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Contents • February 2017 • Volume 61, No. 2 CONTENTS • FEBRUARY 2017 • VOLUME 61, NO. 2 COMMENTARY Doi R Carbapenemase-Producing Enterobacteriaceae in Swine Production in the United e02348-16 Commentaries States: Impact and Opportunities Timothy J. Johnson MECHANISMS OF ACTION: PHYSIOLOGICAL EFFECTS Ambrose T Fludioxonil Induces Drk1, a Fungal Group III Hybrid Histidine Kinase, To e01414-16 PHYSIOLOGICAL EFFECTS Dephosphorylate Its Downstream Target, Ypd1 Stephanie M. Lawry, Brad Tebbets, Iain Kean, Douglas Stewart, Joel Hetelle, Bruce S. Klein Milhous T Novel Effects of Lapatinib Revealed in the African Trypanosome by Using e01865-16 PHYSIOLOGICAL EFFECTS Hypothesis-Generating Proteomics and Chemical Biology Strategies Paul J. Guyett, Ranjan Behera, Yuko Ogata, Michael Pollastri, Kojo Mensa-Wilmot Shlaes T Novel Detection Strategy To Rapidly Evaluate the Efficacy of Antichlamydial Agents e02202-16 PHYSIOLOGICAL EFFECTS Yan Zhang, Yuqi Xian, Leiqiong Gao, Hiba Elaasar, Yao Wang, Lamiya Tauhid, Ziyu Hua, Li Shen MECHANISMS OF RESISTANCE Arias T In Vitro Tolerance of Drug-Naive Staphylococcus aureus Strain FDA209P to e01154-16 Mech of Resistance Vancomycin Madhuri Singh, Miki Matsuo, Takashi Sasaki, Yuh Morimoto, Tomomi Hishinuma, Keiichi Hiramatsu Henry F. Chambers T The Loop 2 Region of Ribosomal Protein uS5 Influences Spectinomycin e01186-16 Mech of Resistance Sensitivity, Translational Fidelity, and Ribosome Biogenesis Divya Kamath, Steven T. Gregory, Michael O’Connor Sevtap T Echinocandin Resistance in Candida Species Isolates from Liver Transplant Recipients e01229-16 Arikan-Akdagli Mech of Resistance Gwénolé Prigent, Nawel Aït-Ammar, Eric Levesque, Arnaud Fekkar, Jean-Marc Costa, Sarra El Anbassi, Françoise Foulet, Christophe Duvoux, Jean-Claude Merle, Eric Dannaoui, Françoise Botterel Nuermberger T Molecular Investigation of Resistance to Second-Line Injectable Drugs in e01299-16 Mech of Resistance Multidrug-Resistant Clinical Isolates of Mycobacterium tuberculosis in France Florence Brossier, Anne Pham, Christine Bernard, Alexandra Aubry, Vincent Jarlier, Nicolas Veziris, Wladimir Sougakoff, on behalf of the CNR-MyRMA Nuermberger T De Novo Emergence of Genetically Resistant Mutants of Mycobacterium tuberculosis e01343-16 Mech of Resistance from the Persistence Phase Cells Formed against Antituberculosis Drugs In Vitro Jees Sebastian, Sharmada Swaminath, Rashmi Ravindran Nair, Kishor Jakkala, Atul Pradhan, Parthasarathi Ajitkumar Doi S Emergence of Colistin Resistance Gene mcr-1 in Cronobacter sakazakii Producing e01444-16 Mech of Resistance NDM-9 and in Escherichia coli from the Same Animal Bao-Tao Liu, Feng-Jing Song, Ming Zou, Zhi-Hui Hao, Hu Shan Arikan-Akdagli S In Vitro Exposure to Increasing Micafungin Concentrations Easily Promotes e01542-16 Mech of Resistance Echinocandin Resistance in Candida glabrata Isolates María Ángeles Bordallo-Cardona, Pilar Escribano, Elia Gómez G. de la Pedrosa, Laura Judith Marcos-Zambrano, Rafael Cantón, Emilio Bouza, Jesús Guinea Instructions to Authors are available at http://journalitas.asm.org/t/46519. CONTENTS • FEBRUARY 2017 • VOLUME 61, NO. 2 Chambers T Tigecycline Nonsusceptibility Occurs Exclusively in Fluoroquinolone-Resistant e01654-16 Mech of Resistance Escherichia coli Clinical Isolates, Including the Major Multidrug-Resistant Lineages O25b:H4-ST131-H30R and O1-ST648 Toyotaka Sato, Yuuki Suzuki, Tsukasa Shiraishi, Hiroyuki Honda, Masaaki Shinagawa, Soh Yamamoto, Noriko Ogasawara, Hiroki Takahashi, Satoshi Takahashi, Yutaka Tamura, Shin-ichi Yokota David Andes T The Paradoxical Effect of Echinocandins in Aspergillus fumigatus Relies on e01690-16 Mech of Resistance Recovery of the ␤-1,3-Glucan Synthase Fks1 Veronika Loiko, Johannes Wagener Doi T Chromosomal Amplification of the bla Carbapenemase Gene in a Proteus e01697-16 Mech of Resistance OXA-58 mirabilis Clinical Isolate Delphine Girlich, Rémy A. Bonnin, Pierre Bogaerts, Morgane De Laveleye, Daniel T. Huang, Laurent Dortet, Philippe Glaser, Youri Glupczynski, Thierry Naas Doi T A Naturally Occurring Single Nucleotide Polymorphism in a Multicopy Plasmid e01735-16 Mech of Resistance Produces a Reversible Increase in Antibiotic Resistance Alfonso Santos-Lopez, Cristina Bernabe-Balas, Manuel Ares-Arroyo, Rafael Ortega- Huedo, Andreas Hoefer, Alvaro San Millan, Bruno Gonzalez-Zorn Andes T Using In Vitro Dynamic Models To Evaluate Fluoroquinolone Activity against e01756-16 Mech of Resistance Emergence of Resistant Salmonella enterica Serovar Typhimurium Seung-Jin Lee, Elias Gebru Awji, Na-hye Park, Seung-Chun Park Poirel S Genetic Environment of the bla Gene in a Klebsiella pneumoniae Isolate That e01856-16 Mech of Resistance KPC-2 May Have Been Imported to Russia from Southeast Asia Vladimir Ageevets, Julia Sopova, Irina Lazareva, Maya Malakhova, Elena Ilina, Elena Kostryukova, Vladislav Babenko, Alessandra Carattoli, Yuri Lobzin, Alexander Uskov, Sergey Sidorenko Doi T Molecular Characterization of OXA-48-Like-Producing Enterobacteriaceae in the e01889-16 Mech of Resistance Czech Republic and Evidence for Horizontal Transfer of pOXA-48-Like Plasmids Anna Skalova, Katerina Chudejova, Veronika Rotova, Matej Medvecky, Vendula Studentova, Eva Chudackova, Pavel Lavicka, Tamara Bergerova, Vladislav Jakubu, Helena Zemlickova, Costas C. Papagiannitsis, Jaroslav Hrabak Doi S Chromosome-Encoded Broad-Spectrum Ambler Class A ␤-Lactamase RUB-1 from e01908-16 Mech of Resistance Serratia rubidaea Rémy A. Bonnin, Jennifer Didi, Ayla Ergani, Sandra Lima, Thierry Naas Doi T Exploring the Role of the ⍀-Loop in the Evolution of Ceftazidime Resistance in e01941-16 Mech of Resistance the PenA ␤-Lactamase from Burkholderia multivorans, an Important Cystic Fibrosis Pathogen Krisztina M. Papp-Wallace, Scott A. Becka, Magdalena A. Taracila, Elise T. Zeiser, Julian A. Gatta, John J. LiPuma, Robert A. Bonomo Doi T Mutations Associated with Decreased Susceptibility to Seven Antimicrobial e01983-16 Mech of Resistance Families in Field and Laboratory-Derived Mycoplasma bovis Strains Kinga M. Sulyok, Zsuzsa Kreizinger, Eniko˝ Wehmann, Inna Lysnyansky, Krisztián Bányai, Szilvia Marton, Ákos Jerzsele, Zsuzsanna Rónai, Ibolya Turcsányi, László Makrai, Szilárd Jánosi, Sára Ágnes Nagy, Miklós Gyuranecz Doi S IncP Plasmid Carrying Colistin Resistance Gene mcr-1 in Klebsiella pneumoniae e02229-16 Mech of Resistance from Hospital Sewage Feifei Zhao, Yu Feng, Xiaoju Lü, Alan McNally, Zhiyong Zong February 2017 Volume 61 Issue 2 Antimicrobial Agents and Chemotherapy aac.asm.org iii CONTENTS • FEBRUARY 2017 • VOLUME 61, NO. 2 Shlaes T Identification of a Novel Lincomycin Resistance Mutation Associated with e02247-16 Mech of Resistance Activation of Antibiotic Production in Streptomyces coelicolor A3(2) Guojun Wang, Masumi Izawa, Xiaoge Yang, Dongbo Xu, Yukinori Tanaka, Kozo Ochi Nuermberger S Missense Mutations in the Unfoldase ClpC1 of the Caseinolytic Protease Complex e02342-16 Mech of Resistance Are Associated with Pyrazinamide Resistance in Mycobacterium tuberculosis Michelle Yee, Pooja Gopal, Thomas Dick Shlaes S Plazomicin Activity against 346 Extended-Spectrum-␤-Lactamase/AmpC-Producing e02454-16 Mech of Resistance Escherichia coli Urinary Isolates in Relation to Aminoglycoside-Modifying Enzymes Maria del Carmen López-Diaz, Esther Culebras, Iciar Rodríguez-Avial, Esther Rios, José Manuel Viñuela-Prieto, Juan J. Picazo, Carmen Rodríguez-Avial SUSCEPTIBILITY Milhous T Significant Divergence in Sensitivity to Antimalarial Drugs between Neighboring e01689-16 Susceptibility Plasmodium falciparum Populations along the Eastern Border of Myanmar Weilin Zeng, Yao Bai, Meilian Wang, Zenglei Wang, Shuang Deng, Yonghua Ruan, Shi Feng, Zhaoqing Yang, Liwang Cui Nuermberger S In Vitro Susceptibility Testing of Bedaquiline against Mycobacterium avium Complex e01798-16 Susceptibility Barbara A. Brown-Elliott, Julie V. Philley, David E. Griffith, Foram Thakkar, Richard J. Wallace, Jr. Doi S In Vitro Activity of Ceftazidime-Avibactam against Isolates in a Phase 3 Open- e01820-16 Susceptibility Label Clinical Trial for Complicated Intra-Abdominal and Urinary Tract Infections Caused by Ceftazidime-Nonsusceptible Gram-Negative Pathogens Gregory G. Stone, Patricia A. Bradford, Paul Newell, Angela Wardman Rice S In Vitro Activities of Lefamulin and Other Antimicrobial Agents against e02008-16 Susceptibility Macrolide-Susceptible and Macrolide-Resistant Mycoplasma pneumoniae from the United States, Europe, and China Ken B. Waites, Donna M. Crabb, Lynn B. Duffy, Jorgen S. Jensen, Yang Liu, Susanne Paukner Nuermberger T Genotyping and Prevalence of Pyrazinamide- and Moxifloxacin-Resistant e02170-16 Susceptibility Tuberculosis in China, 2000 to 2010 Yu Pang, Zhijian Zhang, Yufeng Wang, Shengfen Wang, Yuanyuan Song, Bing Zhao, Yang Zhou, Xichao Ou, Qiang Li, Hui Xia, Yang Zheng, Xiangqun Fang, Yanlin Zhao BIOLOGIC RESPONSE MODIFIERS Nuermberger T Long-Chain Fatty Acyl Coenzyme A Ligase FadD2 Mediates Intrinsic e02130-16 Modifiers Pyrazinamide Resistance in Mycobacterium tuberculosis Brandon C. Rosen, Nicholas A. Dillon, Nicholas D. Peterson, Yusuke Minato, Anthony D. Baughn ANTIVIRAL AGENTS Ambrose T Evaluation of Doravirine Pharmacokinetics When Switching from Efavirenz to e01757-16 Antiviral Doravirine in Healthy Subjects Ka Lai Yee, Rosa I. Sanchez, Patrice Auger, Rachael Liu, Li Fan, Ilias Triantafyllou, Ming-Tain Lai, Mike Di Spirito, Marian Iwamoto, Sauzanne G. Khalilieh iv aac.asm.org Antimicrobial Agents and Chemotherapy Volume 61 Issue 2 February 2017 CONTENTS • FEBRUARY 2017 • VOLUME 61, NO. 2 Martinez T Phase 2 Randomized,
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