Oxidative Stress in Asthmatic and Non‐
View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by Repositório Aberto da Universidade do Porto Accepted: 23 April 2017 DOI: 10.1111/pai.12729 ORIGINAL ARTICLE Upper Airways Oxidative stress in asthmatic and non- asthmatic adolescent swimmers—A breathomics approach Mariana Couto1,2,3 | Corália Barbosa4 | Diana Silva1,5 | Alisa Rudnitskaya6 | Luís Delgado1,3,5 | André Moreira1,5,7 | Sílvia M. Rocha4 1Basic and Clinical Immunology Unit, Department of Pathology, Faculty of Abstract Medicine, University of Porto, Porto, Portugal We hypothesize that oxidative stress induced by trichloramine exposure during swim- 2 Immunoallergology, Hospital & Instituto CUF ming could be related to etiopathogenesis of asthma among elite swimmers. Porto, Porto, Portugal Aim: To investigate the effect of a swimming training session on oxidative stress mark- 3CINTESIS, University of Porto, Porto, Portugal ers of asthmatic compared to non- asthmatic elite swimmers using exhaled breath (EB) 4Department of Chemistry & metabolomics. QOPNA, University of Aveiro, Aveiro, Portugal Methods: Elite swimmers annually screened in our department (n=27) were invited and 5Imunoalergologia, Centro Hospitalar São ® João, EPE, Porto, Portugal those who agreed to participate (n=20, of which 9 with asthma) had EB collected (Tedlar 6Department of Chemistry & bags) before and after a swimming training session. SPME fiber (DVB/CAR/PDMS) was CESAM, University of Aveiro, Aveiro, Portugal used to extract EB metabolites followed by a multidimensional gas chromatography anal- 7EPIUnit Institute of Public Health, University of Porto, Porto, Portugal ysis (GC×GC- ToFMS). Dataset comprises eight metabolites end products of lipid peroxi- dation: five aliphatic alkanes (nonane, 2,2,4,6,6- pentamethylheptane, decane, dodecane, Correspondence Mariana Couto, Serviço e Laboratório and tetradecane) and three aldehydes (nonanal, decanal, and dodecanal).
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