Supplementary data

Supplementary figure 1. Heatmap of common response, 2 and 6 hours after irradiation.

Heatmap of the common response to 4 Gy irradiation in all 32 cell lines, adapted from the BRB-array tools time course plug-in output.

Supplementary table 1 gives an overview of cell line characteristics.

Supplementary table 2 describes the patient characteristics for the 34 patients in the validation cohort.

Supplementary table 3 describes the references used for the definition of miR functions stated in table 1.

Supplementary table 4 lists 1226 significantly correlated with radioresistance from a BRB time course plug-in analysis.

Supplementary table 5 lists the genes in our and DNA repair signatures.

Supplementary table 6 lists the HNSCC EMT-scores for the 32 cell lines.

Supplementary table 7 lists the 1189 genes in the HNSCC-EMT signature.

Supplementary table 8 shows results of testing sets for reactive oxygen species, DNA repair, cell cycle phase and several means of cell death against the EMT gene set.

Supplementary figure 1. Heatmap of common response, 2 and 6 hours after irradiation. Heatmap of the common response to 4 Gy irradiation in all 32 cell lines, adapted from the BRB-array tools time course plug-in output.

Supplementary table 1. Overview of cell line characteristics for the 32 cell lines.

Cell line Radiosens- Passage Patient Primary Location T N M Type of Grade Previous itivity (AUC) tested sex Specimen Treatment UT-SCC-1A 1.7 19 F gingiva 2 1 0 rT 2 RT mandibulae UT-SCC-2 1.8 12 M floor of mouth 4 1 0 pT 2 no UT-SCC-4 1.7 9 F supraglottic 3 0 0 rN 2 RT UT-SCC-5 2.3 14 M tongue 1 1 0 ppT 2 RT UT-SCC-6A 2.6 27 F supraglottic 2 1 0 rT 1 RT UT-SCC-7 2 12 M cutis regio 1 0 0 rN 2 RT temporalis UT-SCC-8 1.9 27 M supraglottic 2 0 0 pT 1 no UT-SCC-9 1.4 13 M glottic larynx 2 1 0 N 1 RT UT-SCC-12 2.1 14 F cutis nasi 2 0 0 pT 1 no UT-SCC-15 2.1 15 M tongue 1 0 0 rT 1 RT UT-SCC-16A 1.8 17 F tongue 3 0 0 pT 3 RT UT-SCC-19A 1.7 14 M glottic larynx 4 0 0 pT 2 no UT-SCC-19B 1.7 14 M glottic larynx 4 0 0 ppT 2 RT UT-SCC-20A 2.1 19 F floor of mouth 1 0 0 pT 2 RT UT-SCC-22 1.8 25 M glottic larynx 1 0 0 rT 2 RT UT-SCC-23 1.6 22 M glottic larynx 3 0 0 ppT 1 RT UT-SCC-24A 2.6 24 M tongue 2 0 0 pT 2 no UT-SCC-25 2.2 12 M tongue 2 0 0 pT 1 RT UT-SCC-27 1.9 12 M gingiva 2 0 0 rT 3 RT mandibulae UT-SCC-32 1.7 16 M tongue 3 0 0 ppT 1 RT UT-SCC-36 2.2 8 M floor of mouth 4 1 0 pT 3 no UT-SCC-42A 2.1 7 M supraglottic 4 3 0 pT 3 no UT-SCC-45 2 17 M floor of mouth 3 1 0 pT 3 no UT-SCC-46A 1.6 11 M gingiva maxillae 1 0 0 pT 3 no UT-SCC-47 2 13 M floor of mouth 2 0 0 pT 3 no UT-SCC-48 1.6 15 M parotid gland 3 0 0 pT 2 no UT-SCC-54C 2.3 14 F buccal mucosa 0 0 0 rN 0 RT UT-SCC-60B 2.2 13 M tonsil 4 1 0 ppN 1 RT UT-SCC-76A 2.5 13 M tongue 3 0 0 pT 2 no UT-SCC-77 2.5 23 M tongue 1 0 0 rN 2 no UT-SCC-79A 2.4 14 F parotid gland 2 0 0 rT 2 no UT-SCC-90 2.2 20 M tongue 1 0 0 rT 2 RT Supplementary table 1: Overview of the properties of all 32 cell lines. p= primary tumor, r= recurrent tumor, pp = persistent primary tumor, T=from the primary tumor location, N = from the lymph node.

Supplementary table 2: patient characteristics for the 34 patients in the validation cohort.

Cures Recurrences N 17 17 Sex Male 59% 59% Female 41% 41% Age (years) Average 68 67 Treatment year Average 2007 2007 T-stage T2 65% 59% T3 35% 41% Subsite Glottic 47% 47% Supraglottic 53% 53% Follow up Average 3.9 3.7 (years)

Supplementary table 3: references for the miR functions, as stated in table 1. miR miR function miR-203a Inhibit growth, self-renewal, migration, invasion and EMT (1–4) miR-205-5p Promote , inhibit growth, migration, invasion and EMT (5–8) miR-452-5p Reduce stem-like traits and tumorigenesis, EMT (9,10) miR-200b-3p Reduced proliferation, migration, invasion and EMT (5,11–16) miR-429 Inhibit proliferation and EMT (5,15,17,18) miR-141-3p Inhibit EMT (5,19) miR-200a-3p Inhibit EMT (5,15,16) miR-7-5p Inhibit invasion, self renewal and EMT (20,21). Promote apoptosis (22) miR-138-5p Inhibit proliferation, invasion, migration, modify DNA damage response (23,24) miR-34a-5p Inhibit proliferation, invasion, metastasis, stemness, EMT (25,26) miR-142-3p Maintenance of dendritic cells (27) Inhibit growth and stemness (28) miR-33b-5p Reduce proliferation, induce G1 arrest (29), cholesterol transport (30) miR-130a-3p enhances cell proliferation and migration (31), reduce trail resistance and migration (32) miR-193b-3p Proliferation, differentiation, apoptosis (33) miR-151a-5p Increased migration, invasion (34–36), also inhibition of EMT (37) miR-10a-5p Apoptosis (33) miR-424-5p Increased proliferation, migration and invasion, inhibit apoptosis (38,39) miR-15a-5p Sensitize cells to apoptosis (40,41)

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Supplementary table 4: Bold green: top upregulated genes in resistant cells in figure 2B. Bold red: top downregulated genes in resistant cells in figure 2 A. 1226 genes significantly correlated with radioresistance in 2 groups (AUC < and > 2.0) from the BRB time course plug-in No. in Gene p-value False Discovery Mean expression Mean p-value of 3 p- BRB symbol from BRB Rate (cut-off < difference (sensitive values from t-tests output 0.05) from BRB - resistant cells) between sensitive and resistant groups performed on t=0h, t=2h and t=6h datasets

16 GGT6 0 0 3 0.00005 2 ALDH3B2 0 0 3.4 0.00021 56 TMPRSS13 0 0 2.2 0.00026 17 ILDR1 0 0 2.7 0.00039 301 GDPD3 0 0 1.3 0.0004 24 LY6D 0 0 3.6 0.00041 346 SULT2B1 0 0 1.3 0.00041 100 RPL22L1 0 0 1.9 0.0005 60 A2ML1 0 0 2.1 0.00133 35 SLURP1 0 0 3.1 0.00141 42 SPRR2C 0 0 3.7 0.00148 97 SIAE 0 0 1.8 0.00149 5 ARMCX1 0 0 -2.8 0.00154 143 CNFN 0 0 1.9 0.00173 36 SNRPN 0 0 -4.4 0.00188 330 AAK1 0 0 1.2 0.00188 83 LYPD3 0 0 2.2 0.00205 12 CRCT1 0 0 3.3 0.00209 6 ASPRV1 0 0 2.8 0.00212 591 IL1F10 0 0.0014 1 0.00212 37 SNURF 0 0 -2.3 0.00214 13 CYP4F11 0 0 2.7 0.00254 348 DNAJB5 0 0 -1.3 0.0026 46 SPRR3 0 0 4.2 0.00274 43 SPRR2E 0 0 4.5 0.00291 80 C9orf169 0 0 2.1 0.00295 32 SBSN 0 0 2.5 0.00308 211 C1orf116 0 0 1.4 0.00321 10 CEACAM6 0 0 3.7 0.00322 342 STEAP4 0 0 1.2 0.00322 3 ANKRD22 0 0 2.2 0.0033 8 C6orf15 0 0 3.7 0.00353 144 C9orf152 0 0 1.6 0.00354 87 IL1RN 0 0 2.2 0.00367 50 ZNF750 0 0 2.4 0.00381 1020 MRPL21 0.0013 0.0239 0.8 0.00385 374 TSPAN4 0 0.0001 -1.2 0.004 980 TUBB6 0.0011 0.0204 -0.7 0.00405 34 SLC39A2 0 0 3.1 0.0041 202 TGM5 0 0 1.7 0.0041 313 IL36RN 0 0 1.2 0.00423 208 MALL 0 0 1.5 0.00446 81 RDH12 0 0 1.9 0.00449 21 KRTDAP 0 0 3.1 0.00461 71 SEMA4A 0 0 2.3 0.00468 1043 ILK 0.0015 0.0264 -0.8 0.00478 105 DLG4 0 0 -1.8 0.00511 509 DENND5A 0 0.0005 -1.3 0.00533 91 RAPGEFL1 0 0 2.2 0.00537 178 FAM84A 0 0 1.4 0.0054 373 PRR15L 0 0.0001 1.2 0.00563 73 TMPRSS4 0 0 2.2 0.0057 113 KLK6 0 0 2 0.00576 888 AKIP1 0.0006 0.0129 -0.9 0.00585 283 ZNF615 0 0 -1.3 0.00637 470 LRRC8A 0 0.0003 1.3 0.00644 125 GBP6 0 0 1.7 0.00661 7 BARX1 0 0 -2.7 0.00664 49 VTCN1 0 0 2.6 0.00668 28 RHCG 0 0 2.5 0.00676 219 MUC16 0 0 1.4 0.00708 497 LYNX1 0 0.0004 1.1 0.00718 312 FAM63A 0 0 1.2 0.00759 47 TJP3 0 0 2.8 0.00811 140 ST6GALNAC1 0 0 1.7 0.00883 29 S100A7 0 0 3.2 0.00886 391 ZNF177 0 0.0001 -1.2 0.00888 4 ANXA9 0 0 2.7 0.0095 39 SPRR1A 0 0 3.8 0.00974 76 KLK11 0 0 2.1 0.00988 127 CADM1 0 0 -2 0.00996 254 BNIPL 0 0 1.7 0.01015 1168 NTAN1 0.0026 0.0415 -0.8 0.01024 40 SPRR1B 0 0 3.3 0.01051 779 S100A16 0.0003 0.0063 0.9 0.01072 98 SLPI 0 0 1.8 0.01074 31 S100P 0 0 3.1 0.01088 79 PRSS27 0 0 2.2 0.01093 15 DUOXA1 0 0 2.4 0.01124 194 FAM3D 0 0 1.6 0.01137 116 EXD3 0 0 1.7 0.01142 41 SPRR2A 0 0 3.8 0.01148 159 CYP2C18 0 0 1.7 0.01181 242 ZNF285 0 0 -1.5 0.01207 72 LCN2 0 0 2.1 0.01258 45 SPRR2G 0 0 2.9 0.01267 148 KLK12 0 0 1.8 0.01271 62 KIAA1211L 0 0 2.1 0.01279 390 PIK3CD 0 0.0001 -1 0.01291 351 GPR56 0 0 1.3 0.01302 54 HLA-DRA 0 0 2.3 0.01323 110 MMP28 0 0 1.8 0.01339 549 KRT78 0 0.0009 1 0.01342 198 OR7E91P 0 0 1.7 0.01355 124 ST3GAL2 0 0 -1.5 0.01364 196 LCE3E 0 0 1.5 0.01373 142 BBOX1 0 0 1.6 0.01405 119 FXYD3 0 0 2 0.01421 661 RGMB 0.0001 0.0026 -1 0.0143 102 ACAA2 0 0 -2.1 0.01451 495 KRT33A 0 0.0004 1.1 0.01456 150 HYAL1 0 0 1.8 0.01457 48 VIM 0 0 -3.6 0.01477 44 SPRR2F 0 0 3.3 0.01501 1053 LPCAT1 0.0016 0.0283 -0.8 0.01519 167 CPQ 0 0 -1.7 0.01532 349 PHYH 0 0 -1.4 0.01556 26 NREP 0 0 -2.7 0.01573 356 CPE 0 0 1.1 0.01603 187 FYN 0 0 -1.5 0.01613 22 LEMD1 0 0 2.2 0.01631 204 KRT16 0 0 1.5 0.01642 607 TPRXL 0.0001 0.0017 1.1 0.0168 496 DNASE1L3 0 0.0004 1.2 0.01714 151 OVOL1 0 0 1.9 0.01742 318 PVRL4 0 0 1.4 0.01761 14 DEFB1 0 0 2.4 0.01823 38 SPINK7 0 0 2.3 0.01829 598 CCL22 0 0.0014 0.8 0.01847 117 PLA2G4F 0 0 2 0.01858 174 RDH16 0 0 1.7 0.01885 172 VSTM2L 0 0 -1.7 0.01887 674 DBN1 0.0001 0.0029 -0.9 0.01912 90 TTYH1 0 0 2.1 0.0196 85 DAB2 0 0 -2 0.02015 387 LIPH 0 0.0001 1.4 0.02023 676 INPPL1 0.0001 0.0029 -0.8 0.02044 30 S100A8 0 0 2.8 0.02055 63 APOE 0 0 -2 0.02068 622 APH1B 0.0001 0.002 -0.9 0.02079 53 S100A12 0 0 2 0.02086 265 MUCL1 0 0 1.3 0.02098 27 PDZK1IP1 0 0 2.7 0.02107 320 GRHL3 0 0 1.3 0.02114 1163 PIGP 0.0025 0.041 0.7 0.02153 77 MAGED1 0 0 -1.9 0.02182 95 KLK8 0 0 2 0.0219 245 SH2B3 0 0 -1.6 0.02234 256 TMEM121 0 0 -1.3 0.02234 404 HOPX 0 0.0001 1.3 0.02269 1225 NPR2 0.0032 0.0493 -0.7 0.02286 190 CSPG4 0 0 -1.4 0.02301 195 VILL 0 0 1.7 0.02332 162 TBX2 0 0 -1.8 0.02353 590 TMEM79 0 0.0014 1.2 0.02376 89 SLC47A2 0 0 1.8 0.02457 155 COCH 0 0 -1.7 0.02465 248 SDCBP2 0 0 1.4 0.02519 357 CEACAM5 0 0 1.1 0.02526 600 NRSN2 0 0.0015 -0.8 0.02535 19 KRT13 0 0 3 0.0255 281 SCEL 0 0 1.3 0.02551 66 HOXB2 0 0 2.1 0.02554 859 FADD 0.0005 0.0102 0.9 0.02559 171 ABP1 0 0 1.4 0.02572 547 HABP4 0 0.0008 -1.1 0.02579 75 LRRC26 0 0 2 0.02594 233 TSPAN1 0 0 1.5 0.02598 350 KLK10 0 0 1.5 0.02604 850 CTSZ 0.0004 0.0098 -1 0.02607 25 MSLN 0 0 2.7 0.02628 803 FMO9P 0.0003 0.0074 0.8 0.02642 93 CPT1C 0 0 -1.9 0.02643 635 CHST14 0.0001 0.0022 -1 0.02663 377 SLC5A1 0 0.0001 1.4 0.02692 542 FXYD5 0 0.0008 1.2 0.02719 515 PI16 0 0.0006 1.1 0.02721 1 ALDH3A1 0 0 3.2 0.02765 721 GABARAPL1 0.0002 0.004 -1 0.02766 302 PPL 0 0 1.2 0.02785 904 LDLRAD1 0.0007 0.0146 0.9 0.02794 115 KRT1 0 0 1.9 0.02822 212 MICAL1 0 0 -1.1 0.02868 214 BRSK1 0 0 -1.3 0.03037 235 BARX2 0 0 1.6 0.03053 305 SHROOM2 0 0 1.4 0.0306 589 CDH16 0 0.0013 1 0.03069 258 RASEF 0 0 1.4 0.03072 610 C11orf49 0.0001 0.0017 -0.7 0.03083 290 ZNF185 0 0 1.3 0.03099 18 KLK5 0 0 3.4 0.031 441 EDAR 0 0.0002 1.1 0.03121 560 HOOK1 0 0.001 1 0.03139 220 NIPAL1 0 0 1.2 0.03183 229 CTGF 0 0 -1.6 0.03184 304 JAM2 0 0 -1.2 0.03185 785 SLC9A3R1 0.0003 0.0066 1 0.03194 57 GCNT3 0 0 1.7 0.03241 392 CMTM3 0 0.0001 -1 0.03263 323 DNAJC18 0 0 -1.7 0.03309 177 PRR5L 0 0 -1.8 0.03326 653 FGFR3 0.0001 0.0025 1.1 0.03335 765 CARD14 0.0002 0.0058 1.2 0.03336 1088 FLG 0.0019 0.0332 0.8 0.03391 278 ICAM4 0 0 1.5 0.03422 96 LYPD2 0 0 1.8 0.03511 33 SGCE 0 0 -2.8 0.03526 243 HSD17B1 0 0 1.4 0.03527 101 RYR1 0 0 2 0.03534 149 NPL 0 0 1.4 0.03544 130 COL6A2 0 0 -1.8 0.0355 181 RAET1L 0 0 1.6 0.03565 112 CSTA 0 0 1.8 0.03572 67 MYADM 0 0 -2 0.03578 427 RAET1G 0 0.0001 1.2 0.03604 1116 VPS37D 0.0021 0.036 -0.7 0.03607 710 CSTF3 0.0001 0.0036 -1.2 0.03626 743 PMP22 0.0002 0.0047 -0.9 0.03629 222 DKK3 0 0 -1.6 0.03637 501 IRF6 0 0.0004 1 0.03646 293 FKBP1B 0 0 -1.1 0.0366 1031 VAT1 0.0014 0.0249 -0.7 0.03666 308 LAD1 0 0 1.3 0.03706 138 HKDC1 0 0 1.8 0.03707 923 CYSTM1 0.0008 0.0161 -0.8 0.03727 907 MYO10 0.0007 0.0151 -0.9 0.03734 1044 ABCC9 0.0015 0.0264 -0.8 0.0375 476 TXNDC15 0 0.0003 -1.1 0.03781 111 HES2 0 0 1.7 0.03808 137 IRF7 0 0 -1.5 0.03857 221 PTPRM 0 0 -1.5 0.03857 403 FN1 0 0.0001 -1.2 0.03879 69 ANO1 0 0 1.9 0.0388 407 HOXB4 0 0.0001 1.2 0.03922 11 CLDN11 0 0 -2.7 0.03979 445 CYP4B1 0 0.0002 1.2 0.03984 359 EVPL 0 0 1.3 0.04003 658 PTDSS2 0.0001 0.0026 -0.8 0.04009 264 RNASE1 0 0 1.3 0.04021 1058 CYP4F2 0.0016 0.0289 0.9 0.04033 347 C1orf64 0 0 1.1 0.0405 1181 ZNF34 0.0027 0.0429 -0.7 0.0405 253 CYP27A1 0 0 -1.1 0.04059 1034 ZCCHC6 0.0014 0.0254 1 0.04063 852 KDELR3 0.0004 0.0099 -0.9 0.04094 1022 C8orf40 0.0013 0.0239 0.7 0.04107 306 PCOLCE 0 0 -1.1 0.04113 266 FFAR2 0 0 1.6 0.04154 472 KCNK7 0 0.0003 1.2 0.04164 260 EPHX2 0 0 1.4 0.04189 88 SCG5 0 0 -2.1 0.04197 74 PSCA 0 0 2.2 0.0424 745 THSD4 0.0002 0.0048 -0.7 0.04257 161 DRAM1 0 0 -1.9 0.0426 307 SPRR4 0 0 1.2 0.04263 433 MSRB3 0 0.0002 -1.2 0.0427 544 SLC5A10 0 0.0008 1.1 0.04281 61 IL24 0 0 -2.2 0.0437 385 HAND1 0 0.0001 -1.1 0.04393 726 ACAT2 0.0002 0.0042 -1.1 0.04436 531 IFITM3 0 0.0007 -1 0.0444 343 KRBA2 0 0 -1.3 0.0446 855 PLCD4 0.0005 0.0101 -0.9 0.04495 705 AZGP1 0.0001 0.0036 0.9 0.04515 268 EPN3 0 0 1.6 0.04516 147 S100A14 0 0 1.7 0.04517 94 TCN1 0 0 1.6 0.04526 548 KCNIP3 0 0.0009 -0.7 0.04527 529 MGC50722 0 0.0007 1.3 0.04543 1071 CNIH2 0.0017 0.03 -0.5 0.04549 409 DPCD 0 0.0001 -1.2 0.04555 397 SALL2 0 0.0001 -1 0.04575 761 SPRR2B 0.0002 0.0054 0.7 0.0459 382 FAM101A 0 0.0001 -1.1 0.04594 277 PSORS1C2 0 0 1.8 0.04597 64 S100A9 0 0 2.1 0.04612 129 LCE3D 0 0 1.8 0.04614 141 TCF7L1 0 0 -1.4 0.04617 326 HOXA6 0 0 1.2 0.04637 217 GAA 0 0 1.5 0.04664 123 PLIN2 0 0 -1.9 0.04667 133 CYP2E1 0 0 2 0.04676 238 REEP2 0 0 -1.1 0.04768 492 IFITM2 0 0.0004 -1 0.04779 486 CYP4F22 0 0.0004 1.2 0.0488 263 ZNF597 0 0 1.4 0.04887 1068 C2orf54 0.0017 0.0298 0.9 0.04912 811 GAST 0.0003 0.0077 0.9 0.04926 173 ALOX12B 0 0 1.8 0.04937 9 CDKN2A 0 0 -2.9 0.0497 1219 TRPM6 0.0031 0.0479 0.6 0.05007 1108 AK1 0.0021 0.0354 0.8 0.05033 52 AKR1B15 0 0 1.9 0.05057 869 TRIM31 0.0005 0.0112 1.1 0.05081 1106 RBKS 0.0021 0.0353 0.8 0.05085 791 STK10 0.0003 0.007 -0.8 0.05088 968 SLC2A1 0.001 0.0199 0.8 0.05091 332 ARRDC4 0 0 1.1 0.05103 861 RAB13 0.0005 0.0102 -0.9 0.05165 381 BEX1 0 0.0001 -1.2 0.05235 1160 HR 0.0025 0.0406 0.7 0.05235 20 KRT4 0 0 2.9 0.05298 134 MMP3 0 0 -1.8 0.05378 963 VAV3 0.001 0.019 0.7 0.05382 230 SYT11 0 0 -1.5 0.05384 788 VWA5A 0.0003 0.0069 -0.9 0.05387 121 VSNL1 0 0 1.4 0.05389 55 SCNN1A 0 0 2.4 0.05422 430 IRX5 0 0.0002 1.2 0.05424 339 OLFML2A 0 0 1.1 0.05428 335 RGS4 0 0 -1.4 0.05451 714 ADPRHL1 0.0001 0.0038 1 0.05459 169 SPRR2D 0 0 1.8 0.0546 993 PHF1 0.0011 0.0212 -0.5 0.05467 191 SYDE1 0 0 -1.2 0.05476 774 GPR143 0.0002 0.0061 1 0.05491 572 OPTN 0 0.0011 -1.2 0.05497 109 CYP24A1 0 0 -2.1 0.05535 474 NLGN2 0 0.0003 -0.7 0.05592 259 FAM131A 0 0 -1.3 0.05605 228 STK32B 0 0 -1.2 0.05614 767 MXRA7 0.0002 0.0058 -0.8 0.05649 421 MSMB 0 0.0001 0.9 0.05687 406 TRIM29 0 0.0001 1.3 0.05723 1208 GALNT10 0.003 0.0463 -0.9 0.0573 355 PROM2 0 0 1.3 0.05742 92 LEPREL2 0 0 -1.5 0.05765 82 CDH2 0 0 -2.3 0.0577 424 TGFB1I1 0 0.0001 -0.9 0.05787 514 CD36 0 0.0006 1.1 0.05799 203 COL5A2 0 0 -1.5 0.05803 995 TSPYL2 0.0011 0.0213 -0.8 0.05804 477 TFF3 0 0.0003 1.1 0.05841 84 TUBB2B 0 0 -1.6 0.05844 1123 TBC1D2 0.0022 0.0366 0.8 0.05851 1060 ZNF524 0.0016 0.0289 0.9 0.059 458 ETNK2 0 0.0002 -0.9 0.05923 797 TRIM44 0.0003 0.0072 -1 0.05956 139 FUT2 0 0 1.9 0.05967 104 VWF 0 0 2.1 0.05968 275 NOXA1 0 0 1.4 0.05977 333 MAPK8IP1 0 0 -1 0.06015 273 MOXD1 0 0 -1.5 0.06022 756 PPP3CC 0.0002 0.0051 -1.1 0.06053 422 WFDC3 0 0.0001 1.2 0.06058 685 ZNF701 0.0001 0.0032 -1.3 0.06067 503 OGDHL 0 0.0005 -1 0.06068 950 PKP1 0.0009 0.0179 0.9 0.06079 371 GADD45G 0 0.0001 1.4 0.06088 249 PRICKLE1 0 0 1.3 0.06154 314 KRT80 0 0 1.4 0.06186 468 S100A7A 0 0.0003 1.3 0.06238 972 EFCAB6 0.001 0.0201 0.7 0.06297 1125 TBX18 0.0022 0.0366 0.9 0.0631 186 SFTPD 0 0 1.9 0.06312 694 C20orf94 0.0001 0.0034 1 0.06319 106 HIST3H2A 0 0 1.9 0.06363 482 PBX3 0 0.0003 -1.2 0.06375 451 FAM101B 0 0.0002 -1 0.06385 484 GJB5 0 0.0004 1.4 0.06386 734 CD52 0.0002 0.0043 0.9 0.06401 354 HLA-DOB 0 0 1.3 0.06407 946 RPL28 0.0009 0.0176 1 0.06411 507 CREB3L2 0 0.0005 -1.3 0.06429 205 DUOX1 0 0 1.6 0.06431 226 NRGN 0 0 -1.4 0.06435 602 C12orf36 0 0.0016 0.8 0.06498 68 FLNC 0 0 -2.2 0.06517 192 S100A2 0 0 1.6 0.06526 179 FUT3 0 0 1.4 0.06538 751 APLP1 0.0002 0.005 -1.1 0.06596 872 C8orf47 0.0005 0.0113 -0.8 0.06599 379 C14orf37 0 0.0001 0.8 0.06601 247 TMEM184A 0 0 1.6 0.06615 513 CYP3A5 0 0.0005 1.1 0.06616 300 BTBD16 0 0 1.4 0.06662 461 XK 0 0.0002 1.2 0.06688 462 DDIT4L 0 0.0002 -1.2 0.06688 164 DNER 0 0 -1.9 0.06701 418 EPOR 0 0.0001 -1.1 0.06715 1016 AXIN2 0.0013 0.0235 -0.7 0.06779 322 C1orf106 0 0 1.4 0.0684 483 TRPC1 0 0.0003 -1.1 0.06857 798 ITGB8 0.0003 0.0073 0.8 0.06868 23 LGALS7B 0 0 2.5 0.06901 683 SLC16A3 0.0001 0.003 -0.9 0.06933 122 NEFL 0 0 1.8 0.06993 287 PROSAPIP1 0 0 -1.4 0.07026 956 CMTM8 0.0009 0.0186 0.8 0.0704 1152 SLC25A42 0.0024 0.0389 -0.5 0.07074 584 ST3GAL5 0 0.0013 -1.3 0.07115 525 GATM 0 0.0006 1.1 0.07117 627 AGPAT9 0.0001 0.0021 0.9 0.07131 577 GUCY1A2 0 0.0012 -1 0.07177 257 ITGB7 0 0 1.7 0.07207 827 PADI4 0.0004 0.0084 0.8 0.07207 252 NGEF 0 0 1.5 0.07251 681 MYL5 0.0001 0.003 1 0.07257 804 MSX2 0.0003 0.0074 -1.2 0.07257 231 TSHZ3 0 0 -1.7 0.07268 206 RAB25 0 0 1.7 0.07277 858 TSC22D3 0.0005 0.0101 0.8 0.07344 434 LAMB1 0 0.0002 -1.4 0.07376 582 STX2 0 0.0012 -0.9 0.07379 702 SLC44A5 0.0001 0.0035 1.2 0.07382 964 BNC2 0.001 0.019 -0.7 0.07393 1191 AP2A2 0.0028 0.0445 -0.6 0.07405 712 PTPRH 0.0001 0.0038 1.1 0.07431 255 ZNF433 0 0 -2.1 0.07434 429 KLF9 0 0.0002 -1.3 0.07446 725 ZNF514 0.0002 0.0042 -1 0.07455 689 CNTD2 0.0001 0.0034 1.1 0.07459 1003 FGD2 0.0012 0.022 0.9 0.07464 361 SYTL1 0 0 1.4 0.07492 757 GSC 0.0002 0.0052 -0.6 0.0751 576 SLC22A1 0 0.0012 -0.8 0.07515 912 CD109 0.0007 0.0153 0.8 0.07534 463 ARHGAP32 0 0.0003 1 0.07576 415 FOXQ1 0 0.0001 1.3 0.07635 634 NANP 0.0001 0.0022 -0.9 0.0764 885 ZNF775 0.0006 0.0126 -0.6 0.07645 834 XKRX 0.0004 0.0086 0.9 0.0768 210 SYK 0 0 1.2 0.07714 199 PGBD5 0 0 1.5 0.07717 882 CDH3 0.0006 0.0121 0.7 0.07731 201 APOBEC3G 0 0 -1.7 0.07792 633 LMNB1 0.0001 0.0022 -1.1 0.07804 853 FBLN7 0.0005 0.01 -1 0.07832 815 HKR1 0.0003 0.0078 -0.9 0.07839 145 GPNMB 0 0 1.4 0.07847 787 C5 0.0003 0.0068 1 0.07858 604 EFHC1 0.0001 0.0016 -1 0.07872 948 MAPRE3 0.0009 0.0178 0.9 0.07892 1156 TFPT 0.0024 0.0396 -0.7 0.07916 583 CCDC136 0 0.0013 -1.2 0.07945 975 ITGB3 0.001 0.0202 -0.8 0.07953 1111 KIAA1958 0.0021 0.0359 0.6 0.07968 845 ACOT4 0.0004 0.0095 0.9 0.08027 546 CDKN2B-AS1 0 0.0008 -0.8 0.08066 938 ZSCAN12 0.0008 0.0168 -0.9 0.08096 51 AKR1B10 0 0 1.9 0.08104 176 SLC37A2 0 0 2 0.08105 500 FZD2 0 0.0004 -0.9 0.0811 673 LUM 0.0001 0.0029 -1.1 0.0811 1200 DHCR24 0.0029 0.0454 0.6 0.0813 364 CH25H 0 0 1.1 0.08152 587 IFFO1 0 0.0013 -0.7 0.08159 699 LCE1B 0.0001 0.0035 0.9 0.08159 844 FAM81A 0.0004 0.0094 1.2 0.08161 440 C1QL4 0 0.0002 -1.1 0.08217 250 TM4SF1 0 0 1.2 0.08249 443 ACTA2 0 0.0002 -1 0.08249 480 NELL2 0 0.0003 1.3 0.08272 1089 C16orf74 0.0019 0.0332 0.8 0.08286 218 FAM25E 0 0 1.6 0.083 457 DDAH2 0 0.0002 -1 0.08317 605 CELSR2 0.0001 0.0016 0.9 0.0838 597 CLDN4 0 0.0014 0.8 0.08395 207 FSTL1 0 0 -1.5 0.08411 724 PAX6 0.0002 0.0042 -1.1 0.08442 905 DENND2D 0.0007 0.0148 0.8 0.08477 915 HOXC9 0.0008 0.0157 -0.7 0.08521 365 DPYSL2 0 0 -1.4 0.08532 840 TRIM55 0.0004 0.0089 -0.9 0.08551 1223 FBXO2 0.0031 0.0486 -0.8 0.08551 366 OTOP3 0 0 1.5 0.08628 569 ITGB2 0 0.0011 1 0.0869 448 KRTAP4-1 0 0.0002 1.2 0.08712 197 UPK2 0 0 1.7 0.08765 261 RHOD 0 0 1.3 0.08789 297 KLK7 0 0 1.3 0.08803 559 AGMAT 0 0.001 1 0.08825 565 SH3PXD2B 0 0.0011 -0.9 0.08844 246 KIAA1324 0 0 1.5 0.08865 262 AJAP1 0 0 -1.4 0.08884 566 RAB38 0 0.0011 0.7 0.08886 453 CRABP2 0 0.0002 1.2 0.08902 86 CCND2 0 0 -2 0.08948 437 AIF1L 0 0.0002 1.1 0.08978 367 CALB2 0 0.0001 1.2 0.09048 877 DNAAF1 0.0005 0.0116 0.9 0.0906 272 HSPB8 0 0 1.3 0.09094 163 TH 0 0 1.8 0.09104 623 SLC4A11 0.0001 0.002 1.1 0.09115 778 SSH3 0.0003 0.0062 1 0.09143 713 FOXF1 0.0001 0.0038 -0.8 0.09147 118 ZNF329 0 0 -1.9 0.09192 291 GPR114 0 0 1.4 0.092 454 TNFRSF18 0 0.0002 1.2 0.09211 65 CYB5A 0 0 -2.4 0.09219 209 ARMCX6 0 0 -1.4 0.09244 951 LHX6 0.0009 0.018 -0.7 0.0927 650 MOB3B 0.0001 0.0024 -1.1 0.09271 934 POU4F1 0.0008 0.0167 -0.8 0.09303 728 HIST1H2BH 0.0002 0.0042 -0.8 0.09357 867 PTK6 0.0005 0.0111 1 0.09457 680 PTX3 0.0001 0.003 -1.1 0.09469 967 TMEM45B 0.001 0.0198 0.8 0.09516 657 MEG3 0.0001 0.0026 -1 0.09547 586 MMP24 0 0.0013 -0.7 0.09557 471 ANKRD10 0 0.0003 1 0.0959 232 RPL3L 0 0 1.8 0.09603 70 NCCRP1 0 0 2.2 0.0963 671 SIRT4 0.0001 0.0028 -0.9 0.09644 78 SERPINB13 0 0 1.7 0.09661 292 HOXA5 0 0 1.2 0.09708 289 CEBPA 0 0 1.5 0.09727 663 ITGA5 0.0001 0.0026 -0.8 0.09731 847 CDC42EP2 0.0004 0.0097 -0.7 0.09738 557 FAM210B 0 0.001 -1.5 0.09753 386 PRAF2 0 0.0001 -1 0.09759 541 NR5A1 0 0.0008 1.3 0.09766 108 NLRP7 0 0 1.8 0.09783 929 TMEM40 0.0008 0.0163 0.8 0.09783 564 FCHSD2 0 0.001 -1 0.09804 1171 OTUD5 0.0026 0.042 -0.6 0.09824 891 SLC37A1 0.0006 0.0131 0.9 0.09832 99 FAM83C 0 0 2.2 0.0984 603 ABCB6 0.0001 0.0016 1.1 0.09849 227 COL5A1 0 0 -1.4 0.09875 530 FAXC 0 0.0007 -1.3 0.09876 411 HIP1 0 0.0001 -1.2 0.09886 358 FBN2 0 0 -1.1 0.09889 742 FZD8 0.0002 0.0046 -1 0.09915 608 ABHD8 0.0001 0.0017 -0.8 0.09917 659 ENDOV 0.0001 0.0026 1 0.09929 303 WTIP 0 0 -1.1 0.0998 1211 PRRG2 0.003 0.0465 0.9 0.09987 175 CSF2RA 0 0 1.5 0.09994 505 AQP11 0 0.0005 -0.8 0.09996 398 C11orf52 0 0.0001 1.1 0.10038 545 PTGER4 0 0.0008 -1.2 0.10049 1196 ERCC2 0.0028 0.0451 -0.6 0.10085 781 ASS1 0.0003 0.0064 0.8 0.10086 992 HDAC8 0.0011 0.0211 -0.8 0.10086 678 MORN4 0.0001 0.0029 -1.1 0.10137 1222 GALNT9 0.0031 0.0486 1 0.1015 1074 FBLN5 0.0017 0.0305 -0.7 0.10166 780 ALPK2 0.0003 0.0064 -1.1 0.10184 372 ODZ3 0 0.0001 -1.3 0.10207 1204 GNA15 0.0029 0.0457 0.7 0.10221 554 REEP6 0 0.0009 1.3 0.10252 296 FAM50A 0 0 -1.2 0.10301 408 ST6GALNAC2 0 0.0001 1.4 0.10312 524 NMU 0 0.0006 0.9 0.10325 168 TGM1 0 0 1.6 0.10341 686 ZNF585A 0.0001 0.0032 -0.9 0.10488 958 KRT3 0.0009 0.0186 0.6 0.10491 353 STC1 0 0 -1.5 0.10532 1051 CTAGE6P 0.0016 0.0283 0.9 0.10547 648 WARS2 0.0001 0.0024 -1.4 0.10554 58 CALML3 0 0 2.3 0.10565 876 RNASEL 0.0005 0.0116 0.7 0.10588 152 UGT1A6 0 0 1.6 0.10615 808 SDSL 0.0003 0.0076 0.8 0.10682 1128 SPTLC2 0.0022 0.0368 -0.8 0.10687 325 BCL2L10 0 0 1.2 0.10693 843 TGFBRAP1 0.0004 0.0093 0.7 0.10748 717 SRL 0.0002 0.004 1.1 0.10755 363 CYP4F12 0 0 1.1 0.10827 183 CHFR 0 0 -1.7 0.10834 1045 FAM84B 0.0015 0.0267 0.7 0.10841 649 CYR61 0.0001 0.0024 -1.1 0.1087 59 LGALS7 0 0 2.2 0.10876 533 LETM2 0 0.0007 1.2 0.10884 166 EGFLAM 0 0 -1.6 0.10902 1159 ERV3-1 0.0025 0.0405 0.8 0.10934 1035 ORAOV1 0.0014 0.0258 0.8 0.10935 860 MPP4 0.0005 0.0102 -0.8 0.10942 1009 ARID3A 0.0012 0.0227 -0.7 0.11034 224 SERPINB3 0 0 1.3 0.11036 641 KANK2 0.0001 0.0023 -1.1 0.11053 611 RHOQ 0.0001 0.0017 -1.4 0.11056 1170 DACT1 0.0026 0.0419 -0.6 0.11058 626 FAM65B 0.0001 0.002 -1 0.11111 1073 FGGY 0.0017 0.0303 0.7 0.11136 1076 CAMP 0.0018 0.0309 0.9 0.11143 1036 ARL10 0.0014 0.0258 -0.9 0.11181 375 AUTS2 0 0.0001 1 0.11187 617 FAM49A 0.0001 0.0018 0.8 0.1119 270 GFPT2 0 0 -1.4 0.11202 1184 C1orf53 0.0027 0.0436 0.7 0.11218 481 TMEM105 0 0.0003 1.2 0.11222 991 ATP6V1E2 0.0011 0.0211 0.8 0.11278 311 SNCG 0 0 1.3 0.11314 128 SCGB1A1 0 0 1.8 0.11333 473 KCNMB4 0 0.0003 -0.8 0.11339 793 SIRPA 0.0003 0.0071 -0.8 0.11369 987 CXXC5 0.0011 0.0209 0.7 0.11371 662 SMARCA1 0.0001 0.0026 -1.2 0.11378 561 PPAP2C 0 0.001 1.2 0.11387 417 MAGEA6 0 0.0001 -1.1 0.11396 499 TYROBP 0 0.0004 1 0.11432 981 NAV2 0.0011 0.0206 -1.1 0.11538 595 HOXB5 0 0.0014 1.2 0.11543 637 CTPS2 0.0001 0.0023 -1.1 0.11552 1048 CSAG2 0.0015 0.027 -0.6 0.11556 985 REPS2 0.0011 0.0208 -0.8 0.11597 1176 DEF6 0.0026 0.0425 0.9 0.11625 490 IL12RB1 0 0.0004 1.5 0.11635 601 NRARP 0 0.0015 1 0.11636 578 ARHGEF37 0 0.0012 0.7 0.11675 136 TPM2 0 0 -1.7 0.11683 114 CCL2 0 0 -1.5 0.11684 1167 FMO4 0.0026 0.0414 0.7 0.1173 574 APIP 0 0.0011 -1.2 0.11752 935 PLCL2 0.0008 0.0168 -1 0.11758 156 IGFL1 0 0 1.8 0.11759 528 SERPINB5 0 0.0006 0.7 0.11767 669 CNTNAP1 0.0001 0.0028 -1 0.11774 170 AXL 0 0 -1.6 0.11803 1203 NBR2 0.0029 0.0456 0.6 0.11814 922 CLCA4 0.0008 0.0159 0.9 0.11859 593 CTSK 0 0.0014 -0.9 0.11878 310 IFITM1 0 0 -1.2 0.11893 1001 SEMA5A 0.0012 0.0218 -0.8 0.11943 428 CTHRC1 0 0.0002 -1.1 0.12001 536 PMEL 0 0.0007 1.1 0.12017 825 SLC10A4 0.0004 0.0084 -0.9 0.12021 286 SRPX2 0 0 1.2 0.12043 854 NNMT 0.0005 0.01 -0.9 0.12054 185 KRT15 0 0 1.7 0.12064 456 PODXL 0 0.0002 -1.4 0.12096 455 HEG1 0 0.0002 -1.4 0.12187 925 PRKD1 0.0008 0.0161 -0.8 0.12208 449 CXCL5 0 0.0002 -1.3 0.12223 769 OR7E37P 0.0002 0.0058 1.3 0.12235 1146 AS3MT 0.0023 0.038 -0.8 0.1224 875 MICB 0.0005 0.0116 -0.7 0.12244 739 TMEM136 0.0002 0.0045 -0.8 0.12274 614 RASAL1 0.0001 0.0018 1.3 0.1232 807 FAM114A1 0.0003 0.0076 -1 0.12329 718 EPHB3 0.0002 0.004 1 0.1234 758 HLA-DQB1 0.0002 0.0053 -1 0.1234 775 SV2A 0.0003 0.0062 -0.9 0.12348 341 HES5 0 0 1.5 0.1235 763 IL11RA 0.0002 0.0055 -0.7 0.1237 1050 SOX15 0.0015 0.0278 0.9 0.12384 933 RAP1GAP 0.0008 0.0166 1.1 0.12387 1091 SNORA7B 0.0019 0.0333 0.7 0.1247 666 ABLIM1 0.0001 0.0028 0.9 0.12521 435 ZNF529 0 0.0002 -1.3 0.1254 941 OSGIN1 0.0008 0.0169 1.1 0.12543 973 COL15A1 0.001 0.0202 0.6 0.12553 835 DACT3 0.0004 0.0086 -0.4 0.12554 856 COL8A1 0.0005 0.0101 -0.9 0.126 193 APOBEC3B 0 0 1.4 0.12654 1081 PTAFR 0.0018 0.032 0.7 0.12668 802 NKX3-2 0.0003 0.0073 -0.8 0.12672 479 KLHL35 0 0.0003 -0.8 0.12694 747 TNFAIP3 0.0002 0.0049 -1.2 0.12803 890 PDGFRL 0.0006 0.0131 -0.7 0.12832 894 GABRP 0.0007 0.0138 0.9 0.12848 754 PSMB9 0.0002 0.0051 -0.8 0.12857 806 SPIN1 0.0003 0.0075 0.7 0.12884 733 ANXA2R 0.0002 0.0043 -0.7 0.12894 324 PNLIPRP3 0 0 1 0.12905 1177 KLHDC7B 0.0026 0.0425 0.8 0.12947 703 HOXD11 0.0001 0.0035 1.2 0.12987 340 FAM176A 0 0 -1.5 0.13003 723 APCDD1 0.0002 0.0041 0.9 0.13115 131 AMTN 0 0 1.5 0.13156 955 ETV5 0.0009 0.0184 -1.1 0.13185 928 TIGD7 0.0008 0.0163 -1.1 0.13218 135 MUC20 0 0 1.9 0.13236 730 STXBP6 0.0002 0.0042 -0.9 0.13248 744 FAM212A 0.0002 0.0047 1 0.13253 285 PID1 0 0 -1.7 0.1327 103 NLRP2 0 0 2 0.13272 930 LRRC37B 0.0008 0.0163 -0.9 0.13286 378 GDPD5 0 0.0001 -0.9 0.13303 570 SMARCD3 0 0.0011 -1.1 0.1331 328 TNFSF12 0 0 -1 0.13312 344 HAS3 0 0 1.4 0.13332 412 PYROXD2 0 0.0001 -1 0.13342 833 LRRC32 0.0004 0.0086 -0.9 0.13401 506 GALNT12 0 0.0005 0.9 0.13406 1006 USH1G 0.0012 0.0223 0.8 0.13435 478 FUZ 0 0.0003 -0.9 0.13442 620 HSD17B14 0.0001 0.0019 -0.8 0.13475 393 B4GALNT4 0 0.0001 -1 0.13576 345 FGFBP1 0 0 1 0.13596 436 SH3GL3 0 0.0002 1.2 0.13619 402 FAM167A 0 0.0001 -1.5 0.13644 535 MILR1 0 0.0007 1.1 0.13652 1137 PPP2R3B 0.0022 0.0371 -0.5 0.13724 1098 SNPH 0.002 0.0339 -0.5 0.13783 826 SNORD43 0.0004 0.0084 0.9 0.13789 1078 ZNF439 0.0018 0.0311 -1.1 0.13816 829 VIPR1 0.0004 0.0085 1 0.13832 1164 SFN 0.0025 0.041 0.7 0.13916 1096 ARHGAP8 0.002 0.0337 1 0.1392 368 WDR66 0 0.0001 1.2 0.13945 732 GALNT5 0.0002 0.0043 0.5 0.13979 388 ASB9 0 0.0001 0.9 0.13999 1054 PDLIM7 0.0016 0.0285 -0.6 0.14014 818 ROPN1L 0.0004 0.0081 -0.8 0.14055 901 CCNG2 0.0007 0.0143 -0.8 0.14056 917 UBE2S 0.0008 0.0158 -0.6 0.14061 738 CDC42EP1 0.0002 0.0044 1.2 0.14099 464 WNT10A 0 0.0003 1 0.1411 656 SCG2 0.0001 0.0025 -1 0.14179 1161 KHDRBS3 0.0025 0.0409 -0.8 0.14193 251 CCDC106 0 0 -1 0.14214 1166 SLC20A2 0.0025 0.0411 0.5 0.14235 616 MORN3 0.0001 0.0018 1 0.14296 863 RUSC2 0.0005 0.0108 -0.8 0.14328 184 DSG3 0 0 1.2 0.14329 519 ACSS1 0 0.0006 -0.9 0.14346 274 PODXL2 0 0 -1.3 0.14352 154 GNG11 0 0 -1.7 0.14364 1033 PLCXD3 0.0014 0.0252 -0.8 0.14368 295 GJB2 0 0 1.1 0.14377 279 S100A4 0 0 1.3 0.14393 1202 ANXA6 0.0029 0.0455 -0.8 0.14429 438 CDH11 0 0.0002 -1.1 0.14515 236 C1orf51 0 0 -1.1 0.14569 1220 TPM1 0.0031 0.0481 -0.7 0.14586 1049 NEURL 0.0015 0.0274 -0.6 0.14598 439 LYPD6B 0 0.0002 1 0.147 491 HHEX 0 0.0004 -1 0.14719 764 TRAM2 0.0002 0.0057 -1.2 0.1473 568 FAR2 0 0.0011 -1 0.14738 225 KLK9 0 0 1.4 0.1486 1209 ZKSCAN1 0.003 0.0463 0.4 0.1489 693 SLC15A2 0.0001 0.0034 0.7 0.1493 182 KRT8 0 0 -1.6 0.14941 585 ZNF134 0 0.0013 -1.2 0.14978 132 CMTM7 0 0 -1.5 0.15064 1217 DUS1L 0.003 0.0474 0.8 0.15091 1070 C13orf33 0.0017 0.03 -0.8 0.15094 959 CEP72 0.0009 0.0187 -0.6 0.15112 200 TP53 0 0 1.8 0.15177 897 CSAG3 0.0007 0.014 -0.8 0.15249 819 PARVA 0.0004 0.0081 -0.9 0.1526 581 KLHL13 0 0.0012 0.9 0.15267 120 MLPH 0 0 -1.6 0.15293 299 CLIC3 0 0 1.5 0.15365 271 WNT4 0 0 1.6 0.15379 405 ATP6V1B1 0 0.0001 1.2 0.15478 1012 SGSH 0.0012 0.0229 -0.6 0.15486 338 C10orf99 0 0 1.2 0.15517 772 FLJ35934 0.0002 0.006 -0.6 0.15519 488 CALU 0 0.0004 -1.5 0.15531 452 CERS4 0 0.0002 1.4 0.15541 1132 NADSYN1 0.0022 0.0371 0.7 0.15567 282 ATOH8 0 0 -1.4 0.15575 647 PPP1R14C 0.0001 0.0024 0.8 0.1559 823 HOXA9 0.0004 0.0084 0.7 0.15665 107 MT1M 0 0 -1.7 0.15695 1205 ZNF354A 0.0029 0.0457 -0.4 0.15703 1165 TLX2 0.0025 0.041 -0.6 0.15726 280 C11orf70 0 0 -1.6 0.15776 1127 LINC00174 0.0022 0.0367 0.9 0.15787 213 PADI3 0 0 1.6 0.15827 319 GSTT2 0 0 1.5 0.15948 831 MXD1 0.0004 0.0085 0.8 0.15976 370 ID2 0 0.0001 0.8 0.16002 799 RND2 0.0003 0.0073 -0.8 0.16009 1008 ZNF512B 0.0012 0.0226 -0.6 0.16038 562 EML1 0 0.001 -1 0.16048 543 RNF215 0 0.0008 -0.8 0.1607 916 GTF2H2 0.0008 0.0158 -1 0.16106 996 STX19 0.0011 0.0213 0.7 0.1612 609 KIAA1324L 0.0001 0.0017 0.9 0.16127 1186 DNAI2 0.0028 0.0442 -1.1 0.16136 126 CLCA2 0 0 1.2 0.16163 949 CRB3 0.0009 0.0179 0.8 0.16174 784 SH3BP1 0.0003 0.0065 1.1 0.16221 947 PLCH2 0.0009 0.0177 0.9 0.16244 914 PHTF1 0.0007 0.0154 -0.6 0.16262 334 ZG16B 0 0 1.3 0.16311 984 ASAP1 0.0011 0.0207 -1 0.16322 816 ELF3 0.0003 0.0079 1 0.16334 321 TMEM27 0 0 0.9 0.16383 1107 PVRL1 0.0021 0.0353 0.9 0.16418 423 APCDD1L 0 0.0001 1.3 0.16436 990 NF2 0.0011 0.021 -0.6 0.1645 1207 GJB3 0.0029 0.0461 0.9 0.16545 1199 PHRF1 0.0029 0.0453 -0.7 0.16584 410 GLT8D2 0 0.0001 -1.3 0.16597 362 FAAH 0 0 1.5 0.16622 337 LOR 0 0 1.1 0.16656 924 IRS1 0.0008 0.0161 0.8 0.16694 720 VAV1 0.0002 0.004 1 0.16738 1095 NGB 0.0019 0.0336 0.8 0.16867 630 SLC29A2 0.0001 0.0021 1.3 0.16878 632 ST14 0.0001 0.0021 1.1 0.16885 518 GSTT2B 0 0.0006 1.4 0.16895 494 TMC4 0 0.0004 1.3 0.16903 288 SPOCK1 0 0 -1.4 0.16927 188 FAM181B 0 0 1.7 0.1698 813 C19orf66 0.0003 0.0077 -0.5 0.17068 1120 CCDC120 0.0021 0.0362 0.9 0.17082 153 CST6 0 0 1.7 0.17092 643 BAIAP2L2 0.0001 0.0023 1.2 0.17094 571 RHOV 0 0.0011 1.2 0.17148 592 VSTM1 0 0.0014 -0.9 0.17155 665 PLEKHA7 0.0001 0.0027 0.9 0.1721 1101 ZNF519 0.002 0.0347 -0.6 0.17334 315 IGFBP4 0 0 -1.3 0.17394 655 AIM2 0.0001 0.0025 0.6 0.17418 792 IGFBP7 0.0003 0.0071 -1 0.17464 1130 CPS1 0.0022 0.0368 0.7 0.17576 380 HSD11B2 0 0.0001 1.6 0.17593 921 RPRML 0.0008 0.0159 -0.6 0.1761 695 SPON2 0.0001 0.0034 1 0.1763 942 ORAI2 0.0009 0.0173 -0.6 0.17735 698 HOMER2 0.0001 0.0035 0.7 0.17818 621 WBSCR28 0.0001 0.0019 1.2 0.17824 606 PLA2G10 0.0001 0.0016 1.2 0.17933 1087 FOXA1 0.0019 0.0331 0.7 0.17966 664 DUSP7 0.0001 0.0026 1.2 0.17967 317 DPYSL3 0 0 -1.3 0.18047 704 COL1A2 0.0001 0.0035 -0.9 0.18136 522 ECM1 0 0.0006 1.3 0.18204 828 PNPLA7 0.0004 0.0085 1 0.18253 540 C10orf54 0 0.0008 1 0.18299 998 S1PR1 0.0011 0.0217 -0.7 0.18301 1062 NKX2-3 0.0016 0.0294 -0.6 0.18343 675 ECI2 0.0001 0.0029 -1.3 0.18388 697 GPR87 0.0001 0.0035 0.6 0.18499 688 CD14 0.0001 0.0033 1 0.18504 1133 ABCA13 0.0022 0.0371 0.8 0.18519 810 PCMTD2 0.0003 0.0076 -1 0.1856 1189 RASSF5 0.0028 0.0444 0.7 0.18574 687 SLC22A4 0.0001 0.0032 -1 0.18589 741 ACE2 0.0002 0.0045 0.5 0.18599 997 ZBTB46 0.0011 0.0214 -0.8 0.1861 244 PPP1R3C 0 0 -2 0.18624 629 PSG6 0.0001 0.0021 -1.1 0.18641 624 MTMR12 0.0001 0.002 -0.9 0.18657 715 HCAR3 0.0001 0.0039 1 0.18727 1142 PNMA2 0.0023 0.0375 -0.7 0.18756 1102 EMP3 0.002 0.0349 -0.6 0.18817 384 CD38 0 0.0001 1.1 0.18843 575 FAT2 0 0.0012 0.8 0.18852 284 KRT6A 0 0 1.4 0.18863 1028 FAM83F 0.0013 0.0247 1 0.18869 746 FAM43B 0.0002 0.0048 -0.5 0.18906 1162 FAM89A 0.0025 0.041 0.9 0.18922 750 ACSL1 0.0002 0.005 0.6 0.18961 1210 NOD2 0.003 0.0465 0.7 0.18966 157 IL36G 0 0 1.6 0.19067 234 FBP1 0 0 1.6 0.19086 396 TAGLN 0 0.0001 -1.1 0.19104 986 LURAP1 0.0011 0.0208 -0.5 0.19119 618 WFDC5 0.0001 0.0019 1.1 0.19193 1136 FCRLA 0.0022 0.0371 -0.6 0.19244 1105 ASB10 0.0021 0.0352 -0.5 0.19276 556 BASP1 0 0.001 -1.1 0.19344 755 ALOXE3 0.0002 0.0051 1.1 0.1936 1085 KRTAP1-3 0.0019 0.0331 -0.8 0.19366 903 SLC2A6 0.0007 0.0146 -0.7 0.19367 447 C12orf54 0 0.0002 1 0.19382 1059 PTPN13 0.0016 0.0289 0.8 0.19399 1155 TRIM78P 0.0024 0.0396 -0.7 0.19468 1206 C10orf116 0.0029 0.046 0.8 0.19491 459 TMEM52B 0 0.0002 1.3 0.19501 394 UPRT 0 0.0001 -1.5 0.19526 898 SYT8 0.0007 0.0141 1.2 0.19526 580 HSD3B1 0 0.0012 -1.2 0.19561 870 TRIM16 0.0005 0.0113 1.1 0.19572 759 GPR115 0.0002 0.0053 1 0.19574 692 KIF3C 0.0001 0.0034 -1.1 0.19578 331 SAMD9 0 0 0.8 0.19582 1112 ZNF649 0.0021 0.036 -1 0.19595 1195 CREG1 0.0028 0.045 0.4 0.19679 165 KCNS1 0 0 -1.7 0.19725 640 CYP26B1 0.0001 0.0023 -0.7 0.19732 189 BMP7 0 0 1.7 0.19766 910 FAM26E 0.0007 0.0152 -0.8 0.1983 1037 PSMC3IP 0.0014 0.026 -0.8 0.19863 413 LTB 0 0.0001 -1 0.19927 475 HOGA1 0 0.0003 1.3 0.19975 520 CDH1 0 0.0006 0.8 0.1999 1147 CETP 0.0023 0.0381 0.7 0.19994 892 CCDC88B 0.0006 0.0134 0.8 0.20003 645 RAB17 0.0001 0.0024 1.1 0.20007 1013 KIF4A 0.0012 0.023 -1 0.20014 553 CGN 0 0.0009 0.7 0.20051 628 GPR176 0.0001 0.0021 -0.9 0.20075 768 RALGAPB 0.0002 0.0058 -1.2 0.2008 814 DNAJC24 0.0003 0.0078 -1.2 0.20142 832 SLC9A5 0.0004 0.0085 -0.4 0.20163 599 HOXD10 0 0.0015 1 0.2033 510 SERPINB7 0 0.0005 0.8 0.20367 708 CHST10 0.0001 0.0036 -0.8 0.20373 146 HOXB7 0 0 1.7 0.20393 999 GPRIN1 0.0011 0.0217 -0.6 0.20426 1150 CDKN1A 0.0023 0.0386 0.9 0.20434 783 RBM47 0.0003 0.0064 0.7 0.20478 679 ESPN 0.0001 0.003 1.1 0.20491 158 SUSD2 0 0 1.6 0.20514 1067 RAC2 0.0017 0.0297 0.8 0.20518 329 ZNF256 0 0 -1.5 0.20551 1055 SLC2A9 0.0016 0.0287 0.9 0.2057 1040 JUP 0.0014 0.0263 0.8 0.20624 442 RNASE7 0 0.0002 1.3 0.20675 419 PAPSS2 0 0.0001 -1.4 0.20677 871 IGFL2 0.0005 0.0113 0.7 0.20712 223 HS3ST3A1 0 0 -1.6 0.20761 654 C14orf132 0.0001 0.0025 -0.8 0.20833 594 MAP2 0 0.0014 0.9 0.20895 537 TMEM125 0 0.0007 1.1 0.20951 526 LAPTM5 0 0.0006 1.1 0.2098 267 HSD17B11 0 0 -1.9 0.21021 696 ANPEP 0.0001 0.0035 -0.9 0.21044 1183 ARHGEF3 0.0027 0.0432 0.4 0.21146 376 NOTCH3 0 0.0001 1.4 0.2115 465 HCAR2 0 0.0003 1.4 0.21235 776 CARD10 0.0003 0.0062 1 0.21313 727 ATL1 0.0002 0.0042 0.7 0.21337 812 LMO1 0.0003 0.0077 0.9 0.21346 1129 ZNF630 0.0022 0.0368 -0.9 0.21369 460 TIMP3 0 0.0002 -1.4 0.21385 401 ICA1 0 0.0001 1.2 0.21421 1143 SLC2A14 0.0023 0.0375 -1.1 0.21503 316 ARL14 0 0 0.6 0.21504 1141 CCDC34 0.0023 0.0374 -1 0.21528 466 IRX4 0 0.0003 1.3 0.21541 1064 KISS1R 0.0017 0.0296 0.9 0.216 416 HRASLS 0 0.0001 1.1 0.21602 1075 EPHX4 0.0017 0.0307 -0.8 0.21615 971 SYTL2 0.001 0.0201 0.7 0.21645 487 ALOX5AP 0 0.0004 -1 0.21715 1099 COL3A1 0.002 0.0339 -0.8 0.21755 521 FNDC4 0 0.0006 -0.6 0.21756 830 TMEM154 0.0004 0.0085 0.6 0.21806 160 CALML5 0 0 1.7 0.21807 180 AKR1C2 0 0 1.6 0.21902 1201 MXD4 0.0029 0.0454 -0.5 0.21924 1174 KAZN 0.0026 0.0422 0.9 0.21933 857 LIX1L 0.0005 0.0101 -0.7 0.21943 352 RTTN 0 0 -1.6 0.21957 817 MEIS3P1 0.0003 0.0079 -0.6 0.21958 1000 FAM46B 0.0011 0.0217 0.9 0.21996 539 S1PR3 0 0.0007 -0.9 0.2205 1158 FAM181A 0.0024 0.0398 0.8 0.22076 1002 TNNC2 0.0012 0.0218 0.5 0.22172 369 LHX2 0 0.0001 -0.8 0.22272 336 CAPNS2 0 0 1 0.22322 1015 BCMO1 0.0013 0.0234 0.5 0.22425 276 MLF1 0 0 -1.5 0.2246 1080 HIST1H4J 0.0018 0.0317 -0.7 0.22518 638 PCSK5 0.0001 0.0023 0.9 0.22567 446 HENMT1 0 0.0002 -1.4 0.22605 838 SERPINB4 0.0004 0.0088 0.7 0.22608 216 SERPINA3 0 0 1.8 0.22636 1023 _SEPT3 0.0013 0.0243 -0.9 0.22646 555 IGSF9 0 0.001 1.4 0.22743 504 GPX8 0 0.0005 -1.4 0.22823 1039 KLHDC8B 0.0014 0.0262 -0.5 0.22899 865 PAK6 0.0005 0.0111 1 0.22964 1066 INPP5D 0.0017 0.0297 0.9 0.23022 625 DSC2 0.0001 0.002 0.8 0.23047 511 MFNG 0 0.0005 1.4 0.23051 237 MAL2 0 0 0.8 0.23078 551 RFTN1 0 0.0009 -1 0.23219 1213 ZNF83 0.003 0.0466 -1 0.23275 918 DOM3Z 0.0008 0.0158 -0.6 0.23453 668 FHL1 0.0001 0.0028 -0.9 0.23544 1173 PRR4 0.0026 0.0421 -1 0.23548 426 MTAP 0 0.0001 -1.6 0.23554 550 EFNB3 0 0.0009 -0.7 0.23692 701 PTGS1 0.0001 0.0035 0.8 0.23764 1153 PRR5 0.0024 0.0395 0.8 0.23798 1122 PAX9 0.0022 0.0365 0.7 0.23874 716 C1QTNF1 0.0001 0.0039 -0.9 0.23876 766 SLC25A18 0.0002 0.0058 0.9 0.23892 864 SOCS1 0.0005 0.0109 -0.6 0.2397 1010 GDF15 0.0012 0.0227 0.9 0.24126 1119 GFI1 0.0021 0.0362 0.5 0.24192 966 TP53AIP1 0.001 0.0196 0.7 0.24209 1172 NUDT8 0.0026 0.042 0.7 0.24238 619 WNT5A 0.0001 0.0019 -1 0.24321 644 DCUN1D4 0.0001 0.0024 -1.3 0.24322 796 PLEKHO1 0.0003 0.0072 -0.4 0.24421 652 ZMYND15 0.0001 0.0025 1.3 0.24648 1030 SLC44A4 0.0014 0.0249 1 0.24696 977 ACAT1 0.001 0.0203 -1 0.24775 1092 TPCN1 0.0019 0.0335 -0.6 0.24891 800 SOCS2 0.0003 0.0073 -1 0.24921 1077 ENTPD3 0.0018 0.031 0.6 0.24939 1175 S100A3 0.0026 0.0424 0.8 0.25018 848 PLA2G4C 0.0004 0.0097 -0.6 0.25059 729 RAI14 0.0002 0.0042 -1.2 0.25066 1149 MAMLD1 0.0023 0.0382 1.1 0.25198 940 FAM171A1 0.0008 0.0169 -0.9 0.25204 753 SLCO2A1 0.0002 0.0051 -0.9 0.25267 709 FAM107B 0.0001 0.0036 -1.2 0.25311 485 DUSP23 0 0.0004 1.1 0.25316 1148 SEC24D 0.0023 0.0382 -0.9 0.25336 771 DGKG 0.0002 0.006 1 0.25369 383 GPX7 0 0.0001 -1.1 0.25464 667 CES1 0.0001 0.0028 0.8 0.255 1135 APOBEC3F 0.0022 0.0371 -0.9 0.25508 1052 ASPHD1 0.0016 0.0283 -0.4 0.25618 889 CDS1 0.0006 0.0129 0.5 0.25628 842 CKMT1B 0.0004 0.0092 0.7 0.25645 932 FKBP11 0.0008 0.0165 -0.8 0.25706 866 C12orf23 0.0005 0.0111 -1.2 0.25708 493 PSG9 0 0.0004 -1.3 0.25709 974 MAST4 0.001 0.0202 0.7 0.25736 1021 SERPINF1 0.0013 0.0239 0.9 0.25738 294 WDR72 0 0 1 0.25771 1032 C1R 0.0014 0.025 -0.9 0.25862 1103 ATP6V0E2- 0.0021 0.0352 -0.6 0.25948 AS1 821 MUC1 0.0004 0.0084 1.1 0.25975 1121 RNF212 0.0022 0.0364 -0.9 0.25988 309 SERPINB2 0 0 1.2 0.26083 795 ATP6V0E2 0.0003 0.0071 -0.7 0.26115 1038 CBLN2 0.0014 0.0262 -0.6 0.26165 1126 NFIB 0.0022 0.0367 -0.9 0.26229 651 STAT4 0.0001 0.0024 0.5 0.26378 642 S1PR4 0.0001 0.0023 1.2 0.26395 880 RGL1 0.0006 0.0119 -0.6 0.26426 240 MMP1 0 0 -1.9 0.26456 1192 CEP68 0.0028 0.0446 -0.4 0.26506 886 MICAL2 0.0006 0.0128 -1.3 0.26507 677 TTC33 0.0001 0.0029 -1.4 0.26511 735 GJB4 0.0002 0.0043 1.2 0.26705 1193 CKMT1A 0.0028 0.0446 0.7 0.26716 298 GJB6 0 0 1.1 0.26726 636 TRPV2 0.0001 0.0023 1.4 0.26747 239 ERP27 0 0 1.2 0.26798 532 SVEP1 0 0.0007 0.6 0.26841 1194 ANKK1 0.0028 0.0447 0.7 0.26875 450 _MARCH4 0 0.0002 -1.2 0.26913 895 CDK14 0.0007 0.0139 -1 0.27014 613 SNORD46 0.0001 0.0018 0.8 0.27381 432 LXN 0 0.0002 -1.5 0.27403 913 PRKCA 0.0007 0.0154 -0.8 0.27619 749 SRPX 0.0002 0.005 -0.9 0.2762 920 CCDC74A 0.0008 0.0158 -0.6 0.27624 395 SLCO1B3 0 0.0001 0.8 0.27667 269 SPARC 0 0 -1.9 0.27691 1131 SEMA3F 0.0022 0.0368 0.7 0.277 878 SAMD4A 0.0005 0.0116 -0.6 0.27747 770 SLC7A7 0.0002 0.0059 -0.8 0.27855 849 SCARNA9 0.0004 0.0097 0.3 0.27856 1117 FAM92A1 0.0021 0.0361 -0.9 0.27893 1221 TRPV6 0.0031 0.0483 1 0.27897 700 PLAT 0.0001 0.0035 -0.9 0.27927 1072 CGB5 0.0017 0.0303 1 0.28012 469 TCEAL8 0 0.0003 -1.3 0.28018 579 SELM 0 0.0012 -1 0.28054 1178 BATF 0.0027 0.0427 0.6 0.28063 822 HEY2 0.0004 0.0084 1 0.28114 414 LAYN 0 0.0001 -1.2 0.28166 467 LOX 0 0.0003 -1.3 0.28201 1140 CADM4 0.0023 0.0374 0.7 0.283 596 TMSB15A 0 0.0014 -1.1 0.28545 516 GLB1L2 0 0.0006 1.1 0.28702 1179 TBC1D17 0.0027 0.0427 -0.5 0.2882 809 SPRED1 0.0003 0.0076 -1.3 0.28857 1145 PCTP 0.0023 0.038 0.3 0.28912 899 KLK13 0.0007 0.0141 1 0.28937 884 TRIM2 0.0006 0.0125 0.7 0.29052 502 SERPINE1 0 0.0004 -1.3 0.29095 944 SPIRE1 0.0009 0.0175 -1.1 0.29103 1187 SLC9A3R2 0.0028 0.0442 0.8 0.29116 1004 PPAPDC1A 0.0012 0.022 -0.6 0.29119 1090 SYT12 0.0019 0.0332 1 0.29166 1212 SH3RF1 0.003 0.0465 -0.9 0.2922 512 HLA-DPA1 0 0.0005 1.2 0.29444 1134 ABTB2 0.0022 0.0371 -0.6 0.29557 1065 GPRC5C 0.0017 0.0296 0.9 0.29586 1100 TRPV4 0.002 0.0347 1 0.29664 961 FKBP10 0.001 0.0189 -0.8 0.29696 1215 OSMR 0.003 0.047 -0.8 0.29867 960 PSG7 0.001 0.0189 -0.9 0.29918 1115 RPH3AL 0.0021 0.036 1.1 0.29984 989 ARHGAP44 0.0011 0.0209 -0.9 0.30103 508 TSPAN7 0 0.0005 1 0.30104 1069 SYNGR3 0.0017 0.0298 -0.3 0.30154 567 APOD 0 0.0011 1.1 0.30159 1216 CGB 0.003 0.047 0.9 0.30189 1198 RNF39 0.0029 0.0452 0.9 0.30227 498 TGM2 0 0.0004 -0.8 0.30258 631 TXNIP 0.0001 0.0021 0.7 0.30259 836 AP1S2 0.0004 0.0087 -1.2 0.30262 841 ATP2C2 0.0004 0.0089 1 0.30325 868 NLRP3 0.0005 0.0112 -0.7 0.30389 945 ANO6 0.0009 0.0175 -0.8 0.30481 737 CAMK1 0.0002 0.0043 -0.8 0.30504 573 CLDN1 0 0.0011 0.7 0.30525 684 SLC35G2 0.0001 0.003 -1.3 0.30633 824 PLOD2 0.0004 0.0084 -1.1 0.30639 927 SCARF2 0.0008 0.0163 -0.3 0.30755 327 MYEOV 0 0 1.4 0.30804 1018 IFI27 0.0013 0.0235 0.6 0.30821 1151 BMP2 0.0024 0.0389 0.5 0.30852 425 DENND2A 0 0.0001 -0.9 0.30889 690 ITPR1 0.0001 0.0034 0.4 0.30901 1047 RAB31 0.0015 0.027 -1 0.30903 1086 MST1R 0.0019 0.0331 1 0.3092 1097 AMMECR1 0.002 0.0339 0.6 0.30957 1082 SPANXB2 0.0019 0.0324 0.2 0.30962 782 CCBP2 0.0003 0.0064 0.8 0.31123 982 TNNC1 0.0011 0.0206 0.9 0.31271 881 NME4 0.0006 0.0119 -0.8 0.31289 978 WNT7A 0.001 0.0203 0.9 0.31648 420 KRT6B 0 0.0001 1.3 0.31801 883 CRISPLD2 0.0006 0.0123 -1 0.31842 805 KRTAP1-5 0.0003 0.0075 -0.8 0.3189 612 RPS4Y2 0.0001 0.0018 -1.1 0.3201 1188 DHRS2 0.0028 0.0444 -0.6 0.32058 979 CSF1R 0.0011 0.0203 0.9 0.32074 389 TNFSF10 0 0.0001 0.7 0.3212 552 CXCR7 0 0.0009 0.9 0.32233 558 IL20RB 0 0.001 1 0.32409 1157 ANKRD2 0.0024 0.0398 1.2 0.32414 399 DPYSL4 0 0.0001 -0.7 0.32489 588 GPSM3 0 0.0013 -0.4 0.32674 615 MYL9 0.0001 0.0018 -0.7 0.32954 954 TRAK2 0.0009 0.0184 -1 0.33118 719 RRAGD 0.0002 0.004 -1.2 0.33144 1041 GK 0.0014 0.0263 -1 0.33149 752 ARMCX2 0.0002 0.0051 -1.1 0.33154 431 CXCL6 0 0.0002 -1.3 0.33184 1180 GALR2 0.0027 0.0427 1.1 0.33292 873 INA 0.0005 0.0115 -0.8 0.33305 919 ZNF385A 0.0008 0.0158 1 0.33348 1061 C1QL1 0.0016 0.029 -0.8 0.33425 1114 HLA-DRB5 0.0021 0.036 0.9 0.33431 527 PCSK1N 0 0.0006 -0.9 0.33444 773 PXDN 0.0002 0.006 -0.9 0.33552 896 CA2 0.0007 0.014 0.6 0.33575 1057 COPG2 0.0016 0.0288 -1.3 0.3368 1007 POLM 0.0012 0.0226 -0.6 0.33737 786 MLLT11 0.0003 0.0067 -0.9 0.3378 670 LIMCH1 0.0001 0.0028 0.7 0.33848 1042 CD55 0.0015 0.0264 0.5 0.3396 962 TIMP4 0.001 0.019 1 0.3419 672 ADAM8 0.0001 0.0029 1.2 0.34236 1154 CALHM2 0.0024 0.0395 -0.7 0.34385 937 WDR69 0.0008 0.0168 -1.2 0.34597 837 COL6A1 0.0004 0.0088 -0.9 0.34861 926 LRG1 0.0008 0.0163 0.8 0.34876 1218 COL1A1 0.0031 0.0477 -0.6 0.34885 736 DLX5 0.0002 0.0043 1.4 0.34909 241 GPX2 0 0 1.7 0.35026 1224 RAB36 0.0031 0.0486 0.8 0.35032 957 FAM132A 0.0009 0.0186 1 0.35086 731 THY1 0.0002 0.0042 -0.7 0.35189 360 MSC 0 0 -1 0.35246 523 MGST1 0 0.0006 1 0.35255 691 JSRP1 0.0001 0.0034 1 0.3537 1083 RPP25 0.0019 0.0326 0.7 0.35412 1118 ALDH7A1 0.0021 0.0361 -0.8 0.35631 1139 NOG 0.0022 0.0373 -0.5 0.35636 706 KRT14 0.0001 0.0036 1 0.35654 874 ABCD1 0.0005 0.0115 1.1 0.3581 1027 ANTXR2 0.0013 0.0247 -1.1 0.35848 931 PNLDC1 0.0008 0.0163 -0.8 0.3609 1182 RLTPR 0.0027 0.0429 -0.5 0.36195 722 HOXA4 0.0002 0.0041 1.3 0.3623 988 STC2 0.0011 0.0209 -1 0.36298 760 ARHGAP4 0.0002 0.0053 1 0.3646 862 CKM 0.0005 0.0105 0.8 0.36541 790 SERP2 0.0003 0.007 -0.8 0.36668 893 KDELC2 0.0006 0.0136 -1 0.36698 489 IGFBP5 0 0.0004 -1.2 0.36902 1005 CTSH 0.0012 0.0221 0.6 0.37141 794 CPLX1 0.0003 0.0071 1.3 0.37224 762 NUCB2 0.0002 0.0054 -1.4 0.37535 748 KISS1 0.0002 0.005 1 0.37696 215 KRT6C 0 0 1.4 0.37884 444 EPDR1 0 0.0002 1 0.37917 534 GOLT1A 0 0.0007 1.3 0.37987 983 RARRES3 0.0011 0.0206 0.8 0.38016 1025 RAB7B 0.0013 0.0244 0.7 0.38085 970 ACP5 0.001 0.02 1.2 0.38387 839 TAGLN3 0.0004 0.0088 -0.7 0.38406 936 PSG4 0.0008 0.0168 -0.7 0.38933 906 CEL 0.0007 0.015 0.9 0.39002 707 LOC645553 0.0001 0.0036 0.8 0.39126 1226 ABCA1 0.0032 0.0496 -0.7 0.39165 851 CORO1A 0.0004 0.0098 -0.7 0.39517 1109 RRAD 0.0021 0.0354 1 0.39968 711 ANKRD1 0.0001 0.0037 -1.4 0.40172 538 PI3 0 0.0007 1.3 0.40272 846 IQCG 0.0004 0.0096 -0.9 0.40284 1056 ASCL2 0.0016 0.0287 0.8 0.40415 1124 TLE2 0.0022 0.0366 -0.8 0.4047 789 NRG4 0.0003 0.0069 0.6 0.4048 660 TNFRSF6B 0.0001 0.0026 -0.7 0.40514 517 LOXL4 0 0.0006 1.1 0.40689 965 FOXA3 0.001 0.0193 0.7 0.40714 1024 MT1G 0.0013 0.0243 -0.8 0.40722 911 SAA4 0.0007 0.0152 1 0.40754 639 AKR1C3 0.0001 0.0023 0.7 0.40811 1079 GALM 0.0018 0.0316 0.7 0.40859 1063 TMEM74B 0.0017 0.0294 -0.5 0.41046 1046 LHB 0.0015 0.0269 1.3 0.41361 994 WISP2 0.0011 0.0212 0.9 0.4161 1138 VSIG2 0.0022 0.0371 0.9 0.41685 1104 GTSF1 0.0021 0.0352 -0.6 0.41945 563 EFEMP2 0 0.001 -0.8 0.42092 952 COL9A2 0.0009 0.0183 1 0.42301 820 IVD 0.0004 0.0082 -0.9 0.42387 646 TP63 0.0001 0.0024 0.4 0.42633 1026 PLAC8 0.0013 0.0247 0.7 0.42679 1014 IL6 0.0012 0.0231 -0.9 0.42692 939 PRODH 0.0008 0.0168 1 0.42713 740 UCP2 0.0002 0.0045 -0.5 0.42876 879 ADH7 0.0005 0.0118 0.8 0.42999 976 DHRS9 0.001 0.0202 0.4 0.43171 1197 TEKT4P2 0.0029 0.0451 -0.3 0.43259 1144 TMSB15B 0.0023 0.0375 -0.8 0.43285 1084 PDZK1 0.0019 0.0328 0.4 0.43479 1093 HBQ1 0.0019 0.0335 -0.6 0.43849 400 UCHL1 0 0.0001 -1.2 0.43858 1011 DEFB4A 0.0012 0.0229 0.7 0.43865 1017 C21orf56 0.0013 0.0235 -0.5 0.44134 908 NUP62CL 0.0007 0.0151 0.3 0.44751 900 THBS1 0.0007 0.0141 -1.2 0.4539 909 SFRP1 0.0007 0.0151 -1 0.47099 1019 TRIML2 0.0013 0.0237 -1.1 0.47106 1214 CPVL 0.003 0.0468 -1 0.47877 1029 DACT2 0.0014 0.0249 -0.5 0.4794 777 MMP7 0.0003 0.0062 0.5 0.48567 1190 SHISA2 0.0028 0.0444 -1 0.50432 1169 SRGN 0.0026 0.0415 -1 0.5245 1113 CSF2 0.0021 0.036 -0.6 0.52631 682 H19 0.0001 0.003 1.1 0.52799 801 GPX3 0.0003 0.0073 1 0.52813 887 IFI44 0.0006 0.0128 0 0.53038 1185 FAM174B 0.0027 0.0438 -0.4 0.53304 953 VGLL1 0.0009 0.0183 1 0.53721 943 GAL 0.0009 0.0174 1 0.56679 1094 TFPI2 0.0019 0.0335 -0.9 0.5753 969 NDN 0.001 0.02 -0.7 0.58843 902 KRT81 0.0007 0.0143 0.7 0.61741 1110 RPS4Y1 0.0021 0.0356 -0.7 0.68811

Supplementary table 5 lists the genes in our p53 and DNA repair signatures.

Supplementary table 5: gene symbols used for p53 and DNA-repair gene sets p53 DNA-repair AIMP2 APEX1 ANKRD2 APEX2 APTX ATM ATF3 ATR ATM ATRIP ATR BRCA1 AURKA BRCA2 BAK1 BRIP1 BARD1 C19orf40 BLM CHEK1 BRCA1 CHEK2 BRCA2 CLK2 BRCC3 DCLRE1C BRE DMC1 CCNG1 EME1 CCNH EME2 CDC14A FANCA CDC14B FANCB CDK1 FANCC CDK7 FANCD2 CDKN2A FANCE CEBPZ FANCF CFLAR FANCG CHEK1 FANCI CREB1 FANCL CREBBP FANCM CYCLIN H HUS1 DNA-PKCS LIG3 LIG4 EFEMP2 MBD4 EGR1 MDC1 EIF2AK2 MPG ELL MRE11A EP300 MRE11A ERCC3 MUS81 ERCC6 MUTYH GNL3 NBN GPS2 NEIL1 GSK3B NEIL2 HIF1A NHEJ1 HIPK1 NTHL1 HIPK2 OGG1 HMGB1 PALB2 HSP90AA1 PARP1 HSPA9 PARP2 HTT PER1 ING1 PNKP ING4 POLB ING5 POLD1 KPNB1 POLE LMO3 POLL MAPK9 POLM MDM2 PRKDC MDM4 RAD1 MED1 RAD17 MNAT1 RAD50 NCL RAD50 NDN RAD51 NF-?B RAD51C NFKB1 RAD51L1 NFKBIA RAD51L3 NUMB RAD52 P16 RAD54B PARC RAD54L PARP1 RAD9A PHB RAD9B PIAS1 RBBP8 PIN1 SHFM1 PLAGL1 SMUG1 PLK3 TDG PML TP53 PRKDC UNG PRKRA XRCC1 PSME3 XRCC2 PTEN XRCC3 PTK2 XRCC4 PTTG1 XRCC5 RAD51 XRCC6 RCHY1 RELA RPA1 RPL11 S100B SMARCA4 SMARCB1 SMN1 STAT3 SUMO1 TBP TFAP2A TFDP1 TIGAR TOP1 TOP2A TOP2B TP53BP1 TP53BP2 TP53INP1 TSG101 UBC UBE2A UBE2I USP7 WRN WWOX XPB YBX1 YPEL3 YWHAZ ZIF268 ZNF148

Supplementary table 6: HNSCC EMT- scores for the 32 cell lines. Cell line HNSCC EMT score UT-SCC-12 0.205977 UT-SCC-15 0.196029 UT-SCC-16A 0.20065 UT-SCC-19A 0.099285 UT-SCC-19B 0.182286 UT-SCC-1A 0.187411 UT-SCC-2 0.230857 UT-SCC-20A 0.435741 UT-SCC-22 0.075508 UT-SCC-23 0.072909 UT-SCC-24A 0.241454 UT-SCC-25 0.588411 UT-SCC-27 0.263608 UT-SCC-32 0.081289 UT-SCC-36 0.43094 UT-SCC-4 0.057487 UT-SCC-42A 0.216028 UT-SCC-45 0.203932 UT-SCC-46A 0.146515 UT-SCC-47 0.185189 UT-SCC-48 0.186662 UT-SCC-5 0.304758 UT-SCC-54C 0.236002 UT-SCC-60B 0.243949 UT-SCC-6A 0.262366 UT-SCC-7 0.143038 UT-SCC-76A 0.194756 UT-SCC-77 0.225147 UT-SCC-79A 0.348128 UT-SCC-8 0.090321 UT-SCC-9 0.093657 UT-SCC-90 0.214004

Supplementary table 7: HNSCC-EMT signature Gene symbol Average expression in FaDu-HIF- 1α(∆ODD) and UT-SCC-43A-Snail cell lines ABCG1 1.48 ABLIM1 3.68 ACOT4 1.65 ACP5 1.61 ACVR1 9.26 ADAM19 9.08 ADAM8 1.55 ADAMTS6 5.39 ADAMTSL1 5.64 ADAP1 7.05 ADAR 9.17 AFAP1L2 1.9 AGAP3 4.96 AHNAK 3.18 AIF1L 4.71 AIG1 6.25 AIM1L 1.65 AK4 6.71 AKR1A1 8.9 AKR1C2 4.21 AKR1C4 4.84 ALAS1 5.51 ALDH1A3 2.46 ALDH3A1 2.13 ALDH3B2 1.42 ALG1L 2.27 AMOT 5.19 ANAPC13 10.68 ANKLE1 3.29 ANKRD10 5.08 ANKRD22 2.59 ANKRD33 7.09 ANKRD57 7.37 ANO1 1.49 ANPEP 7.75 ANTXR1 7.15 ANTXR2 7.94 ANXA10 2.44 ANXA3 3.62 ANXA6 6.72 ANXA8 1.72 ANXA8L2 3.67 ANXA9 1.87 AOX1 7.07 AP1B1 7.43 AP1G2 4.77 AP1S2 7.27 AP4M1 5.55 APEH 9.09 APH1B 7.25 APLP2 4.45 APOBEC3F 4.35 APOE 7.63 APOL3 2.19 AQP11 6.07 ARHGAP25 2 ARHGAP32 5.21 ARHGAP33 7.71 ARHGAP8 2.04 ARHGDIB 9.82 ARHGEF16 2.85 ARHGEF19 5.65 ARHGEF3 5.72 ARHGEF35 6.65 ARHGEF4 1.83 ARHGEF5 5.72 ARHGEF6 5.86 ARMCX1 6.39 ARMCX6 7.88 ARRB1 5.9 ARRDC1 3.07 ARTN 1.75 ASAP3 6.7 ASB9 3.31 ASCL2 2.57 ASPH 6.92 ASPHD2 2.87 ASS1 3.71 ASTN2 4.78 ATN1 6.75 ATOX1 11.26 ATP1A1 8.49 ATP2B4 6.63 ATP2C2 2.18 ATP5G2 8.57 ATP5S 5.96 ATP6V1B1 2.3 ATP6V1E2 5.72 ATP8B2 6.94 ATPAF1 7.61 AVPI1 9.07 B3GALT4 3.01 B3GALT6 8.49 B4GALNT1 5.74 B9D2 7.84 BACE2 3.08 BAG4 5.13 BAIAP2 7.11 BATF3 7.36 BCAM 1.75 BCL11B 1.56 BCR 2.51 BCYRN1 12.23 BDKRB2 1.52 BDNF 5.8 BEX1 8.42 BHLHE40 7.26 BIK 1.51 BMP1 4.97 BMP2 1.92 BMP7 1.55 BNIP3 9.29 BOLA1 5.51 BOLA2 5.42 BRI3 11.16 BRI3BP 6.38 BST2 2.14 BTG2 2.24 BTG3 7.58 BVES 6.27 C10orf116 3.36 C10orf47 3.71 C10orf54 2.02 C10orf58 7.24 C10orf88 5.83 C11orf17 6.24 C11orf67 8.35 C11orf74 6.77 C12orf54 1.74 C14orf135 7.35 C14orf43 5.92 C15orf39 5.61 C16orf5 4.43 C16orf62 4.63 C16orf7 6.55 C16orf74 5.82 C17orf81 5.95 C19orf21 3.58 C19orf33 5.36 C19orf63 3.42 C19orf66 4.65 C1orf106 1.93 C1orf116 2.37 C1orf159 6.92 C1orf172 1.89 C1orf86 8.41 C1QL1 6.29 C1QL4 4.68 C1QTNF1 2.58 C1QTNF6 4.48 C20orf196 5.26 C20orf54 2.78 C21orf7 7.3 C2orf55 1.32 C2orf88 5.68 C3orf54 4.41 C5orf13 6.94 C5orf35 7.01 C6orf168 5.58 C6orf48 10.68 C7orf10 6.87 C7orf43 6.12 C9orf169 4.39 C9orf25 5.37 C9orf30 10.17 C9orf40 7.88 C9orf5 7.12 C9orf9 6.38 CACHD1 4.93 CALCOCO1 4.88 CAMK2D 5.47 CAMK2N1 7.59 CAND2 6.22 CAPN1 9.38 CAPN5 7.28 CARD10 8.98 CARD11 4.82 CASP4 4.8 CAV1 10.04 CAV2 7.36 CBLC 2.54 CCDC107 5.96 CCDC120 3.98 CCDC134 3.79 CCDC51 6.66 CCDC74A 6.08 CCDC74B 5.34 CCDC77 7.1 CCDC90B 7.13 CCDC99 7.02 CCL5 3.62 CCNA1 3.96 CCND2 2.36 CD14 2.91 CD151 7.64 CD163L1 6.63 CD44 9.7 CD9 7.29 CD99L2 8.9 CDC34 8.99 CDC42SE1 6.14 CDH1 1.55 CDH3 2.23 CDK11A 5.8 CDK11B 6.78 CDK18 1.79 CDK2AP2 6.12 CDK5RAP2 6.6 CDK5RAP3 8.29 CDKN2B 4.83 CDR2L 9.3 CDS1 1.61 CEACAM1 2.2 CEBPD 6.88 CEL 2.83 CELSR2 2.88 CENPP 5.99 CEP164 6.46 CERCAM 5.99 CGNL1 6.47 CHCHD10 8.74 CHMP4C 2.1 CHN1 6.73 CHRNA5 5.36 CHST15 6.06 CIDECP 4.16 CINP 6.66 CLCC1 5.67 CLDN7 1.61 CLIC4 7.54 CMBL 8.63 CMIP 7.47 CMTM3 8.5 CNIH2 4.98 CNKSR3 7.45 CNNM2 3.05 CNPY4 6.26 CNRIP1 5.85 CNTNAP1 6.64 COL13A1 5.16 COL17A1 5.08 COL6A2 5.76 COL7A1 5.11 CORO2A 4.52 CPSF4 5.7 CRAT 5.7 CRB3 2.36 CREG1 3.02 CRIM1 6.84 CSF2 2.15 CSNK1A1 6.08 CSNK2A1P 7.87 CSPG4 5.34 CST6 2.2 CSTA 1.28 CT45A1 4.42 CTDSPL 7.88 CTGF 12.16 CTH 3.08 CTHRC1 6.79 CTIF 7.34 CTNNB1 6.4 CTSC 8.4 CTSF 5.86 CTSH 3.07 CTSL1 7.4 CTU2 5.77 CWF19L2 3.23 CXCL1 3.63 CXCL16 3.95 CXCR7 1.31 CYB561 4.87 CYBRD1 7.59 CYP26B1 4.11 CYP27B1 3.28 CYP2S1 3.08 CYP4F11 1.85 CYTH4 2.04 D2HGDH 7.85 DAB2 7.61 DBN1 8.63 DBNDD1 7.86 DCBLD2 9.4 DCHS1 5.28 DCLK2 4.1 DCTN3 7.02 DDAH2 5.69 DDIT3 6.51 DDIT4 6.14 DDR1 5.78 DEF6 3.39 DENND2D 1.91 DGKA 4.91 DGKH 2.99 DHDDS 7.79 DHRS1 7.25 DHRS3 4.61 DHX58 1.81 DKK3 10.25 DLG3 2.18 DLGAP4 5.36 DLK2 4.55 DLL1 2.79 DLX1 6.27 DLX3 3.04 DMKN 2.83 DMRTA2 2.94 DNAJA4 3.17 DNAJB5 5.4 DNAJC22 5.19 DOCK10 6.56 4.8 DOK7 2.74 DPYSL2 10.28 DPYSL3 9.85 DSC2 2.86 DSC3 2.96 DSG3 2.14 DSP 2.95 DTNA 7.3 DTNBP1 7.07 DTWD1 5.78 DUOX1 1.78 DUSP10 4.28 DUSP4 1.79 DUSP7 3.12 DUT 5.59 EDARADD 4.33 EFEMP1 4.26 EFNA1 3.35 EFNB1 4.52 EGFR 3.94 EGLN3 1.96 EGR1 7.09 EIF4E3 2.27 ELAVL2 2.09 ELF3 5.27 ELMO1 2.81 ELMO3 3 EME1 5.75 EMILIN2 7.51 EML1 6.71 EMP3 12.15 ENSA 5.33 EPAS1 5.64 EPB41L2 6.48 EPCAM 2.38 EPG5 4.48 EPHA1 1.71 EPHB2 3.07 EPHB6 1.37 EPN3 1.77 EPOR 5.53 EPS8L1 2.54 EPSTI1 2.75 ERBB3 3.37 ERLIN2 5.57 ERMP1 3.73 ESRP1 1.93 ETS2 6.53 ETV5 8.11 EVPL 2.47 F11R 2.41 F3 6.17 FAHD2A 6.29 FAM101A 5.51 FAM101B 7.18 FAM108C1 6.24 FAM110C 1.76 FAM116B 3.68 FAM127A 9.5 FAM127C 5.59 FAM156A 6.68 FAM158A 7.26 FAM160B1 5.91 FAM164A 5.86 FAM176B 7.61 FAM179A 1.38 FAM181B 2.1 FAM20C 3.42 FAM24B 6.35 FAM25E 2.02 FAM46B 7.39 FAM49B 6.58 FAM53A 7.31 FAM71E1 3.47 FAM83A 1.46 FAM83H 5.71 FAM84B 2.35 FAM86B1 5.57 FAM89A 3.99 FARP1 7.79 FAT2 1.61 FBXO17 6.31 FBXW7 3.5 FECH 4.91 FEZ1 5.5 FGD3 2.21 FGF1 4.45 FGF2 4.59 FGF5 5.37 FGFBP1 1.62 FGFR1 2.8 FGFR3 5.04 FHDC1 2.31 FHL1 7.54 FKBP11 7.05 FLCN 4.93 FLNC 12.41 FLOT2 10.23 FNBP1 9.81 FOS 3.09 FOXA1 4.29 FOXA2 3.5 FOXD1 10.96 FOXQ1 2.44 FRMD4A 4.78 FSD1 5.82 FST 7.17 FSTL1 6.56 FUT3 1.77 FXYD3 1.52 FYB 1.22 FYN 6.61 FZD6 4.24 FZD7 6.86 G0S2 8.76 GAB2 6.31 GABARAPL1 7.54 GAD1 6.56 GADD45A 9.01 GADD45B 6.94 GALK1 10.32 GALNT12 2.5 GALNTL4 3.07 GART 7.24 GBP4 1.62 GCLC 5.52 GDF15 4.64 GDPD3 1.67 GEM 5.76 GFPT2 6.27 GHDC 1.84 GJB2 2.85 GJB3 1.61 GJB4 1.69 GJB5 1.23 GLIPR2 7.68 GMCL1 3.88 GNA15 5.13 GPR110 1.8 GPR115 1.33 GPR176 5.43 GPR37 6.02 GPR56 5.8 GPR87 2.99 GPR98 1.69 GPRC5A 7 GPRC5C 2.97 GPRIN1 6.38 GPX2 1.9 GPX8 8.56 GRAMD4 2.81 GRB14 2.99 GRB7 1.82 GRHL2 1.88 GRTP1 2.42 GSDMC 1.45 GSDMD 4.72 GSTO2 4.2 H19 1.73 HABP4 7.67 HAS3 3.5 HAUS4 6.62 HCG4 6.17 HCP5 4.07 HDAC9 3.79 HECW2 4.73 HEG1 7.33 HERC5 7.58 HERC6 5.47 HES1 2.37 HES4 8.67 HEY1 4.45 HEYL 5.85 HIP1R 2.91 HIPK2 7.32 HIST1H2BK 10.79 HIST1H3C 2.76 HIST1H3F 4.71 HIST1H3J 2.54 HIST3H2A 5.16 HLA-F 3.87 HLX 6.89 HMG20B 10.05 HMGCL 6.61 HMOX1 8.82 HNRNPAB 10.39 HOXA10 5.96 HOXB2 8.85 HOXC6 8.12 HOXC8 7.65 HOXD11 4.45 HPCAL1 7.71 HPS1 6.75 HRAS 9.25 HRASLS 5.79 HS3ST1 2.02 HS3ST3A1 9.72 HSD17B1 2.51 HSF2BP 3.4 HSH2D 1.15 HSPBP1 5.31 HYAL1 1.8 ICK 4.47 ID1 7.52 ID3 9.35 IDH1 7.29 IFFO1 7.07 IFI16 4 IFI27 4.26 IFI30 3.79 IFI44 4.78 IFI44L 1.52 IFIT1 5.51 IFIT2 4.08 IFIT3 3.3 IFITM1 3.74 IFITM3 10.71 IGF1R 2.59 IGFBP6 8.66 IGSF3 3.6 IGSF8 2.6 IGSF9 1.57 IL12A 5.82 IL1A 2.14 IL1B 3.9 IL1R2 2.3 IL1RAPL1 4.69 IL1RL1 2.02 IL1RN 2.37 IL24 2.74 IL4R 5.86 IMPA2 8.85 INHBB 3.4 INPP5D 1.53 INPPL1 9.3 IQCG 3.95 IRF1 7.38 IRF6 2.23 IRF7 3.71 IRF9 7.07 IRS2 4.36 IRX2 3.84 IRX4 2.32 ISG15 9.5 ISG20 5.8 ITGA5 9.08 ITGB2 5.78 ITGB3 3.64 ITGB4 3.33 ITPK1 7.47 ITPKA 7.55 JAG1 4.37 JAG2 3.78 JAM2 5.52 JAZF1 5.73 JOSD1 7.77 JUNB 5.18 JUP 2.43 KANK2 7.03 KBTBD7 2.57 KCND1 4.14 KCNIP3 5.31 KCNJ8 5.57 KCNK1 1.52 KCNS3 1.73 KDELC2 7.6 KIAA0355 7.53 KIAA0564 4.18 KIAA1199 1.88 KIAA1324 4.45 KIAA1522 5.63 KIAA1539 7.78 KIAA1549 4.04 KLC3 1.56 KLF10 3.06 KLF2 9.91 KLF5 2.68 KLF6 9.03 KLHL13 2.88 KLK10 1.85 KLK11 1.68 KLK3 2.64 KLK5 1.46 KLK6 1.89 KLK8 1.55 KLK9 1.26 KRT13 1.49 KRT14 1.39 KRT15 3.55 KRT16 2.64 KRT17 2.02 KRT19 1.95 KRT34 6.12 KRT5 1.18 KRT6A 1.8 KRT7 3.29 KRT8 9.04 KRT80 7.4 KRT81 5.98 KRT86 1.84 KRTCAP3 2.3 LACTB 6.5 LAD1 1.86 LAMA3 1.68 LAMA5 5.97 LAYN 7.66 LBH 2.31 LCN2 2.51 LCP1 4.77 LEF1 6.95 LEPREL2 5.69 LGALS3BP 7.17 LGALS7B 1.99 LGALS8 3.57 LHX2 7.98 LIMK2 3.69 LITAF 8.89 LIX1L 8.39 LLGL2 2.33 LOC346887 7.34 LOX 8.24 LOXL1 6.1 LOXL4 4.15 LPAR2 4.9 LPCAT2 3.01 LRG1 1.97 LRRC1 5.81 LRRC61 2.08 LRRC8A 7.17 LSG1 7.13 LSR 3.26 LTB 1.73 LTBP3 6.82 LY6E 9.16 LY96 7 LYN 8.24 LYPD1 2.89 LYPD2 2.49 LYPD3 1.82 LYPD5 2.32 LYPD6B 1.66 MAGED1 9.23 MAGED2 5.68 MAL2 1.12 MALL 2.24 MAMLD1 5.81 MANBA 4.48 MAP1LC3A 9.81 MAP1LC3B 8.51 MAP2K3 7.68 MAP4 4.63 MAP7 4.37 MAPK13 5.36 MAPK7 7.11 MAPK8IP1 4.11 MARCH3 4.97 MARCH4 9.3 MARVELD3 1.81 MAX 3.96 MB 1.34 MBP 2.64 MEF2D 6.87 MEST 1.4 METTL11A 7.6 MFGE8 10.2 MFNG 1.99 MFSD6 2.78 MGAT4B 8.22 MGLL 6.76 MGST2 3.21 MICALCL 1.73 MICALL2 2.72 MID1IP1 6.62 MLLT6 7.26 MMP10 2.21 MMP28 1.94 MN1 2.76 MOCS1 6.84 MOSC1 1.5 MOSC2 3.44 MOXD1 6.48 MPP1 7.51 MPP4 6.41 MPV17L2 6.3 MPZL2 2.24 MR1 3.39 MSN 11.8 MSRA 8.08 MSRB3 5.79 MST1R 1.27 MT1F 4.52 MT1H 2 MTFP1 7.33 MTSS1 4.11 MUC1 3.69 MUC20 1.28 MX1 4.67 MXRA7 7.33 MYD88 4.35 MYEOV 2.37 MYO1D 2.06 NAAA 2.56 NAPRT1 7.96 NAV1 5.51 NBPF3 5.82 NDRG1 4.89 NDST1 7.69 NDUFV3 4.43 NECAB3 4.93 NEK6 8.32 NET1 5.52 NFASC 2.42 NIPAL3 7.17 NIPAL4 1.82 NKX2-2 6.86 NKX3-2 6.4 NMU 3.5 NOXO1 1.81 NR2F1 5.2 NR2F2 8.75 NRARP 1.7 NRGN 7.03 NRIP3 10.5 NRSN2 8.51 NTF4 1.44 NUDT15 6.43 NUP98 5.04 OAS1 3.13 OAS2 1.98 OAS3 5.57 OASL 3.85 OCIAD2 6.09 ODZ3 6.81 OGFRL1 6.31 ORMDL2 3.69 OSBPL6 6.77 OSCP1 3.79 OSGEP 7.06 OSGIN1 8.21 OVOL1 1.69 OVOL2 1.93 P2RY2 2.02 PADI3 2.06 PAK6 1.81 PAM 9.81 PAPSS2 8.42 PARD6G 2.18 PARP10 4.32 PARP9 4.2 PATZ1 2.88 PBX3 8.95 PBX4 4.2 PC 5.66 PCDH1 2.53 PCK2 4.32 PCOLCE 5.97 PCOLCE2 8.12 PCSK6 1.72 PCSK9 2.22 PCYOX1L 5.01 PDGFB 3.2 PDLIM1 8.87 PDLIM3 5.58 PDPN 1.57 PEA15 11.41 PEG10 6.11 PER2 5.34 PERP 7.17 PHF17 4.31 PHGDH 10.67 PHYH 5.69 PI3 1.84 PICK1 4.93 PIK3C2B 2.96 PIK3CD 6.86 PISD 6.98 PJA1 4.79 PKD2 5.75 PKP2 3.76 PKP3 2.35 PKP4 7.78 PLA2G10 1.98 PLAC8 9.93 PLCG2 5.77 PLEK2 6.7 PLEKHA4 2.98 PLEKHA7 2.22 PLEKHG3 6.67 PLEKHG4 7.55 PLEKHG6 1.97 PLEKHO1 7.11 PLEKHO2 6.08 PLLP 3.67 PLSCR3 10.19 PLXNA2 2.24 PLXNB1 1.95 PMEPA1 3.97 PMP22 7.56 POLR1D 6.21 POLR1E 9.16 POMZP3 8.02 PON3 1.8 POPDC3 6.91 PORCN 2.99 POU3F2 4.08 PPAP2A 6.71 PPL 3.44 PPM1A 2.59 PPP1R15A 9.98 PRDX2 4.21 PRICKLE3 3.23 PRKCA 8.25 PRMT2 6.55 PROM2 3.04 PRPS1L1 5.37 PRR5 3.91 PRR5L 4.67 PRR7 7.19 PRRG2 3.05 PRRG4 1.6 PRRX2 6.06 PRSS12 5.11 PRSS16 3.07 PRSS22 1.4 PRSS8 2.08 PSD4 3.49 PSEN2 5.59 PSMB8 6.49 PSME2 10.16 PSTPIP2 3.44 PTGES 1.89 PTGFRN 3.48 PTGS1 3.78 PTGS2 2.56 PTK6 2.53 PTMS 10.27 PTPN6 1.45 PTPRA 6.3 PTPRB 4.41 PTPRK 6.2 PTPRR 6.2 PTPRU 2.19 PVRL1 3.69 QSOX1 7.83 RAB11FIP5 7.91 RAB15 5.91 RAB17 1.37 RAB20 2.24 RAB24 7.27 RAB25 2.11 RAB38 4.79 RAB3B 6.39 RAB3IP 7.06 RAB8B 6.7 RAC1 5.97 RAC2 7.23 RAGE 9.54 RAI14 7.96 RAP1GAP 3.62 RAP1GAP2 8.3 RAPGEFL1 3.63 RARA 6.56 RARRES3 3.69 RASSF1 5.96 RASSF5 4.81 RBM24 6.09 RBM47 1.46 RBMS3 4.57 RBP7 6.67 RBPMS2 9.25 RGL1 5.46 RGS4 5.31 RHOBTB3 6.81 RHOD 5.11 RHOQ 7.7 RNASE7 1.46 RNF157 4.98 RNF165 1.87 RNF166 5.39 RNF213 3.21 RNF39 1.62 RNMTL1 9.69 ROGDI 4.09 RPL14 9.61 RPL41 7.43 RPS23 10.16 RPS26 8.6 RSAD2 1.98 RSU1 6.14 RTN1 7.69 RTN4R 3.76 RUNDC1 6.84 RUNDC3B 4.83 RUNX1 5.09 RUNX3 7.43 RUSC2 6.31 RWDD2A 6.94 RXRA 7.53 RYR1 2.42 S100A13 5.85 S100A14 2.59 S100A16 8.39 S100A2 3.99 S100A4 4.47 S100A9 1.5 S100P 1.43 S1PR1 7.3 SAMD11 3.99 SAMD4A 7.43 SAT1 8.91 SCARF2 6.24 SCMH1 4.48 SCNN1A 3.93 SEC14L1 7.96 SEC14L2 3.87 SEMA3F 2.4 SEMA4A 2.32 SEMA4B 7.17 SEPT5 6.93 SERINC2 2.71 SERPINA1 2.39 SERPINB5 3.76 SERPINE1 11.53 SERPINF1 1.47 SEZ6L2 4.55 SFN 1.92 SFRP1 7.14 SH2D3A 2.01 SH3BP1 5.19 SH3PXD2A 5.63 SH3PXD2B 4.82 SH3RF2 7.76 SH3TC1 2.2 SH3YL1 2.49 SHFM1 7.82 SHISA2 2.85 SHMT1 5.86 SHROOM2 2.04 SHROOM3 4.09 SIAE 2.14 SIK1 1.87 SLC10A4 5.05 SLC15A2 1.68 SLC22A18AS 3.3 SLC22A23 3.6 SLC25A39 9.75 SLC26A6 4.14 SLC27A3 4.35 SLC29A2 4.17 SLC29A3 2.38 SLC2A1 9.12 SLC2A3 8.96 SLC2A9 1.58 SLC35B4 5.31 SLC37A1 2.82 SLC38A7 4.54 SLC39A4 5.43 SLC3A2 7.98 SLC44A3 3.85 SLC46A1 2.96 SLC47A1 7.03 SLC47A2 1.5 SLC6A15 3.83 SLC6A9 3.11 SLC7A5 11.06 SLCO4A1 5.45 SLFN11 3.38 SLIT3 4.57 SLMO1 6.42 SLPI 1.52 SLX1A 4.39 SMARCA1 6.53 SMOC2 1.79 SNAI2 4.31 SNCA 4.07 SNCG 1.65 SNX24 6.09 SNX30 6.56 SORBS3 8.36 SOX15 3.56 SOX18 6.43 SOX4 3.79 SOX7 2.25 SPHK1 8.63 SPINT1 1.69 SPINT2 4.24 SPP1 7.76 SQSTM1 12.14 SRC 8.14 SRPX 9.21 SRXN1 9.77 SSH3 5.8 ST14 1.8 ST6GALNAC5 1.86 ST6GALNAC6 8.08 STAP2 2.53 STARD13 5.62 STARD8 5.29 STAT1 7.58 STAT3 7.25 STAT5A 3.54 STEAP1 8.23 STK24 8.72 STX11 6.36 STX2 7.64 STXBP1 5.82 SUCLA2 5.83 SUGP2 5.23 SULF2 1.97 SULT1A1 3.93 SULT1A3 4.54 SV2A 3.13 SVEP1 1.45 SYDE1 9.03 SYK 1.65 SYT11 6.11 SYT7 2.1 SYT8 1.42 SYTL2 5.41 TACC1 8.63 TACSTD2 5.53 TAF12 7.65 TAF6 6.48 TAF9B 5.53 TAPBPL 3.35 TATDN3 6.5 TBC1D20 6.84 TBC1D22A 4.62 TBC1D4 6.31 TBKBP1 3.61 TBX2 5.45 TCEA3 7.56 TCEAL4 9.46 TENC1 3.43 TES 2.99 TFAP2A 7.97 TFPI 5.83 TGFA 3.9 TH 1.63 TIAM2 4.73 TIMP2 8.75 TIMP4 3.16 TINAGL1 2.16 TINF2 6.81 TJP2 3.28 TJP3 2.32 TLN2 7.12 TM4SF1 11.58 TM9SF2 10.21 TMC6 4.1 TMED10P1 10.37 TMEM125 1.65 TMEM154 2.65 TMEM158 12.26 TMEM171 6.74 TMEM184A 1.68 TMEM189 7.63 TMEM189- 6.21 UBE2V1 TMEM200A 7.56 TMEM201 5.78 TMEM216 7.68 TMEM22 6.57 TMEM27 3.36 TMEM30B 1.86 TMEM40 2.03 TMEM44 6.42 TMEM50B 5.36 TMEM69 7.43 TMEM70 6.59 TMPRSS3 1.29 TMSB15A 4.43 TMSB15B 5.13 TMX4 6.66 TNFAIP2 2.23 TNFAIP3 5.36 TNFAIP8L3 4.52 TNFRSF10D 6.3 TNFRSF21 8.44 TNNI2 1.56 TNS4 2.27 TOM1L2 6.49 TP53INP2 7.93 TP53TG3 6.33 TP63 1.71 TPD52L1 4.7 TPM1 11.27 TRAF3IP2 6.51 TRAF4 5.12 TRAF7 6.2 TRIB2 1.86 TRIM16 2.17 TRIM29 2.43 TRIM52 3.54 TRIM55 3.92 TRIM58 6.75 TRIM6 5.88 TRIML2 3.18 TSC22D3 3.97 TSHZ3 5.59 TSKU 7.34 TSPAN1 3.16 TSPAN13 5.59 TSPYL4 5.82 TTC1 8.05 TTC13 5.02 TTL 8.52 TTLL12 8.83 TUBA4A 4.67 TUBAL3 1.99 TUBB2A 9.16 TWIST1 8.93 TXNIP 3.17 TXNRD2 9.45 TYRO3 8.14 UBASH3B 6.89 UBE2J2 6.8 UBE2L6 7.36 UBL3 5.07 UBL7 6.92 UCN 4.55 UCP2 6.44 UGT1A6 1.33 UNC13D 1.93 UNC93B1 6.24 UNKL 6.68 UPK3B 2.61 UPP1 5.41 USP21 7.05 UST 5.4 VAMP8 6.68 VANGL2 3.74 VAPA 4.02 VEGFA 3.79 VGLL1 2.59 VIM 13.65 VPS37D 6.22 VPS8 5.71 VSNL1 1.42 VWA1 2.96 VWF 1.63 WASH3P 7.57 WBP5 8.17 WDR26 5.01 WDR33 6.91 WFS1 9.18 WIPF1 4.51 WIPI1 6.96 WNK4 4.46 WNT10A 2.54 WNT3A 1.24 WNT5B 9.17 WNT7A 2 WNT7B 3.16 WTIP 5.32 XBP1 8.99 YJEFN3 2.72 ZBTB49 4.15 ZC3HAV1 5.51 ZEB2 4.76 ZFP64 3.44 ZHX2 4.16 ZHX3 5.86 ZMAT3 6.7 ZMYM3 5.46 ZNF165 5.02 ZNF20 6.13 ZNF219 5.91 ZNF23 4.51 ZNF32 7.54 ZNF385A 3.37 ZNF585A 6.14 ZNF613 3.69 ZNF750 1.85 ZNF775 5.48 ZNF821 5.74 ZSCAN16 1.62 ZWINT 6.76

Supplementary table 8: results of testing gene sets for reactive oxygen species, DNA repair, cell cycle phase and several means of cell death against the EMT gene set.

Hypothesis for increase of Gene set Correlation with UT-scc-43A-snail FaDu_HIF intrinsic resistance EMT gene set in (compared to (compared 32 HNSCC cell control) to control) lines 1. Less damage ROS-scavengers -0.3 down down 2. Better repair of damage 2a. More time in G2 checkpoint genes 0.5 up up checkpoint 2b. Better DNA repair NHEJ 0.6 down up HR 0.4 up up BER/SSBR 0.0 down down 3. Less cell death Apoptosis -0.1 down up Necrosis -0.1 down same Autophagy 0.3 up up