Contents • February 2017 • Volume 61, No. 2

CONTENTS • FEBRUARY 2017 • VOLUME 61, NO. 2

COMMENTARY Doi R Carbapenemase-Producing Enterobacteriaceae in Swine Production in the United e02348-16 Commentaries States: Impact and Opportunities Timothy J. Johnson

MECHANISMS OF ACTION: PHYSIOLOGICAL EFFECTS Ambrose T Fludioxonil Induces Drk1, a Fungal Group III Hybrid Histidine Kinase, To e01414-16 PHYSIOLOGICAL EFFECTS Dephosphorylate Its Downstream Target, Ypd1 Stephanie M. Lawry, Brad Tebbets, Iain Kean, Douglas Stewart, Joel Hetelle, Bruce S. Klein Milhous T Novel Effects of Lapatinib Revealed in the African Trypanosome by Using e01865-16 PHYSIOLOGICAL EFFECTS Hypothesis-Generating Proteomics and Chemical Biology Strategies Paul J. Guyett, Ranjan Behera, Yuko Ogata, Michael Pollastri, Kojo Mensa-Wilmot Shlaes T Novel Detection Strategy To Rapidly Evaluate the Efﬁcacy of Antichlamydial Agents e02202-16 PHYSIOLOGICAL EFFECTS Yan Zhang, Yuqi Xian, Leiqiong Gao, Hiba Elaasar, Yao Wang, Lamiya Tauhid, Ziyu Hua, Li Shen

MECHANISMS OF RESISTANCE Arias T In Vitro Tolerance of Drug-Naive Staphylococcus aureus Strain FDA209P to e01154-16 Mech of Resistance Vancomycin Madhuri Singh, Miki Matsuo, Takashi Sasaki, Yuh Morimoto, Tomomi Hishinuma, Keiichi Hiramatsu Henry F. Chambers T The Loop 2 Region of Ribosomal Protein uS5 Inﬂuences Spectinomycin e01186-16 Mech of Resistance Sensitivity, Translational Fidelity, and Ribosome Biogenesis Divya Kamath, Steven T. Gregory, Michael O’Connor Sevtap T Echinocandin Resistance in Candida Species Isolates from Liver Transplant Recipients e01229-16 Arikan-Akdagli Mech of Resistance Gwénolé Prigent, Nawel Aït-Ammar, Eric Levesque, Arnaud Fekkar, Jean-Marc Costa, Sarra El Anbassi, Françoise Foulet, Christophe Duvoux, Jean-Claude Merle, Eric Dannaoui, Françoise Botterel Nuermberger T Molecular Investigation of Resistance to Second-Line Injectable Drugs in e01299-16 Mech of Resistance Multidrug-Resistant Clinical Isolates of Mycobacterium tuberculosis in France Florence Brossier, Anne Pham, Christine Bernard, Alexandra Aubry, Vincent Jarlier, Nicolas Veziris, Wladimir Sougakoff, on behalf of the CNR-MyRMA Nuermberger T De Novo Emergence of Genetically Resistant Mutants of Mycobacterium tuberculosis e01343-16 Mech of Resistance from the Persistence Phase Cells Formed against Antituberculosis Drugs In Vitro Jees Sebastian, Sharmada Swaminath, Rashmi Ravindran Nair, Kishor Jakkala, Atul Pradhan, Parthasarathi Ajitkumar Doi S Emergence of Colistin Resistance Gene mcr-1 in Cronobacter sakazakii Producing e01444-16 Mech of Resistance NDM-9 and in Escherichia coli from the Same Animal Bao-Tao Liu, Feng-Jing Song, Ming Zou, Zhi-Hui Hao, Hu Shan Arikan-Akdagli S In Vitro Exposure to Increasing Micafungin Concentrations Easily Promotes e01542-16 Mech of Resistance Echinocandin Resistance in Candida glabrata Isolates María Ángeles Bordallo-Cardona, Pilar Escribano, Elia Gómez G. de la Pedrosa, Laura Judith Marcos-Zambrano, Rafael Cantón, Emilio Bouza, Jesús Guinea

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Chambers T Tigecycline Nonsusceptibility Occurs Exclusively in Fluoroquinolone-Resistant e01654-16 Mech of Resistance Escherichia coli Clinical Isolates, Including the Major Multidrug-Resistant Lineages O25b:H4-ST131-H30R and O1-ST648 Toyotaka Sato, Yuuki Suzuki, Tsukasa Shiraishi, Hiroyuki Honda, Masaaki Shinagawa, Soh Yamamoto, Noriko Ogasawara, Hiroki Takahashi, Satoshi Takahashi, Yutaka Tamura, Shin-ichi Yokota David Andes T The Paradoxical Effect of Echinocandins in Aspergillus fumigatus Relies on e01690-16 Mech of Resistance Recovery of the ␤-1,3-Glucan Synthase Fks1 Veronika Loiko, Johannes Wagener Doi T Chromosomal Ampliﬁcation of the bla Carbapenemase Gene in a Proteus e01697-16 Mech of Resistance OXA-58 mirabilis Clinical Isolate Delphine Girlich, Rémy A. Bonnin, Pierre Bogaerts, Morgane De Laveleye, Daniel T. Huang, Laurent Dortet, Philippe Glaser, Youri Glupczynski, Thierry Naas Doi T A Naturally Occurring Single Nucleotide Polymorphism in a Multicopy Plasmid e01735-16 Mech of Resistance Produces a Reversible Increase in Antibiotic Resistance Alfonso Santos-Lopez, Cristina Bernabe-Balas, Manuel Ares-Arroyo, Rafael Ortega- Huedo, Andreas Hoefer, Alvaro San Millan, Bruno Gonzalez-Zorn Andes T Using In Vitro Dynamic Models To Evaluate Fluoroquinolone Activity against e01756-16 Mech of Resistance Emergence of Resistant Salmonella enterica Serovar Typhimurium Seung-Jin Lee, Elias Gebru Awji, Na-hye Park, Seung-Chun Park Poirel S Genetic Environment of the bla Gene in a Klebsiella pneumoniae Isolate That e01856-16 Mech of Resistance KPC-2 May Have Been Imported to Russia from Southeast Asia Vladimir Ageevets, Julia Sopova, Irina Lazareva, Maya Malakhova, Elena Ilina, Elena Kostryukova, Vladislav Babenko, Alessandra Carattoli, Yuri Lobzin, Alexander Uskov, Sergey Sidorenko Doi T Molecular Characterization of OXA-48-Like-Producing Enterobacteriaceae in the e01889-16 Mech of Resistance Czech Republic and Evidence for Horizontal Transfer of pOXA-48-Like Plasmids Anna Skalova, Katerina Chudejova, Veronika Rotova, Matej Medvecky, Vendula Studentova, Eva Chudackova, Pavel Lavicka, Tamara Bergerova, Vladislav Jakubu, Helena Zemlickova, Costas C. Papagiannitsis, Jaroslav Hrabak Doi S Chromosome-Encoded Broad-Spectrum Ambler Class A ␤-Lactamase RUB-1 from e01908-16 Mech of Resistance Serratia rubidaea Rémy A. Bonnin, Jennifer Didi, Ayla Ergani, Sandra Lima, Thierry Naas Doi T Exploring the Role of the ⍀-Loop in the Evolution of Ceftazidime Resistance in e01941-16 Mech of Resistance the PenA ␤-Lactamase from Burkholderia multivorans, an Important Cystic Fibrosis Pathogen Krisztina M. Papp-Wallace, Scott A. Becka, Magdalena A. Taracila, Elise T. Zeiser, Julian A. Gatta, John J. LiPuma, Robert A. Bonomo Doi T Mutations Associated with Decreased Susceptibility to Seven Antimicrobial e01983-16 Mech of Resistance Families in Field and Laboratory-Derived Mycoplasma bovis Strains Kinga M. Sulyok, Zsuzsa Kreizinger, Eniko˝ Wehmann, Inna Lysnyansky, Krisztián Bányai, Szilvia Marton, Ákos Jerzsele, Zsuzsanna Rónai, Ibolya Turcsányi, László Makrai, Szilárd Jánosi, Sára Ágnes Nagy, Miklós Gyuranecz Doi S IncP Plasmid Carrying Colistin Resistance Gene mcr-1 in Klebsiella pneumoniae e02229-16 Mech of Resistance from Hospital Sewage Feifei Zhao, Yu Feng, Xiaoju Lü, Alan McNally, Zhiyong Zong

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Shlaes T Identiﬁcation of a Novel Lincomycin Resistance Mutation Associated with e02247-16 Mech of Resistance Activation of Antibiotic Production in Streptomyces coelicolor A3(2) Guojun Wang, Masumi Izawa, Xiaoge Yang, Dongbo Xu, Yukinori Tanaka, Kozo Ochi Nuermberger S Missense Mutations in the Unfoldase ClpC1 of the Caseinolytic Protease Complex e02342-16 Mech of Resistance Are Associated with Pyrazinamide Resistance in Mycobacterium tuberculosis Michelle Yee, Pooja Gopal, Thomas Dick Shlaes S Plazomicin Activity against 346 Extended-Spectrum-␤-Lactamase/AmpC-Producing e02454-16 Mech of Resistance Escherichia coli Urinary Isolates in Relation to Aminoglycoside-Modifying Enzymes Maria del Carmen López-Diaz, Esther Culebras, Iciar Rodríguez-Avial, Esther Rios, José Manuel Viñuela-Prieto, Juan J. Picazo, Carmen Rodríguez-Avial

SUSCEPTIBILITY Milhous T Significant Divergence in Sensitivity to Antimalarial Drugs between Neighboring e01689-16 Susceptibility Plasmodium falciparum Populations along the Eastern Border of Myanmar Weilin Zeng, Yao Bai, Meilian Wang, Zenglei Wang, Shuang Deng, Yonghua Ruan, Shi Feng, Zhaoqing Yang, Liwang Cui Nuermberger S In Vitro Susceptibility Testing of Bedaquiline against Mycobacterium avium Complex e01798-16 Susceptibility Barbara A. Brown-Elliott, Julie V. Philley, David E. Griffith, Foram Thakkar, Richard J. Wallace, Jr. Doi S In Vitro Activity of Ceftazidime-Avibactam against Isolates in a Phase 3 Open- e01820-16 Susceptibility Label Clinical Trial for Complicated Intra-Abdominal and Urinary Tract Infections Caused by Ceftazidime-Nonsusceptible Gram-Negative Pathogens Gregory G. Stone, Patricia A. Bradford, Paul Newell, Angela Wardman Rice S In Vitro Activities of Lefamulin and Other Antimicrobial Agents against e02008-16 Susceptibility Macrolide-Susceptible and Macrolide-Resistant Mycoplasma pneumoniae from the United States, Europe, and China Ken B. Waites, Donna M. Crabb, Lynn B. Duffy, Jorgen S. Jensen, Yang Liu, Susanne Paukner Nuermberger T Genotyping and Prevalence of Pyrazinamide- and Moxifloxacin-Resistant e02170-16 Susceptibility Tuberculosis in China, 2000 to 2010 Yu Pang, Zhijian Zhang, Yufeng Wang, Shengfen Wang, Yuanyuan Song, Bing Zhao, Yang Zhou, Xichao Ou, Qiang Li, Hui Xia, Yang Zheng, Xiangqun Fang, Yanlin Zhao

BIOLOGIC RESPONSE MODIFIERS Nuermberger T Long-Chain Fatty Acyl Coenzyme A Ligase FadD2 Mediates Intrinsic e02130-16 Modiﬁers Pyrazinamide Resistance in Mycobacterium tuberculosis Brandon C. Rosen, Nicholas A. Dillon, Nicholas D. Peterson, Yusuke Minato, Anthony D. Baughn

ANTIVIRAL AGENTS Ambrose T Evaluation of Doravirine Pharmacokinetics When Switching from Efavirenz to e01757-16 Antiviral Doravirine in Healthy Subjects Ka Lai Yee, Rosa I. Sanchez, Patrice Auger, Rachael Liu, Li Fan, Ilias Triantafyllou, Ming-Tain Lai, Mike Di Spirito, Marian Iwamoto, Sauzanne G. Khalilieh

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Martinez T Phase 2 Randomized, Double-Blind, Placebo-Controlled Trial of RG7667, a e01794-16 Antiviral Combination Monoclonal Antibody, for Prevention of Cytomegalovirus Infection in High-Risk Kidney Transplant Recipients Julie H. Ishida, Anita Patel, Aneesh K. Mehta, Philippe Gatault, Jacqueline M. McBride, Tracy Burgess, Michael A. Derby, David R. Snydman, Brinda Emu, Becket Feierbach, Ashley E. Fouts, Mauricio Maia, Rong Deng, Carrie M. Rosenberger, Lynn A. Gennaro, Natalee S. Striano, X. Charlene Liao, Jorge A. Tavel Martinez T Frequent Cross-Resistance to Dapivirine in HIV-1 Subtype C-Infected Individuals e01805-16 Antiviral after First-Line Antiretroviral Therapy Failure in South Africa Kerri J. Penrose, Carole L. Wallis, Chanson J. Brumme, Kristen A. Hamanishi, Kelley C. Gordon, Raquel V. Viana, P. Richard Harrigan, John W. Mellors, Urvi M. Parikh

EPIDEMIOLOGY AND SURVEILLANCE Bonomo S Chromosome-Based bla -Like Variants in Shewanella Species Isolates from e01013-16 Epidemiology OXA-48 Food-Producing Animals, Fish, and the Aquatic Environment Daniela Ceccarelli, Alieda van Essen-Zandbergen, Kees T. Veldman, Nedzib Tafro, Olga Haenen, Dik J. Mevius Arikan-Akdagli T High Prevalence of Pneumocystis jirovecii Dihydropteroate Synthase Gene Mutations e01290-16 Epidemiology in Patients with a First Episode of Pneumocystis Pneumonia in Santiago, Chile, and Clinical Response to Trimethoprim-Sulfamethoxazole Therapy Carolina A. Ponce, Magali Chabé, Claudio George, Alejandra Cárdenas, Luisa Durán, Julia Guerrero, Rebeca Bustamante, Olga Matos, Laurence Huang, Robert F. Miller, Sergio L. Vargas Doi T Carbapenemase-Producing Enterobacteriaceae Recovered from the Environment e01298-16 Epidemiology of a Swine Farrow-to-Finish Operation in the United States Dixie F. Mollenkopf, Jason W. Stull, Dimitria A. Mathys, Andrew S. Bowman, Sydnee M. Feicht, Susan V. Grooters, Joshua B. Daniels, Thomas E. Wittum Doi T A Prolonged Outbreak of KPC-3-Producing Enterobacter cloacae and Klebsiella e01516-16 Epidemiology pneumoniae Driven by Multiple Mechanisms of Resistance Transmission at a Large Academic Burn Center Hajime Kanamori, Christian M. Parobek, Jonathan J. Juliano, David van Duin, Bruce A. Cairns, David J. Weber, William A. Rutala Yohei Doi T Identiﬁcation of IncA/C Plasmid Replication and Maintenance Genes and e01740-16 Epidemiology Development of a Plasmid Multilocus Sequence Typing Scheme Steven J. Hancock, Minh-Duy Phan, Kate M. Peters, Brian M. Forde, Teik Min Chong, Wai-Fong Yin, Kok-Gan Chan, David L. Paterson, Timothy R. Walsh, Scott A. Beatson, Mark A. Schembri Yohei Doi T Occurrence of Diverse AbGRI1-Type Genomic Islands in Acinetobacter baumannii e01972-16 Epidemiology Global Clone 2 Isolates from South Korea Dae Hun Kim, Sook-In Jung, Ki Tae Kwon, Kwan Soo Ko Doi S Prevalence of Extended-Spectrum-␤-Lactamase- and/or Carbapenemase-Producing e02071-16 Epidemiology Escherichia coli Isolated from Yellow-Legged Gulls from Barcelona, Spain Andrea Vergara, Cristina Pitart, Tomás Montalvo, Ignasi Roca, Sara Sabaté, Juan Carlos Hurtado, Raquel Planell, Francesc Marco, Beatriz Ramírez, Víctor Peracho, Mercé de Simón, Jordi Vila

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Doi S Prevalence of mcr-1 in the Cecal Contents of Food Animals in the United States e02244-16 Epidemiology Richard J. Meinersmann, Scott R. Ladely, Jodie R. Plumblee, Kimberly L. Cook, Eileen Thacker

EXPERIMENTAL THERAPEUTICS Rice T Pharmacokinetic-Pharmacodynamic Evaluation of Gepotidacin against Gram- e00115-16 Experimental Positive Organisms Using Data from Murine Infection Models Catharine C. Bulik, Ólanrewaju O. Okusanya, Elizabeth A. Lakota, Alan Forrest, Sujata M. Bhavnani, Jennifer L. Hoover, David R. Andes, Paul G. Ambrose Arias T Structure-Activity Relationships of a Series of Echinocandins and the Discovery e01541-16 Experimental of CD101, a Highly Stable and Soluble Echinocandin with Distinctive Pharmacokinetic Properties Kenneth D. James, Christopher P. Laudeman, Navdeep B. Malkar, Radha Krishnan, Karen Polowy Milhous T In Vitro and In Vivo Activities of Sulfur-Containing Linear Bisphosphonates e01590-16 Experimental against Apicomplexan Parasites Sergio H. Szajnman, Tamila Galaka, Zhu-Hong Li, Catherine Li, Nathan M. Howell, María N. Chao, Boris Striepen, Vasant Muralidharan, Silvia N. J. Moreno, Juan B. Rodriguez Milhous T High-Throughput Screening and Prediction Model Building for Novel Hemozoin e01607-16 Experimental Inhibitors Using Physicochemical Properties Nguyen Tien Huy, Pham Lan Chi, Jun Nagai, Tran Ngoc Dang, Evaristus Chibunna Mbanefo, Ali Mahmoud Ahmed, Nguyen Phuoc Long, Le Thi Bich Thoa, Le Phi Hung, Afaf Titouna, Kaeko Kamei, Hiroshi Ueda, Kenji Hirayama Doi T Classical ␤-Lactamase Inhibitors Potentiate the Activity of Daptomycin against e01745-16 Experimental Methicillin-Resistant Staphylococcus aureus and Colistin against Acinetobacter baumannii George Sakoulas, Warren Rose, Andrew Berti, Joshua Olson, Jason Munguia, Poochit Nonejuie, Eleanna Sakoulas, Michael J. Rybak, Joseph Pogliano, Victor Nizet Louis B. Rice T Activity of Electrical Current in Experimental Propionibacterium acnes Foreign- e01863-16 Experimental Body Osteomyelitis Suzannah M. Schmidt-Malan, Cassandra L. Brinkman, Kerryl E. Greenwood- Quaintance, Melissa J. Karau, Jayawant N. Mandrekar, Robin Patel Milhous T Genetic Evidence for Cytochrome b Q Site Inhibition by 4(1H)-Quinolone-3- e01866-16 Experimental i Diarylethers and Antimycin in Toxoplasma gondii P. Holland Alday, Igor Bruzual, Aaron Nilsen, Sovitj Pou, Rolf Winter, Choukri Ben Mamoun, Michael K. Riscoe, J. Stone Doggett Boucher S Telavancin Is Active against Experimental Aortic Valve Endocarditis Caused by e01877-16 Experimental Daptomycin- and Methicillin-Resistant Staphylococcus aureus Strains Wessam Abdelhady, Arnold S. Bayer, Rachelle Gonzales, Liang Li, Yan Q. Xiong Silverman S Intracellular Staphylococcus aureus Control by Virulent Bacteriophages within e01990-16 Experimental MAC-T Bovine Mammary Epithelial Cells Lili Zhang, Lichang Sun, Ruicheng Wei, Qiang Gao, Tao He, Cunfa Xu, Xianjin Liu, Ran Wang

Andes T N-Acetyl-L-Cysteine and Cysteamine as New Strategies against Mixed Bioﬁlms of e01992-16 Experimental Nonencapsulated Streptococcus pneumoniae and Nontypeable Haemophilus inﬂuenzae Mirian Domenech, Ernesto García

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Silverman T Glycoside Hydrolases Degrade Polymicrobial Bacterial Biofilms in Wounds e01998-16 Experimental Derek Fleming, Laura Chahin, Kendra Rumbaugh Milhous T Inhibition of Plasmodium Liver Infection by Ivermectin e02005-16 Experimental António M. Mendes, Inês S. Albuquerque, Marta Machado, Joana Pissarra, Patrícia Meireles, Miguel Prudêncio Andes T Cephalosporin-3=-Diazeniumdiolate NO Donor Prodrug PYRRO-C3D Enhances e02086-16 Experimental Azithromycin Susceptibility of Nontypeable Haemophilus influenzae Biofilms Samuel A. Collins, Michael J. Kelso, Ardeshir Rineh, Nageshwar R. Yepuri, Janice Coles, Claire L. Jackson, Georgia D. Halladay, Woolf T. Walker, Jeremy S. Webb, Luanne Hall-Stoodley, Gary J. Connett, Martin Feelisch, Saul N. Faust, Jane S. A. Lucas, Raymond N. Allan

CLINICAL THERAPEUTICS Arikan-Akdagli T Safety and Pharmacokinetics of CD101 IV, a Novel Echinocandin, in Healthy Adults e01627-16 Clinical Taylor Sandison, Voon Ong, Jonathan Lee, Dirk Thye Silverman T Activity of Tedizolid in Methicillin-Resistant Staphylococcus epidermidis e01644-16 Clinical Experimental Foreign Body-Associated Osteomyelitis Kyung-Hwa Park, Kerryl E. Greenwood-Quaintance, Audrey N. Schuetz, Jayawant N. Mandrekar, Robin Patel Boucher T Rifampin-Based Combination Therapy Is Active in Foreign-Body Osteomyelitis e01822-16 Clinical after Prior Rifampin Monotherapy Cassandra L. Brinkman, Suzannah M. Schmidt-Malan, Jayawant N. Mandrekar, Robin Patel Milhous T Estimation of the In Vivo MIC of Cipargamin in Uncomplicated Plasmodium e01940-16 Clinical falciparum Malaria Tran Tinh Hien, Nicholas J. White, Nguyen Thanh Thuy-Nhien, Nhu Thi Hoa, Phung Duc Thuan, Joel Tarning, François Nosten, Baldur Magnusson, Jay Prakash Jain, Kamal Hamed Poirel T Ceftazidime-Avibactam as Salvage Therapy for Infections Caused by e01964-16 Clinical Carbapenem-Resistant Organisms Elizabeth Temkin, Julian Torre-Cisneros, Bojana Beovic, Natividad Benito, Maddalena Giannella, Raúl Gilarranz, Cameron Jeremiah, Belén Loeches, Isabel Machuca, María José Jiménez-Martín, José Antonio Martínez, Marta Mora-Rillo, Enrique Navas, Michael Osthoff, Juan Carlos Pozo, Juan Carlos Ramos Ramos, Marina Rodriguez, Miguel Sánchez-García, Pierluigi Viale, Michel Wolff, Yehuda Carmeli Boucher T Multicenter Observational Study of Ceftaroline Fosamil for Methicillin-Resistant e02015-16 Clinical Staphylococcus aureus Bloodstream Infections Evan J. Zasowski, Trang D. Trinh, Kimberly C. Claeys, Anthony M. Casapao, Noor Sabagha, Abdalhamid M. Lagnf, Kenneth P. Klinker, Susan L. Davis, Michael J. Rybak Shlaes T Nephrotoxicity during Vancomycin Therapy in Combination with Piperacillin- e02089-16 Clinical Tazobactam or Cefepime W. Cliff Rutter, Jessica N. Cox, Craig A. Martin, Donna R. Burgess, David S. Burgess Shlaes T Clinical Beneﬁt of Appropriate Empirical Fluoroquinolone Therapy for Adults with e02174-16 Clinical Community-Onset Bacteremia in Comparison with Third-Generation-Cephalosporin Therapy Ching-Chi Lee, Jiun-Ling Wang, Chung-Hsun Lee, Chih-Chia Hsieh, Yuan-Pin Hung, Ming-Yuan Hong, Hung-Jen Tang, Wen-Chien Ko

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Nuermberger T Clinical Characteristics and Treatment Outcomes of Patients with Macrolide- e02189-16 Clinical Resistant Mycobacterium massiliense Lung Disease Hayoung Choi, Su-Young Kim, Hyun Lee, Byung Woo Jhun, Hye Yun Park, Kyeongman Jeon, Dae Hun Kim, Hee Jae Huh, Chang-Seok Ki, Nam Yong Lee, Seung-Heon Lee, Sung Jae Shin, Charles L. Daley, Won-Jung Koh

PHARMACOLOGY Wilbur K. Milhous T Antischistosomiasis Liver Fibrosis Effects of Chlorogenic Acid through IL-13/miR- e01347-16 Pharmacology 21/Smad7 Signaling Interactions In Vivo and In Vitro Yao Wang, Fan Yang, Jun Xue, Xuan Zhou, Lei Luo, Qian Ma, Yun-Fei Chen, Juan Zhang, Shu-Ling Zhang, Lei Zhao Ambrose T Results of a Doravirine-Atorvastatin Drug-Drug Interaction Study e01364-16 Pharmacology Sauzanne Khalilieh, Ka Lai Yee, Rosa I. Sanchez, Ilias Triantafyllou, Li Fan, Noha Maklad, Heather Jordan, Maureen Martell, Marian Iwamoto Andes T Safety, Tolerability, and Pharmacokinetics of Liposomal Amphotericin B in e01477-16 Pharmacology Immunocompromised Pediatric Patients Nita L. Seibel, Aziza T. Shad, Ihor Bekersky, Andreas H. Groll, Corina Gonzalez, Lauren V. Wood, Paul Jarosinski, Donald Buell, William W. Hope, Thomas J. Walsh Arikan-Akdagli T Low Caspofungin Exposure in Patients in Intensive Care Units e01582-16 Pharmacology Kim C. M. van der Elst, Anette Veringa, Jan G. Zijlstra, Albertus Beishuizen, Rob Klont, Petra Brummelhuis-Visser, Donald R. A. Uges, Daan J. Touw, Jos G. W. Kosterink, Tjip S. van der Werf, Jan-Willem C. Alffenaar Ambrose T Pharmacokinetics of the First-Line Antituberculosis Drugs in Ghanaian Children e01701-16 Pharmacology with Tuberculosis with or without HIV Coinfection Sampson Antwi, Hongmei Yang, Anthony Enimil, Anima M. Sarfo, Fizza S. Gillani, Daniel Ansong, Albert Dompreh, Antoinette Orstin, Theresa Opoku, Dennis Bosomtwe, Lubbe Wiesner, Jennifer Norman, Charles A. Peloquin, Awewura Kwara Arikan-Akdagli S In Vitro Antifungal Susceptibility Proﬁles of 12 Antifungal Drugs against 55 e01753-16 Pharmacology Trichophyton schoenleinii Isolates from Tinea Capitis Favosa Patients in Iran, Turkey, and China Shuwen Deng, Saham Ansari, Macit Ilkit, Haleh Rafati, Mohammad T. Hedayati, Mojtaba Taghizadeh-Armaki, Ayatollah Nasrollahi-Omran, Ali Tolooe, Ping Zhan, Wanqing Liao, Henrich A. van der Lee, Paul E. Verweij, Seyedmojtaba Seyedmousavi Ambrose T Are Prophylactic and Therapeutic Target Concentrations Different?: the Case of e01869-16 Pharmacology Lopinavir-Ritonavir or Lamivudine Administered to Infants for Prevention of Mother-to-Child HIV-1 Transmission during Breastfeeding Frantz Foissac, Jörn Blume, Jean-Marc Tréluyer, Thorkild Tylleskär, Chipepo Kankasa, Nicolas Meda, James K. Tumwine, Mandisa Singata-Madliki, Kim Harper, Silvia M. Illamola, Naïm Bouazza, Nicolas Nagot, Philippe Van de Perre, Stéphane Blanche, Déborah Hirt, for the ANRS 12174 Trial Group Andes T Pharmacokinetics of Anidulafungin in Critically Ill Intensive Care Unit Patients e01894-16 Pharmacology with Suspected or Proven Invasive Fungal Infections R. J. M. Brüggemann, V. Middel-Baars, D. W. de Lange, A. Colbers, A. R. J. Girbes, P. Pickkers, E. L. Swart Silverman T Effects of Oritavancin on Coagulation Tests in the Clinical Laboratory e01968-16 Pharmacology Adam Belley, Richard Robson, John L. Francis, Dorothy M. Adcock, Stefan Tiefenbacher, Christopher M. Rubino, Greg Moeck, David Sylvester, Michael N. Dudley, Jeffery Loutit

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Andes T Polymyxin B in Combination with Rifampin and Meropenem against Polymyxin e02121-16 Pharmacology B-Resistant KPC-Producing Klebsiella pneumoniae John K. Diep, David M. Jacobs, Rajnikant Sharma, Jenna Covelli, Dana R. Bowers, Thomas A. Russo, Gauri G. Rao Ambrose T Pharmacokinetic Evaluation of Darunavir Administered Once or Twice Daily in e02135-16 Pharmacology Combination with Ritonavir or the Three-Direct-Acting Antiviral Regimen of Ombitasvir/Paritaprevir/Ritonavir and Dasabuvir in Adults Coinfected with Hepatitis C and Human Immunodeﬁciency Viruses Jennifer R. King, Amit Khatri, Roger Trinh, Rolando M. Viani, Bifeng Ding, Jiuhong Zha, Rajeev Menon

LETTERS TO THE EDITOR Silverman L Activity of Fosfomycin on Clinical Isolates of Campylobacter jejuni and e02317-16 Letters Campylobacter coli of Enteric Origin Antonio Sorlózano-Puerto, José María Navarro-Marí, José Gutiérrez-Fernández Silverman L Reply to “Activity of Fosfomycin on Clinical Isolates of Campylobacter jejuni and e02448-16 Letters Campylobacter coli of Enteric Origin” Juan Aguilar-Company, Ibai Los-Arcos, Carlos Pigrau, Benito Almirante

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