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Identification of Organic Compounds

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Identification of Organic Compounds Chemistry 7B IDENTIFICATION OF ORGANIC COMPOUNDS I. Preliminary Examination A. Physical State B. Crystalline Form C. Color D. Odor E. Ignition Test II. Physical Constants and Purity A. Melting Point B. Boiling Point C. Refractive Index D. Density E. Freezing Point F. Purification (if necessary) III. Solubility Tests A. Water (check pH) B. 5% Hydrochloric Acid C. 5% Sodium Hydroxide D. 5% sodium bicarbonate E. Concentrated Sulfuric Acid F. Organic Solvents (ether, etc.) IV. Elemental Analysis A. Sodium Fusion 1. nitrogen a. p-nitrobenzaldehyde in DMSO b. Prussian blue test 2. sulfur a. sodium nitroprusside test b. lead acetate test c. p-nitrobenzaldehyde in DMSO 3. halogens a. silver halide test b. oxidation of halide ion B. Beilstein Test for Halogens C. Metals and Other Inorganic Elements 1. qualitative inorganic analysis schemes 2. spectral tests V. Spectroscopy A. IR B. NMR C. Others (UV, mass spectroscopy, etc.) VI. Chemical Classification Tests A. Alkanes 1. none B. Alkenes and Alkynes 1. bromine/carbon tetrachloride 2. Baeyer test C. Aromatic Hydrocarbons 1. aluminum chloride/chloroform D. Halides 1. Beilstein test 2. ethanolic silver nitrate 3. sodium iodide/acetone E. Alcohols 1. Lucas test 2. chromic acid 3. acetyl chloride 4. iodoform test F. Phenols 1. ferric chloride solution 2. bromine water 3. acetyl chloride 4. colored phenoxide ion G. Ethers 1. none H. Aldehydes and Ketones 1. 2,4-dinitrophenylhydrazine 2. iodoform test 3. ferric chloride solution (for compounds with high enol content) 4. For Aldehydes Only a. chromic acid b. Tollens’ test c. Benedict’s test I. Carboxylic Acids 1. sodium bicarbonate solutions 2. ethanolic silver nitrate J. Amines 1. nitrous acid 2. acetyl chloride 3. Hinsberg test K. Nitro Compounds 1. ferrous hydroxide test L. Nitriles 1. ferric hydroximate test 2. ammonia liberation from base hydrolysis M. Esters 1. ferric hydroximate test N. Amides 1. ferric hydroximate test 2. ammonia or amines liberated from base hydrolysis O. Acid Chlorides 1. ferric hydroximate test 2. ethanolic silver nitrate P. Acid Anhydrides 1. ferric hydroximate test Q. Others such as thiols, quinones, sulfonamides, etc. VII. Preparation of Derivatives A. Alkanes 1. none B. Alkenes and Alkynes 1. none C. Aromatic Hydrocarbons 1. side chain oxidation 2. nitro derivatives D. Halides 1. none E. Alcohols 1. 3,5-dinitrobenzoates 2. phenylurethanes 3. -naphthylurethanes F. Phenols 1. same as alcohols 2. bromo derivatives G. Ethers 1. bromo derivatives (if aromatic ether) H. Aldehydes and Ketones 1. 2,4-dinitrophenylhydrazones 2. semicarbazones 3. oximes I. Carboxylic Acids 1. amides 2. anilides 3. p-toluidides 4. neutralization equivalent J. Amines 1. benzamides 2. benzenesulfonamides 3. acetamides 4. methiodides 5. picrates K. Nitro Compounds 1. reduction to amines (amine derivatives) 2. nitro derivatives (if aromatic nitro compound) L. Nitriles 1. hydrolysis to carboxylic acids (carboxylic acid derivatives) M. Esters 1. transesterification to alcohol derivatives 2. hydrolysis to carboxylic acids and alcohols (carboxylic acid and alcohol derivatives) 3. saponification equivalent N. Amides 1. hydrolysis to carboxylic acids and amines or NH3 (carboxylic acid and amine derivatives) O. Acid Chlorides 1. same as carboxylic acid derivatives 2. hydrolysis to carboxylic acids P. Acid Anhydrides 1. same as acid chloride derivatives VIII. Confirmation of Identity A. Comparison to an "Authentic" Sample 1. physical properties and constants 2. IR and NMR spectra .
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