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Quantum Biology: an Update and Perspective
quantum reports Review Quantum Biology: An Update and Perspective Youngchan Kim 1,2,3 , Federico Bertagna 1,4, Edeline M. D’Souza 1,2, Derren J. Heyes 5 , Linus O. Johannissen 5 , Eveliny T. Nery 1,2 , Antonio Pantelias 1,2 , Alejandro Sanchez-Pedreño Jimenez 1,2 , Louie Slocombe 1,6 , Michael G. Spencer 1,3 , Jim Al-Khalili 1,6 , Gregory S. Engel 7 , Sam Hay 5 , Suzanne M. Hingley-Wilson 2, Kamalan Jeevaratnam 4, Alex R. Jones 8 , Daniel R. Kattnig 9 , Rebecca Lewis 4 , Marco Sacchi 10 , Nigel S. Scrutton 5 , S. Ravi P. Silva 3 and Johnjoe McFadden 1,2,* 1 Leverhulme Quantum Biology Doctoral Training Centre, University of Surrey, Guildford GU2 7XH, UK; [email protected] (Y.K.); [email protected] (F.B.); e.d’[email protected] (E.M.D.); [email protected] (E.T.N.); [email protected] (A.P.); [email protected] (A.S.-P.J.); [email protected] (L.S.); [email protected] (M.G.S.); [email protected] (J.A.-K.) 2 Department of Microbial and Cellular Sciences, School of Bioscience and Medicine, Faculty of Health and Medical Sciences, University of Surrey, Guildford GU2 7XH, UK; [email protected] 3 Advanced Technology Institute, University of Surrey, Guildford GU2 7XH, UK; [email protected] 4 School of Veterinary Medicine, Faculty of Health and Medical Sciences, University of Surrey, Guildford GU2 7XH, UK; [email protected] (K.J.); [email protected] (R.L.) 5 Manchester Institute of Biotechnology, Department of Chemistry, The University of Manchester, -
SM08 Programme
SATELLITE MEETING Regulation of gene expression from a distance: exploring mechanisms The Royal Society at Chicheley Hall, home of the Kavli Royal Society International Centre Organised by Professor Wendy Bickmore and Professor Veronica van Heyningen FRS Wednesday 24 – Thursday 25 October 2012 DAY 1 DAY 2 SESSION 1 SESSION 2 SESSION 3 SESSION 4 Enhancer assays Quantitative and dynamic analysis Quantitative & dynamic analysis of Defining enhancers and their mechanisms – transgenes, genetics, and interactomes of transcription protein binding at regulatory of action Chair: Professor Nick Hastie CBE FRS Chair: elements Chair: Dr Duncan Odom Welcome by RS & lead 09.00 Professor Anne Ferguson-Smith Chair: Professor Constance Bonifer organiser The evolution of global Dynamic use of enhancers in Design rules for bacterial Massively parallel functional 09.05 enhancers 13.30 development 09.00 enhancers 13.15 dissection of mammalian enhancers Professor Denis Duboule Professor Mike Levine Dr Roee Amit Dr Rupali Patwardhan 09.30 Discussion 14.00 Discussion 09.30 Discussion 13.45 Discussion Complex protein dynamics at HERC2 rs12913832 modulates The pluripotent 3D genome Gene expression genomics eukaryotic regulatory human pigmentation by attenuating 09.45 14.15 09.45 Professor Wouter de Laat Dr Sarah Teichmann elements chromatin-loop formation between a 14.00 Dr Gordon Hager long-range enhancer and the OCA2 promoter 10.15 Discussion 14.45 Discussion 10.15 Discussion Dr Robert-Jan Palstra 10.30 Coffee 15.00 Tea 10.30 Coffee 14.15 Tea Maps of open chromatin -
Gene Expression Studies: from Case-Control to Multiple-Population-Based Studies
From the Institute of Human Genetics, Helmholtz Zentrum Munchen,¨ Deutsches Forschungszentrum fur¨ Gesundheit und Umwelt (GmbH) Head: Prof. Dr. Thomas Meitinger Gene expression studies: From case-control to multiple-population-based studies Thesis Submitted for a Doctoral Degree in Natural Sciences at the Faculty of Medicine, Ludwig-Maximilians-Universitat¨ Munchen¨ Katharina Schramm Dachau, Germany 2016 With approval of the Faculty of Medicine Ludwig-Maximilians-Universit¨atM ¨unchen Supervisor/Examiner: Prof. Dr. Thomas Illig Co-Examiners: Prof. Dr. Roland Kappler Dean: Prof. Dr. med. dent. Reinhard Hickel Date of oral examination: 22.12.2016 II Dedicated to my family. III Abstract Recent technological developments allow genome-wide scans of gene expression levels. The reduction of costs and increasing parallelization of processing enable the quantification of 47,000 transcripts in up to twelve samples on a single microarray. Thereby the data collec- tion of large population-based studies was improved. During my PhD, I first developed a workflow for the statistical analyses of case-control stu- dies of up to 50 samples. With large population-based data sets generated I established a pipeline for quality control, data preprocessing and correction for confounders, which re- sulted in substantially improved data. In total, I processed more than 3,000 genome-wide expression profiles using the generated pipeline. With 993 whole blood samples from the population-based KORA (Cooperative Health Research in the Region of Augsburg) study we established one of the largest population-based resource. Using this data set we contributed to a number of transcriptome-wide association studies within national (MetaXpress) and international (CHARGE) consortia. -
Catalysishub NEWSLETTER
CatalysisHub NEWSLETTER The UK Catalysis Hub has created a thriving and successful network of catalytic scientists who are developing and promoting catalytic science in the UK. The Hub has succeeded in coordinating the community and is contributing to the development of new approaches and techniques in the field. It has provided substantial added value and is now recognised widely both in the UK and internationally. It will provide an excellent base for the future development of this crucial area of science in the UK. “The Hub has demonstrated resilience in the current pandemic with the community coming together to support each other through webinars and training courses and we will continue these in more normal times. Our proposal round was very successful with a large number of high quality proposals submitted and we have funded an excellent portfolio of research. The next few months will hopefully see an easing of the lockdown and an increase in our ability to do research. We hope that all are keeping well and safe and we look forward to meeting in person when we can and discussing catalytic research face to face.” ~ Professor Christopher Hardacre, Director Events Highlights of 2020 online via our website, so they will be a future resource for the whole catalysis community. COVID-19 has had a major impact on scientific network and dissemination due to travel UKCC 2020, 7 - 9 January 2020 restrictions and social distancing making face to face meetings and conferences unfeasible. The UK Catalysis Hub winter conference was held virtually and we worked on a vibrant programme of webinars, scientific discussions and other online events. -
EMBC Annual Report 2007
EMBO | EMBC annual report 2007 EUROPEAN MOLECULAR BIOLOGY ORGANIZATION | EUROPEAN MOLECULAR BIOLOGY CONFERENCE EMBO | EMBC table of contents introduction preface by Hermann Bujard, EMBO 4 preface by Tim Hunt and Christiane Nüsslein-Volhard, EMBO Council 6 preface by Marja Makarow and Isabella Beretta, EMBC 7 past & present timeline 10 brief history 11 EMBO | EMBC | EMBL aims 12 EMBO actions 2007 15 EMBC actions 2007 17 EMBO & EMBC programmes and activities fellowship programme 20 courses & workshops programme 21 young investigator programme 22 installation grants 23 science & society programme 24 electronic information programme 25 EMBO activities The EMBO Journal 28 EMBO reports 29 Molecular Systems Biology 30 journal subject categories 31 national science reviews 32 women in science 33 gold medal 34 award for communication in the life sciences 35 plenary lectures 36 communications 37 European Life Sciences Forum (ELSF) 38 ➔ 2 table of contents appendix EMBC delegates and advisers 42 EMBC scale of contributions 49 EMBO council members 2007 50 EMBO committee members & auditors 2007 51 EMBO council members 2008 52 EMBO committee members & auditors 2008 53 EMBO members elected in 2007 54 advisory editorial boards & senior editors 2007 64 long-term fellowship awards 2007 66 long-term fellowships: statistics 82 long-term fellowships 2007: geographical distribution 84 short-term fellowship awards 2007 86 short-term fellowships: statistics 104 short-term fellowships 2007: geographical distribution 106 young investigators 2007 108 installation -
Written Evidence Submitted by the MRC Human Genetics Unit at The
Written evidence submitted by the MRC Human Genetics Unit at the University of Edinburgh and the MRC Protein Phosphorylation and Ubiquitylation Unit at the University of Dundee (USC0001) We write in response to the UK Parliament Scottish Affairs Committee’s Call for Evidence in relation to Universities and Scotland. Our evidence pertains to “How Scottish university research fits in with UK university research”. We write as the directors of two UKRI Medical Research Council (MRC) Units based in Scottish Universities; the MRC Human Genetics Unit at the University of Edinburgh (https://www.ed.ac.uk/mrc-human-genetics-unit) and the MRC Protein Phosphorylation and Ubiquitylation Unit at the University of Dundee (https://www.ppu.mrc.ac.uk). As part of UKRI, the MRC invests 40% of its annual budget on an intramural portfolio of institutes, units and centres. MRC Units are long term investments that tackle important, often high risk, research questions that cannot be addressed adequately through short-term response-mode grant funding. MRC Units develop new methods and research facilities, foster interdisciplinarity, and spearhead training of the next generation of research leaders. Most MRC Units are embedded within universities (MRC University Units) and, because of the scale and sustainability of their research funding - reviewed and renewed every 5 years, they have a major impact on the research landscape of the universities that they are embedded in, including in Scotland. The scale and quality of research funded in MRC Units greatly enhances academic leadership within the host university as well as the Research Excellence Grant (REG) income that the host university receives from the Scottish Funding Council. -
Lectures and Seminars, Michaelmas Term 2014
WEDNESDay 8 octobEr 2014 • SUPPLEMENt (1) to No 5071 • VoL 145 Gazette Supplement Lectures and Seminars, Michaelmas term 2014 Romanes Lecture 26 Pharmacology, anatomical reuters Institute for the Study of Neuropharmacology and Drug Journalism Discovery Seminars Latin american centre Charles Simonyi Lecture 26 Physiology, anatomy and Genetics Foundation for Law, Justice and Society Population Health Maison Française Humanities 26 Psychiatry oxford Martin School Museum of Natural History TORCH | The Oxford Research Centre in Social Sciences 35 the Humanities Population ageing Classics anthropology and Museum Ethnography Ian ramsey centre English Language and Literature Archaeology Rhodes House English /History/History of Art/Theology/ Education McDonald centre for theology, Ethics and Public Life Music International Development (Queen History Elizabeth House) Colleges, Halls and Societies 47 History of Art Internet Institute Linguistics, Philology and Phonetics Law All Souls Medieval and Modern Languages Politics and International relations Green templeton Music Social Policy and Intervention Keble Oriental Studies Socio-legal Studies Kellogg Philosophy Sociology Mansfield Theology and Religion Nuffield Department for Continuing St Antony’s Education 40 Mathematical, Physical and St Catherine’s Life Sciences 32 Kellogg college centre for creative St Edmund Hall Chemistry Writing St Hilda’s Earth Sciences St John’s Institutes, Centres and Engineering Science Somerville Museums 41 e-Research Centre University college Materials ashmolean Museum -
Synthetic Biology
From Molecular Biology to Synthetic Biology, what’s new? Sandra Taylor, Senior Research Technician, BSc (Hons), Mphil, Rsci, MIScT [email protected] (0161) 306 5131 Small beginnings in Norwich, after my first degree • 1987 - First lab job veterinary tests: Bacteriology, post mortems, blood, urine, faeces tests etc. Plant Molecular Genetics 1988 to 1998 – the lab grew from 6 to 16 people and several papers were published on the way that flowering is controlled. 1998 to 2001: Biochemistry Division, School of Biological Sciences, Manchester University – I supported 6 research groups, sharing expertise. Topics from cell division (in toads) to asthma (in horses and people), and cultured human cells. Career Break from 2001 to 2007 • Starting again after 6 years was a challenge but I soon got back up to speed. Technical roles are very varied, never boring, a bit like being a Mum! 2007 to present • I spent 7 years in the Michael Smith Building (Life Sciences) – various roles (cell culture, cloning, yeast two-hybrid) • In 2014 I moved to the MIB – more Chemistry/Biochemistry focussed Nano-scale 3D printing?! Micro-titre plates with 96, 384 or even 1536 sample wells – technology is being developed to “write” strings of DNA into these tiny wells using 3D nano-printing technology. Present Challenges Supporting SYNBIOCHEM • New subject(s) and equipment to learn about • The new SYMBIOCHEM team is 10 people and 4 robots! • IT technology means writing electronic lab notebooks instead of paper ones! • The new team is multidisciplinary so lots to learn but good fun! • This is now the age of writing DNA, as opposed to just reading it Publications (please note publications I contributed prior to 2006 were under my maiden name of Doyle) Structural Basis for Specific Interaction of TGFβ Signaling Regulators SARA/Endofin with HD-PTP. -
Scientists a Step Closer to Developing Renewable Propane 10 April 2015
Scientists a step closer to developing renewable propane 10 April 2015 change. Efforts to find cleaner, more sustainable forms of energy as well as using biotechnology techniques to produce synthetic chemicals are currently being developed at The University of Manchester." Natural metabolic pathways for the renewable biosynthesis of propane do not exist but scientists at the University have developed an alternative microbial biosynthetic pathway to produce renewable propane. The team led by Nigel Scrutton and Dr Patrik Jones from Imperial College, modified existing fermentative butanol pathways using an engineered enzyme variant to redirect the microbial pathway to produce propane as opposed to butanol. The team was able to achieve propane biosynthesis creating a platform for next-generation microbial propane production. Researchers at The University of Manchester have Propane has very good physicochemical properties made a significant breakthrough in the which allow it to be stored and transported in a development of synthetic pathways that will enable compressed liquid form. While under ambient renewable biosynthesis of the gas propane. This conditions it is a clean-burning gas, with existing research is part of a programme of work aimed at global markets and infrastructure for storage, developing the next generation of biofuels. distribution and utilization in a wide range of applications ranging from heating to transport fuel. This study provides new insight and understanding Consequently, propane is an attractive target of the development of next-generation biofuels. In product in research aimed at developing new this latest study, published in the journal renewable alternatives to complement currently Biotechnology for Biofuels, scientists at the used petroleum-derived fuels. -
Smutty Alchemy
University of Calgary PRISM: University of Calgary's Digital Repository Graduate Studies The Vault: Electronic Theses and Dissertations 2021-01-18 Smutty Alchemy Smith, Mallory E. Land Smith, M. E. L. (2021). Smutty Alchemy (Unpublished doctoral thesis). University of Calgary, Calgary, AB. http://hdl.handle.net/1880/113019 doctoral thesis University of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission. Downloaded from PRISM: https://prism.ucalgary.ca UNIVERSITY OF CALGARY Smutty Alchemy by Mallory E. Land Smith A THESIS SUBMITTED TO THE FACULTY OF GRADUATE STUDIES IN PARTIAL FULFILMENT OF THE REQUIREMENTS FOR THE DEGREE OF DOCTOR OF PHILOSOPHY GRADUATE PROGRAM IN ENGLISH CALGARY, ALBERTA JANUARY, 2021 © Mallory E. Land Smith 2021 MELS ii Abstract Sina Queyras, in the essay “Lyric Conceptualism: A Manifesto in Progress,” describes the Lyric Conceptualist as a poet capable of recognizing the effects of disparate movements and employing a variety of lyric, conceptual, and language poetry techniques to continue to innovate in poetry without dismissing the work of other schools of poetic thought. Queyras sees the lyric conceptualist as an artistic curator who collects, modifies, selects, synthesizes, and adapts, to create verse that is both conceptual and accessible, using relevant materials and techniques from the past and present. This dissertation responds to Queyras’s idea with a collection of original poems in the lyric conceptualist mode, supported by a critical exegesis of that work. -
Proteins: from Chemical to Physiological Mechanism 26 October 2001
Meeting report report Proteins: from Chemical to Physiological Mechanism 26 October 2001 The Molecular Enzymology Group of the Biochemical Society by David Trentham held a special 1-day meeting at the Royal Society on ‘Proteins: (National Institute of Medical from Chemical to Physiological Mechanism’.The aim of the Research, Mill Hill) and Downloaded from http://portlandpress.com/biochemist/article-pdf/24/3/31/3597/bio024030031.pdf by guest on 01 October 2021 meeting was to inform and stimulate discussion on kinetic Michael Greeves approaches to the life sciences by bringing together work on (University of Kent) dynamic aspects of protein function.The meeting also honoured Professor H. (Freddie) Gutfreund, FRS, on his 80th birthday. Professor Gutfreund persuaded the Executive Committee of the Society to found the Molecular Enzymology Group, the first sub-group of the Society. His view of the strategic value in Professor Freddie encouraging like-minded biochemists to interact has done much to Gutfreund during his provide the critical mass necessary for sustaining excellence in the presentation ‘Development various sub-disciplines of biochemistry. of kinetics in biology’. The talks reflected Professor about how proteins function. and his family. The dinner was Gutfreund’s many contributions In particular, he has made major followed by entertaining and to the study of biochemistry and contributions to the development affectionate talks presented biophysics. His early prominence of transient and relaxation kinetic by Nigel Scrutton, the present arose from developing the method- methods including stopped-flow, Chairman of the Molecular Speakers and Chairmen: ology to study fast events on quenched-flow and pressure- Enzymology Group, Hugh Back row (from left to enzymes which are now central to jump techniques. -
Computational Protein (Re)Design (Computationele Eiwit(Her)Engineering)
Faculty of Science and Engineering Profile report: Computational Protein (Re)design (Computationele eiwit(her)engineering) - Discipline: Chemistry - Level: Assistant or Associate Professor - Fte: Full time (1.0) 1. Scientific discipline The professor in Computational Protein (Re)Design integrates advances in computer sciences with clever experimental concepts to redesign biological macromolecules towards new or altered functionalities. The envisioned research group uses computer sciences (computational design, multiscale modeling, machine learning) and combines this with existing expertise in biochemistry (enzymology, protein engineering, drug design) to further our understanding of the molecular processes of life and to expand the potential of enzymes and other biomolecules for biotechnological or biomedical purposes. 2. Vacancy This position is offered at the Faculty of Science and Engineering (FSE) of the University of Groningen and will be embedded in the Groningen Biomolecular Sciences and Biotechnology Institute (GBB). The GBB institute has 12 vibrant research groups, targeting challenging biological questions in the focal areas ‘Molecular Mechanisms of Biological Processes’ and ‘Physiology and Systems Biology’. The position has been approved by the Faculty board, is part of the Dutch Sector Plans in Chemistry, and falls within the framework of ‘Career Paths in Science 4’ (‘Bèta’s in Banen 4’). 3. Selection committee - Prof. Bert Poolman (Professor in biochemistry), chair - Prof. Marco Fraaije (Professor in molecular enzymology) - Prof. Siewert Jan Marrink (Professor in molecular dynamics) - Prof. Shirin Faraji (Adjunct Professor in theoretical and computational chemistry) - Prof. Marleen Kamperman (Professor in polymer chemistry) - Prof. Dirk-Jan Scheffers (Director of Education, GBB) - Prof. Nigel Scrutton (Professor in Biological Chemistry, University of Manchester) - Mrs. Gwen Tjallinks (Student member) Additional (external) advisors: - Prof.