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ISSN No: 1757-8175 Volume 11, issue 2 – July 2018 PHARMACOLOGY MATTERS The Anniversary Issue 10 years of Pharmacology Matters 400th anniversary of the Pharmacopoeia Londinensis The Medicines Act 1968 – 50 years on The AllTrials Campaign Gender inequity | Leadership and mentoring | Encouraging inclusion in pharmacology Pharmacology Matters I July 2018 EDITORIAL CONTENTS n the 10th anniversary of Pharmacology Matters, I am proud to deliver our 30th YOUR SOCIETY 03 Jono Brüün edition of the magazine on behalf of the Editorial Board as we celebrate 250 years UPDATES FROM: GLASGOW 04 of pharmacology. I PHARMACOLOGICAL SOCIETY To kick-off our edition, Jono places the focus well and truly on the long-term visions of Abdullah Alzahrani, Charles Kennedy, Eleanna Kritikaki, Yvonne Dempsie the Society on leadership in pharmacology with emphasis on the many ways the Society THE 1618 PHARMACOPOEIA 06 continue to invest and support future leaders through initiatives aimed at enhancing LONDINENSIS leadership opportunities, education and skills development. One successful initiative, Jeff Aronson introduced by the Society in 2015, has been the Ambassadors scheme. We catch up with USING ANIMALS IN BIOMEDICAL 09 one Ambassador, Dr Yvonne Dempsie, who used funding from this scheme to start up the RESEARCH: WHY EDUCATION HOLDS THE KEY Glasgow Pharmacological Society (GPS), which continues to grow in strength with a highly Mike Collis, Dave Lewis, Manasi Nandi, motivated early career membership (pages 4 and 5). Further information on the future Anna Zecharia plans for the Ambassadors Scheme is provided by the Society’s Engagement Manager, UPDATES FROM OUR 11 Teesha Bhuruth (pages 28 and 29). AFFINITY GROUPS David Kendall, Sarah Nickolls, Steve In other initiatives, the Society’s curriculum development team highlight the launch of a Safrany, Gary Stephens, Sarah Hesse new curriculum (with partner organisations) to support skills development in the use of NITRIC OXIDE: FROM POLLUTANT 15 animals in biomedical research (pages 9 and 10). This will be welcome news for our early TO NOBEL PRIZE WINNING DISCOVERY Edward Wickstead career pharmacologists who will benefit from gaining all-important in vivo research skills HEART FAILURE: GETTING TO 17 and awareness of appropriate experimental design. The current challenges in this area THE ‘ROOT’ OF THE PROBLEM in the context of drug discovery are covered by our long-standing Pharmacology Matters Chris Primus editor, Dr Mike Curtis (pages 23 and 24). SOLVING PUZZLES IN 18 NANOTECHNOLOGY: HOW TO Leadership within the Society is further demonstrated through our Affinity Groups. This TRANSFORM AN ARTIFACT INTO time, we hear from members of our ‘Drug Discovery, Development and Evaluation’ group AN ANTIDOTE as David and Sarah cover issues with opioid dependency and emerging targets, whilst our Marcelo Bispo de Jesus Molecular and Cellular Pharmacology group provide updates on the contributions they THE MEDICINES ACT 1968 – 20 50 YEARS ON have made over the past year to pharmacology meetings world-wide (pages 11-14). Other Mary Joan Macleod initiatives supported by the Society include the AllTrials Campaign (pages 25-27) and PERSPECTIVES IN PHARMACOLOGY 23 movements towards improving Equality, Diversity and Inclusion (EDI, page 30). Mike Curtis Gender inequality in STEM subjects continues to be a major concern, and as Dr Karen ALLTRIALS: HAVE YOU REPORTED 25 ALL OF YOUR YOUR TRIALS? Gregory (pages 31-34) illustrates, the field of pharmacology has room to improve in this Síle Lane area. Earlier this year I was fortunate to be selected to become part of the Ingenious & THE FUTURE OF THE 28 Enterprising Women Programme (supported by the Scottish Funding Council) and as a AMBASSADORS SCHEME result I have gained tremendously from the experience and the supportive network that Teesha Bhuruth has since formed. Here, we showcase other opportunities that exist in the form of world- INCLUSION AT THE BRITISH 30 wide leadership (pages 35-37) and UK mentoring schemes (pages 38 and 39) for early career PHARMACOLOGICAL SOCIETY Teesha Bhuruth, Lisa Hevey female scientists, in the hope that we can inspire our young members to seek out similar EVIDENCE FOR GENDER INEQUITY 31 opportunities to support their career development. IN PHARMACOLOGY: RAISING AWARENESS AND MOTIVATING I hope you enjoy the latest edition of Pharmacology Matters. CHANGE Margaret Karen Gregory AN ANTARCTIC EXPEDITION FOR 35 WOMEN IN SCIENCE LEADERSHIP Katherine Duncan Disclaimer SUSTAIN – ENABLING FEMALE 38 Editorial Team SCIENTISTS TO THRIVE Opinions expressed in Pharmacology Matters are not necessarily Editor-in-Chief Ruth Lowe those of the British Pharmacological Society. The publishers, Margaret Cunningham authors, and designers cannot accept liability for errors or MUSIC, THE MEDICINE FOR 40 omissions. All rights reserved. No parts of this publication may MY MIND Managing Editor be reproduced in any form without the prior written permission Steve Tucker Emma Needham of the copyright holder and the publisher, application for which ON PARLIAMENT, POLICY AND 42 should be made to the publisher, the British Pharmacological Editorial Board PHARMACOLOGY Society. Registered office: The Schild Plot, 16 Angel Gate, City Aisah Aubdool, Vedia Can, Ajay Shah, Harriette Brennan Road, London, EC1V 2PT. Tel: +44(0)20 7239 0171; Fax: +44(0)20 Mike Curtis, Felicity Gavins, 74170114; Website: www.bps.ac.uk. British Pharmacological AN UPDATE FROM OUR 44 Fraz Mir, Steven Tucker, Society is a company limited by guarantee, registered in England MEETINGS TEAM Edward Wickstead with No. 2877400, registered charity No, 1030623. John Challiss, Lindsay McClenaghan, Aisah Aubdool 2 YOUR SOCIETY n my last article for PM I shared a few helpful to medical educators and healthcare thoughts about our new five-year strategy. systems in other countries. The project is a great IAs you would expect from me as Chief example of the Society contributing to a hugely Executive, our long-term goals are never far important issue on a global stage. from my mind, so I want to return to the subject Young members setting the agenda here to consider how we have begun to take that plan forward. Where the strategy talks about “support[ing] JONO BRÜÜN the next generation of learners” and Chief Executive All about leadership “support[ing] pharmacology educators in their In the new strategy, Council wanted to commit personal and professional development”, it’s the Society to demonstrating leadership. The important to be clear that this is about far more language of the strategy is peppered with talk than the Society doing things for our members. of being proactive, “setting the agenda”, “being It is also about members taking an opportunity the leader”. So it has been great to see that or a platform that we give them and making it being taken forward in some of the recent work their own. that the Society has delivered. That is why I was so impressed by the timely For example, last month we launched – with and articulate blog we posted in June by two support from some 30 organisations across of our younger members about their fears the life sciences – a new curriculum for the for a looming mental health crisis among use of research animals. The UK is already a PhD students and early career researchers. world leader in the appropriate and ethical Aidan Seeley, our Young Pharmacologist use of animals in research. But as well as being Trustee on Council, and Niamh McKerr from designed to build on that strength, our new the Young Pharmacologists Advisory Group, our new curriculum challenges educators to place not only drew attention to this very important greater focus on experimental design, data problem; they made it real by sharing their curriculum interpretation, ethics and animal welfare. own experiences. And they appealed to their “ We wanted to build a cross-sector coalition to fellow members, whatever their age or career challenges create a highly skilled and well informed next stage, to help us as a community of members to generation of researchers, and I’m delighted start a conversation about what can be done to to see that we have been able to take the first improve the environment for students. educators to steps towards that. Please do take a look at Coincidentally, we are now in the middle of the curriculum itself, and the article explaining the application period to elect an Early Career place greater the thinking behind it on pages 9 and 10 of Trustee position on Council, which will be this edition. focus on vacated by Aidan Seeley at the end of the year. Another example of how our stated aim to Full details of the role and selection process are “set the agenda in education and skills” is available on the website. experimental coming to life is the ongoing development If you are eligible, and if you share the Society’s of the education and assessment offer appetite for leadership, I hope you choose to design, data from BPS Assessment Ltd (BPSA). BPSA has apply. recently gone live with a new website – www. interpretation, bpsassessment.com – which showcases the new and developing prescribing eLearning and ethics and assessment capabilities available through its Prescribing Skills Assessment. The purpose of animal BPSA is to drive improvements in medication safety worldwide through safer prescribing welfare and a knowledge of clinical pharmacology and therapeutics. We hope that the example we have set by delivering the Prescribing Safety ” Assessment in partnership in the UK will be 3 Pharmacology Matters I July 2018 UPDATES FROM: ABDULLAH ALZAHRANI Abdullah Alzahrani gained his Master of Pharmacy (MPharm) from Liverpool John Moores University and then moved to the University of Birmingham and obtained his MSc in Toxicology. Abdullah is now a PhD student at Strathclyde Institute of Pharmacy and Biomedical Sciences (SIPBS) funded by the Saudi Arabian government. Abdullah’s current research is focusing on finding new anti-diabetic and anti-obesity drugs from natural sources such as plants.
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