Programme
Wednesday 06 September 2017 15:45 - 18:00 Arrival / Registration with light refreshments ATC Reception and Foyer
18:00 - 18:15 Welcome remarks ATC Auditorium
18:15 - 19:00 Keynote: Ramanujan Hegde Chair: Rachel Green ATC Auditorium
Quality control of nascent proteins 1 Ramanujan Hegde MRC Laboratory of Molecular Biology, United Kingdom
19:00 - 19:45 Keynote: Davide Ruggero Chair: Jamie Cate ATC Auditorium
5'UTR sequence specificity shapes cell growth, immune 2 recognition, and metastasis Davide Ruggero University of California, San Francisco, United States of America
19:45 - 20:15 Coffee break ATC Foyer
20:15 - 21:15 Keynote history talk: Witold Filipowicz Chair: Fátima Gebauer ATC Auditorium
Make Translation great again: Lessons from the past and 3 ideas for the future Witold Filipowicz Friedrich Miescher Institute for Biomedical Research, Switzerland
21:15 - 22:30 Welcome reception with light refreshments ATC Foyer
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Thursday 07 September 2017 09:00 - 12:30 Session 1: Translation initiation Chair: Encarna Martínez-Salas ATC Auditorium
09:00 - 09:30 RNA-binding proteins controlling internal initiation of 4 translation in RNA viruses Encarna Martínez-Salas Centro de Biología Molecular Severo Ochoa, CSIC-UAM, Spain
09:30 - 09:45 The N-terminal domain (NTD) of eIF5 plays a crucial role in 5 stabilization of the closed state of the 48S preinitiation complex Jagpreet Nanda National Institute of Health, United States of America
09:45 - 10:00 CDK11/p58 represses general translation during mitosis 6 through eIF3F phosphorylations Sihyeon An POSTECH, Republic of Korea
10:00 - 10:15 Crystal structure of the human ribosome in complex with 7 DENR-MCT-1 Ivan Lomakin Yale University, United States of America
10:15 - 10:30 4EHP selectively binds and requires GIGYF1/2 proteins to 8 repress target mRNA expression Daniel Peter MPI for Developmental Biology, Germany
10:30 - 11:00 Coffee break ATC Foyer
11:00 - 11:15 Reconstitution of mRNA-specific mechanisms of Ded1 9 stimulation of 48S translation pre-initiation complex assembly Neha Gupta National Institutes of Health, United States of America
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11:15 - 11:30 The RNA helicase Ded1p suppresses translation initiation 10 from near-cognate start codons Ulf-Peter Guenther EMBL Heidelberg, Germany
11:30 - 11:45 RAN Translation at CGG repeats regulates both basal and 11 activity-driven FMRP synthesis in neurons. Caitlin Rodriguez University of Michigan, United States of America
11:45 - 12:00 Involvement of ES6S region of 40S subunit in mRNA entry 12 and scanning Irene Diaz Centro de Biologia Molecular Severo Ochoa, Spain
12:00 - 12:15 IRES binding to the 40S subunit occurs in two successive 13 steps mediated by eS25 Sunnie Thompson University of Alabama at Birmingham, United States of America
12:15 - 12:30 Ribosomal-induced conformational switching: altering the 14 rate of translation using a structured 3’UTR Erik Hartwick University of Colorado Denver School of Medicine, United States of America
12:30 - 14:00 Lunch ATC Foyer
14:00 - 17:45 Session 2: Systems approaches Chair: Wendy Gilbert ATC Auditorium
14:00 - 14:30 Intrinsic RNA-Binding Preferences of Core Initiation 15 Factors, Translational Enhancer Elements, and Their Contributions to Competitive Discrimination of Different mRNAs
Wendy Gilbert Yale University, United States of America
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14:30 - 14:45 Regulation of Neuronal Translation and Excitability 16 Through an Alternative Splicing Network Linked to Autism Spectrum Disorders Thomas Gonatopoulos-Pournatzis University of Toronto, Donnelly Centre, Canada
14:45 - 15:00 Regulation of PTBP1 translation mediated by translation 17 initiation factor eIF3 Luisa Arake de Tacca University of California, Berkeley, United States of America
15:00 - 15:15 The role of Shine-Dalgarno motifs in recruiting bacterial 18 ribosomes Allen Buskirk Johns Hopkins University School of Medicine, United States of America
15:15 - 15:30 Translation initiation events on structured eukaryotic 19 mRNAs generate gene expression noise Estelle Dacheux University of Warwick, United Kingdom
15:30 - 15:45 Quantitating Translational Control: mRNA 20 Abundance-Dependent and Independent Contributions and the mRNA Sequences that Specify Them Mark Biggin Lawrence Berkeley National Laboratory, United States of America
15:45 - 16:00 Dissecting the genetic basis of transcriptional and 21 translational regulation in heart failure. Franziska Kreuchwig Max-Delbrück-Center for Molecular Medicine Berlin, Germany
16:00 - 16:45 Coffee break & Meet the Speakers ATC Foyer
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16:45 - 17:00 Dynamic Translational Regulation in the Yeast Metabolic 22 Cycle Daniel Santos University of California, San Francisco, United States of America
17:00 - 17:15 AMD1 mRNA employs ribosome queuing as a mechanism 23 for molecular memory formation. Martina Yordanova School of Biochemistry and Cell Biology, University College Cork, Ireland
17:15 - 17:30 High-throughput inverse toeprinting for the discovery and 24 analysis of ribosome-arresting peptides Britta Seip University of Bordeaux, INSERM U1212, CNRS UMR 5320, France
17:30 - 17:45 Massively parallel interrogation of 3’UTR elements reveals 25 mechanisms and interactions of RNA binding proteins and microRNAs Sergej Djuranovic Washington University in St. Louis, School of Medicine, United States of America
17:45 - 18:00 Pre-dinner drinks ATC Foyer
18:00 - 19:30 Dinner ATC Canteen
19:30 - 21:30 Poster Session I (odd numbers) ATC Helices
21:30 - 22:30 Wine & Cheese ATC Rooftop Lounge
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Friday 08 September 2017 09:00 - 12:30 Session 3: Metabolism and disease Chair: Xiang-Lei Yang ATC Auditorium
09:00 - 09:30 Tyrosyl-tRNA synthetase prevents overstimulation of 26 translation after oxidative stress Xiang-Lei Yang The Scripps Research Institute, United States of America
09:30 - 09:45 Sensing stress in cancer: a novel therapy targeting protein 27 synthesis through the unfolded protein response in aggressive prostate cancer Crystal Conn University of California, San Francisco, United States of America
09:45 - 10:00 ATF4-induced 4E-BP bias in cellular translation drives the 28 Drosophila innate immune response Deepika Vasudevan New York University School of Medicine, United States of America
10:00 - 10:15 Viral protein selects Rho-like small GTPase to directly 29 activate target of rapamycin (TOR) in translation Mikhail Schepetilnikov Institute of Plant Molecular Biology, IBMP2357 CNRS, France
10:15 - 10:30 Tight translational control of glycolysis and fatty acid 30 synthesis regulates CD4+ T cell metabolic reprogramming and balances inflammatory and regulatory phenotypes Nicola Manfrini INGM "Romeo ed Enrica Invernizzi" Milan, Italy
10:30 - 11:00 Coffee break ATC Foyer
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11:00 - 11:15 EIF4F Links translation to energy stress response in 31 cancer Laura Hulea Lady Davis Institute, McGill University, Canada
11:15 - 11:30 C/EBPß-LIP regulates the let-7/Lin28 translational circuit 32 to control cellular metabolism Cornelis Calkhoven University Medical Centre Groningen, The Netherlands
11:30 - 11:45 Hidden functions of uORFs: inhibitors of PKCs kinase 33 activity Sigal Frost Ben Gurion University, Israel
11:45 - 12:00 Translation repression via modulating the cytoplasmic 34 poly(A) binding protein in inflammatory response Wenqian Hu Mayo Clinic, United States of America
12:00 - 12:15 Ribonuclease Inhibitor (RNH1) is a ribosome-associated 35 protein and regulates erythropoiesis by controlling GATA1-specific mRNA translation Ramanjaneyulu Allam Inselspital, University Bern, Switzerland
12:15 - 12:30 Translation regulation through wobble tRNA modification 36 in cancer Pierre Close University of Liege, Belgium
12:30 - 17:00 Free time / Sightseeing
17:00 - 19:00 Session 4: Interconnections and turnover Chair: Niels Gehring ATC Auditorium
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17:00 - 17:30 Protection and surveillance of the transcriptome by the 37 exon junction complex Niels H. Gehring University of Cologne, Germany
17:30 - 17:45 RNase-based Rheostat Regulating Animal Homeostasis 38
Rafal Ciosk Friedrich Miescher Institute for Biomedical Research, Switzerland
17:45 - 18:00 Functional relation of hnRNP K - rpS19 crosstalk in 39 erythroid cell maturation Isabel S. Naarmann-de Vries University Hospital, RWTH Aachen University, Germany
18:00 - 18:15 mt-tRNA Val and mt-tRNA Phe are interchangeable 40 components of mammalian mitochondrial ribosomes Joanna Rorbach Karolinska Institutet, Sweden
18:15 - 18:30 Identification of functional tetramolecular RNA 41 G-quadruplexes derived from transfer RNAs Pavel Ivanov Brigham and Women's Hospital, Harvard Medical School, United States of America
18:30 - 18:45 Lso2 is a conserved ribosome-bound protein required for 42 translational recovery in yeast Yinuo Wang Yale University, United States of America
18:45 - 19:00 Detector and Terminator: two succesive and mutually 43 exclusive NMD complexes in yeast Cosmin Saveanu Institut Pasteur, France
19:00 - 19:15 Pre-dinner drinks ATC Foyer
19:15 - 20:30 Dinner ATC Canteen
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Programme
20:30 - 22:30 Poster Session II (even numbers) ATC Helices
22:30 - 23:30 Wine & Cheese ATC Rooftop Lounge
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Saturday 09 September 2017 09:00 - 12:30 Session 5: Ribosome, elongation, termination Chair: Scott Blanchard ATC Auditorium
09:00 - 09:30 Regulating gene expression through transient factor 44 interactions with the translating ribosome Scott Blanchard Cornell Med, United States of America
09:30 - 09:45 Visualizing mRNA decoding by ensemble cryo-EM 45 Andrei Korostelev University of Massachusetts Medical School, United States of America
09:45 - 10:00 The force-sensing peptide VemP employs extreme 46 compaction and secondary structure formation to induce ribosomal stalling Ting Su LMU Munich, Germany
10:00 - 10:15 Release factor-mediated dynamics of the ribosome during 47 translation termination monitored by single-molecule FRET Sarah Adio MPI for Biophysical Chemistry, Germany
10:15 - 10:30 Cellular levels of readthrough inducing tRNAs and their 48 consequences in yeast and mammals Petra Beznoskova Institute of Microbiology of the CAS, Czech Republic
10:30 - 11:00 Coffee break ATC Foyer
11:00 - 11:15 Ternatin and didemnin trap distinct conformational states 49 of ribosome-bound eEF1A and exert distinct cellular phenotypes Jack Taunton University of California, San Francisco, United States of America
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11:15 - 11:30 Role of eIF5A in polyamine regulation of translation 50 Byung-Sik Shin NICHD, United States of America
11:30 - 11:45 Translation Termination Factors are Recruited to 51 Ribosomes Undergoing Translational Recoding Driven by 2A peptides Man Balola Newcastle University, United Kingdom
11:45 - 12:00 Structure of the 40S–ABCE1 post-splitting complex in 52 ribosome recycling and translation initiation Milan Gerovac Goethe University, Germany
12:00 - 12:15 The structure of a native translational pre-initiation 53 complex from Trypanosoma cruzi reveals kinetoplastid-specific aspects of translation Jailson Brito Querido University of Strasbourg, CNRS, France
12:15 - 12:30 Defining Ribosome States During Elongation by Ribosome 54 Profiling Colin Wu Johns Hopkins University School of Medicine, United States of America
12:30 - 14:00 Lunch ATC Canteen
14:00 - 16:00 Poster Session III (all numbers) ATC Helices
16:00 - 19:00 Session 6: RNA-protein complexes Chair: Gunter Meister ATC Auditorium
16:00 - 16:30 To be presented onsite 55 Gunter Meister University of Regensburg, Germany
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16:30 - 16:45 Self-assembly of RNA and its implications for RNP granule 56 assembly Briana Van Treeck University of Colorado Boulder, United States of America
16:45 - 17:00 P-bodies are involved in coordinated translational 57 repression but not in mRNA decay Dominique Weil CNRS, France
17:00 - 17:15 Identification of protein cofactors and mRNA targets of 58 tiRNA mediated translation repression Shawn Lyons Harvard Medical School / Brigham and Women's Hospital, United States of America
17:15 - 17:30 Co-translational protein complex assembly in eukaryotes 59 revealed by ribosome profiling, at near residue resolution Ayala Shiber The Center for Molecular Biology, ZMBH-DKFZ Alliance, Heidelberg University, Germany
17:30 - 18:00 Coffee break & Meet the Speakers ATC Foyer
18:00 - 18:15 Paradoxical role for ribosomes in Ago2-mediated mRNA 60 cleavage Marvin Tanenbaum Hubrecht Institute, The Netherlands
18:15 - 18:30 Dual Regulation of Translation of Programmed Cell Death 61 4 mRNA by the RNA-binding protein ANXA2 Monalisa Mondal Indian Institute of Science Education and Research Kolkata, India
18:30 - 18:45 A post-transcriptional program coordinated by CSDE1 62 prevents intrinsic neural differentiation of human embryonic stem cells Hyun Ju Lee CECAD, University of Cologne, Germany
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18:45 - 19:00 The small non-coding vault RNA1-1 acts as a 63 riboregulator of autophagy Rastislav Horos EMBL Heidelberg, Germany
19:00 - 19:10 Closing remarks ATC Auditorium
19:10 - 19:30 Pre-dinner drinks ATC Foyer
19:30 - 21:30 Banquet Dinner ATC Canteen
21:30 - 00:30 Conference Party with band ATC Foyer
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