-18T Tumor and normal M 61 yes unknown S panpleuropneumonectomy CT-19T Tumor and normal M 68 yes yes B panpleuropneumonectomy CT-20T Tumor and normal M 60 yes unknown E panpleuropneumonectomy CT-21T Tumor and normal M 71 yes yes S panpleuropneumonectomy CT-22T Tumor and normal M 58 yes no E panpleuropneumonectomy CT-23T Tumor and normal F 52 yes unknown E panpleuropneumonectomy CT-24T Tumor and normal M 65 yes yes B panpleuropneumonectomy CT-33T Tumor and normal M 55 yes yes B panpleuropneumonectomy CT-46T Tumor and normal M 41 yes unknown B panpleuropneumonectomy Abbreviations: B, Biphasic; E, Epithelial; S, Sarcomatous; F, Female; M, Male. SUPPLEMENTARY TABLE S3. Hippo pathway genes sequenced in this study. Gene symbol Target HGNC ID Function Location LATS1 exon + intron HGNC:6514 LATS, large tumor suppressor, homolog 1 (Drosophila) 6q25.1 LATS2 exon + intron HGNC:6515 LATS, large tumor suppressor, homolog 2 (Drosophila) 13q11-q12 FAT4 exon HGNC:23109 FAT tumor suppressor homolog 4 (Drosophila) 4q28.1 CRB1 exon HGNC:2343 crumbs homolog 1 (Drosophila) 1q31-q32.1 CRB2 exon HGNC:18688 crumbs homolog 2 (Drosophila) 9q33.2 CRB3 exon HGNC:20237 crumbs homolog 3 (Drosophila) 19p13.3 NF2 exon HGNC:7773 neurofibromin 2 (merlin) 22q12.2 FRMD1 exon HGNC:21240 FERM domain containing 1 6q27 RASSF2 exon HGNC:9883 Ras association (RalGDS/AF-6) domain family member 2 20p13 RASSF3 exon HGNC:14271 Ras association (RalGDS/AF-6) domain family member 3 12q14.2 RASSF4 exon HGNC:20793 Ras association (RalGDS/AF-6) domain family member 4 10q11.1 RASSF5 exon HGNC:17609 Ras association (RalGDS/AF-6) domain family member 5 1q31 RASSF6 exon HGNC:20796 Ras association (RalGDS/AF-6) domain family member 6 4q21.1 KIBRA exon HGNC:29435 WW and C2 domain containing 1 5q34 MST2 exon HGNC:11406 serine/threonine kinase 3 8q22.2 MST3 exon HGNC:11403 serine/threonine kinase 24 13q31.2-q32.3 MST4 exon Gene ID: 51765 Serine/threonine protein kinase MST4 Xq26.2 MOB3C exon HGNC:29800 MOB kinase activator 3C 1p34.1 MOB4 exon HGNC:17261 MOB family member 4, phocein 2q33.1 MOB1B exon HGNC:29801 MOB kinase activator 1B 4q13.3 MOB2 exon HGNC:24904 MOB kinase activator 2 11p15.5 MOB3A exon HGNC:29802 MOB kinase activator 3A 19p13.3 MOB3B exon HGNC:23825 MOB kinase activator 3B 9p21.1 FRMD6 exon HGNC:19839 FERM domain containing 6 14q22.1 RASSF1A exon HGNC:9882 Ras association (RalGDS/AF-6) domain family member 1 3p21.3 SAV1 exon HGNC:17795 salvador homolog 1 (Drosophila) 14q13-q23 MST1 exon HGNC:7380 macrophage stimulating 1 (hepatocyte growth factor-like) 3p21 MOB1A exon HGNC:16015 MOB kinase activator 1A 2p13.1 TAZ exon HGNC:11577 tafazzin Xq28 YWHAB exon HGNC:12849 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 20q13.1 YWHAE exon HGNC:12851 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 17p13.3 YWHAG exon HGNC:12852 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 7q11.23 YWHAH exon HGNC:12853 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide 22q12.1-q13.1 YWHAQ exon HGNC:12854 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide 2p25.2-p25.1 YWHAZ exon HGNC:12855 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 8q22.3 YWHAS exon HGNC:10773 stratifin 1p36.11 TEAD1 exon HGNC:11714 TEA domain family member 1 (SV40 transcriptional enhancer factor) 11p15.4 TEAD2 exon HGNC:11715 TEA domain family member 2 19q13.3 TEAD3 exon HGNC:11716 TEA domain family member 3 6p21.2 TEAD4 exon HGNC:11717 TEA domain family member 4 12p13.3-p13.2 SUPPLEMENTARY TABLE S4. Whole-exon sequencing of 6 MM cell lines. No. Gene symbol Chr RefSeqb cDNA Amino acid Type 211H H2452 H28 MESO4 H2052 MESO1 1 EI24 11 NM_001007277 c.732_733insC p.R244fs frameshift insertion ○ ○ ○ ○ ○ ○ 2 KRTAP4-8 17 NM_031960 c.C204A p.S68R nonsynonymous SNV - - ○ - - ○ KRTAP4-8 17 NM_031960 c.2_3insA p.M1fs frameshift insertion ○ ○ ○ ○ ○ ○ 3 PRIM2 6 NM_000947 c.889_890insA p.E297fs frameshift insertion ○ ○ ○ ○ ○ ○ PRIM2 6 NM_000947 c.C916T p.R306X stopgain SNV - ○ - - - - 4 PRSS1 7 NM_002769 c.A508G p.K170E nonsynonymous SNV ○ ○ - - ○ ○ PRSS1 7 NM_002769 c.G512A p.C171Y nonsynonymous SNV ○ - - ○ - - PRSS1 7 NM_002769 c.G542A p.S181N nonsynonymous SNV ○ ○ ○ ○ ○ ○ 5 PRSS2 7 NM_002770 c.C10T p.P4S nonsynonymous SNV - - ○ ○ - - PRSS2 7 NM_002770 c.C47T p.T16I nonsynonymous SNV ○ ○ ○ ○ ○ ○ PRSS2 7 NM_002770 c.C95A p.S32Y nonsynonymous SNV ○ ○ ○ ○ ○ ○ 6 PRSS3 9 NM_001197098 c.284_285del p.95_95del frameshift deletion ○ - ○ - - - PRSS3 9 NM_001197098 c.A493G p.K165E nonsynonymous SNV - ○ - - - - PRSS3 9 NM_001197098 c.G524A p.S175N nonsynonymous SNV ○ ○ ○ ○ ○ ○ PRSS3 9 NM_001197098 c.639delT p.C213fs frameshift deletion - - ○ - - - 7 ZNF595 4 NM_182524 c.600_601insA p.Y200fs frameshift insertion ○ ○ ○ ○ ○ ○ 8 DDHD1 14 NM_001160148 c.337_338insGGCGGC p.S113delinsGGS nonframeshift insertion ○ ○ - ○ ○ ○ 9 KRT10 17 NM_000421 c.1637_1638del p.546_546del frameshift deletion - - ○ - - - KRT10 17 NM_000421 c.1468_1479del p.490_493del nonframeshift deletion ○ - - ○ ○ ○ KRT10 17 NM_000421 c.1473_1477del p.491_493del frameshift deletion - - ○ - - - 10 MLL3 7 NM_170606 c.A11405G p.D3802G nonsynonymous SNV - - - - ○ - MLL3 7 NM_170606 c.2448_2449insA p.Y816_I817delinsX stopgain SNV ○ ○ ○ - - ○ 11 OR1B1 9 NM_001004450 c.45_46insT p.L15fs frameshift insertion ○ ○ ○ ○ ○ - 12 ZAN 7 NM_173059 c.3290_3292del p.1097_1098del nonframeshift deletion - ○ - - ○ - ZAN 7 NM_003386 c.5767_5768insG p.F1923fs frameshift insertion ○ ○ - ○ - ○ 13 ALMS1 2 NM_015120 c.1570_1571insCTC p.S524delinsSP nonframeshift insertion ○ ○ - - ○ ○ 14 FZD1 7 NM_003505 c.264_265insCCG p.Q88delinsQP nonframeshift insertion ○ - ○ - ○ ○ 15 HOXD9 2 NM_014213 c.794_795insGCA p.P265delinsPQ nonframeshift insertion ○ ○ ○ ○ - - 16 KDM6B 17 NM_001080424 c.752_753insACCACC p.L251delinsLPP nonframeshift insertion - ○ - - ○ - KDM6B 17 NM_001080424 c.753_755del p.251_252del nonframeshift deletion - - - ○ - - KDM6B 17 NM_001080424 c.C1881G p.S627R nonsynonymous SNV - - ○ - - - 17 SLC9B1 4 NM_139173 c.1338_1339del p.446_447del frameshift deletion - - ○ ○ ○ ○ 18 AHNAK 11 NM_001620 c.C8897T p.P2966L nonsynonymous SNV ○ - - - - - AHNAK 11 NM_001620 c.C7225T p.P2409S nonsynonymous SNV - - - - ○ - AHNAK 11 NM_001620 c.C5565G p.I1855M nonsynonymous SNV - - - - - ○ 19 C15orf40 15 NM_001160113 c.396_397insT p.L132fs frameshift insertion ○ ○ - - - - C15orf40 15 NM_001160113 c.395delT p.L132X stopgain SNV - - - - - ○ 20 CDC27 17 NM_001114091 c.C818G p.A273G nonsynonymous SNV ○ - - ○ ○ - 21 COL6A6 3 NM_001102608 c.T3410C p.I1137T nonsynonymous SNV ○ - - - - - COL6A6 3 NM_001102608 c.C3883T p.R1295X stopgain SNV - - - - ○ - COL6A6 3 NM_001102608 c.T5542C p.F1848L nonsynonymous SNV - - ○ - - - 22 LOC388946 2 NM_001145051 c.462delG p.E154fs frameshift deletion ○ - - - ○ ○ 23 MAGEF1 3 NM_022149 c.477_478insGGA p.D159delinsED nonframeshift insertion ○ ○ ○ - - - 24 MCC 5 NM_001085377 c.64_65insGGC p.S22delinsGS nonframeshift insertion - ○ - ○ - ○ 25 MEGF9 9 NM_001080497 c.89_94del p.30_32del nonframeshift deletion - ○ ○ ○ - - 26 NBPF9 1 NM_001037675 c.116_117insAG p.K39fs frameshift insertion ○ ○ - ○ - - 27 NUDT11 X NM_018159 frameshift deletion ○ - - ○ - ○ 28 OVGP1 1 NM_002557 c.1560_1561insA p.G520fs frameshift insertion ○ - - - ○ ○ 29 RBMX X NM_002139 c.906_907insCC p.P302fs frameshift insertion ○ - - - ○ - RBMX X NM_002139 c.316_317insTT p.P106fs frameshift insertion ○ - ○ - ○ - 30 TDG 12 NM_003211 c.286_287insA p.E96fs frameshift insertion - ○ ○ ○ - - 31 ZFHX3 16 NM_001164766 c.2482_2483insCAA p.A828delinsQA nonframeshift insertion - - ○ - - - ZFHX3 16 NM_001164766 c.2476_2481del p.826_827del nonframeshift deletion - - - - - ○ ZFHX3 16 NM_006885 c.C1114G p.R372G nonsynonymous SNV - - - ○ - - 32 ABCA7 19 NM_019112 c.1180_1190del p.394_397del frameshift deletion - - ○ - - - ABCA7 19 NM_019112 c.C3808T p.R1270W nonsynonymous SNV - - - ○ - - ABCA7 19 NM_019112 c.A4762G p.M1588V nonsynonymous SNV - - ○ - - - 33 ADAMTS19 5 NM_133638 c.594_595insCCCGGC p.N198delinsNPG nonframeshift insertion - - - - ○ ○ 34 AKNA 9 NM_030767 c.C1450T p.H484Y nonsynonymous SNV - ○ - - - - AKNA 9 NM_030767 c.A647T p.D216V nonsynonymous SNV ○ - - - - - 35 ANK1 8 NM_020477 c.G3727A p.V1243I nonsynonymous SNV - - ○ - - - ANK1 8 NM_020477 c.G3235A p.E1079K nonsynonymous SNV - - - ○ - - ANK1 8 NM_020477 c.A1979G p.N660S nonsynonymous SNV - - - ○ - - 36 ANK3 10 NM_020987 c.G6632A p.S2211N nonsynonymous SNV - - - ○ - - ANK3 10 NM_020987 c.T4043C p.F1348S nonsynonymous SNV - - - - - ○ 37 ANKS1B 12 NM_152788 c.G2215T p.D739Y nonsynonymous SNV - - - ○ - - ANKS1B 12 NM_152788 c.A1439G p.D480G nonsynonymous SNV - - ○ - - - 38 ANKZF1 2 NM_001042410 c.T422C p.L141S nonsynonymous SNV - - ○ - - - ANKZF1 2 NM_001042410 c.G1999A p.A667T nonsynonymous SNV - - - - - ○ 39 ASPHD1 16 NM_181718 c.510_511insGGT p.Q170delinsQG nonframeshift insertion ○ ○ - - - - 40 BAIAP2L2 22 NM_025045 c.1235_1236insC p.N412fs frameshift insertion - - - ○ - ○ 41 COBL 7 NM_015198 c.G3400A p.G1134R nonsynonymous SNV - - ○ - - - COBL 7 NM_015198 c.T3118G p.S1040A nonsynonymous SNV ○ - - - - - 42 CRIPAK 4 NM_175918 c.76_77insCA p.S26fs frameshift insertion - ○ - - - ○ CRIPAK 4 NM_175918 c.C332G p.P111R nonsynonymous SNV - ○ - - - ○ 43 CROCC 1 NM_014675 c.C1478T p.P493L nonsynonymous SNV ○ - ○ - - - 44 CSMD1 8 NM_033225 c.A6914G p.Q2305R nonsynonymous SNV - - ○ - - - CSMD1 8 NM_033225 c.C6396A p.N2132K nonsynonymous SNV - ○ - - - - 45 DNMT3L 21 NM_175867 c.G325A p.G109R nonsynonymous SNV ○ - - - - - DNMT3L 21 NM_175867 c.G85T p.V29F nonsynonymous SNV - - ○ - - - 46 DOCK6 19 NM_020812 c.C4012T p.R1338X stopgain SNV - ○ - - - - DOCK6 19 NM_020812 c.G1258A p.E420K nonsynonymous SNV - - - ○ - - 47 F13A1 6 NM_000129 c.C1150T p.P384S nonsynonymous SNV - - - - - ○ F13A1 6 NM_000129 c.C83A p.P28H nonsynonymous SNV - ○ - - - - 48 FAM132A 1 NM_001014980 c.G745A p.V249I nonsynonymous SNV - - - ○ - - FAM132A 1 NM_001014980 c.C238G p.R80G nonsynonymous SNV ○ - - - - - 49 FAM171B 2 NM_177454 c.129_130insCAG p.Q43delinsQQ nonframeshift insertion - ○ ○ - - - 50 FAM22A 10 NM_001099338 c.2438_2440del p.813_814del nonframeshift deletion - - - ○ - ○ 51 FAM22F 9 NM_017561 c.C1766G p.A589G nonsynonymous SNV - - - ○ - ○ 52 FAM58A X NM_001130997 c.53_54insG p.A18fs frameshift insertion - - ○ - - ○ FAM58A X NM_001130997 c.17_18insG p.A6fs frameshift insertion - - - - - ○ 53 FAM75C2 9 NM_001166137 c.3013_3014insCCT p.S1005delinsPS nonframeshift insertion - - ○ - - - FAM75C2 9 NM_001166137 c.T1030C p.W344R nonsynonymous SNV - - - - - ○ 54 FER1L6 8 NM_001039112 c.G3478A p.V1160I nonsynonymous SNV - - ○ - - - FER1L6 8 NM_001039112 c.5436delC p.C1812fs frameshift deletion - - - - - ○ 55 FLG 1 NM_002016 c.G9830T p.R3277L nonsynonymous SNV - - - - - ○ FLG 1 NM_002016 c.G2857C p.E953Q nonsynonymous SNV - - ○ - - - 56 FNDC1 6 NM_032532 c.T4583A p.M1528K nonsynonymous SNV - - ○ - - - FNDC1 6 NM_032532 c.A4697C p.E1566A nonsynonymous SNV - - - ○ - - 57 FRG2B 10 NM_001080998 c.A511C p.I171L nonsynonymous SNV - - ○ - ○ - FRG2B 10 NM_001080998 c.G485A p.R162Q nonsynonymous SNV - - ○ - ○ - 58 GTF2I 7 NM_032999 c.1398_1401del p.466_467del frameshift deletion - - - ○ - ○ 59 HTR3D 3 NM_001163646 c.G154A p.A52T nonsynonymous SNV - - ○ - - - HTR3D 3 NM_182537 c.C706T p.H236Y nonsynonymous SNV - - - - ○ - 60 MYO1H 12 NM_001101421 c.G169A p.E57K nonsynonymous SNV - - - - - ○ MYO1H 12 NM_001101421 c.666_678del p.222_226del frameshift deletion - - ○ - - - 61 NBPF10 1 NM_001039703 c.G10373T p.R3458M nonsynonymous SNV - - - ○ ○ - 62 NUP88 17 NM_002532 c.A2149C p.I717L nonsynonymous SNV ○ - - - - - NUP88 17 NM_002532 c.T1928C p.L643P nonsynonymous SNV - - ○ - - - 63 OBSL1 2 NM_015311 c.G2887A p.E963K nonsynonymous SNV ○ - - - - - OBSL1 2 NM_015311 c.G751T p.A251S nonsynonymous SNV - - ○ - - - 64 OR5AU1 14 NM_001004731 c.A1034T p.N345I nonsynonymous SNV - - - - - ○ OR5AU1 14 NM_001004731 c.686_688del p.229_230del nonframeshift deletion - - ○ - - - 65 OR5K3 3 NM_001005516 c.897_898insA p.M299fs frameshift insertion - - ○ - ○ - 66 PABPC3 13 NM_030979 c.761_762insT p.K254fs frameshift insertion - - - ○ ○ - 67 PKD1L2 16 NM_052892 c.G7050T p.W2350C nonsynonymous SNV - - ○ - - - PKD1L2 16 NM_052892 c.T220C p.F74L nonsynonymous SNV - - - ○ - - 68 PLCD4 2 NM_032726 c.G406C p.D136H nonsynonymous SNV ○ - - - - - PLCD4 2 NM_032726 c.T1961A p.L654Q nonsynonymous SNV - - - ○ - - 69 PLEC 8 NM_201381 c.G5557A p.A1853T nonsynonymous SNV - - - ○ - - PLEC 8 NM_201381 c.G1621A p.E541K nonsynonymous SNV - ○ - - - - 70 PLIN5 19 NM_001013706 c.C1238T p.P413L nonsynonymous SNV - - ○ - - - PLIN5 19 NM_001013706 c.G1043A p.R348Q nonsynonymous SNV - ○ - - - - 71 PRDM15 21 NM_022115 c.263_264insC p.R88fs frameshift insertion ○ ○ - - - - 72 RAB32 6 NM_006834 c.5_6insG p.A2fs frameshift insertion ○ ○ - - - - 73 RABL2A 2 NM_013412 c.231delG p.T77fs frameshift deletion - - - ○ - ○ 74 ROBO4 11 NM_019055 c.G1345A p.E449K nonsynonymous SNV - ○ - - - - ROBO4 11 NM_019055 c.A1210G p.T404A nonsynonymous SNV - - - - - ○ 75 SEC16A 9 NM_014866 c.G3934A p.E1312K nonsynonymous SNV - - ○ - - - SEC16A 9 NM_014866 c.C1921T p.R641C nonsynonymous SNV - - - ○ - - 76 SIGLEC1 20 NM_023068 c.T3902C p.L1301P nonsynonymous SNV - - - ○ - - SIGLEC1 20 NM_023068 c.C2474A p.A825D nonsynonymous SNV - - - - ○ - 77 SLC35B1 17 NM_005827 c.222delT p.F74fs frameshift deletion - ○ - - - - SLC35B1 17 NM_005827 c.T173C p.I58T nonsynonymous SNV - - ○ - - - 78 SPATA21 1 NM_198546 c.1084_1085insAAG p.L362delinsKL nonframeshift insertion ○ - ○ - - - 79 SPTBN5 15 NM_016642 c.G8449T p.A2817S nonsynonymous SNV - - - ○ - - SPTBN5 15 NM_016642 c.G254A p.R85Q nonsynonymous SNV - - ○ - - - 80 SREK1 5 NM_001077199 c.C581T p.T194M nonsynonymous SNV - - - ○ - ○ 81 SSPO 7 NM_198455 c.2059_2060insC p.T687fs frameshift insertion - - ○ - - - SSPO 7 NM_198455 c.C11332T p.R3778W nonsynonymous SNV - - - - - ○ 82 TNRC18 7 NM_001080495 c.C5428T p.R1810C nonsynonymous SNV - - - - - ○ TNRC18 7 NM_001080495 c.G457A p.D153N nonsynonymous SNV - - - ○ - - 83 TRIM64C 11 NM_001206631 c.A1019G p.K340R nonsynonymous SNV - - - - ○ - TRIM64C 11 NM_001206631 c.G55A p.V19M nonsynonymous SNV - - ○ - - - 84 UTRN 6 NM_007124 c.C1210T p.L404F nonsynonymous SNV - - - ○ - - UTRN 6 NM_007124 c.T2921C p.L974P nonsynonymous SNV - ○ - - - - 85 ZFYVE19 15 NM_001077268 c.112_113insGGGGC p.W38fs frameshift insertion - ○ - ○ - - 86 ABCA10 17 NM_080282 c.3697_3698insTTCCAGGT p.E1233fs frameshift insertion - - ○ - - - 87 ABCA13 7 NM_152701 c.G11230T p.A3744S nonsynonymous SNV - - - - - ○ 88 ABCC1 16 NM_019862 c.T4090A p.C1364S nonsynonymous SNV - ○ - - - - 89 ABCC4 13 NM_001105515 c.A847G p.I283V nonsynonymous SNV - - - - ○ - 90 ACAD10 12 NM_025247 c.T1705A p.S569T nonsynonymous SNV - - - ○ - - 91 ACAP1 17 NM_014716 c.C1747T p.P583S nonsynonymous SNV - ○ - - - - 92 ACCS 11 NM_032592 c.A485G p.E162G nonsynonymous SNV - - - - ○ - 93 ACE 17 NM_001178057 c.G22A p.A8T nonsynonymous SNV - - - ○ - - 94 ACLY 17 NM_198830 c.G1139T p.G380V nonsynonymous SNV - - ○ - - - 95 ACOT8 20 NM_005469 c.910delC p.Q304fs frameshift deletion - - - - ○ - 96 ACSM2B 16 NM_001105069 c.C187T p.R63X stopgain SNV - - - ○ - - 97 ACTL8 1 NM_030812 c.G584A p.R195K nonsynonymous SNV - - - ○ - - 98 ADAM15 1 NM_207196 c.G1416T p.Q472H nonsynonymous SNV - - - ○ - - 99 ADAM29 4 NM_001130704 c.2068_2070del p.690_690del nonframeshift deletion - - - - ○ - 100 ADAMTS16 5 NM_139056 c.A740G p.H247R nonsynonymous SNV - - - - - ○ 101 ADAMTS20 12 NM_025003 c.G5648A p.G1883E nonsynonymous SNV - - - ○ - - 102 ADAMTSL1 9 NM_001040272 c.T4987C p.S1663P nonsynonymous SNV - ○ - - - - 103 ADRA2B 2 NM_000682 c.C539T p.S180F nonsynonymous SNV - ○ - - - - 104 AFF3 2 NM_002285 c.1781_1785del p.594_595del frameshift deletion - - - - ○ - 105 AGAP6 10 NM_001077665 c.1338_1351del p.446_451del frameshift deletion - - - - - ○ 106 AGPAT2 9 NM_001012727 c.52_53insCTG p.V18delinsLV nonframeshift insertion - ○ - - - - 107 AGTPBP1 9 NM_015239 c.A1412G p.Q471R nonsynonymous SNV ○ - - - - - 108 AGXT2L2 5 NM_153373 c.C1210G p.P404A nonsynonymous SNV - ○ - - - - 109 AHI1 6 NM_001134832 c.A199G p.I67V nonsynonymous SNV - - ○ - - - 110 AIFM3 22 NM_001018060 c.T721C p.S241P nonsynonymous SNV ○ - - - - - 111 AIM1 6 NM_001624 c.1786delC p.P596fs frameshift deletion - - - ○ - - 112 AKAP3 12 NM_006422 c.2103_2104insG p.G701fs frameshift insertion - - - - - ○ 113 AKD1 6 NM_001145128 c.G4205A p.R1402H nonsynonymous SNV - - ○ - - - 114 ALDH7A1 5 NM_001202404 c.A1126G p.I376V nonsynonymous SNV - - - ○ - - 115 ALOX15 17 NM_001140 c.218_228del p.73_76del frameshift deletion - - - - - ○ 116 ALOX15B 17 NM_001039131 c.A677G p.E226G nonsynonymous SNV - - - ○ - - 117 ALOXE3 17 NM_021628 c.G1469C p.C490S nonsynonymous SNV ○ - - - - - 118 ALS2CR8 2 NM_001104586 c.C2056T p.L686F nonsynonymous SNV - - ○ - - - 119 ANK2 4 NM_001148 c.G6361T p.D2121Y nonsynonymous SNV - - - ○ - - 120 ANKAR 2 NM_144708 c.T3577A p.F1193I nonsynonymous SNV - - - ○ - - 121 ANKLE2 12 NM_015114 c.C1807T p.L603F nonsynonymous SNV - - - ○ - - 122 ANKRD10 13 NM_017664 c.T562G p.F188V nonsynonymous SNV - - - ○ - - 123 ANKRD11 16 NM_013275 c.A5213G p.D1738G nonsynonymous SNV - - - - ○ - 124 ANKRD24 19 NM_133475 c.G1827A p.M609I nonsynonymous SNV ○ - - - - - 125 ANKRD32 5 NM_032290 c.C295T p.R99C nonsynonymous SNV - ○ - - - - 126 ANKRD36 2 NM_001164315 c.A2828G p.E943G nonsynonymous SNV - - - ○ - - 127 ANO9 11 NM_001012302 c.G1114A p.E372K nonsynonymous SNV - - ○ - - - 128 ANXA1 9 NM_000700 c.T845G p.L282R nonsynonymous SNV - - - ○ - - 129 AP3S1 5 NM_001284 c.69_70insA p.Y23fs frameshift insertion - - - - ○ - 130 APC2 19 NM_005883 c.2519_2520insGGCCAA p.A840delinsAAK nonframeshift insertion - ○ - - - - 131 APCDD1L 20 NM_153360 c.C1106A p.A369D nonsynonymous SNV - - - ○ - - 132 APOB 2 NM_000384 c.G13146C p.M4382I nonsynonymous SNV - - ○ - - - 133 APOBEC3B 22 NM_004900 c.783delG p.L261fs frameshift deletion - - ○ - - - 134 AQP12A 2 NM_198998 c.419delG p.S140fs frameshift deletion - - - ○ - - 135 AQP12B 2 NM_001102467 c.455delG p.S152fs frameshift deletion - - - ○ - - 136 AQPEP 5 NM_173800 c.206delC p.T69fs frameshift deletion ○ - - - - - 137 ARAP1 11 NM_001040118 c.G1414A p.E472K nonsynonymous SNV - - ○ - - - 138 ARAP3 5 NM_022481 c.G2161C p.E721Q nonsynonymous SNV - - ○ - - - 139 ARHGAP32 11 NM_014715 c.G4273A p.D1425N nonsynonymous SNV - - ○ - - - 140 ARHGEF26 3 NM_001251963 c.410_415del p.137_139del nonframeshift deletion - - - - - ○ 141 ARHGEF33 2 NM_001145451 c.G1562C p.S521T nonsynonymous SNV ○ - - - - - 142 ARHGEF7 13 NM_001113512 c.C298T p.R100C nonsynonymous SNV - - - - - ○ 143 ARMC9 2 NM_025139 c.G842A p.S281N nonsynonymous SNV - - ○ - - - 144 ASB15 7 NM_080928 c.C8T p.T3I nonsynonymous SNV - - - ○ - - 145 ASPM 1 NM_001206846 c.C5506A p.Q1836K nonsynonymous SNV - - - ○ - - 146 ATAD1 10 NM_032810 c.A463G p.I155V nonsynonymous SNV - - - ○ - - ATAD1 10 NM_032810 c.C302T p.T101M nonsynonymous SNV - - - ○ - - 147 ATAD5 17 NM_024857 c.A2411G p.Q804R nonsynonymous SNV ○ - - - - - 148 ATP13A3 3 NM_024524 c.G3070A p.G1024S nonsynonymous SNV - - - - ○ - 149 ATP2B4 1 NM_001001396 c.A143G p.Y48C nonsynonymous SNV - - - ○ - - 150 ATP6V1A 3 NM_001690 c.G1824A p.M608I nonsynonymous SNV ○ - - - - - 151 ATXN2L 16 NM_145714 c.C43T p.Q15X stopgain SNV - - ○ - - - 152 AUP1 2 NM_181575 c.A388C p.M130L nonsynonymous SNV - - - ○ - - 153 AVIL 12 NM_006576 c.T1487C p.F496S nonsynonymous SNV - ○ - - - - 154 B4GALT6 18 NM_004775 c.C116T p.A39V nonsynonymous SNV - ○ - - - - 155 BAAT 9 NM_001127610 c.C250T p.P84S nonsynonymous SNV - - ○ - - - 156 BAHCC1 17 NM_001080519 c.G3380A p.R1127Q nonsynonymous SNV - - - - ○ - 157 BAP1 3 NM_004656 c.20delA p.E7fs frameshift deletion - - - ○ - - 158 BBX 3 NM_020235 c.A581G p.Q194R nonsynonymous SNV - - - - ○ - 159 BCAS1 20 NM_003657 c.G1168C p.G390R nonsynonymous SNV - ○ - - - - BCAS1 20 NM_003657 c.C288A p.F96L nonsynonymous SNV - ○ - - - - 160 BMPR1A 10 NM_004329 c.G359A p.R120Q nonsynonymous SNV - - - - - ○ 161 BRCA2 13 NM_000059 c.C7769G p.S2590C nonsynonymous SNV - - ○ - - - 162 BSN 3 NM_003458 c.C1765G p.Q589E nonsynonymous SNV - - ○ - - - 163 BTBD10 11 NM_032320 c.T269C p.V90A nonsynonymous SNV - - - ○ - - 164 BZRAP1 17 NM_004758 c.G5096A p.R1699K nonsynonymous SNV - - - ○ - - 165 C10orf27 10 NM_152710 c.G1014T p.Q338H nonsynonymous SNV - - ○ - - - 166 C11orf40 11 NM_144663 c.286_287insC p.K96fs frameshift insertion - - - - ○ - 167 C11orf41 11 NM_012194 c.T927A p.S309R nonsynonymous SNV - - ○ - - - 168 C14orf135 14 NM_022495 c.2419_2420insTAT p.P807delinsLS nonframeshift insertion - - ○ - - - 169 C16orf71 16 NM_139170 c.T955C p.C319R nonsynonymous SNV - - - ○ - - 170 C17orf57 17 NM_001195192 c.1179_1192del p.393_398del frameshift deletion - - ○ - - - 171 C19orf38 19 NM_001136482 c.C242T p.A81V nonsynonymous SNV - - ○ - - - 172 C19orf50 19 NM_001171949 c.T126A p.N42K nonsynonymous SNV ○ - - - - - 173 C1orf141 1 NM_001013674 c.1017_1021del p.339_341del frameshift deletion - ○ - - - - 174 C1QTNF1 17 NM_198593 c.C56T p.A19V nonsynonymous SNV - - - - ○ - 175 C1QTNF7 4 NM_031911 c.T803C p.F268S nonsynonymous SNV - - - - ○ - 176 C20orf194 20 NM_001009984 c.G3245A p.R1082Q nonsynonymous SNV ○ - - - - - 177 C20orf203 20 NM_182584 c.C133T p.R45W nonsynonymous SNV - - - ○ - - 178 C2orf44 2 NM_025203 c.1592_1609del p.531_537del nonframeshift deletion - - - ○ - - 179 C2orf54 2 NM_001085437 c.G124A p.V42M nonsynonymous SNV ○ - - - - - 180 C2orf61 2 NM_001163561 c.G133A p.A45T nonsynonymous SNV - - ○ - - - 181 C3 19 NM_000064 c.C2700G p.I900M nonsynonymous SNV - - - ○ - - 182 C3orf55 3 NM_001099777 c.C319T p.R107W nonsynonymous SNV - ○ - - - - 183 C3orf77 3 NM_001145030 c.T280C p.S94P nonsynonymous SNV - - ○ - - - 184 C5orf34 5 NM_198566 c.C245T p.P82L nonsynonymous SNV ○ - - - - - 185 C5orf42 5 NM_023073 c.C1115T p.T372M nonsynonymous SNV ○ - - - - - 186 C6orf163 6 NM_001010868 c.G958C p.V320L nonsynonymous SNV ○ - - - - - 187 C6orf165 6 NM_001031743 c.A964G p.I322V nonsynonymous SNV - - ○ - - - 188 C7orf65 7 NM_001123065 c.A241C p.I81L nonsynonymous SNV - - ○ - - - 189 C9orf102 9 NM_001010895 c.C1989G p.H663Q nonsynonymous SNV - - - - ○ - 190 C9orf171 9 NM_207417 c.645_647del p.215_216del nonframeshift deletion - ○ - - - - 191 CACNA1S 1 NM_000069 c.C2467T p.R823W nonsynonymous SNV - - ○ - - - 192 CACNB3 12 NM_001206915 c.C1055G p.S352C nonsynonymous SNV - ○ - - - - 193 CACNG6 19 NM_145815 c.43_44insG p.R15fs frameshift insertion - - - - - ○ 194 CALCA 11 NM_001033953 c.C94G p.L32V nonsynonymous SNV - - ○ - - - CALCA 11 NM_001033953 c.G91C p.A31P nonsynonymous SNV - - ○ - - - 195 CAMK1G 1 NM_020439 c.A976G p.S326G nonsynonymous SNV - ○ - - - - 196 CAPN11 6 NM_007058 c.1914_1915insT p.L638fs frameshift insertion - - ○ - - - 197 CAPN14 2 NM_001145122 c.727_729del p.243_243del nonframeshift deletion - - - - - ○ 198 CARD8 19 NM_001184901 c.292_293insAA p.V98fs frameshift insertion - - - - - ○ 199 CASC4 15 NM_177974 c.A200G p.N67S nonsynonymous SNV - - - ○ - - 200 CASP8AP2 6 NM_001137667 c.C1718G p.P573R nonsynonymous SNV - - - - ○ - CASP8AP2 6 NM_012115 c.4698delG p.L1566fs frameshift deletion - - - - ○ - 201 CATSPER1 11 NM_053054 c.G310A p.A104T nonsynonymous SNV - - - - ○ - 202 CC2D2A 4 NM_001080522 c.4842_4845del p.1614_1615del frameshift deletion ○ - - - - - 203 CCDC102B 18 NM_001093729 c.C176G p.A59G nonsynonymous SNV ○ - - - - - 204 CCDC104 2 NM_080667 c.C814T p.R272X stopgain SNV - - - - - ○ 205 CCDC108 2 NM_194302 c.T1940C p.F647S nonsynonymous SNV - - - - - ○ 206 CCDC39 3 NM_181426 c.2661_2662insT p.L887fs frameshift insertion ○ - - - - - 207 CCDC61 19 NM_001080402 c.T100G p.W34G nonsynonymous SNV - - ○ - - - 208 CCDC78 16 NM_001031737 c.G668A p.R223H nonsynonymous SNV - - ○ - - - 209 CCDC96 4 NM_153376 c.A938C p.K313T nonsynonymous SNV - - ○ - - - 210 CCL17 16 NM_002987 c.A116T p.K39M nonsynonymous SNV ○ - - - - - 211 CCNE2 8 NM_057749 c.125_126insA p.R42fs frameshift insertion - - - ○ - - 212 CCT4 2 NM_006430 c.G1168T p.V390F nonsynonymous SNV - - - ○ - - 213 CD109 6 NM_133493 c.A1862C p.Y621S nonsynonymous SNV - - - ○ - - 214 CDC42BPA 1 NM_014826 c.G4777A p.D1593N nonsynonymous SNV - ○ - - - - 215 CDKN2AIP 4 NM_017632 c.G163A p.A55T nonsynonymous SNV - - ○ - - - 216 CEACAM7 19 NM_006890 c.G475A p.E159K nonsynonymous SNV ○ - - - - - 217 CEACAM8 19 NM_001816 c.A590G p.N197S nonsynonymous SNV - - - - ○ - 218 CEBPZ 2 NM_005760 c.G1409A p.R470Q nonsynonymous SNV - - ○ - - - 219 CEL 9 NM_001807 c.C2176G p.P726A nonsynonymous SNV - ○ - - - - 220 CEP152 15 NM_001194998 c.T2878C p.W960R nonsynonymous SNV - ○ - - - - 221 CEP76 18 NM_024899 c.G1327T p.V443F nonsynonymous SNV - - - ○ - - 222 CHD6 20 NM_032221 c.A4871C p.Q1624P nonsynonymous SNV - - - - - ○ 223 CHD7 8 NM_017780 c.G8615C p.G2872A nonsynonymous SNV ○ - - - - - 224 CHIC2 4 NM_012110 c.C411G p.S137R nonsynonymous SNV - - ○ - - - 225 CHL1 3 NM_006614 c.C3131T p.T1044I nonsynonymous SNV - - - ○ - - 226 CHML 1 NM_001821 c.A1606G p.T536A nonsynonymous SNV - - - ○ - - 227 CHRD 3 NM_003741 c.C2608T p.R870W nonsynonymous SNV - ○ - - - - 228 CHTF18 16 NM_022092 c.C1210T p.R404C nonsynonymous SNV - - - ○ - - 229 CILP 15 NM_003613 c.G3527C p.R1176T nonsynonymous SNV - ○ - - - - 230 CKM 19 NM_001824 c.G109A p.E37K nonsynonymous SNV - - - ○ - - 231 CLASP1 2 NM_001207051 c.G3506A p.G1169E nonsynonymous SNV - - ○ - - - 232 CLCA4 1 NM_012128 c.C2234A p.P745Q nonsynonymous SNV - - - ○ - - 233 CLCN2 3 NM_001171087 c.1884_1885insCCG p.R628delinsRR nonframeshift insertion ○ - - - - - 234 CLDN17 21 NM_012131 c.G358C p.G120R nonsynonymous SNV - - - ○ - - 235 CLDN24 4 NM_001185149 c.C91T p.P31S nonsynonymous SNV - - ○ - - - 236 CLEC11A 19 NM_002975 c.819_820insGCCCA p.G273fs frameshift insertion ○ - - - - - 237 CLN6 15 NM_017882 c.A425G p.Y142C nonsynonymous SNV - - - ○ - - 238 CLSPN 1 NM_022111 c.3595_3597del p.1199_1199del nonframeshift deletion - ○ - - - - 239 CLSTN2 3 NM_022131 c.G2294A p.R765Q nonsynonymous SNV - ○ - - - - 240 CNN2 19 NM_201277 c.C185T p.T62I nonsynonymous SNV - ○ - - - - 241 CNTN6 3 NM_014461 c.G1822A p.D608N nonsynonymous SNV - - ○ - - - 242 COBLL1 2 NM_014900 c.T1376C p.I459T nonsynonymous SNV - - - ○ - - 243 COG5 7 NM_001161520 c.C407T p.T136M nonsynonymous SNV - - - - - ○ 244 COL1A2 7 NM_000089 c.T1536G p.H512Q nonsynonymous SNV - - - - - ○ 245 COL22A1 8 NM_152888 c.A2399C p.K800T nonsynonymous SNV - - - ○ - - 246 COL4A4 2 NM_000092 c.G778A p.V260I nonsynonymous SNV - - ○ - - - 247 COL5A1 9 NM_000093 c.G5263A p.A1755T nonsynonymous SNV - - - - - ○ 248 COL6A3 2 NM_004369 c.T4085A p.F1362Y nonsynonymous SNV - - - ○ - - 249 COL8A2 1 NM_005202 c.G585T p.E195D nonsynonymous SNV - - ○ - - - 250 CORIN 4 NM_006587 c.C2345A p.S782Y nonsynonymous SNV ○ - - - - - 251 CPA2 7 NM_001869 c.T345G p.S115R nonsynonymous SNV ○ - - - - - 252 CPAMD8 19 NM_015692 c.G572A p.R191Q nonsynonymous SNV - - ○ - - - 253 CPNE1 20 NM_152925 c.1204_1205insT p.A402fs frameshift insertion ○ - - - - - 254 CPT1A 11 NM_001031847 c.G1340A p.R447Q nonsynonymous SNV - - ○ - - - 255 CRISP3 6 NM_001190986 c.A371C p.Y124S nonsynonymous SNV - - - ○ - - 256 CRNKL1 20 NM_016652 c.T2258C p.M753T nonsynonymous SNV - - - ○ - - 257 CTCFL 20 NM_080618 c.A1435G p.T479A nonsynonymous SNV - - ○ - - - 258 CTDP1 18 NM_048368 c.C2374T p.P792S nonsynonymous SNV ○ - - - - - 259 CTTNBP2 7 NM_033427 c.4787_4789del p.1596_1597del nonframeshift deletion - - - - - ○ 260 CUX1 7 NM_001202543 c.G3815A p.R1272Q nonsynonymous SNV - - - ○ - - 261 CXorf22 X NM_152632 c.C1432T p.P478S nonsynonymous SNV - - - - - ○ 262 CYLC2 9 NM_001340 c.A1G p.M1V nonsynonymous SNV - ○ - - - - 263 CYP2C8 10 NM_001198854 c.T728C p.M243T nonsynonymous SNV - ○ - - - - 264 CYP4F8 19 NM_007253 c.C97T p.R33C nonsynonymous SNV - - ○ - - - 265 DACT2 6 NM_214462 c.C755T p.P252L nonsynonymous SNV - ○ - - - - 266 DBF4 7 NM_006716 c.A1655G p.H552R nonsynonymous SNV ○ - - - - - 267 DBNDD2 20 NM_001197140 c.G473C p.G158A nonsynonymous SNV - - ○ - - - 268 DCHS2 4 NM_017639 c.6180_6181insAAC p.T2060delinsTT nonframeshift insertion - - ○ - - - 269 DDRGK1 20 NM_023935 c.G440A p.R147Q nonsynonymous SNV - - - - - ○ 270 DGCR2 22 NM_001173534 c.G919A p.V307I nonsynonymous SNV - - - ○ - - 271 DHDDS 1 NM_001243564 c.C867A p.D289E nonsynonymous SNV - - - ○ - - 272 DLGAP2 8 NM_004745 c.A398C p.Q133P nonsynonymous SNV - - - ○ - - 273 DMBT1 10 NM_007329 c.C683A p.S228Y nonsynonymous SNV ○ - - - - - 274 DNAAF1 16 NM_178452 c.T1808C p.L603P nonsynonymous SNV - - - ○ - - 275 DNAH14 1 NM_001373 c.A9725G p.E3242G nonsynonymous SNV - - ○ - - - 276 DNAH9 17 NM_001372 c.A7471G p.K2491E nonsynonymous SNV - - - ○ - - 277 DNAJB12 10 NM_001002762 c.A152C p.K51T nonsynonymous SNV - - - ○ - - 278 DNAJB3 2 NM_001001394 c.C199T p.R67C nonsynonymous SNV - ○ - - - - 279 DNAJC13 3 NM_015268 c.T4343C p.V1448A nonsynonymous SNV - - - ○ - - 280 DNAJC28 21 NM_017833 c.A656G p.N219S nonsynonymous SNV - - ○ - - - 281 DNAJC4 11 NM_005528 c.C208T p.P70S nonsynonymous SNV - ○ - - - - 282 DNAJC7 17 NM_001144766 c.T108A p.D36E nonsynonymous SNV - - - ○ - - 283 DNHD1 11 NM_144666 c.C13264T p.P4422S nonsynonymous SNV - ○ - - - - 284 DPH1 17 NM_001383 c.C1191G p.N397K nonsynonymous SNV - - ○ - - - 285 DSCC1 8 NM_024094 c.T725C p.I242T nonsynonymous SNV - - - ○ - - 286 DYDC2 10 NM_032372 c.T89C p.I30T nonsynonymous SNV - - - ○ - - 287 DYNC1H1 14 NM_001376 c.A4148G p.Y1383C nonsynonymous SNV - - ○ - - - 288 DYNC1I1 7 NM_001135557 c.G662T p.R221L nonsynonymous SNV - - - - - ○ 289 DYNC1LI1 3 NM_016141 c.C1009A p.H337N nonsynonymous SNV - - - ○ - - 290 DYNC2H1 11 NM_001377 c.T9814A p.L3272I nonsynonymous SNV - - ○ - - - 291 EDEM3 1 NM_025191 c.G1573A p.D525N nonsynonymous SNV - - - ○ - - 292 EEFSEC 3 NM_021937 c.C1111G p.Q371E nonsynonymous SNV - - ○ - - - 293 EFCAB4B 12 NM_001144958 c.G1927A p.V643M nonsynonymous SNV - - - - - ○ 294 EFNA3 1 NM_004952 c.208_219del p.70_73del nonframeshift deletion ○ - - - - - 295 EFNA4 1 NM_182690 c.C472T p.L158F nonsynonymous SNV - - - ○ - - 296 EFTUD1 15 NM_024580 c.A2326G p.M776V nonsynonymous SNV - - - - ○ - 297 EIF2AK2 2 NM_001135651 c.A268G p.T90A nonsynonymous SNV - - - ○ - - 298 EIF4G1 3 NM_001194947 c.1416_1424del p.472_475del nonframeshift deletion ○ - - - - - 299 EIF5B 2 NM_015904 c.1478_1478del p.493_493del frameshift deletion ○ - - - - - 300 ELMO3 16 NM_024712 c.C1036A p.L346M nonsynonymous SNV - - ○ - - - 301 ELN 7 NM_001081753 c.G1612A p.G538R nonsynonymous SNV ○ - - - - - 302 EMR1 19 NM_001974 c.A1129G p.T377A nonsynonymous SNV - - - - - ○ 303 ENO2 12 NM_001975 c.C799T p.P267S nonsynonymous SNV - ○ - - - - 304 EP300 22 NM_001429 c.A1666G p.M556V nonsynonymous SNV - - - - - ○ 305 EPB42 15 NM_000119 c.T99A p.D33E nonsynonymous SNV - - - - - ○ 306 EPHX1 1 NM_001136018 c.G445A p.G149S nonsynonymous SNV ○ - - - - - 307 EPPK1 8 NM_031308 c.G7132C p.D2378H nonsynonymous SNV - - - - - ○ EPPK1 8 NM_031308 c.G7091A p.R2364Q nonsynonymous SNV - - - - - ○ 308 EPX 17 NM_000502 c.A1552G p.I518V nonsynonymous SNV - ○ - - - - 309 ERCC6L X NM_017669 c.A148G p.I50V nonsynonymous SNV ○ - - - - - 310 ERP44 9 NM_015051 c.G589C p.D197H nonsynonymous SNV ○ - - - - - 311 ESYT2 7 NM_020728 c.C592T p.R198W nonsynonymous SNV - ○ - - - - 312 ETS1 11 NM_005238 c.C631T p.R211X stopgain SNV - - - - ○ - 313 F2RL1 5 NM_005242 c.G706C p.V236L nonsynonymous SNV - - ○ - - - 314 FADD 11 NM_003824 c.G307A p.V103I nonsynonymous SNV - ○ - - - - 315 FAM120C X NM_017848 c.2989delG p.E997fs frameshift deletion - ○ - - - - 316 FAM134A 2 NM_024293 c.C1355A p.P452Q nonsynonymous SNV - - - ○ - - 317 FAM161A 2 NM_001201543 c.G686A p.R229Q nonsynonymous SNV - - - - ○ - 318 FAM167A 8 NM_053279 c.A616G p.I206V nonsynonymous SNV ○ - - - - - 319 FAM43A 3 NM_153690 c.A176G p.K59R nonsynonymous SNV - - - - - ○ 320 FAM53C 5 NM_001135647 c.A20T p.E7V nonsynonymous SNV - - - ○ - - 321 FAM71B 5 NM_130899 c.C1402T p.R468W nonsynonymous SNV ○ - - - - - 322 FAM75C1 9 NM_001145124 c.C3466T p.R1156X stopgain SNV - - - ○ - - 323 FAM75D3 9 NM_207416 c.A2734T p.I912L nonsynonymous SNV - - ○ - - - 324 FAM83D 20 NM_030919 c.327_328insGCG p.G109delinsGA nonframeshift insertion - ○ - - - - 325 FAM83H 8 NM_198488 c.G793C p.E265Q nonsynonymous SNV ○ - - - - - 326 FAM86C1 11 NM_001099653 c.C254T p.A85V nonsynonymous SNV - ○ - - - - 327 FAM98A 2 NM_015475 c.G1220T p.G407V nonsynonymous SNV - - - - - ○ 328 FAM98C 19 NM_174905 c.1029_1030insAAG p.R343delinsRK nonframeshift insertion - - - ○ - - 329 FAT1 4 NM_005245 c.3200_3202del p.1067_1068del nonframeshift deletion - - - - - ○ 330 FAT2 5 NM_001447 c.C5138T p.S1713F nonsynonymous SNV - - - - - ○ 331 FBL 19 NM_001436 c.C548T p.P183L nonsynonymous SNV - - - ○ - - 332 FBLN2 3 NM_001998 c.C3454T p.R1152W nonsynonymous SNV - - - - ○ - 333 FBP2 9 NM_003837 c.C395T p.S132F nonsynonymous SNV - - - ○ - - 334 FBXL14 12 NM_152441 c.C1201T p.R401X stopgain SNV - - ○ - - - 335 FBXL21 5 NM_012159 c.90_91insA p.L30fs frameshift insertion - - - - ○ - 336 FBXW7 4 NM_033632 c.C409T p.H137Y nonsynonymous SNV ○ - - - - - 337 FCER2 19 NM_001220500 c.489_493del p.163_165del frameshift deletion - - - ○ - - 338 FDX1L 19 NM_001031734 c.110_111insG p.V37fs frameshift insertion - - - ○ - - 339 FERMT2 14 NM_001134999 c.C402A p.H134Q nonsynonymous SNV - - - - ○ - 340 FGFR2 10 NM_001144918 c.C863T p.T288M nonsynonymous SNV ○ - - - - - 341 FIGNL1 7 NM_001042762 c.T1742C p.M581T nonsynonymous SNV ○ - - - - - 342 FILIP1 6 NM_015687 c.3542delT p.L1181fs frameshift deletion - ○ - - - - 343 FLJ42280 7 NM_001201451 c.A326G p.Y109C nonsynonymous SNV - - ○ - - - 344 FMN2 1 NM_020066 c.A5012T p.D1671V nonsynonymous SNV - - - ○ - - 345 FOXA3 19 NM_004497 c.C743A p.T248N nonsynonymous SNV - - ○ - - - 346 FOXD4 9 NM_207305 c.C604T p.R202C nonsynonymous SNV - - ○ - - - 347 FOXD4L1 2 NM_012184 c.225_226insGGC p.E75delinsEG nonframeshift insertion - - - ○ - - 348 FREM3 4 NM_001168235 c.425_426insTGCTGC p.Q142delinsLLQ nonframeshift insertion - - - ○ - - 349 FRYL 4 NM_015030 c.A6193C p.K2065Q nonsynonymous SNV - - - ○ - - 350 FRZB 2 NM_001463 c.C692T p.P231L nonsynonymous SNV - - - ○ - - 351 FZD10 12 NM_007197 c.C726A p.S242R nonsynonymous SNV - - - ○ - - 352 G6PC 17 NM_000151 c.461delT p.I154fs frameshift deletion - - ○ - - - 353 GALC 14 NM_001201401 c.A853T p.N285Y nonsynonymous SNV - - ○ - - - 354 GALNT13 2 NM_052917 c.T1007C p.V336A nonsynonymous SNV - - - - - ○ 355 GALNTL1 14 NM_020692 c.827_829del p.276_277del nonframeshift deletion ○ - - - - - 356 GATA6 18 NM_005257 c.1449_1450insA p.M483fs frameshift insertion - - ○ - - - 357 GBA2 9 NM_020944 c.A25C p.M9L nonsynonymous SNV - - ○ - - - 358 GLI2 2 NM_005270 c.G4115A p.R1372Q nonsynonymous SNV - - ○ - - - 359 GLIPR1L2 12 NM_152436 c.C432G p.Y144X stopgain SNV ○ - - - - - 360 GNB1L 22 NM_053004 c.G350A p.R117Q nonsynonymous SNV - - ○ - - - 361 GNB3 12 NM_002075 c.C494G p.T165R nonsynonymous SNV - ○ - - - - 362 GNPAT 1 NM_014236 c.A1082G p.D361G nonsynonymous SNV - ○ - - - - 363 GOLGA6B 15 NM_018652 c.G1035T p.M345I nonsynonymous SNV - ○ - - - - 364 GOLGB1 3 NM_004487 c.T8228C p.L2743S nonsynonymous SNV - - ○ - - - 365 GON4L 1 NM_032292 c.G4085C p.S1362T nonsynonymous SNV - - - ○ - - 366 GP1BA 17 NM_000173 c.1285delG p.E429fs frameshift deletion - - - - - ○ 367 GPR110 6 NM_153840 c.A185C p.K62T nonsynonymous SNV - - - - ○ - 368 GPR112 X NM_153834 c.T2083C p.Y695H nonsynonymous SNV - - - - - ○ 369 GPR179 17 NM_001004334 c.G5812A p.D1938N nonsynonymous SNV - - ○ - - - GPR179 17 NM_001004334 c.C2639A p.A880D nonsynonymous SNV - - ○ - - - 370 GPR182 12 NM_007264 c.55_65del p.19_22del frameshift deletion ○ - - - - - 371 GPR98 5 NM_032119 c.G14405A p.R4802Q nonsynonymous SNV - - - - - ○ 372 GRB10 7 NM_001001555 c.G871A p.A291T nonsynonymous SNV - - - ○ - - 373 GREB1 2 NM_014668 c.G4246A p.D1416N nonsynonymous SNV - - ○ - - - 374 GRHPR 9 NM_012203 c.G512A p.R171H nonsynonymous SNV - - - ○ - - 375 GRID2IP 7 NM_001145118 c.T1328C p.V443A nonsynonymous SNV - - - ○ - - 376 GRIN3A 9 NM_133445 c.G2181T p.L727F nonsynonymous SNV - - - - ○ - 377 GSN 9 NM_001127664 c.G1939A p.V647I nonsynonymous SNV - - ○ - - - 378 GTPBP4 10 NM_012341 c.G411A p.M137I nonsynonymous SNV - - ○ - - - 379 GTPBP5 20 NM_015666 c.G841A p.G281S nonsynonymous SNV - - - - ○ - 380 HARS2 5 NM_012208 c.G546C p.Q182H nonsynonymous SNV - ○ - - - - 381 HCAR3 12 NM_006018 c.1086_1087insTCCTT p.S362fs frameshift insertion - - - ○ - - 382 HERC1 15 NM_003922 c.A4984G p.S1662G nonsynonymous SNV - - ○ - - - 383 HIC1 17 NM_001098202 c.C1689A p.F563L nonsynonymous SNV ○ - - - - - 384 HIC2 22 NM_015094 c.C500T p.T167M nonsynonymous SNV - - - ○ - - 385 HILPDA 7 NM_001098786 c.167_168insA p.P56fs frameshift insertion - - ○ - - - 386 HIP1R 12 NM_003959 c.C1939T p.H647Y nonsynonymous SNV - ○ - - - - 387 HIST1H1D 6 NM_005320 c.G22A p.A8T nonsynonymous SNV - - - - - ○ 388 HIST1H2BE 6 NM_003523 c.G180A p.M60I nonsynonymous SNV - - ○ - - - 389 HIST1H2BG 6 NM_003518 c.C272T p.T91I nonsynonymous SNV - - ○ - - - 390 HNRNPM 19 NM_031203 c.1127_1135del p.376_379del nonframeshift deletion - - ○ - - - 391 HOXA1 7 NM_153620 c.C393G p.I131M nonsynonymous SNV - - - - - ○ 392 HOXB3 17 NM_002146 c.A862T p.S288C nonsynonymous SNV - - - - ○ - 393 HS3ST4 16 NM_006040 c.G1076A p.R359Q nonsynonymous SNV - - - ○ - - 394 HSD17B12 11 NM_016142 c.T845A p.I282N nonsynonymous SNV - - - - ○ - 395 HSF5 17 NM_001080439 c.203_204insGGGCCG p.E68delinsGAE nonframeshift insertion - - - - ○ - 396 HUS1 7 NM_004507 c.C401T p.P134L nonsynonymous SNV - - ○ - - - 397 IDO2 8 NM_194294 c.G901T p.E301X stopgain SNV - - ○ - - - 398 IER5L 9 NM_203434 c.906_919del p.302_307del frameshift deletion - ○ - - - - 399 IFIT1 10 NM_001548 c.A1376G p.Y459C nonsynonymous SNV ○ - - - - - 400 IFT122 3 NM_052990 c.C653T p.A218V nonsynonymous SNV - - ○ - - - 401 IGDCC4 15 NM_020962 c.G3554A p.G1185E nonsynonymous SNV - - - ○ - - 402 IGSF10 3 NM_178822 c.2833_2835del p.945_945del nonframeshift deletion - - - ○ - - 403 IL10RA 11 NM_001558 c.C1012A p.P338T nonsynonymous SNV - - ○ - - - 404 IL28RA 1 NM_170743 c.A677G p.N226S nonsynonymous SNV - - - - - ○ 405 INO80E 16 NM_173618 c.G370A p.G124R nonsynonymous SNV - - ○ - - - 406 INTS10 8 NM_018142 c.C374T p.T125M nonsynonymous SNV - - - ○ - - 407 IPO13 1 NM_014652 c.A1822T p.K608X stopgain SNV - - - ○ - - 408 IQCD 12 NM_138451 c.967_969del p.323_323del nonframeshift deletion - - ○ - - - 409 IQGAP2 5 NM_006633 c.G1958A p.R653H nonsynonymous SNV ○ - - - - - 410 IQSEC1 3 NM_001134382 c.A751G p.T251A nonsynonymous SNV ○ - - - - - 411 IRAK1 X NM_001025242 c.C911T p.T304I nonsynonymous SNV - - - - - ○ 412 IRS1 2 NM_005544 c.C3661T p.R1221C nonsynonymous SNV - - - ○ - - 413 IRX6 16 NM_024335 c.620_622del p.207_208del nonframeshift deletion - - ○ - - - 414 ITGA5 12 NM_002205 c.C1718G p.T573S nonsynonymous SNV - - ○ - - - 415 ITGA7 12 NM_001144996 c.G3053A p.R1018Q nonsynonymous SNV - - - - - ○ 416 ITGA9 3 NM_002207 c.C850G p.R284G nonsynonymous SNV - - - ○ - - 417 ITPRIPL1 2 NM_001163524 c.938delG p.W313fs frameshift deletion - - - - ○ - 418 IZUMO2 19 NM_152358 c.C511T p.R171C nonsynonymous SNV ○ - - - - - 419 JARID2 6 NM_004973 c.A342C p.Q114H nonsynonymous SNV - - ○ - - - 420 JMJD1C 10 NM_004241 c.A1046T p.D349V nonsynonymous SNV - ○ - - - - 421 KBTBD12 3 NM_207335 c.T897G p.F299L nonsynonymous SNV - - - ○ - - 422 KCNA10 1 NM_005549 c.A467G p.N156S nonsynonymous SNV - - - - - ○ 423 KCNK10 14 NM_138318 c.C679T p.R227X stopgain SNV - - ○ - - - 424 KCNMA1 10 NM_001014797 c.138_139insCTC p.S46delinsSS nonframeshift insertion - - - ○ - - 425 KCNN3 1 NM_001204087 c.111_112insGCA p.Q37delinsQQ nonframeshift insertion - - ○ - - - 426 KCTD3 1 NM_016121 c.C1870G p.R624G nonsynonymous SNV - - ○ - - - 427 KDM2B 12 NM_032590 c.C3151G p.P1051A nonsynonymous SNV - - ○ - - - 428 KDR 4 NM_002253 c.G3908A p.S1303N nonsynonymous SNV ○ - - - - - 429 KIAA0146 8 NM_001080394 c.T947A p.M316K nonsynonymous SNV - - ○ - - - KIAA0146 8 NM_001080394 c.C1208T p.P403L nonsynonymous SNV - - ○ - - - 430 KIAA0415 7 NM_014855 c.G536A p.R179Q nonsynonymous SNV - ○ - - - - 431 KIAA0586 14 NM_001244190 c.G4156A p.G1386S nonsynonymous SNV ○ - - - - - 432 KIAA1009 6 NM_014895 c.C1221A p.D407E nonsynonymous SNV - - - ○ - - 433 KIAA1161 9 NM_020702 c.41_42insC p.R14fs frameshift insertion - - - ○ - - 434 KIAA1199 15 NM_018689 c.4068_4070del p.1356_1357del nonframeshift deletion - ○ - - - - 435 KIAA1456 8 NM_001099677 c.G166A p.G56R nonsynonymous SNV - - ○ - - - 436 KIAA1467 12 NM_020853 c.C341T p.S114L nonsynonymous SNV - - ○ - - - 437 KIAA1522 1 NM_001198972 c.C715T p.R239C nonsynonymous SNV - - - ○ - - 438 KIAA1530 4 NM_020894 c.C1276T p.R426W nonsynonymous SNV - - - - ○ - 439 KIAA1751 1 NM_001080484 c.A1862G p.D621G nonsynonymous SNV - - - - - ○ 440 KIF1A 2 NM_001244008 c.G3703A p.D1235N nonsynonymous SNV - - - ○ - - 441 KIF27 9 NM_017576 c.A532G p.S178G nonsynonymous SNV - - - ○ - - 442 KLC3 19 NM_177417 c.1273_1275del p.425_425del nonframeshift deletion - - - - ○ - 443 KLC4 6 NM_201522 c.G682A p.E228K nonsynonymous SNV - - ○ - - - 444 KLK15 19 NM_017509 c.G689A p.C230Y nonsynonymous SNV - - - ○ - - 445 KPNA5 6 NM_002269 c.247_249del p.83_83del nonframeshift deletion - - ○ - - - 446 KPRP 1 NM_001025231 c.G1364A p.C455Y nonsynonymous SNV - - ○ - - - 447 KRBA1 7 NM_032534 c.A430G p.T144A nonsynonymous SNV - - ○ - - - KRBA1 7 NM_032534 c.G2530T p.A844S nonsynonymous SNV - - ○ - - - 448 KRI1 19 NM_023008 c.A2021G p.E674G nonsynonymous SNV - - - ○ - - 449 KRR1 12 NM_007043 c.A84T p.Q28H nonsynonymous SNV - - - - ○ - 450 KRT33A 17 NM_004138 c.G1208C p.G403A nonsynonymous SNV ○ - - - - - 451 KRT33B 17 NM_002279 c.G77A p.C26Y nonsynonymous SNV - - - - - ○ 452 KRT5 12 NM_000424 c.C1171T p.R391W nonsynonymous SNV - - - - ○ - 453 KRT7 12 NM_005556 c.G415A p.D139N nonsynonymous SNV - - - - - ○ 454 KRT76 12 NM_015848 c.C1280T p.T427M nonsynonymous SNV - - ○ - - - 455 KRT78 12 NM_173352 c.C1235T p.T412I nonsynonymous SNV - - - ○ - - 456 KRTAP10-1 21 NM_198691 c.78_80del p.26_27del nonframeshift deletion - - ○ - - - 457 KRTAP1-5 17 NM_031957 c.396delC p.P132fs frameshift deletion - - - - ○ - 458 KRTAP4-7 17 NM_033061 c.C91G p.Q31E nonsynonymous SNV - - ○ - - - 459 KRTAP4-9 17 NM_001146041 c.G119A p.C40Y nonsynonymous SNV - - - - - ○ 460 KRTAP5-8 11 NM_021046 c.T457A p.C153S nonsynonymous SNV - - - - - ○ 461 KSR1 17 NM_014238 c.C629T p.T210M nonsynonymous SNV - - - - - ○ 462 KSR2 12 NM_173598 c.C830T p.T277I nonsynonymous SNV - - - ○ - - 463 LAMC3 9 NM_006059 c.C1693A p.P565T nonsynonymous SNV - - ○ - - - 464 LASP1 17 NM_006148 c.A548G p.Y183C nonsynonymous SNV - - - ○ - - 465 LDHAL6B 15 NM_033195 c.964_965insTT p.V322fs frameshift insertion - - ○ - - - 466 LEMD2 6 NM_181336 c.A923G p.Y308C nonsynonymous SNV - - ○ - - - 467 LEPREL2 12 NM_014262 c.C820T p.R274X stopgain SNV ○ - - - - - 468 LGALS8 1 NM_201544 c.A297C p.R99S nonsynonymous SNV - - - ○ - - 469 LGALS9C 17 NM_001040078 c.397delA p.T133fs frameshift deletion ○ - - - - - 470 LILRA6 19 NM_024318 c.G10A p.A4T nonsynonymous SNV - ○ - - - - 471 LIPA 10 NM_001127605 c.C309A p.S103R nonsynonymous SNV - - ○ - - - 472 LIPJ 10 NM_001010939 c.A257G p.N86S nonsynonymous SNV - ○ - - - - 473 LOC100129924 1 NM_001242750 c.613delG p.V205fs frameshift deletion - - ○ - - - 474 LOC100509575 X NM_001205103 c.A218G p.N73S nonsynonymous SNV - - - ○ - - 475 LOXL2 8 NM_002318 c.C565T p.R189X stopgain SNV - - - ○ - - 476 LOXL3 2 NM_032603 c.T868A p.S290T nonsynonymous SNV ○ - - - - - 477 LPO 17 NM_001160102 c.T1475C p.L492P nonsynonymous SNV - - ○ - - - 478 LRRC16A 6 NM_017640 c.C1045G p.L349V nonsynonymous SNV ○ - - - - - 479 LRRC16B 14 NM_138360 c.C3251A p.P1084H nonsynonymous SNV ○ - - - - - 480 LRRC30 18 NM_001105581 c.G50A p.R17K nonsynonymous SNV - - - - ○ - 481 LRRC4B 19 NM_001080457 c.G619A p.V207I nonsynonymous SNV ○ - - - - - 482 LRRC72 7 NM_001195280 c.C28T p.R10C nonsynonymous SNV - - ○ - - - 483 LRRIQ4 3 NM_001080460 c.A1496T p.K499M nonsynonymous SNV - - - - - ○ 484 LRRN4 20 NM_152611 c.C2077G p.L693V nonsynonymous SNV - - - ○ - - 485 LRRTM3 10 NM_178011 c.858delT p.D286fs frameshift deletion - - ○ - - - 486 LRSAM1 9 NM_138361 c.G695A p.R232Q nonsynonymous SNV - - - ○ - - 487 LTBP3 11 NM_001130144 c.106_107insCTGCTG p.G36delinsLLG nonframeshift insertion - ○ - - - - 488 LTBP4 19 NM_001042544 c.A476G p.N159S nonsynonymous SNV - - - - ○ - 489 LTF 3 NM_001199149 c.C1046T p.A349V nonsynonymous SNV - - - - - ○ 490 LTN1 21 NM_015565 c.G909T p.Q303H nonsynonymous SNV - - - ○ - - 491 MACF1 1 NM_012090 c.C6929T p.A2310V nonsynonymous SNV - - - ○ - - 492 MADCAM1 19 NM_130760 c.A761C p.Q254P nonsynonymous SNV - - - - ○ - 493 MAGEA10 X NM_001251828 c.G1062T p.M354I nonsynonymous SNV - - - ○ - - MAGEA10 X NM_001251828 c.T1061G p.M354R nonsynonymous SNV - - - ○ - - 494 MAGEA4 X NM_001011550 c.G917A p.R306H nonsynonymous SNV - - - - - ○ 495 MAGEC2 X NM_016249 c.C229T p.P77S nonsynonymous SNV - - - - - ○ 496 MALT1 18 NM_173844 c.T488G p.M163R nonsynonymous SNV ○ - - - - - 497 MAN1B1 9 NM_016219 c.G1682A p.R561Q nonsynonymous SNV - - ○ - - - 498 MAN1C1 1 NM_020379 c.C1289T p.P430L nonsynonymous SNV - - - ○ - - 499 MAP3K4 6 NM_005922 c.81_82insCCG p.P27delinsPP nonframeshift insertion - ○ - - - - 500 MAPKAP1 9 NM_001006618 c.G532A p.D178N nonsynonymous SNV - ○ - - - - 501 MAPKBP1 15 NM_014994 c.C2759G p.S920C nonsynonymous SNV - - - ○ - - 502 MARCH10 17 NM_001100875 c.C2260G p.L754V nonsynonymous SNV - - - - - ○ 503 MARCO 2 NM_006770 c.G172T p.A58S nonsynonymous SNV ○ - - - - - 504 MATN2 8 NM_030583 c.G1934A p.R645Q nonsynonymous SNV - ○ - - - - 505 MC1R 16 NM_002386 c.84_85insA p.A28fs frameshift insertion - ○ - - - - 506 MC4R 18 NM_005912 c.G116A p.G39E nonsynonymous SNV - - ○ - - - 507 MCF2 X NM_001099855 c.G1507C p.V503L nonsynonymous SNV - - - - ○ - 508 MCHR2 6 NM_001040179 c.C494A p.A165E nonsynonymous SNV - - - ○ - - 509 MDN1 6 NM_014611 c.14361_14372del p.4787_4791del nonframeshift deletion - - ○ - - - 510 MDP1 14 NM_001199822 c.360_362del p.120_121del nonframeshift deletion - - ○ - - - 511 ME1 6 NM_002395 c.G990T p.K330N nonsynonymous SNV - - - - - ○ 512 MED12 X NM_005120 c.279_280insC p.K93fs frameshift insertion - - - ○ - - MED12 X NM_005120 c.5305_5308del p.1769_1770del frameshift deletion - - - ○ - - 513 MED15 22 NM_001003891 c.750_751insCAG p.Q250delinsQQ nonframeshift insertion - - ○ - - - 514 MED23 6 NM_004830 c.C2614T p.R872C nonsynonymous SNV ○ - - - - - 515 METAP1 4 NM_015143 c.A677G p.N226S nonsynonymous SNV ○ - - - - - 516 MFGE8 15 NM_005928 c.1001_1002insC p.Q334fs frameshift insertion - - - - - ○ 517 MFSD6 2 NM_017694 c.C2321T p.P774L nonsynonymous SNV ○ - - - - - 518 MICALL1 22 NM_033386 c.T1031G p.L344R nonsynonymous SNV - - - - - ○ 519 MKLN1 7 NM_013255 c.G2065T p.G689C nonsynonymous SNV - - - - - ○ 520 MLL2 12 NM_003482 c.G659A p.G220E nonsynonymous SNV ○ - - - - - 521 MLL5 7 NM_182931 c.A3065G p.D1022G nonsynonymous SNV - - ○ - - - 522 MND1 4 NM_032117 c.G352T p.E118X stopgain SNV - - ○ - - - 523 MOGAT1 2 NM_058165 c.833delG p.R278fs frameshift deletion ○ - - - - - 524 MPDZ 9 NM_003829 c.A3022G p.T1008A nonsynonymous SNV - - - - - ○ MPDZ 9 NM_003829 c.A382T p.N128Y nonsynonymous SNV - - - - - ○ 525 MPL 1 NM_005373 c.C1469G p.A490G nonsynonymous SNV - ○ - - - - 526 MPND 19 NM_001159846 c.G869A p.R290Q nonsynonymous SNV - - ○ - - - 527 MPP7 10 NM_173496 c.C1204T p.H402Y nonsynonymous SNV - ○ - - - - 528 MRS2 6 NM_020662 c.A1147G p.M383V nonsynonymous SNV - ○ - - - - 529 MSH2 2 NM_000251 c.T266C p.V89A nonsynonymous SNV - - - ○ - - 530 MTM1 X NM_000252 c.G877T p.G293X stopgain SNV - - ○ - - - 531 MYADM 19 NM_001020818 c.C182T p.T61M nonsynonymous SNV - - - - ○ - 532 MYBBP1A 17 NM_014520 c.T3831G p.H1277Q nonsynonymous SNV ○ - - - - - 533 MYBPC3 11 NM_000256 c.G3385C p.A1129P nonsynonymous SNV - ○ - - - - 534 MYCBPAP 17 NM_032133 c.2132_2146del p.711_716del nonframeshift deletion - - - - - ○ 535 MYH14 19 NM_001077186 c.C559A p.Q187K nonsynonymous SNV - - - ○ - - 536 MYH15 3 NM_014981 c.C5479G p.L1827V nonsynonymous SNV - - ○ - - - 537 MYH4 17 NM_017533 c.C1272A p.Y424X stopgain SNV - - - ○ - - 538 MYH8 17 NM_002472 c.C605T p.A202V nonsynonymous SNV - - - ○ - - 539 MYL1 2 NM_079420 c.2_3insA p.M1fs frameshift insertion - - ○ - - - 540 MYO15A 17 NM_016239 c.4610_4612del p.1537_1538del nonframeshift deletion - - - ○ - - 541 MYO18B 22 NM_032608 c.G6854A p.G2285E nonsynonymous SNV - - ○ - - - 542 MYO1E 15 NM_004998 c.C1679T p.T560I nonsynonymous SNV - - - - - ○ 543 MYO9B 19 NM_001130065 c.C334T p.R112C nonsynonymous SNV - ○ - - - - 544 MYOM3 1 NM_152372 c.C1297T p.P433S nonsynonymous SNV - ○ - - - - 545 MYRIP 3 NM_015460 c.C1234A p.P412T nonsynonymous SNV - - ○ - - - 546 NAAA 4 NM_001042402 c.G425A p.R142Q nonsynonymous SNV - - ○ - - - 547 NADK 1 NM_001198994 c.G1755C p.E585D nonsynonymous SNV ○ - - - - - 548 NARG2 15 NM_024611 c.T20A p.I7K nonsynonymous SNV - - - ○ - - 549 NBAS 2 NM_015909 c.C1501T p.R501X stopgain SNV ○ - - - - - 550 NBN 8 NM_002485 c.G866A p.W289X stopgain SNV - - - ○ - - 551 NCAM1 11 NM_000615 c.G1735A p.A579T nonsynonymous SNV - - ○ - - - 552 NCOA6 20 NM_014071 c.C5273A p.P1758H nonsynonymous SNV - - - - - ○ 553 NDUFA6 22 NM_002490 c.T2A p.M1K nonsynonymous SNV - - ○ - - - 554 NDUFS3 11 NM_004551 c.G355A p.V119I nonsynonymous SNV - - - ○ - - 555 NECAB3 20 NM_031232 c.C773T p.P258L nonsynonymous SNV - - - - - ○ 556 NEDD4L 18 NM_001144965 c.G724A p.A242T nonsynonymous SNV - - - ○ - - 557 NEIL3 4 NM_018248 c.168_169insAAT p.L56delinsLN nonframeshift insertion - - ○ - - - 558 NEK4 3 NM_001193533 c.C752T p.S251L nonsynonymous SNV ○ - - - - - 559 NINL 20 NM_025176 c.T809C p.L270P nonsynonymous SNV ○ - - - - - 560 NLGN4Y Y NM_001206850 c.552delC p.D184fs frameshift deletion - ○ - - - - 561 NLRP2 19 NM_001174083 c.C1690T p.R564X stopgain SNV - ○ - - - - 562 NME4 16 NM_005009 c.T340A p.Y114N nonsynonymous SNV - ○ - - - - 563 NOBOX 7 NM_001080413 c.G325A p.G109R nonsynonymous SNV - - - ○ - - 564 NOMO2 16 NM_173614 c.635delT p.L212fs frameshift deletion - - ○ - - - 565 NOP14 4 NM_003703 c.C2150A p.A717D nonsynonymous SNV - - - - ○ - 566 NOP56 20 NM_006392 c.T1042C p.Y348H nonsynonymous SNV - - - - ○ - 567 NOTCH2 1 NM_001200001 c.17_18del p.6_6del frameshift deletion - - ○ - - - 568 NOX1 X NM_013955 c.G1309T p.A437S nonsynonymous SNV - - ○ - - - 569 NRAP 10 NM_198060 c.G3199A p.E1067K nonsynonymous SNV - - - ○ - - 570 NRP2 2 NM_201266 c.G2317A p.E773K nonsynonymous SNV ○ - - - - - 571 NT5DC3 12 NM_001031701 c.A1338C p.R446S nonsynonymous SNV ○ - - - - - 572 NUAK1 12 NM_014840 c.A1249G p.I417V nonsynonymous SNV - ○ - - - - 573 NUBP2 16 NM_012225 c.278_281del p.93_94del frameshift deletion - - - ○ - - 574 NUCB2 11 NM_005013 c.C77G p.P26R nonsynonymous SNV - ○ - - - - 575 NUDT6 4 NM_007083 c.G23A p.G8D nonsynonymous SNV - - - ○ - - 576 NXPH3 17 NM_007225 c.G655A p.V219I nonsynonymous SNV - - - - ○ - 577 ODC1 2 NM_002539 c.G945A p.M315I nonsynonymous SNV ○ - - - - - 578 ODF3B 22 NM_001014440 c.623_624insAA p.T208fs frameshift insertion - - - - - ○ 579 ODZ1 X NM_014253 c.G1621T p.E541X stopgain SNV - - ○ - - - 580 OLFML1 11 NM_198474 c.G317A p.R106Q nonsynonymous SNV - - - ○ - - 581 OLFML2A 9 NM_182487 c.C295T p.P99S nonsynonymous SNV - - - - ○ - OLFML2A 9 NM_182487 c.A332G p.K111R nonsynonymous SNV - - - - ○ - 582 OPN5 6 NM_181744 c.T562A p.W188R nonsynonymous SNV - ○ - - - - 583 OPRK1 8 NM_000912 c.C873A p.H291Q nonsynonymous SNV - - ○ - - - 584 OR10G2 14 NM_001005466 c.G223A p.D75N nonsynonymous SNV - - - ○ - - 585 OR10S1 11 NM_001004474 c.C937A p.L313M nonsynonymous SNV - - ○ - - - 586 OR11H2 14 NM_001197287 c.G574A p.V192I nonsynonymous SNV ○ - - - - - 587 OR11L1 1 NM_001001959 c.G454C p.G152R nonsynonymous SNV - - - - - ○ 588 OR1L3 9 NM_001005234 c.C733A p.L245I nonsynonymous SNV - - - ○ - - 589 OR2F2 7 NM_001004685 c.G220A p.A74T nonsynonymous SNV - - ○ - - - 590 OR4M2 15 NM_001004719 c.A23G p.K8R nonsynonymous SNV - - - ○ - - 591 OR51Q1 11 NM_001004757 c.C499T p.R167X stopgain SNV - - - - - ○ 592 OR52H1 11 NM_001005289 c.A772G p.M258V nonsynonymous SNV - - - ○ - - 593 OR5H2 3 NM_001005482 c.95_103del p.32_35del nonframeshift deletion - - ○ - - - 594 OR6P1 1 NM_001160325 c.97_98insT p.A33fs frameshift insertion - - ○ - - - 595 OR8B3 11 NM_001005467 c.551_552insC p.L184fs frameshift insertion - ○ - - - - 596 OR8S1 12 NM_001005203 c.G950A p.W317X stopgain SNV - - ○ - - - 597 ORAI1 12 NM_032790 c.G655A p.A219T nonsynonymous SNV - - - - ○ - 598 OSBP2 22 NM_030758 c.T741G p.S247R nonsynonymous SNV - - - ○ - - 599 OSGIN1 16 NM_182981 c.C913T p.R305C nonsynonymous SNV - - ○ - - - 600 OSTC 4 NM_021227 c.C27G p.F9L nonsynonymous SNV ○ - - - - - 601 P2RX2 12 NM_170683 c.C625T p.H209Y nonsynonymous SNV - - - - ○ - 602 PAFAH2 1 NM_000437 c.C188A p.A63D nonsynonymous SNV - ○ - - - - 603 PAMR1 11 NM_015430 c.A542G p.Y181C nonsynonymous SNV - - - - ○ - 604 PAPPA 9 NM_002581 c.G4336A p.D1446N nonsynonymous SNV - - - ○ - - 605 PARD3 10 NM_001184791 c.A1252G p.I418V nonsynonymous SNV - - ○ - - - 606 PAX4 7 NM_006193 c.C767T p.P256L nonsynonymous SNV - - - ○ - - 607 PCCA 13 NM_001178004 c.G895C p.V299L nonsynonymous SNV - - ○ - - - 608 PCDH11Y Y NM_032973 c.G610A p.G204R nonsynonymous SNV - - ○ - - - 609 PCDH12 5 NM_016580 c.C163G p.R55G nonsynonymous SNV - - - ○ - - 610 PCDHA6 5 NM_018909 c.G1711A p.G571S nonsynonymous SNV ○ - - - - - 611 PCDHB1 5 NM_013340 c.G1303A p.E435K nonsynonymous SNV - - - ○ - - 612 PCDHB4 5 NM_018938 c.G1942C p.E648Q nonsynonymous SNV ○ - - - - - 613 PCDHB6 5 NM_018939 c.G609C p.E203D nonsynonymous SNV - ○ - - - - 614 PCDHB7 5 NM_018940 c.T1769C p.V590A nonsynonymous SNV - - - ○ - - 615 PCDHGA11 5 NM_018914 c.2060_2062del p.687_688del nonframeshift deletion ○ - - - - - 616 PCDHGA5 5 NM_018918 c.G1809A p.W603X stopgain SNV - - - ○ - - 617 PCDHGA6 5 NM_032086 c.A758T p.E253V nonsynonymous SNV - - - ○ - - 618 PCDHGA7 5 NM_032087 c.G1712A p.G571D nonsynonymous SNV - ○ - - - - 619 PCDHGB1 5 NM_032095 c.1452_1454del p.484_485del nonframeshift deletion - - ○ - - - 620 PCF11 11 NM_015885 c.C3052G p.L1018V nonsynonymous SNV - - - - ○ - 621 PCM1 8 NM_006197 c.C3869T p.S1290F nonsynonymous SNV - - ○ - - - 622 PCSK9 1 NM_174936 c.C791T p.T264I nonsynonymous SNV - - - ○ - - 623 PDE1B 12 NM_000924 c.C599T p.P200L nonsynonymous SNV - - ○ - - - 624 PEAR1 1 NM_001080471 c.C2611T p.R871C nonsynonymous SNV - - - ○ - - 625 PEG3 19 NM_001146185 c.1431_1432insACGTGA p.E477delinsERE nonframeshift insertion - - ○ - - - 626 PELI3 11 NM_001243135 c.T603G p.N201K nonsynonymous SNV - - - - - ○ 627 PELO 5 NM_015946 c.C155G p.S52C nonsynonymous SNV - - ○ - - - 628 PEPD 19 NM_001166056 c.G152A p.G51E nonsynonymous SNV ○ - - - - - 629 PER1 17 NM_002616 c.G1114A p.D372N nonsynonymous SNV - - - ○ - - 630 PGM2L1 11 NM_173582 c.G1559T p.C520F nonsynonymous SNV - - ○ - - - 631 PHLDA2 11 NM_003311 c.358_359insC p.A120fs frameshift insertion - - - - ○ - 632 PHRF1 11 NM_020901 c.C3698T p.T1233M nonsynonymous SNV - - - - ○ - 633 PIEZO1 16 NM_001142864 c.C4381T p.R1461W nonsynonymous SNV - ○ - - - - 634 PIGQ 16 NM_148920 c.G1274A p.R425Q nonsynonymous SNV - ○ - - - - 635 PKD1 16 NM_000296 c.A12310C p.I4104L nonsynonymous SNV - - - - - ○ 636 PKHD1 6 NM_138694 c.C10867A p.P3623T nonsynonymous SNV ○ - - - - - 637 PKNOX1 21 NM_004571 c.G1126A p.V376M nonsynonymous SNV ○ - - - - - 638 PKP3 11 NM_007183 c.G830C p.R277P nonsynonymous SNV - ○ - - - - 639 PLA2G4B 15 NM_001114633 c.T334G p.F112V nonsynonymous SNV - - - ○ - - 640 PLCL1 2 NM_006226 c.G946T p.V316L nonsynonymous SNV - - ○ - - - 641 PLIN1 15 NM_002666 c.182delG p.G61fs frameshift deletion - - ○ - - - 642 PLXNA4 7 NM_020911 c.C2066A p.S689Y nonsynonymous SNV - - ○ - - - 643 PLXND1 3 NM_015103 c.G2735A p.R912Q nonsynonymous SNV - - ○ - - - 644 PMVK 1 NM_006556 c.G100A p.G34R nonsynonymous SNV - - - - - ○ 645 PNISR 6 NM_032870 c.C1674G p.H558Q nonsynonymous SNV - - - - - ○ 646 PNMA2 8 NM_007257 c.605delA p.K202fs frameshift deletion - - - - - ○ 647 POC5 5 NM_001099271 c.T377C p.L126S nonsynonymous SNV - - - - ○ - 648 PODXL 7 NM_001018111 c.C1622T p.P541L nonsynonymous SNV - - ○ - - - 649 POLE 12 NM_006231 c.C1717T p.R573W nonsynonymous SNV ○ - - - - - 650 POLQ 3 NM_199420 c.G863T p.R288L nonsynonymous SNV ○ - - - - - 651 POLR1A 2 NM_015425 c.C793G p.L265V nonsynonymous SNV - ○ - - - - 652 POLR1C 6 NM_203290 c.G149A p.R50H nonsynonymous SNV - - ○ - - - 653 POM121 7 NM_172020 c.G2356A p.A786T nonsynonymous SNV ○ - - - - - 654 POT1 7 NM_001042594 c.A82G p.M28V nonsynonymous SNV - ○ - - - - 655 POTEF 2 NM_001099771 c.G241A p.G81S nonsynonymous SNV - - ○ - - - 656 PPFIBP1 12 NM_001198915 c.A1291C p.K431Q nonsynonymous SNV ○ - - - - - 657 PPFIBP2 11 NM_003621 c.T2095A p.C699S nonsynonymous SNV - - - - - ○ 658 PPL 16 NM_002705 c.G4078C p.E1360Q nonsynonymous SNV - - ○ - - - 659 PPM1A 14 NM_021003 c.G7A p.A3T nonsynonymous SNV - - ○ - - - 660 PPM1F 22 NM_014634 c.G818A p.G273E nonsynonymous SNV - ○ - - - - 661 PPP1R12A 12 NM_001244992 c.T2273C p.I758T nonsynonymous SNV - - ○ - - - 662 PPP1R12B 1 NM_001197131 c.C17A p.T6N nonsynonymous SNV ○ - - - - - 663 PPP1R21 2 NM_152994 c.A372G p.I124M nonsynonymous SNV - - - ○ - - 664 PPP1R3D 20 NM_006242 c.C670T p.R224C nonsynonymous SNV - - ○ - - - 665 PPP2R3A 3 NM_181897 c.G490T p.A164S nonsynonymous SNV - - - ○ - - 666 PRAM1 19 NM_032152 c.C757G p.P253A nonsynonymous SNV - - ○ - - - 667 PRAMEF11 1 NM_001146344 c.630delA p.P210fs frameshift deletion - - - - - ○ 668 PRAMEF12 1 NM_001080830 c.1415_1416insCC p.C472fs frameshift insertion - - - - - ○ 669 PRICKLE3 X NM_006150 c.1567_1568insCATCAC p.N523delinsHHN nonframeshift insertion - - ○ - - - 670 PRKDC 8 NM_001081640 c.A4239G p.I1413M nonsynonymous SNV - - ○ - - - 671 PRR4 12 NM_007244 c.G278A p.R93Q nonsynonymous SNV ○ - - - - - 672 PRRT2 16 NM_145239 c.T522G p.S174R nonsynonymous SNV - - - ○ - - 673 PSD3 8 NM_015310 c.T797C p.V266A nonsynonymous SNV - - ○ - - - 674 PSG5 19 NM_002781 c.C58T p.L20F nonsynonymous SNV - - - - ○ - 675 PSMA8 18 NM_001025096 c.G586A p.A196T nonsynonymous SNV - - - - - ○ 676 PTPN13 4 NM_080683 c.G2128C p.E710Q nonsynonymous SNV - - ○ - - - 677 PTPN23 3 NM_015466 c.C3769G p.P1257A nonsynonymous SNV - - - - ○ - 678 PTPN5 11 NM_032781 c.A1180C p.I394L nonsynonymous SNV - - - ○ - - 679 PTPRZ1 7 NM_001206838 c.C2195T p.S732F nonsynonymous SNV - - - ○ - - 680 PTS 11 NM_000317 c.363_364del p.121_122del frameshift deletion ○ - - - - - 681 PVRL2 19 NM_002856 c.G943A p.V315I nonsynonymous SNV - - - - - ○ 682 PVRL3 3 NM_015480 c.T1576A p.Y526N nonsynonymous SNV - - - - - ○ 683 PXDN 2 NM_012293 c.C2591G p.P864R nonsynonymous SNV - ○ - - - - 684 QPCT 2 NM_012413 c.G511C p.A171P nonsynonymous SNV - ○ - - - - 685 RAB40B 17 NM_006822 c.C424T p.Q142X stopgain SNV - - - ○ - - 686 RABEPK 9 NM_001174152 c.399delC p.S133fs frameshift deletion - ○ - - - - 687 RAD50 5 NM_005732 c.T1924G p.L642V nonsynonymous SNV - - - - - ○ 688 RAD51AP1 12 NM_006479 c.408delT p.D136fs frameshift deletion - - ○ - - - 689 RASSF2 20 NM_170774 c.G880T p.E294X stopgain SNV - - - - ○ - 690 RASSF6 4 NM_201431 c.464_465insA p.R155fs frameshift insertion - - - ○ - - 691 RBBP6 16 NM_006910 c.C3197T p.T1066I nonsynonymous SNV - - - ○ - - 692 RBM11 21 NM_144770 c.G16C p.E6Q nonsynonymous SNV - - - - - ○ 693 RBM12 20 NM_001198838 c.2505_2506insCGGCCC p.P835delinsPGP nonframeshift insertion - ○ - - - - 694 RBMXL1 1 NM_019610 c.G232A p.A78T nonsynonymous SNV - - - - ○ - 695 RC3H2 9 NM_018835 c.C1031T p.P344L nonsynonymous SNV - ○ - - - - 696 RECQL4 8 NM_004260 c.2576_2577insTGCACC p.Q859delinsLHQ nonframeshift insertion - - ○ - - - 697 RELN 7 NM_005045 c.1_2insGGCGGC p.M1delinsGGM nonframeshift insertion - ○ - - - - 698 REXO1 19 NM_020695 c.2884_2886del p.962_962del nonframeshift deletion - - - - - ○ 699 RFPL2 22 NM_001098527 c.C1117T p.R373C nonsynonymous SNV - - ○ - - - 700 RFX4 12 NM_213594 c.T1495A p.L499M nonsynonymous SNV - - - ○ - - 701 RFX5 1 NM_001025603 c.A1658C p.E553A nonsynonymous SNV - - - ○ - - 702 RGP1 9 NM_001080496 c.G383A p.R128Q nonsynonymous SNV ○ - - - - - 703 RGS4 1 NM_001113380 c.G507C p.K169N nonsynonymous SNV - ○ - - - - 704 RNF17 13 NM_001184993 c.A1897G p.S633G nonsynonymous SNV - - - - - ○ 705 RNF38 9 NM_022781 c.12_12del p.4_4del frameshift deletion - ○ - - - - 706 RNMTL1 17 NM_018146 c.A533G p.D178G nonsynonymous SNV ○ - - - - - 707 ROBO1 3 NM_002941 c.C4438A p.L1480I nonsynonymous SNV - - ○ - - - 708 ROCK2 2 NM_004850 c.C2692T p.Q898X stopgain SNV - - - ○ - - 709 RP1 8 NM_006269 c.G2894T p.S965I nonsynonymous SNV - - - ○ - - 710 RP1L1 8 NM_178857 c.3935_3937del p.1312_1313del nonframeshift deletion - - - ○ - - 711 RPAP3 12 NM_001146075 c.A1360G p.T454A nonsynonymous SNV - - - ○ - - 712 RPL29 3 NM_000992 c.392_393insCCAAGG p.D131delinsAKD nonframeshift insertion - - - - ○ - 713 RPL8 8 NM_033301 c.C323T p.P108L nonsynonymous SNV - - ○ - - - 714 RRP12 10 NM_015179 c.C2120G p.P707R nonsynonymous SNV - - - - ○ - 715 RRP36 6 NM_033112 c.22_27del p.8_9del nonframeshift deletion - - - ○ - - 716 RSPH1 21 NM_080860 c.C398T p.T133M nonsynonymous SNV - - ○ - - - 717 RSPO1 1 NM_001242909 c.A590G p.N197S nonsynonymous SNV - - - ○ - - 718 RTN4RL1 17 NM_178568 c.C788T p.A263V nonsynonymous SNV - ○ - - - - 719 RUFY4 2 NM_198483 c.T1519G p.W507G nonsynonymous SNV ○ - - - - - 720 RUNX2 6 NM_001015051 c.G1091A p.R364H nonsynonymous SNV - - - ○ - - 721 RUSC1 1 NM_001105204 c.T895C p.W299R nonsynonymous SNV - - - ○ - - RUSC1 1 NM_001105204 c.1138_1139insC p.A380fs frameshift insertion - - - ○ - - 722 SAE1 19 NM_005500 c.C611A p.T204K nonsynonymous SNV ○ - - - - - 723 SAMD1 19 NM_138352 c.C836T p.P279L nonsynonymous SNV - - ○ - - - 724 SAMD11 1 NM_152486 c.682_683insT p.P228fs frameshift insertion ○ - - - - - 725 SAMD9 7 NM_017654 c.1552_1553insA p.A518fs frameshift insertion - - ○ - - - 726 SAMD9L 7 NM_152703 c.G3890A p.S1297N nonsynonymous SNV - - - ○ - - 727 SAP130 2 NM_024545 c.C386T p.T129M nonsynonymous SNV - - ○ - - - 728 SASH1 6 NM_015278 c.39_40insGAGCCC p.P13delinsPEP nonframeshift insertion - - - - - ○ 729 SBF1 22 NM_002972 c.C847T p.P283S nonsynonymous SNV ○ - - - - - 730 SCAMP3 1 NM_052837 c.G91A p.A31T nonsynonymous SNV - - ○ - - - 731 SCARF1 17 NM_145352 c.36_37insGCT p.L12delinsLL nonframeshift insertion - - - - ○ - 732 SCFD1 14 NM_182835 c.T821A p.V274D nonsynonymous SNV - - - - - ○ 733 SCMH1 1 NM_001172222 c.G1201A p.D401N nonsynonymous SNV - - - ○ - - 734 SCPEP1 17 NM_021626 c.763delA p.K255fs frameshift deletion - - - ○ - - 735 SDHAF2 11 NM_017841 c.A37T p.M13L nonsynonymous SNV ○ - - - - - 736 SDPR 2 NM_004657 c.C1238T p.P413L nonsynonymous SNV - - - ○ - - 737 SEC14L3 22 NM_174975 c.G59A p.R20Q nonsynonymous SNV ○ - - - - - 738 SEL1L2 20 NM_025229 c.A1688C p.Y563S nonsynonymous SNV - ○ - - - - 739 SELO 22 NM_031454 c.G1717A p.A573T nonsynonymous SNV - - ○ - - - 740 SEMA4C 2 NM_017789 c.A2453G p.Q818R nonsynonymous SNV - - - - ○ - 741 SENP1 12 NM_014554 c.C652T p.H218Y nonsynonymous SNV - - - - - ○ 742 SERPINA9 14 NM_175739 c.554delA p.N185fs frameshift deletion - - - - - ○ 743 SETBP1 18 NM_015559 c.C584T p.T195M nonsynonymous SNV - - - - ○ - 744 SETDB1 1 NM_001145415 c.395_399del p.132_133del frameshift deletion - - - - - ○ 745 SEZ6 17 NM_178860 c.A410G p.E137G nonsynonymous SNV - - ○ - - - 746 SGIP1 1 NM_032291 c.G1334A p.R445Q nonsynonymous SNV - - - - - ○ 747 SGK494 17 NM_001174103 c.G376C p.D126H nonsynonymous SNV - - - - - ○ 748 SGTA 19 NM_003021 c.A47G p.H16R nonsynonymous SNV - - ○ - - - 749 SH3GL3 15 NM_003027 c.G872A p.R291H nonsynonymous SNV - - - - ○ - 750 SHF 15 NM_138356 c.A256G p.T86A nonsynonymous SNV - ○ - - - - 751 SHISA6 17 NM_207386 c.G1063A p.V355I nonsynonymous SNV - - - - - ○ 752 SHROOM4 X NM_020717 c.3384_3385insACAGCAGCAGCA p.Q1128delinsQQQQQ nonframeshift insertion - - ○ - - - 753 SIGLEC12 19 NM_033329 c.G401C p.R134T nonsynonymous SNV - - - ○ - - 754 SLC13A3 20 NM_001193339 c.A572G p.H191R nonsynonymous SNV ○ - - - - - 755 SLC16A13 17 NM_201566 c.322_323insT p.L108fs frameshift insertion - - - ○ - - 756 SLC25A28 10 NM_031212 c.G178A p.G60S nonsynonymous SNV - - - - ○ - 757 SLC25A33 1 NM_032315 c.A560G p.Y187C nonsynonymous SNV - ○ - - - - 758 SLC26A3 7 NM_000111 c.C1744G p.Q582E nonsynonymous SNV - - - - ○ - 759 SLC34A1 5 NM_003052 c.271_291del p.91_97del nonframeshift deletion - - - - ○ - 760 SLC36A3 5 NM_001145017 c.T1465C p.Y489H nonsynonymous SNV - ○ - - - - 761 SLC39A9 14 NM_018375 c.G611A p.R204Q nonsynonymous SNV - - - - ○ - 762 SLC43A3 11 NM_017611 c.1265_1266insCCACT p.F422fs frameshift insertion - - ○ - - - 763 SLC4A1 17 NM_000342 c.G1354A p.A452T nonsynonymous SNV - - - ○ - - 764 SLC4A11 20 NM_001174089 c.A1061G p.K354R nonsynonymous SNV - - ○ - - - 765 SLC7A6OS 16 NM_032178 c.A835G p.R279G nonsynonymous SNV ○ - - - - - 766 SLC8A2 19 NM_015063 c.C1294T p.R432C nonsynonymous SNV - - - - ○ - 767 SLC9A4 2 NM_001011552 c.G1940A p.W647X stopgain SNV - ○ - - - - 768 SLCO1B7 12 NM_001009562 c.C1181T p.T394I nonsynonymous SNV - - ○ - - - 769 SLCO4A1 20 NM_016354 c.G227A p.R76Q nonsynonymous SNV - - - - ○ - 770 SMARCA4 19 NM_003072 c.G3575A p.R1192H nonsynonymous SNV - - - - - ○ 771 SMARCD2 17 NM_001098426 c.G1106A p.R369H nonsynonymous SNV - - ○ - - - 772 SMG7 1 NM_201569 c.G889C p.V297L nonsynonymous SNV - - - - - ○ 773 SMPD1 11 NM_000543 c.103_114del p.35_38del nonframeshift deletion - ○ - - - - 774 SMPDL3A 6 NM_006714 c.A1202G p.K401R nonsynonymous SNV - - - - ○ - 775 SMTNL1 11 NM_001105565 c.G679C p.G227R nonsynonymous SNV - - - - - ○ 776 SMYD5 2 NM_006062 c.G468C p.R156S nonsynonymous SNV - - - ○ - - 777 SNIP1 1 NM_024700 c.C862T p.R288C nonsynonymous SNV ○ - - - - - 778 SNX13 7 NM_015132 c.T2517A p.D839E nonsynonymous SNV - - ○ - - - 779 SNX29 16 NM_032167 c.C1897T p.P633S nonsynonymous SNV ○ - - - - - 780 SORCS3 10 NM_014978 c.C3235A p.Q1079K nonsynonymous SNV - ○ - - - - 781 SP100 2 NM_001080391 c.A1516G p.T506A nonsynonymous SNV - - - ○ - - 782 SPAG17 1 NM_206996 c.3307delA p.S1103fs frameshift deletion - ○ - - - - 783 SPATA5L1 15 NM_024063 c.A1438G p.I480V nonsynonymous SNV - - - ○ - - 784 SPDYE4 17 NM_001128076 c.G20A p.R7H nonsynonymous SNV - - - ○ - - 785 SPOCK1 5 NM_004598 c.G1253A p.R418Q nonsynonymous SNV - - - - - ○ 786 SPRYD5 11 NM_032681 c.G952A p.D318N nonsynonymous SNV - - - - - ○ 787 SPTAN1 9 NM_001195532 c.G3703A p.A1235T nonsynonymous SNV - - - - ○ - 788 SPTB 14 NM_000347 c.A3761G p.D1254G nonsynonymous SNV - - - ○ - - 789 SPTBN2 11 NM_006946 c.G6136A p.D2046N nonsynonymous SNV ○ - - - - - 790 SRGAP1 12 NM_020762 c.A1748G p.Y583C nonsynonymous SNV - - - ○ - - 791 SRSF7 2 NM_001031684 c.A496C p.I166L nonsynonymous SNV - - ○ - - - 792 SSC5D 19 NM_001144950 c.C3308T p.S1103F nonsynonymous SNV - - - - ○ - 793 SSTR4 20 NM_001052 c.G790A p.V264I nonsynonymous SNV ○ - - - - - 794 STARD6 18 NM_139171 c.G258C p.R86S nonsynonymous SNV - - - ○ - - 795 STARD8 X NM_014725 c.T1840C p.S614P nonsynonymous SNV - - - - - ○ 796 SULT6B1 2 NM_001032377 c.T704C p.I235T nonsynonymous SNV - - - ○ - - 797 SUPT5H 19 NM_001111020 c.113_115del p.38_39del nonframeshift deletion - - ○ - - - 798 SURF4 9 NM_033161 c.A673G p.I225V nonsynonymous SNV - ○ - - - - 799 SV2C 5 NM_014979 c.C715A p.Q239K nonsynonymous SNV - - - - - ○ 800 SVEP1 9 NM_153366 c.A2415C p.K805N nonsynonymous SNV - - ○ - - - 801 SYNPO2L 10 NM_001114133 c.G76A p.E26K nonsynonymous SNV - - - ○ - - 802 TAF15 17 NM_003487 c.1342_1344del p.448_448del nonframeshift deletion - - - - ○ - 803 TAF6 7 NM_139315 c.G1976T p.G659V nonsynonymous SNV - - - ○ - - 804 TARS 5 NM_152295 c.G43A p.G15S nonsynonymous SNV - - - ○ - - 805 TARSL2 15 NM_152334 c.C1954G p.L652V nonsynonymous SNV - - - - - ○ 806 TAS1R1 1 NM_177540 c.C1562T p.A521V nonsynonymous SNV - - ○ - - - 807 TAS2R19 12 NM_176888 c.C660A p.S220R nonsynonymous SNV ○ - - - - - TAS2R19 12 NM_176888 c.G659A p.S220N nonsynonymous SNV ○ - - - - - 808 TAS2R5 7 NM_018980 c.A239G p.Y80C nonsynonymous SNV - - - - - ○ 809 TBC1D9B 5 NM_198868 c.C3373G p.Q1125E nonsynonymous SNV - - - - - ○ 810 TBCCD1 3 NM_001134415 c.G1312C p.V438L nonsynonymous SNV - - ○ - - - 811 TCHHL1 1 NM_001008536 c.G1172A p.R391K nonsynonymous SNV - - - ○ - - TCHHL1 1 NM_001008536 c.T1167A p.D389E nonsynonymous SNV - - - ○ - - 812 TDRD6 6 NM_001168359 c.T5557C p.S1853P nonsynonymous SNV - - - ○ - - 813 TDRKH 1 NM_001083964 c.G568C p.A190P nonsynonymous SNV - - - ○ - - 814 TECPR1 7 NM_015395 c.G2087A p.R696H nonsynonymous SNV ○ - - - - - 815 TECTA 11 NM_005422 c.G5908A p.A1970T nonsynonymous SNV - - - - - ○ 816 TET3 2 NM_144993 c.C1529T p.P510L nonsynonymous SNV - - ○ - - - 817 TFAP2E 1 NM_178548 c.64_65insGGGC p.A22fs frameshift insertion - ○ - - - - 818 TFIP11 22 NM_012143 c.A746C p.K249T nonsynonymous SNV ○ - - - - - 819 TGM6 20 NM_198994 c.C1478T p.P493L nonsynonymous SNV - - - ○ - - 820 TGOLN2 2 NM_001206840 c.C770T p.P257L nonsynonymous SNV - - - - ○ - 821 THBS1 15 NM_003246 c.A1690G p.S564G nonsynonymous SNV - - - ○ - - 822 TIAM1 21 NM_003253 c.G349A p.V117I nonsynonymous SNV - - ○ - - - 823 TIAM2 6 NM_012454 c.G2440T p.V814F nonsynonymous SNV - - ○ - - - 824 TICAM1 19 NM_182919 c.1102_1103insCCT p.S368delinsPS nonframeshift insertion - ○ - - - - 825 TIMM8A X NM_004085 c.C223G p.Q75E nonsynonymous SNV - - ○ - - - 826 TINAG 6 NM_014464 c.T1197A p.N399K nonsynonymous SNV - - - - - ○ 827 TLE2 19 NM_003260 c.C452T p.T151M nonsynonymous SNV - - - - ○ - 828 TM4SF19 3 NM_001204898 c.G544A p.E182K nonsynonymous SNV - ○ - - - - 829 TM6SF2 19 NM_001001524 c.G787T p.A263S nonsynonymous SNV - ○ - - - - 830 TMEM119 12 NM_181724 c.A266T p.D89V nonsynonymous SNV ○ - - - - - 831 TMEM132C 12 NM_001136103 c.C2107T p.R703W nonsynonymous SNV - ○ - - - - 832 TMEM181 6 NM_020823 c.C1099T p.L367F nonsynonymous SNV - ○ - - - - 833 TMEM186 16 NM_015421 c.G323T p.G108V nonsynonymous SNV - - - ○ - - 834 TMEM52 1 NM_178545 c.C452T p.P151L nonsynonymous SNV - - - - - ○ 835 TMEM99 17 NM_145274 c.748_751del p.250_251del frameshift deletion - - ○ - - - 836 TMF1 3 NM_007114 c.C2540T p.A847V nonsynonymous SNV - - ○ - - - 837 TMPRSS5 11 NM_030770 c.707_708insG p.A236fs frameshift insertion - - ○ - - - 838 TNFSF12-TNFSF13 17 NM_172089 c.C386A p.T129K nonsynonymous SNV - - ○ - - - 839 TNIK 3 NM_001161563 c.C1729T p.R577C nonsynonymous SNV - - - - - ○ 840 TNR 1 NM_003285 c.C3917G p.T1306S nonsynonymous SNV - - - - - ○ 841 TOM1L2 17 NM_001082968 c.C247T p.H83Y nonsynonymous SNV - - ○ - - - 842 TOMM40 19 NM_006114 c.G652A p.V218I nonsynonymous SNV ○ - - - - - 843 TP63 3 NM_001114978 c.A233T p.D78V nonsynonymous SNV - - - - - ○ 844 TPM4 19 NM_001145160 c.203_205del p.68_69del nonframeshift deletion - - - - - ○ 845 TPPP 5 NM_007030 c.G413A p.R138H nonsynonymous SNV - - ○ - - - 846 TPR 1 NM_003292 c.G3841A p.E1281K nonsynonymous SNV - - - - ○ - 847 TRAPPC4 11 NM_016146 c.578_581del p.193_194del frameshift deletion - - ○ - - - 848 TRDMT1 10 NM_004412 c.151_152del p.51_51del frameshift deletion - - ○ - - - 849 TRERF1 6 NM_033502 c.C2338T p.R780C nonsynonymous SNV - - - ○ - - 850 TRIM16L 17 NM_001037330 c.G370C p.E124Q nonsynonymous SNV - - - ○ - - 851 TRIM71 3 NM_001039111 c.G49A p.E17K nonsynonymous SNV ○ - - - - - 852 TRMT2A 22 NM_022727 c.1801delC p.H601fs frameshift deletion - ○ - - - - 853 TRO X NM_016157 c.491_492insAC p.I164fs frameshift insertion - - - ○ - - 854 TRPC7 5 NM_020389 c.T539C p.V180A nonsynonymous SNV ○ - - - - - 855 TSHZ2 20 NM_001193421 c.G865A p.V289I nonsynonymous SNV - - - - - ○ 856 TSHZ3 19 NM_020856 c.C974G p.S325C nonsynonymous SNV - - - - - ○ 857 TSNARE1 8 NM_145003 c.G608A p.R203Q nonsynonymous SNV - - - ○ - - 858 TSPAN6 X NM_003270 c.422delG p.S141fs frameshift deletion - - - - - ○ 859 TTBK1 6 NM_032538 c.G2836C p.G946R nonsynonymous SNV ○ - - - - - 860 TTC31 2 NM_022492 c.C1120T p.R374W nonsynonymous SNV ○ - - - - - 861 TTLL9 20 NM_001008409 c.T232C p.C78R nonsynonymous SNV ○ - - - - - 862 TUBA3E 2 NM_207312 c.C517A p.P173T nonsynonymous SNV - - ○ - - - 863 TUBGCP2 10 NM_006659 c.A1118G p.Q373R nonsynonymous SNV - - ○ - - - 864 TWISTNB 7 NM_001002926 c.843_845del p.281_282del nonframeshift deletion - - ○ - - - 865 TXNDC11 16 NM_015914 c.1187_1188insG p.V396fs frameshift insertion ○ - - - - - 866 TYK2 19 NM_003331 c.G2102C p.R701T nonsynonymous SNV - - - ○ - - 867 TYW1 7 NM_018264 c.C1506G p.H502Q nonsynonymous SNV - ○ - - - - 868 UBXN11 1 NM_145345 c.1363_1364del p.455_455del frameshift deletion - ○ - - - - 869 UBXN4 2 NM_014607 c.1381_1382insA p.E461fs frameshift insertion - - - ○ - - 870 UMOD 16 NM_003361 c.G1624A p.E542K nonsynonymous SNV ○ - - - - - 871 UMODL1 21 NM_001199527 c.A2020G p.S674G nonsynonymous SNV - - - - ○ - 872 UNC119B 12 NM_001080533 c.C649G p.L217V nonsynonymous SNV - - ○ - - - 873 UNC5B 10 NM_001244889 c.G1691T p.G564V nonsynonymous SNV - - ○ - - - 874 UNC93A 6 NM_001143947 c.A203G p.K68R nonsynonymous SNV - - - ○ - - 875 USP17L2 8 NM_201402 c.G994A p.D332N nonsynonymous SNV - - ○ - - - 876 USP35 11 NM_020798 c.G2794C p.E932Q nonsynonymous SNV - - - ○ - - 877 USP48 1 NM_001032730 c.A1274T p.K425M nonsynonymous SNV - ○ - - - - 878 USP49 6 NM_018561 c.T1322A p.V441E nonsynonymous SNV - - - - ○ - 879 USP6NL 10 NM_014688 c.A532G p.I178V nonsynonymous SNV - - ○ - - - 880 UTS2R 17 NM_018949 c.A100G p.S34G nonsynonymous SNV - - - - ○ - 881 UVRAG 11 NM_003369 c.1755_1757del p.585_586del nonframeshift deletion - - ○ - - - 882 VCAN 5 NM_001164098 c.C2482T p.P828S nonsynonymous SNV - - - - - ○ 883 VEGFA 6 NM_001171629 c.A358G p.M120V nonsynonymous SNV - ○ - - - - 884 VEGFC 4 NM_005429 c.G935A p.R312K nonsynonymous SNV - - ○ - - - 885 VIL1 2 NM_007127 c.A4T p.T2S nonsynonymous SNV - - - ○ - - 886 VPS13C 15 NM_017684 c.A3799G p.I1267V nonsynonymous SNV - - - - ○ - 887 VPS13D 1 NM_018156 c.G3653A p.G1218D nonsynonymous SNV - - - ○ - - 888 VSTM5 11 NM_001144871 c.G448A p.A150T nonsynonymous SNV ○ - - - - - 889 VTCN1 1 NM_024626 c.C523T p.P175S nonsynonymous SNV - - - - - ○ 890 VWA3B 2 NM_144992 c.G1252A p.A418T nonsynonymous SNV ○ - - - - - 891 VWA5A 11 NM_014622 c.C2297T p.S766L nonsynonymous SNV - - - ○ - - 892 VWCE 11 NM_152718 c.G2424A p.M808I nonsynonymous SNV ○ - - - - - 893 VWF 12 NM_000552 c.G4201A p.V1401I nonsynonymous SNV - - ○ - - - 894 WAPAL 10 NM_015045 c.A172C p.I58L nonsynonymous SNV - - ○ - - - 895 WASF3 13 NM_006646 c.A59C p.E20A nonsynonymous SNV - - - ○ - - 896 WBSCR28 7 NM_182504 c.G306T p.M102I nonsynonymous SNV - - - - ○ - 897 WDFY4 10 NM_020945 c.C1750T p.R584W nonsynonymous SNV - - ○ - - - 898 WDR27 6 NM_182552 c.C502T p.R168C nonsynonymous SNV ○ - - - - - 899 WDR36 5 NM_139281 c.C2266T p.L756F nonsynonymous SNV - - - - - ○ 900 WDR59 16 NM_030581 c.A1396G p.K466E nonsynonymous SNV - - ○ - - - 901 WIZ 19 NM_021241 c.119_120insG p.E40fs frameshift insertion - - - - ○ - 902 WSCD2 12 NM_014653 c.G53A p.R18H nonsynonymous SNV - ○ - - - - 903 XIRP2 2 NM_001199144 c.C7687G p.P2563A nonsynonymous SNV - - ○ - - - 904 XKR6 8 NM_173683 c.G1168A p.V390M nonsynonymous SNV - - - - - ○ 905 XPNPEP3 22 NM_022098 c.C499T p.R167X stopgain SNV ○ - - - - - 906 XPO5 6 NM_020750 c.T683C p.L228P nonsynonymous SNV - - ○ - - - 907 XRN2 20 NM_012255 c.G2454C p.L818F nonsynonymous SNV - - - ○ - - 908 YTHDC2 5 NM_022828 c.G383T p.R128M nonsynonymous SNV - - ○ - - - 909 ZBTB10 8 NM_023929 c.C1366T p.R456X stopgain SNV - - - ○ - - 910 ZBTB41 1 NM_194314 c.A1044T p.L348F nonsynonymous SNV - - - ○ - - 911 ZCCHC6 9 NM_001185074 c.A1510C p.K504Q nonsynonymous SNV ○ - - - - - 912 ZDBF2 2 NM_020923 c.G1082C p.S361T nonsynonymous SNV - ○ - - - - 913 ZFHX4 8 NM_024721 c.9499_9501del p.3167_3167del nonframeshift deletion - - - ○ - - 914 ZFR2 19 NM_015174 c.C2267G p.A756G nonsynonymous SNV - - - ○ - - 915 ZFYVE16 5 NM_014733 c.A3358G p.T1120A nonsynonymous SNV - - - ○ - - 916 ZHX1 8 NM_001017926 c.C1841T p.A614V nonsynonymous SNV - - - - ○ - 917 ZIC5 13 NM_033132 c.1260_1262del p.420_421del nonframeshift deletion ○ - - - - - 918 ZMYM2 13 NM_003453 c.1448delT p.V483fs frameshift deletion - ○ - - - - 919 ZMYM6 1 NM_007167 c.C1204T p.R402C nonsynonymous SNV - - - ○ - - 920 ZNF132 19 NM_003433 c.G1266T p.W422C nonsynonymous SNV ○ - - - - - 921 ZNF205 16 NM_001042428 c.A649T p.N217Y nonsynonymous SNV - - - - - ○ 922 ZNF30 19 NM_001099437 c.G107T p.R36M nonsynonymous SNV - - ○ - - - 923 ZNF317 19 NM_001190791 c.G208A p.E70K nonsynonymous SNV - - ○ - - - 924 ZNF479 7 NM_033273 c.A224G p.Q75R nonsynonymous SNV - ○ - - - - 925 ZNF507 19 NM_001136156 c.A114C p.K38N nonsynonymous SNV - - ○ - - - 926 ZNF517 8 NM_213605 c.879_890del p.293_297del nonframeshift deletion - - ○ - - - 927 ZNF526 19 NM_133444 c.C527G p.P176R nonsynonymous SNV - - ○ - - - 928 ZNF585B 19 NM_152279 c.479_482del p.160_161del frameshift deletion ○ - - - - - 929 ZNF605 12 NM_001164715 c.G1954T p.E652X stopgain SNV - ○ - - - - 930 ZNF611 19 NM_001161499 c.T1472G p.F491C nonsynonymous SNV ○ - - - - - 931 ZNF655 7 NM_024061 c.G502A p.D168N nonsynonymous SNV ○ - - - - - 932 ZNF660 3 NM_173658 c.G209A p.R70Q nonsynonymous SNV ○ - - - - - 933 ZNF687 1 NM_020832 c.C1088T p.A363V nonsynonymous SNV ○ - - - - - 934 ZNF700 19 NM_144566 c.896delG p.S299fs frameshift deletion ○ - - - - - 935 ZNF716 7 NM_001159279 c.G361A p.E121K nonsynonymous SNV - - ○ - - - 936 ZNF721 4 NM_133474 c.G734A p.G245E nonsynonymous SNV - - - - ○ - 937 ZNF780A 19 NM_001010880 c.T320A p.I107K nonsynonymous SNV - - - - ○ - 938 ZNF790 19 NM_206894 c.T1393C p.F465L nonsynonymous SNV - - - - ○ - 939 ZNF791 19 NM_153358 c.G649A p.E217K nonsynonymous SNV - ○ - - - - 940 ZNF792 19 NM_175872 c.A1768G p.M590V nonsynonymous SNV - ○ - - - - 941 ZNF816 19 NM_001031665 c.G1586A p.R529K nonsynonymous SNV - - - - - ○ 942 ZNF831 20 NM_178457 c.C1058T p.A353V nonsynonymous SNV - ○ - - - - 943 ZNF835 19 NM_001005850 c.C548T p.S183F nonsynonymous SNV ○ - - - - - 944 ZNF844 19 NM_001136501 c.A1069G p.M357V nonsynonymous SNV - - ○ - - - ZNF844 19 NM_001136501 c.1381_1382del p.461_461del frameshift deletion - - ○ - - - 945 ZNF90 19 NM_007138 c.1412_1416del p.471_472del frameshift deletion - - - - - ○ 946 ZNF91 19 NM_003430 c.G237A p.M79I nonsynonymous SNV - - - - - ○ 947 ZNF98 19 NM_001098626 c.A419G p.N140S nonsynonymous SNV - - ○ - - - 948 ZNF99 19 NM_001080409 c.C600G p.I200M nonsynonymous SNV - - - - - ○ 949 ZNRF4 19 NM_181710 c.C1061T p.S354L nonsynonymous SNV - - - - ○ - 950 ZPLD1 3 NM_175056 c.G28A p.G10R nonsynonymous SNV ○ - - - - - 951 ZRSR2 X NM_005089 c.1314_1315insAGCCGG p.G438delinsGSR nonframeshift insertion ○ - - - - - 952 ZSCAN18 19 NM_001145544 c.G613A p.A205T nonsynonymous SNV - - ○ - - - SUPPLEMENTARY TABLE S5. Nucleotide alterations of Hippo pathway genes revealed by whole-exon sequencing of MM cell lines. No. SYMBOL CHR RefSeq cDNA Amino acid Type Sample 1 NF2 22 NM_181829 c.C898T p.R300X stopgain SNV H2052 NF2 22 NM_181829 c.C1042T p.Q348X stopgain SNV MESO-1 2 LATS2 13 NM_014572 c.2355_2396del p.785_799del nonframeshift deletion MSTO-211H 3 FAT1 4 NM_005245 c.3200_3202del p.1067_1068del nonframeshift deletion MESO-1 4 FAT2 5 NM_001447 c.C5138T p.S1713F nonsynonymous SNV MESO-1 5 RASSF2 20 NM_170774 c.G880T p.E294X stopgain SNV H2052 6 RASSF6 4 NM_201431 c.464_465insA p.R155fs frameshift insertion MESO-4 Abbreviations: SYMBOL, gene symbol; CHR, chromosome. SUPPLEMENTARY TABLE S6. CNVs of Hippo pathway genes detected in cell lines. Cell Line Gene symbol Official Full Name Location 211H MESO1 H28 MESO4 H2452 H2052 CRB1 crumbs homolog 1 (Drosophila) 1q31-q32.1 0.76 1.06 1.34 0.98 0.72 1.40 CRB2 crumbs homolog 2 (Drosophila) 9q33.2 1.14 1.29 1.41 1.12 1.31 1.96 CRB3 crumbs homolog 3 (Drosophila) 19p13.3 0.99 1.06 1.14 1.17 1.24 1.94 FAT4 FAT tumor suppressor homolog 4 (Drosophila) 4q28.1 0.95 0.68 0.51 0.96 0.48 1.29 FRMD1 FERM domain containing 1 6q27 1.00 1.10 1.05 1.06 1.07 1.11 FRMD6 FERM domain containing 6 14q22.1 1.02 0.78 0.53 1.00 0.53 1.30 LATS1 LATS, large tumor suppressor, homolog 1 (Drosophila) 6q25.1 0.46 1.10 1.05 1.07 1.17 1.15 LATS2 LATS, large tumor suppressor, homolog 2 (Drosophila) 13q11-q12 0.59 0.79 1.04 0.56 1.11 0.18 MOB1A MOB kinase activator 1A 2p13.1 1.04 0.94 1.09 1.02 0.96 2.80 MOB1B MOB kinase activator 1B 4q13.3 1.03 0.70 0.58 1.08 0.54 1.43 MOB2 MOB kinase activator 2 11p15.5 0.86 0.96 0.87 1.01 1.09 2.13 MOB3A MOB kinase activator 3A 19p13.3 0.89 0.92 1.06 1.12 1.23 1.83 MOB3B MOB kinase activator 3B 9p21.1 0.78 0.95 0.51 0.96 0.54 0.07 MOB3C MOB kinase activator 3C 1p34.1 0.57 1.31 1.06 1.23 1.19 1.25 MOB4 MOB family member 4, phocein 2q33.1 1.05 1.13 1.41 1.05 0.81 1.74 MST1 macrophage stimulating 1 (hepatocyte growth factor-like) 3p21 0.91 1.07 1.45 1.03 0.70 1.46 MST4 Serine/threonine protein kinase MST4 Xq26.2 1.05 1.08 1.96 1.00 0.99 1.57 NF2 neurofibromin 2 (merlin) 22q12.2 0.82 1.00 1.14 1.13 0.70 1.57 RASSF1 Ras association (RalGDS/AF-6) domain family member 1 3p21.3 0.79 1.14 1.51 0.61 0.53 1.45 RASSF2 Ras association (RalGDS/AF-6) domain family member 2 20p13 0.86 1.43 0.86 1.01 1.11 2.39 RASSF3 Ras association (RalGDS/AF-6) domain family member 3 12q14.2 1.13 1.07 1.07 1.15 1.07 1.82 RASSF4 Ras association (RalGDS/AF-6) domain family member 4 10q11.1 0.93 1.18 1.12 0.55 1.10 1.84 RASSF5 Ras association (RalGDS/AF-6) domain family member 5 1q31 0.86 1.23 1.56 1.15 0.91 1.69 RASSF6 Ras association (RalGDS/AF-6) domain family member 6 4q21.1 0.97 0.70 0.54 0.97 0.51 1.37 SAV1 salvador homolog 1 (Drosophila) 14q13-q23 1.02 0.87 0.57 0.95 0.57 1.30 YWHAS stratifin 1p36.11 0.76 0.87 0.58 0.77 0.90 1.47 MST3 serine/threonine kinase 24 13q31.2-q32.3 0.82 0.80 1.08 0.56 0.59 2.82 MST2 serine/threonine kinase 3 8q22.2 0.74 1.36 0.81 0.99 0.72 2.87 TAZ tafazzin Xq28 1.16 1.37 1.97 1.16 1.23 2.51 TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 11p15.4 0.81 0.93 0.82 1.06 1.10 2.08 TEAD2 TEA domain family member 2 19q13.3 1.13 0.76 1.09 1.55 0.63 2.04 TEAD3 TEA domain family member 3 6p21.2 0.89 1.16 1.14 1.18 1.10 1.32 TEAD4 TEA domain family member 4 12p13.3-p13.2 1.12 1.17 1.15 0.63 1.16 2.00 KIBRA WW and C2 domain containing 1 5q34 1.08 1.73 1.56 1.11 1.10 1.86 YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 20q13.1 0.78 1.55 1.06 1.05 1.07 2.63 YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 17p13.3 1.11 1.22 0.94 1.16 1.44 1.77 YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 7q11.23 1.12 1.16 1.16 1.17 1.16 1.08 YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide 22q12.1-q13.1 0.82 0.99 1.20 1.16 0.74 1.59 YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide 2p25.2-p25.1 1.03 1.04 1.11 1.12 1.00 2.82 YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 8q22.3 0.80 1.42 0.92 1.07 0.74 2.94 Gain (>2.0 relative to normal DNA) and loss (<0.5) are indicated by blue and red, respectively. SUPPLEMENTARY TABLE S7. Clinical significance of Hippo pathway gene mutation. Hippo pathway gene mutation Nuclear YAP expression Characteristic Positive (n = 8) Negative (n = 15) P -value* Positive (n = 24) Negative (n = 20) P -value* Sex 1 1 Male 7 13 20 17 Female 1 2 4 3

Age 1 0.3293 ≥ 65 years 2 3 5 7 < 65 years 6 12 19 13

Histological subtype 0.4427 0.4995 Biphasic 5 5 10 5 Epithelial 3 8 13 13 Sarcomatous 0 2 1 2

Asbest exposure 1 0.543 Yes 4 7 15 10 No 4 8 9 10

Recurrence 1 0.7456 Present 7 13 18 14 Absent 1 2 6 6 *Fisher's exact test SUPPLEMENTARY TABLE S8. List of antibodies used for immunoblot analysis. No Supplier Cat.# Ab name Dilution Ab type 1 CST #8774 KIBRA ×1,000 Ra Ab 2 CST #3507 Sav1 ×1,000 Ra Ab 3 Epitomics #5562-1 RASSF1 ×1,000 Ra Ab 4 Epitomics #3357-1 Merlin ×50,000 Ra Ab 5 CST #3681 Pho-MST1/MST2 ×1,000 Ra Ab 6 Epitomics #1941-1 MST1 ×1,000 Ra Ab 7 Epitomics #1943-1 MST2 ×1,000 Ra Ab 8 CST #9157 Pho-LATS1(Ser909) ×1,000 Ra Ab 9 CST #3477 LATS1 (C66B5) ×1,000 Ra Ab 10 NB 200-199 LATS2 ×1,000 Ra Ab 11 CST #4911 Pho-YAP (S127) ×1,000 Ra Ab 12 CST #4912 YAP ×1,000 Ra Ab 13 CST #8418 YAP/TAZ ×1,000 Ra Ab 14 CST #8312 14--3--3(pan) ×1,000 Ra Ab Abbreviations: CST, Cell Signaling Technology, Inc. (Danvers, MA); NB, Novus. (St. Louis, Mo, mouse; Ra, rabbit; pAb, polyconal antibody. SUPPLEMENTARY TABLE S9. Primer sequences used for validating fusion transcripts. No Fusion gene Primer sequence (5'-3')-F Primer sequence (5'-3')-R Product (bp) 1 USP4-Y_RNA.735 TGAGTTGCCATTTCAGCAAG GGAGGTGATCCCAGAAAACA 395 2 CNOT10-OSBPL10 TCAGAAATGCCTTGTTGCTG ATACACGTGGCCAAAGGAAC 322 3 GSR-NRG1 TGCTGATTATGGCTTTCCAA TTCTTGGTTGGGTTGTTCCT 177 4 TAF15-MPP2 TCGGATTCTGGAAGTTACGG CGAAGGAAGATCAGGTCCAG 187 5 SLIT2-AC006052 GCAACACCGAGAGACTGGAT CAGAAATGAGTGTTACAGAAATGGA 325 6 LATS1-PSEN1 GCACCTGAAGTGTTGCTACG GGTCCACTTCGTATGCTGGT 205 7 PSEN1-LATS1 AACGCTTTTTCCAGCTCTCA TCGCACCTTTACTCTGATGC 230 8 TRAPPC9-GBA3 CTTTCCCCTGTCCAGTCCTT CTTCTGGCAGCTGAAGATCC 269 9 VRK1-AL445885 ATGAAGCAAATGCCAAAAGG CACGTAATCCCGGTCTTGAT 249 10 RPRD1A-FHOD3 AGAAGCTGTCGGAGTTGAGC CCTCTTGAAACAGGGTGCTG 239 11 TP53-HSF2BP CCTCACCATCATCACACTGG TGCTTCGCTTCATTCAACTG 386 12 ATP9A-KAZN AGGAGATCCGATGCTACGTG GGCTAGCTCCTGCTCCTTCT 237 13 PARD3B-SPHKAP GGTCCTGGTTACTGGGTGAA GTGCTCTGTGCTGCATTCAT 367 14 JHDM1D-RP1-150O5.3 TAGGACTCAGGCTCCCTTCA GGGCGGCATTTTACAGTCTA 319 15 STAT1-CDRT1 TGGGCTCAGCTTTCAGAAGT GCTGATGTGGCAGACTGAAA 281