What Is Spirometry?
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Effects of Calcium on Intestinal Mucin: Implications for Cystic Fibrosis
27. Takcbayi~shi.S.. (;robe. II . von B;~ssca~t/.D. H.. and rliormnn. 11. Ultrastruc- prepnratlon.) tural a\pects of veihel .llteratlon\ In homoc!\t~nur~a.V~rcha\r'r Arch. Aht. .A 33 Wong. P. W. K.. Scliworl. V . and Komro~er.(i. M.: The b~os!nthc\~\of P;~thol Anat . 1154- 4 (1071). c)st:~thlonrnc In pntlcntc s~thhornoc!\tinur~,~. Ped~at.Rer . 2- 149 (196x1. 28. T:~ndler. H. T.. I:rlandson. R. A,, and Wbnder. E. 1.. Rihol1;lvln and mou\c 34 'The authors would l~kcto thank K. Curleq, N. Becker, and k.Jaros~u\ for thcir hepatic cell structure and funct~on.hmer. J. Pnthol.. 52 69 (1968). techn~cal:Is\l\tancc and Dr\. B. Chomet. Orville T B:llle!. and Mar) B. 29. Ti~nikawa, L.: llltrastructurnl A\pect\ of the I iver and Its I)~sordcr\(Igaker Buschman for the~ruggehtlona In the ~ntcrpretation\of braln and Iner electron Shoin. I.td.. Tok!o. 1968). micrograph\. 30. Uhlendorl, B. W.. Concrl!. E. R.. and Mudd. S. H.: tlomoc!st~nur~a:Studle, In 35 Th~sstud! &a\ \upported b! Publrc Health Servlcc Kese;~rch Grant no. KO1 tissue culture. Pediat. Kes.. 7: 645 (1073). N5OX532NlN and a grant from the Illino~\Department of Mental llealth. 31. Wong. P. W. K.. and Fresco. R.: T~\suec!\tathlon~nc in mice trei~tedw~th 36 Requests for reprint\ should be i~ddressed to: Paul W. K. Wong. M.D.. cystelne and homoser~ne.Pedlat. Res . 6 172 (1972) Department of Ped~atric.Prcsh!tcr~an-St. -
In Vitro Modelling of the Mucosa of the Oesophagus and Upper Digestive Tract
21 Review Article Page 1 of 21 In vitro modelling of the mucosa of the oesophagus and upper digestive tract Kyle Stanforth1, Peter Chater1, Iain Brownlee2, Matthew Wilcox1, Chris Ward1, Jeffrey Pearson1 1NUBI, Newcastle University, Newcastle upon Tyne, UK; 2Applied Sciences (Department), Northumbria University, Newcastle upon Tyne, UK Contributions: (I) Conception and design: All Authors; (II) Administrative support: All Authors; (III) Provision of study materials or patients: All Authors; (IV) Collection and assembly of data: All Authors; (V) Data analysis and interpretation: All Authors; (VI) Manuscript writing: All authors; (VII) Final approval of manuscript: All authors. Correspondence to: Kyle Stanforth. NUBI, Medical School, Framlington Place, Newcastle University, NE2 4HH, Newcastle upon Tyne, UK. Email: [email protected]. Abstract: This review discusses the utility and limitations of model gut systems in accurately modelling the mucosa of the digestive tract from both an anatomical and functional perspective, with a particular focus on the oesophagus and the upper digestive tract, and what this means for effective in vitro modelling of oesophageal pathology. Disorders of the oesophagus include heartburn, dysphagia, eosinophilic oesophagitis, achalasia, oesophageal spasm and gastroesophageal reflux disease. 3D in vitro models of the oesophagus, such as organotypic 3D culture and spheroid culture, have been shown to be effective tools for investigating oesophageal pathology. However, these models are not integrated with modelling of the upper digestive tract—presenting an opportunity for future development. Reflux of upper gastrointestinal contents is a major contributor to oesophageal pathologies like gastroesophageal reflux disease and Barratt’s oesophagus, and in vitro models are essential for understanding their mechanisms and developing solutions. -
Standardisation of Spirometry
Eur Respir J 2005; 26: 319–338 DOI: 10.1183/09031936.05.00034805 CopyrightßERS Journals Ltd 2005 SERIES ‘‘ATS/ERS TASK FORCE: STANDARDISATION OF LUNG FUNCTION TESTING’’ Edited by V. Brusasco, R. Crapo and G. Viegi Number 2 in this Series Standardisation of spirometry M.R. Miller, J. Hankinson, V. Brusasco, F. Burgos, R. Casaburi, A. Coates, R. Crapo, P. Enright, C.P.M. van der Grinten, P. Gustafsson, R. Jensen, D.C. Johnson, N. MacIntyre, R. McKay, D. Navajas, O.F. Pedersen, R. Pellegrino, G. Viegi and J. Wanger CONTENTS AFFILIATIONS Background ............................................................... 320 For affiliations, please see Acknowledgements section FEV1 and FVC manoeuvre .................................................... 321 Definitions . 321 CORRESPONDENCE Equipment . 321 V. Brusasco Requirements . 321 Internal Medicine University of Genoa Display . 321 V.le Benedetto XV, 6 Validation . 322 I-16132 Genova Quality control . 322 Italy Quality control for volume-measuring devices . 322 Fax: 39 103537690 E-mail: [email protected] Quality control for flow-measuring devices . 323 Test procedure . 323 Received: Within-manoeuvre evaluation . 324 March 23 2005 Start of test criteria. 324 Accepted after revision: April 05 2005 End of test criteria . 324 Additional criteria . 324 Summary of acceptable blow criteria . 325 Between-manoeuvre evaluation . 325 Manoeuvre repeatability . 325 Maximum number of manoeuvres . 326 Test result selection . 326 Other derived indices . 326 FEVt .................................................................. 326 Standardisation of FEV1 for expired volume, FEV1/FVC and FEV1/VC.................... 326 FEF25–75% .............................................................. 326 PEF.................................................................. 326 Maximal expiratory flow–volume loops . 326 Definitions. 326 Equipment . 327 Test procedure . 327 Within- and between-manoeuvre evaluation . 327 Flow–volume loop examples. 327 Reversibility testing . 327 Method . -
Spirometry (Adult) Guideline
Document Number # QH-GDL-386:2012 Spirometry (Adult) Respiratory Science Custodian/Review Officer: 1. Purpose Chief Allied Health Officer This guideline provides recommendations regarding best practice to support high quality spirometry practice Version no: 1.0 throughout Queensland Health facilities. Applicable To: 2. Scope All Health Practitioners performing adult This guideline provides information for all health spirometry practitioners who perform adult spirometry as part of their clinical duties. Approval Date: 26/11/2012 This guideline provides the minimum requirements for obtaining acceptable and repeatable pre- and post- Effective Date: 26/11/2012 bronchodilator (reversibility) spirometric data using both volume and flow-measuring devices. Next Review Date: 26/11/2013 3. Related documents Authority: This guideline is primarily based on the following Chair – State-wide Clinical Measurements Network documents taken from the series “ATS/ERS Task Force: Standardisation of Lung Function Testing” Approving Officer General considerations for lung function testing 1 Chief Allied Health Officer (2005). Standardisation of spirometry (2005). 2 References from alternate sources of information have Supersedes: Nil been identified in this document. Key Words: spirometry, spiro, respiratory, Policy and Standard/s: measure, spirogram, spirometric, bronchodilator, flow-volume loop, peak Informed Decision-making in Healthcare (QH-POL- flow 346:2011) 3 Accreditation References: Procedures, Guidelines, Protocols EQuIP and other criteria and standards Australian Guidelines for the prevention and control of infection in healthcare (CD33:2010) 4 2005 American Thoracic Society and European Respiratory Society (ATS/ERS) guidelines 1, 2 Version No.: 1.0; Effective From: 26 November 2012 Page 1 of 31 Printed copies are uncontrolled Queensland Health: Spriometry (Adult) Queensland Health Paediatric Spirometry Guideline Forms and templates Nil 4. -
Pulmonary Function Test (PFT)
Pulmonary Function Test (PFT) St. James Mercy Hospital Respiratory Therapy, 1st Floor 411 Canisteo St. Hornell, NY 14843 607-324- 8159 To schedule an appointment: 607-324-2879 To fax to scheduling: 607-324-8221 What is pulmonary function testing and why is it done? Pulmonary function tests (also called PFTs or lung function tests) help determine how well your lungs are functioning. The results of these tests tell your physician how much air your lungs can hold, how quickly you can move air into and out of your lungs, and how well your lungs are able to use oxygen and get rid of carbon dioxide. The tests help your physician determine if you have a lung disease, help provide a measure of how significant your lung disease is, and can show how well the treatment for your lung disease is working. How is a pulmonary function test done? Pulmonary function testing is usually done by a specially trained respiratory therapist or technician. For most pulmonary function tests, you will be asked to wear a nose clip to make sure that no air passes through your nose during the test. You will be asked to breathe into a mouthpiece that is connected to a machine called a spirometer. The technician may encourage you to breathe deeply during parts of the test to get the best results. Following all of the technician's instructions will help provide the most accurate results. How do I prepare for my test? You should not eat a heavy meal just before this test. You should not smoke for six hours before the test. -