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2016 Prohibited List WORLD ANTI-DOPING CODE INTERNATIONAL STANDARD PROHIBITED LIST JANUARY 2016 This List shall come into effect on 1 January 2016. The official text of the Prohibited List shall be maintained by WADA and shall be published in English and French. In the event of any conflict between the English and French versions, the English version shall prevail. IN ACCORDANCE WITH ARTICLE 4.2.2 OF THE WORLD ANTI-DOPING CODE, ALL PROHIBITED SUBSTANCES SHALL BE CONSIDERED AS “SPECIFIED SUBSTANCES” EXCEPT SUBSTANCES IN CLASSES S1, S2, S4.4, S4.5, S6.a, AND PROHIBITED METHODS M1, M2 AND M3. SUBSTANCES & METHODS PROHIBITED AT ALL TIMES (IN- AND OUT-OF-COMPETITION) PROHIBITED SUBSTANCES Gestrinone; NON-APPROVED SUBSTANCES Mestanolone; S0 Any pharmacological substance which is not Mesterolone; addressed by any of the subsequent sections of the List Metandienone (17β-hydroxy-17α-methylandrosta-1,4-dien- and with no current approval by any governmental regula- 3-one); tory health authority for human therapeutic use (e.g. drugs Metenolone; under pre-clinical or clinical development or discontinued, Methandriol; designer drugs, substances approved only for veterinary Methasterone (17β-hydroxy-2α,17α-dimethyl-5α- use) is prohibited at all times. androstan-3-one); Methyldienolone (17β-hydroxy-17α-methylestra-4,9-dien- 3-one); ANABOLIC AGENTS Methyl-1-testosterone (17 -hydroxy-17 -methyl-5 - S1 β α α Anabolic agents are prohibited. androst-1-en-3-one); Methylnortestosterone (17β-hydroxy-17α-methylestr-4-en- 1. ANABOLIC ANDROGENIC STEROIDS (AAS) 3-one); a. Exogenous* AAS, including: Methyltestosterone; Metribolone (methyltrienolone, 17β-hydroxy-17α- 1-Androstenediol (5α-androst-1-ene-3β,17β-diol); methylestra-4,9,11-trien-3-one); 1-Androstenedione (5α-androst-1-ene-3,17-dione); Mibolerone; 1-Testosterone (17β-hydroxy-5α-androst-1-en-3-one); Nandrolone; 4-Hydroxytestosterone (4,17β-dihydroxyandrost-4-en-3-one); Norboletone; 19-Norandrostenedione (estr-4-ene-3,17-dione); Norclostebol; Bolandiol (estr-4-ene-3β,17β-diol ); Norethandrolone; Bolasterone; Oxabolone; Boldenone; Oxandrolone; Boldione (androsta-1,4-diene-3,17-dione); Oxymesterone; Calusterone; Oxymetholone; Clostebol; Prostanozol (17β-[(tetrahydropyran-2-yl)oxy]-1'H- Danazol ([1,2]oxazolo[4',5':2,3]pregna-4-en-20-yn-17α-ol); pyrazolo[3,4:2,3]-5α-androstane); Dehydrochlormethyltestosterone (4-chloro-17β-hydroxy- Quinbolone; 17α-methylandrosta-1,4-dien-3-one); Stanozolol; Desoxymethyltestosterone (17α-methyl-5α- Stenbolone; androst-2-en-17β-ol); Tetrahydrogestrinone (17-hydroxy-18a-homo-19-nor- Drostanolone; 17α-pregna-4,9,11-trien-3-one); Ethylestrenol (19-norpregna-4-en-17α-ol); Trenbolone (17β-hydroxyestr-4,9,11-trien-3-one); Fluoxymesterone; Formebolone; and other substances with a similar chemical structure Furazabol (17α-methyl [1,2,5]oxadiazolo[3',4':2,3]-5α- or similar biological effect(s). androstan-17β-ol); 2 b. Endogenous** AAS when administered exogenously: 2. OTHER ANABOLIC AGENTS Androstenediol (androst-5-ene-3β,17β-diol); Including, but not limited to: Androstenedione (androst-4-ene-3,17-dione); Clenbuterol, selective androgen receptor modulators Dihydrotestosterone (17β-hydroxy-5α-androstan-3-one); (SARMs, e.g. andarine and ostarine), tibolone, zeranol Prasterone (dehydroepiandrosterone, DHEA, and zilpaterol. 3β-hydroxyandrost-5-en-17-one); Testosterone; For purposes of this section: * “exogenous” refers to a substance which is not ordinarily produced by the body naturally. and their metabolites and isomers, including but ** “endogenous” refers to a substance which is ordinarily produced by the body naturally. not limited to: 3 -Hydroxy-5 -androstan-17-one; β α PEPTIDE HORMONES, GROWTH FACTORS, 5 -Androstane-3α,17α-diol; S2 α RELATED SUBSTANCES AND MIMETICS 5α-Androstane-3α,17β-diol; The following substances, and other substances with 5α-Androstane-3β,17α-diol; similar chemical structure or similar biological effect(s), 5α-Androstane-3β,17β-diol; are prohibited: 5β-Androstane-3α,17β-diol; 7α-Hydroxy-DHEA; 1. Erythropoietin-Receptor agonists: 7β-Hydroxy-DHEA; 1.1 Erythropoiesis-Stimulating Agents (ESAs) including e.g. 4-Androstenediol (androst-4-ene-3β, 17β-diol) Darbepoietin (dEPO); 5-Androstenedione (androst-5-ene-3,17-dione); Erythropoietins (EPO); 7-Keto-DHEA; EPO-Fc; 19-Norandrosterone; EPO-mimetic peptides (EMP), e.g. CNTO 530 and 19-Noretiocholanolone. peginesatide; methoxy polyethylene glycol-epoetin Androst-4-ene-3α,17α-diol; beta (CERA). Androst-4-ene-3α,17β-diol; Androst-4-ene-3β,17α-diol; 1.2 Non-erythropoietic EPO-Receptor agonists, e.g. Androst-5-ene-3α,17α-diol; ARA-290; Androst-5-ene-3α,17β-diol; asialo EPO; Androst-5-ene-3β,17α-diol; carbamylated EPO. Androsterone Epi-dihydrotestosterone; 2. Hypoxia-inducible factor (HIF) stabilizers, e.g. cobalt Epitestosterone; and FG-4592; and HIF activators, e.g. argon, xenon; Etiocholanolone. 3. Chorionic Gonadotrophin (CG) and Luteinizing Hormone (LH) and their releasing factors, e.g. buserelin, gonadorelin and leuprorelin, in males; 4. Corticotrophins and their releasing factors, e.g corticorelin; 3 5. G rowth Hormone (GH) and its releasing factors including: S4 HORMONE AND METABOLIC Growth Hormone Releasing Hormone (GHRH) and its MODULATORS analogues, e.g. CJC-1295, sermorelin and tesamorelin; The following hormone and metabolic modulators Growth Hormone Secretagogues (GHS), e.g. ghrelin are prohibited: and ghrelin mimetics, e.g. anamorelin and ipamorelin; GH-Releasing Peptides (GHRPs), e.g. alexamorelin, 1. Aromatase inhibitors including, but not limited to: GHRP-6, hexarelin and pralmorelin (GHRP-2). 4-Androstene-3,6,17 trione (6-oxo); Aminoglutethimide; Additional prohibited growth factors: Anastrozole; Androsta-1,4,6-triene-3,17-dione (androstatrienedione); Fibroblast Growth Factors (FGFs); Exemestane; Hepatocyte Growth Factor (HGF); Formestane; Insulin-like Growth Factor-1 (IGF-1) and its analogues; Letrozole; Mechano Growth Factors (MGFs); Testolactone. Platelet-Derived Growth Factor (PDGF); Vascular-Endothelial Growth Factor (VEGF) 2. Selective estrogen receptor modulators (SERMs) including, but not limited to: and any other growth factor affecting muscle, tendon or Raloxifene; ligament protein synthesis/degradation, vascularisation, Tamoxifen; energy utilization, regenerative capacity or fibre type Toremifene. switching. 3. Other anti-estrogenic substances including, but not limited to: BETA-2 AGONISTS S3 Clomiphene; All beta-2 agonists, including all optical isomers, Cyclofenil; e.g. d- and l- where relevant, are prohibited. Fulvestrant. Except: • Inhaled salbutamol (maximum 1600 micrograms over 4. Agents modifying myostatin function(s) including, but 24 hours); not limited, to: myostatin inhibitors. • Inhaled formoterol (maximum delivered dose 54 micrograms over 24 hours); and 5. Metabolic modulators: • Inhaled salmeterol in accordance with the 5.1 Activators of the AMP-activated protein kinase manufacturers’ recommended therapeutic regimen. (AMPK), e.g. AICAR; and Peroxisome Proliferator Activated Receptor δ The presence in urine of salbutamol in excess of (PPARδ) agonists, e.g. GW 1516; 1000 ng/mL or formoterol in excess of 40 ng/mL is pre- 5.2 Insulins and insulin-mimetics; sumed not to be an intended therapeutic use of the 5.3 Meldonium; substance and will be considered as an Adverse Analytical 5.4 Trimetazidine. Finding (AAF) unless the Athlete proves, through a con- trolled pharmacokinetic study, that the abnormal result was the consequence of the use of the therapeutic inhaled dose up to the maximum indicated above. 4 PROHIBITED METHODS S5 DIURETICS AND MASKING AGENTS M1 MANIPULATION OF BLOOD AND The following diuretics and masking agents are BLOOD COMPONENTS prohibited, as are other substances with a similar chemical The following are prohibited: structure or similar biological effect(s). 1. The Administration or reintroduction of any quantity of autologous, allogenic (homologous) or heterologous Including, but not limited to: blood, or red blood cell products of any origin into the • Desmopressin; probenecid; plasma expanders, e.g. circulatory system. glycerol and intravenous administration of albumin, dextran, hydroxyethyl starch and mannitol. 2. Artificially enhancing the uptake, transport or delivery • Acetazolamide; amiloride; bumetanide; canrenone; of oxygen. Including, but not limited to: chlortalidone; etacrynic acid; furosemide; indapamide; Perfluorochemicals; efaproxiral (RSR13) and modified metolazone; spironolactone; thiazides, e.g. bendroflu- haemoglobin products, e.g. haemoglobin-based blood methiazide, chlorothiazide and hydrochlorothiazide; substitutes and microencapsulated haemoglobin triamterene and vaptans, e.g. tolvaptan. products, excluding supplemental oxygen. Except: 3. Any form of intravascular manipulation of the blood • Drospirenone; pamabrom; and ophthalmic use of or blood components by physical or chemical means. carbonic anhydrase inhibitors (e.g. dorzolamide, brinzolamide). • Local administration of felypressin in dental M2 CHEMICAL AND PHYSICAL anaesthesia. MANIPULATION The following are prohibited: The detection in an Athlete’s Sample at all times or 1. Tampering, or Attempting to Tamper, to alter the In-Competition, as applicable, of any quantity of the integrity and validity of Samples collected during following substances subject to threshold limits: formo- Doping Control. terol, salbutamol, cathine, ephedrine, methylephedrine Including, but not limited to: and pseudoephedrine, in conjunction with a diuretic or Urine substitution and/or adulteration, e.g. proteases. masking
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