MOLECULAR AND CELLULAR BIOLOGY

Volume 30 May 2010 No. 10

SPOTLIGHT

Articles of Significant Interest Selected from This Issue by 2305 the Editors

ARTICLES A Novel Transcriptional Repressor, Rhit, Is Involved in Reiko Iida, Misuzu Ueki, and 2306–2315 Heat-Inducible and Age-Dependent Expression of Mpv17- Toshihiro Yasuda Like Protein, a Participant in Reactive Oxygen Species Metabolism Molecular Basis for Lysine Specificity in the Yeast Martin Sadowski, Randy 2316–2329 Ubiquitin-Conjugating Cdc34 Suryadinata, Xianning Lai, Jo¨rg Heierhorst, and Boris Sarcevic Dominant Role for Signal Transduction in the Sharmistha Kundu and Craig L. 2330–2340 Transcriptional Memory of Yeast GAL Peterson Differential Requirement for H2AX and 53BP1 in Benjamin Orsburn, Beatriz 2341–2352 Organismal Development and Genome Maintenance in the Escudero, Mansi Prakash, Silvia Absence of Poly(ADP)ribosyl Polymerase 1 Gesheva, Guosheng Liu, David L. Huso, and Sonia Franco Separable Functions of the Fission Yeast Spt5 Carboxyl- Susanne Schneider, Yi Pei, Stewart 2353–2364 Terminal Domain (CTD) in Capping Enzyme Binding and Shuman, and Beate Schwer Transcription Elongation Overlap with Those of the RNA Polymerase II CTD The for Aromatase, a Rate-Limiting Enzyme for Local Jae-Hwan Jeong, Youn-Kwan Jung, 2365–2375 Estrogen Biosynthesis, Is a Downstream Target Gene of Hyo-Jin Kim, Jung-Sook Jin, Hyun- Runx2 in Skeletal Tissues Nam Kim, Sang-Min Kang, Shin- Yoon Kim, Andre J. van Wijnen, Janet L. Stein, Jane B. Lian, Gary S. Stein, Shigeaki Kato, and Je-Yong Choi Mechanism of Mediator Recruitment by Tandem Gcn4 Eric Herbig, Linda Warfield, Lisa 2376–2390 Activation Domains and Three Gal11 Activator-Binding Fish, James Fishburn, Bruce A. Domains Knutson, Beth Moorefield, Derek Pacheco, and Steven Hahn SWR1 Complex Poises Heterochromatin Boundaries for Bo O. Zhou, Shan-Shan Wang, Lu- 2391–2400 Antisilencing Activity Propagation Xia Xu, Fei-Long Meng, Yao-Ji Xuan, Yi-Min Duan, Jian-Yong Wang, Hao Hu, Xianchi Dong, Jianping Ding, and Jin-Qiu Zhou C␥ Activation Drives Increased Production of Eunok Im, Ruta Motiejunaite, Jorge 2401–2410 in Endothelial Cells and Lysophosphatidic Acid- Aranda, Eun Young Park, Lorenzo Dependent Regression Federico, Tae-im Kim, Timothy Clair, Mary L. Stracke, Susan Smyth, and Andrius Kazlauskas Identification of SNAPc Subunit Domains That Interact with Mun Kyoung Kim, Yoon Soon 2411–2423 Specific Nucleotide Positions in the U1 and U6 Gene Kang, Hsien-Tsung Lai, Nermeen Promoters H. Barakat, Deodato Magante, and William E. Stumph Positive Regulation of Interferon Regulatory Factor 3 He-Xin Shi, Kai Yang, Xing Liu, 2424–2436 Activation by Herc5 via ISG15 Modification Xin-Yi Liu, Bo Wei, Yu-Fei Shan, Lian-Hui Zhu, and Chen Wang

Continued on following page Continued from preceding page

Cyclin-Dependent Kinase 8 Positively Cooperates with Madesh Belakavadi and Joseph D. 2437–2448 Mediator To Promote Thyroid Hormone Receptor- Fondell Dependent Transcriptional Activation Human AlkB Homolog ABH8 Is a tRNA Methyltransferase Dragony Fu, Jennifer A. N. Brophy, 2449–2459 Required for Wobble Uridine Modification and DNA Clement T. Y. Chan, Kyle A. Damage Survival Atmore, Ulrike Begley, Richard S. Paules, Peter C. Dedon, Thomas J. Begley, and Leona D. Samson RecQL5 Promotes Genome Stabilization through Two M. Nurul Islam, David Fox III, 2460–2472 Parallel Mechanisms—Interacting with RNA Polymerase II Rong Guo, Takemi Enomoto, and and Acting as a Helicase Weidong Wang Expression of a Testis-Specific Form of Gal3st1 (CST), a Teruhiko Suzuki, Natsuki Kosaka- 2473–2484 Gene Essential for Spermatogenesis, Is Regulated by the Suzuki, Svetlana Pack, Dong-Mi CTCF Paralogous Gene BORIS Shin, Jeongheon Yoon, Ziedulla Abdullaev, Elena Pugacheva, Herbert C. Morse III, Dmitri Loukinov, and Victor Lobanenkov The H3K27me3 Demethylase dUTX Is a Suppressor of Hans-Martin Herz, Laurence D. 2485–2497 Notch- and Rb-Dependent Tumors in Drosophila Madden, Zhihong Chen, Clare Bolduc, Eugene Buff, Ravi Gupta, Ramana Davuluri, Ali Shilatifard, Iswar K. Hariharan, and Andreas Bergmann Functional Effects of PTPN11 (SHP2) Mutations Causing Thomas Edouard, Jean-Philippe 2498–2507 LEOPARD Syndrome on Epidermal Growth Factor-Induced Combier, Audrey Ne´de´lec, Sophie Phosphoinositide 3-Kinase/AKT/Glycogen Synthase Kinase Bel-Vialar, Me´lanie Me´trich, 3␤ Signaling Francoise Conte-Auriol, Stanislas Lyonnet, Be´atrice Parfait, Maithe´ Tauber, Jean-Pierre Salles, Frank Lezoualc’h, Armelle Yart, and Patrick Raynal Ephrin-B1 Reverse Signaling Controls a Posttranscriptional Dina N. Arvanitis, Thomas Jungas, 2508–2517 Feedback Mechanism via miR-124 Annie Behar, and Alice Davy Runx1 Directly Promotes Proliferation of Hair Follicle Stem Charlene S. L. Hoi, Song Eun Lee, 2518–2536 Cells and Epithelial Tumor Formation in Mouse Skin Shu-Yang Lu, David J. McDermitt, Karen M. Osorio, Caroline M. Piskun, Rachel M. Peters, Ralf Paus, and Tudorita Tumbar Vasoactive Intestinal Peptide Induces Cell Cycle Arrest and Per Anderson and Elena Gonzalez- 2537–2551 Regulatory Functions in Human T Cells at Multiple Levels Rey A Glycine-Rich Domain of hnRNP H/F Promotes Courtney M. Van Dusen, Lily Yee, 2552–2562 Nucleocytoplasmic Shuttling and Nuclear Import through Lisa M. McNally, and Mark T. an Interaction with Transportin 1 McNally Drosophila RB Proteins Repress Differentiation-Specific Hangnoh Lee, Katsuhito Ohno, 2563–2577 Genes via Two Different Mechanisms Yekaterina Voskoboynik, Linda Ragusano, Anna Martinez, and Dessislava K. Dimova

AUTHOR’S CORRECTION How a Cytokine Is Chaperoned through the Secretory Erwin H. Duitman, Zane Orinska, 2578 Pathway by Complexing with Its Own Receptor: Lessons Elena Bulanova, Ralf Paus, and from Interleukin-15 (IL-15)/IL-15 Receptor ␣ Silvia Bulfone-Paus

Cover photograph (Copyright © 2010, American Society for Microbiology. All Rights Reserved.): A cell overexpressing wild-type p53 (green) strongly suppresses the formation of actin (red)-rich podosomes and maintains well-organized stress fibers (top); p53 (red) induces actin binding protein caldesmon (green), which stabilizes stress fibers and prevents the formation of podosomes (bottom). (See related article in June 2009, vol. 29, no. 11, p. 3088.)