Programme Wednesday 06 September 2017 15:45 - 18:00 Arrival / Registration with light refreshments ATC Reception and Foyer 18:00 - 18:15 Welcome remarks ATC Auditorium 18:15 - 19:00 Keynote: Ramanujan Hegde Chair: Rachel Green ATC Auditorium Quality control of nascent proteins 1 Ramanujan Hegde MRC Laboratory of Molecular Biology, United Kingdom 19:00 - 19:45 Keynote: Davide Ruggero Chair: Jamie Cate ATC Auditorium 5'UTR sequence specificity shapes cell growth, immune 2 recognition, and metastasis Davide Ruggero University of California, San Francisco, United States of America 19:45 - 20:15 Coffee break ATC Foyer 20:15 - 21:15 Keynote history talk: Witold Filipowicz Chair: Fátima Gebauer ATC Auditorium Make Translation great again: Lessons from the past and 3 ideas for the future Witold Filipowicz Friedrich Miescher Institute for Biomedical Research, Switzerland 21:15 - 22:30 Welcome reception with light refreshments ATC Foyer Page 5 EMBO Conference: Protein Synthesis and Translational Control Thursday 07 September 2017 09:00 - 12:30 Session 1: Translation initiation Chair: Encarna Martínez-Salas ATC Auditorium 09:00 - 09:30 RNA-binding proteins controlling internal initiation of 4 translation in RNA viruses Encarna Martínez-Salas Centro de Biología Molecular Severo Ochoa, CSIC-UAM, Spain 09:30 - 09:45 The N-terminal domain (NTD) of eIF5 plays a crucial role in 5 stabilization of the closed state of the 48S preinitiation complex Jagpreet Nanda National Institute of Health, United States of America 09:45 - 10:00 CDK11/p58 represses general translation during mitosis 6 through eIF3F phosphorylations Sihyeon An POSTECH, Republic of Korea 10:00 - 10:15 Crystal structure of the human ribosome in complex with 7 DENR-MCT-1 Ivan Lomakin Yale University, United States of America 10:15 - 10:30 4EHP selectively binds and requires GIGYF1/2 proteins to 8 repress target mRNA expression Daniel Peter MPI for Developmental Biology, Germany 10:30 - 11:00 Coffee break ATC Foyer 11:00 - 11:15 Reconstitution of mRNA-specific mechanisms of Ded1 9 stimulation of 48S translation pre-initiation complex assembly Neha Gupta National Institutes of Health, United States of America Page 6 Programme 11:15 - 11:30 The RNA helicase Ded1p suppresses translation initiation 10 from near-cognate start codons Ulf-Peter Guenther EMBL Heidelberg, Germany 11:30 - 11:45 RAN Translation at CGG repeats regulates both basal and 11 activity-driven FMRP synthesis in neurons. Caitlin Rodriguez University of Michigan, United States of America 11:45 - 12:00 Involvement of ES6S region of 40S subunit in mRNA entry 12 and scanning Irene Diaz Centro de Biologia Molecular Severo Ochoa, Spain 12:00 - 12:15 IRES binding to the 40S subunit occurs in two successive 13 steps mediated by eS25 Sunnie Thompson University of Alabama at Birmingham, United States of America 12:15 - 12:30 Ribosomal-induced conformational switching: altering the 14 rate of translation using a structured 3’UTR Erik Hartwick University of Colorado Denver School of Medicine, United States of America 12:30 - 14:00 Lunch ATC Foyer 14:00 - 17:45 Session 2: Systems approaches Chair: Wendy Gilbert ATC Auditorium 14:00 - 14:30 Intrinsic RNA-Binding Preferences of Core Initiation 15 Factors, Translational Enhancer Elements, and Their Contributions to Competitive Discrimination of Different mRNAs Wendy Gilbert Yale University, United States of America Page 7 EMBO Conference: Protein Synthesis and Translational Control 14:30 - 14:45 Regulation of Neuronal Translation and Excitability 16 Through an Alternative Splicing Network Linked to Autism Spectrum Disorders Thomas Gonatopoulos-Pournatzis University of Toronto, Donnelly Centre, Canada 14:45 - 15:00 Regulation of PTBP1 translation mediated by translation 17 initiation factor eIF3 Luisa Arake de Tacca University of California, Berkeley, United States of America 15:00 - 15:15 The role of Shine-Dalgarno motifs in recruiting bacterial 18 ribosomes Allen Buskirk Johns Hopkins University School of Medicine, United States of America 15:15 - 15:30 Translation initiation events on structured eukaryotic 19 mRNAs generate gene expression noise Estelle Dacheux University of Warwick, United Kingdom 15:30 - 15:45 Quantitating Translational Control: mRNA 20 Abundance-Dependent and Independent Contributions and the mRNA Sequences that Specify Them Mark Biggin Lawrence Berkeley National Laboratory, United States of America 15:45 - 16:00 Dissecting the genetic basis of transcriptional and 21 translational regulation in heart failure. Franziska Kreuchwig Max-Delbrück-Center for Molecular Medicine Berlin, Germany 16:00 - 16:45 Coffee break & Meet the Speakers ATC Foyer Page 8 Programme 16:45 - 17:00 Dynamic Translational Regulation in the Yeast Metabolic 22 Cycle Daniel Santos University of California, San Francisco, United States of America 17:00 - 17:15 AMD1 mRNA employs ribosome queuing as a mechanism 23 for molecular memory formation. Martina Yordanova School of Biochemistry and Cell Biology, University College Cork, Ireland 17:15 - 17:30 High-throughput inverse toeprinting for the discovery and 24 analysis of ribosome-arresting peptides Britta Seip University of Bordeaux, INSERM U1212, CNRS UMR 5320, France 17:30 - 17:45 Massively parallel interrogation of 3’UTR elements reveals 25 mechanisms and interactions of RNA binding proteins and microRNAs Sergej Djuranovic Washington University in St. Louis, School of Medicine, United States of America 17:45 - 18:00 Pre-dinner drinks ATC Foyer 18:00 - 19:30 Dinner ATC Canteen 19:30 - 21:30 Poster Session I (odd numbers) ATC Helices 21:30 - 22:30 Wine & Cheese ATC Rooftop Lounge Page 9 EMBO Conference: Protein Synthesis and Translational Control Friday 08 September 2017 09:00 - 12:30 Session 3: Metabolism and disease Chair: Xiang-Lei Yang ATC Auditorium 09:00 - 09:30 Tyrosyl-tRNA synthetase prevents overstimulation of 26 translation after oxidative stress Xiang-Lei Yang The Scripps Research Institute, United States of America 09:30 - 09:45 Sensing stress in cancer: a novel therapy targeting protein 27 synthesis through the unfolded protein response in aggressive prostate cancer Crystal Conn University of California, San Francisco, United States of America 09:45 - 10:00 ATF4-induced 4E-BP bias in cellular translation drives the 28 Drosophila innate immune response Deepika Vasudevan New York University School of Medicine, United States of America 10:00 - 10:15 Viral protein selects Rho-like small GTPase to directly 29 activate target of rapamycin (TOR) in translation Mikhail Schepetilnikov Institute of Plant Molecular Biology, IBMP2357 CNRS, France 10:15 - 10:30 Tight translational control of glycolysis and fatty acid 30 synthesis regulates CD4+ T cell metabolic reprogramming and balances inflammatory and regulatory phenotypes Nicola Manfrini INGM "Romeo ed Enrica Invernizzi" Milan, Italy 10:30 - 11:00 Coffee break ATC Foyer Page 10 Programme 11:00 - 11:15 EIF4F Links translation to energy stress response in 31 cancer Laura Hulea Lady Davis Institute, McGill University, Canada 11:15 - 11:30 C/EBPß-LIP regulates the let-7/Lin28 translational circuit 32 to control cellular metabolism Cornelis Calkhoven University Medical Centre Groningen, The Netherlands 11:30 - 11:45 Hidden functions of uORFs: inhibitors of PKCs kinase 33 activity Sigal Frost Ben Gurion University, Israel 11:45 - 12:00 Translation repression via modulating the cytoplasmic 34 poly(A) binding protein in inflammatory response Wenqian Hu Mayo Clinic, United States of America 12:00 - 12:15 Ribonuclease Inhibitor (RNH1) is a ribosome-associated 35 protein and regulates erythropoiesis by controlling GATA1-specific mRNA translation Ramanjaneyulu Allam Inselspital, University Bern, Switzerland 12:15 - 12:30 Translation regulation through wobble tRNA modification 36 in cancer Pierre Close University of Liege, Belgium 12:30 - 17:00 Free time / Sightseeing 17:00 - 19:00 Session 4: Interconnections and turnover Chair: Niels Gehring ATC Auditorium Page 11 EMBO Conference: Protein Synthesis and Translational Control 17:00 - 17:30 Protection and surveillance of the transcriptome by the 37 exon junction complex Niels H. Gehring University of Cologne, Germany 17:30 - 17:45 RNase-based Rheostat Regulating Animal Homeostasis 38 Rafal Ciosk Friedrich Miescher Institute for Biomedical Research, Switzerland 17:45 - 18:00 Functional relation of hnRNP K - rpS19 crosstalk in 39 erythroid cell maturation Isabel S. Naarmann-de Vries University Hospital, RWTH Aachen University, Germany 18:00 - 18:15 mt-tRNA Val and mt-tRNA Phe are interchangeable 40 components of mammalian mitochondrial ribosomes Joanna Rorbach Karolinska Institutet, Sweden 18:15 - 18:30 Identification of functional tetramolecular RNA 41 G-quadruplexes derived from transfer RNAs Pavel Ivanov Brigham and Women's Hospital, Harvard Medical School, United States of America 18:30 - 18:45 Lso2 is a conserved ribosome-bound protein required for 42 translational recovery in yeast Yinuo Wang Yale University, United States of America 18:45 - 19:00 Detector and Terminator: two succesive and mutually 43 exclusive NMD complexes in yeast Cosmin Saveanu Institut Pasteur, France 19:00 - 19:15 Pre-dinner drinks ATC Foyer 19:15 - 20:30 Dinner ATC Canteen Page 12 Programme 20:30 - 22:30 Poster Session II (even numbers) ATC Helices 22:30 - 23:30 Wine & Cheese ATC Rooftop Lounge Page 13 EMBO Conference: Protein Synthesis and Translational Control Saturday 09 September 2017 09:00 - 12:30 Session 5: Ribosome, elongation, termination Chair: Scott Blanchard