Unenhanced Areas Revealed by Contrast-Enhanced Abdominal Ultrasonography with Sonazoidtm Potentially Correspond to Colorectal Cancer
4012 EXPERIMENTAL AND THERAPEUTIC MEDICINE 12: 4012-4016, 2016 Unenhanced areas revealed by contrast-enhanced abdominal ultrasonography with SonazoidTM potentially correspond to colorectal cancer MINORU TOMIZAWA1, MIZUKI TOGASHI2, FUMINOBU SHINOZAKI3, RUMIKO HASEGAWA4, YOSHINORI SHIRAI4, MIDORI NORITAKE2, YUKIE MATSUOKA2, HIROAKI KAINUMA2, YASUJI IWASAKI2, KAZUNORI FUGO5, YASUFUMI MOTOYOSHI6, TAKAO SUGIYAMA7, SHIGENORI YAMAMOTO8, TAKASHI KISHIMOTO5 and NAOKI ISHIGE9 Departments of 1Gastroenterology; 2Clinical Laboratory; 3Radiology and 4Surgery, National Hospital Organization, Shimoshizu Hospital, Yotsukaido City, Chiba 284-0003; 5Department of Molecular Pathology, Chiba University Graduate School of Medicine, Chiba City, Chiba 260-8670; Departments of 6Neurology; 7Rheumatology; 8Pediatrics and 9Neurosurgery, National Hospital Organization, Shimoshizu Hospital, Yotsukaido, Yotsukaido City, Chiba 284-0003, Japan Received September 18, 2015; Accepted September 22, 2016 DOI: 10.3892/etm.2016.3868 Abstract. The present study investigated the potential utility of Introduction contrast-enhanced abdominal ultrasonography (CEUS), using SonazoidTM, in colorectal cancer (CRC). Three patients were Colorectal cancer (CRC) is commonly observed in clinical subjected to CEUS with SonazoidTM. Surgical specimens were settings (1). To improve the prognosis in patients with CRC, immunostained for CD31. Numbers of blood vessels positive prompt and accurate diagnosis is essential. Screening for CRC for CD31 were analyzed in each of five fields at x400 magnifi- is performed using fecal occult blood testing, and is diagnosed cation and averaged to determine blood vessel density. Blood with colonoscopy (2). vessel density was compared between non-tumorous and Abdominal ultrasound (US) is useful for the safe and tumorous areas. Prior to the administration of SonazoidTM, easy diagnosis of patients (3-6). During US screening of the CRC was illustrated as irregular-shaped wall thickening.
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