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Understanding Finding A 2015 Understanding DISEASE... Finding a CURE /centenaryinstitute /centenaryinst centenary.org.au OUR Values EXCELLENCE We continue to achieve high levels of productivity, generating useful and lasting knowledge that will impact on how we see and treat diseases in the years to come COMMITMENT We work tirelessly to identify the underlying factors of how diseases operate and ways in which we can control and cure them RELEVANCE We continually refine our work to ensure it is applicable to clinical problems and treatment for patients OUR Vision To improve human health through excellence in medical research OURMission To discover and bring to use innovative therapeutics and diagnostics OURFocus Cancer, inflammation and cardiovascular diseases Being a medical researcher is a labour of love. This love is constantly tested, but driven by OURApproach the dream of making a difference. Understanding disease – Professor Mathew Vadas AO, and finding a cure Executive Director 2 Centenary Institute WHAT Defines us The Centenary Institute (CI) is these skills by focusing on and a world-leading independent enlarging our research efforts in medical research institute the three critical areas of cancer, located at the centre of the inflammation and cardiovascular University of Sydney – Royal disease research. Prince Alfred Hospital precinct. We possess the scientific Many of our senior researchers excellence and technological are specialist clinicians at Royal skills to allow us to understand Prince Alfred Hospital and the cellular and molecular lecturers at the University of drivers of inflammation, Sydney. Their direct, personal placing us in an outstanding experience with patients inspires position to make significant their work to improve and save advances to overcome the lives. Our close ties with the prevalent diseases (cancer and University and Hospital mean our cardiovascular) of our society. scientists are not isolated from the PROFESSOR THE HONOURABLE people who are affected by the Inflammation is the most DAME MARIE BASHIR AD CVO major diseases we are working important fundamental CENTENARY PATRON to overcome. Centenary has mechanism by which the body gained international recognition reacts to injury, such as infection for the quality of its work and the or trauma. Inflammation also “As a trained medical development and application underlies a number of prevalent doctor, I am deeply aware of state of the art complex chronic conditions, such as of the contribution scientific technologies in cytometry, allergies and autoimmune research makes towards the imaging and bioinformatics to diseases, and drives the initiation continued advancement in our research. and progression of cancer and new treatments and diagnosis cardiovascular disease. of disease. If it was not for Our strength is uncovering the work undertaken by disease mechanisms and With 1 in 2 Australian men and the Centenary Institute, we applying obtained knowledge to 1 in 3 Australian women set to would not have new cancer treat patients. Our research spans be diagnosed with cancer by therapies targeting molecules in from investigating molecular the age of 85 years old, and cancer cells that drive tumour mechanisms of disease at the cardiovascular disease killing growth. We would not be as single cell level to translational an Australian every 12 minutes, advanced in our knowledge disease models in complex the need for new diagnostics, of immunology, infectious organisms and to clinical trials. treatments and cures has never and liver disease, and genetic We will continue to build on been more urgent. abnormalities underlying cardiovascular disease, which is causing sudden death in young people in Australia “With ...cardiovascular disease killing an and around the world. This Australian every 12 minutes, the need world-class research is the badge of honour worn by the for new diagnostics, treatments and Centenary Institute, and the cures has never been more urgent.” outstanding work I applaud.” Understanding Disease... Finding a Cure 3 Associate Professor Jeff Holst Head of Origins of Cancer Program “My team is helping to understand how prostate cells transport nutrients. This has revealed a new link between nutrition and prostate cancer.” Professor Jenny Gamble Head of Vascular Biology Program “My team has discovered that inflammation in arteries is prevented by increasing a cell molecule. This has allowed the design and test of a first-of-its-kind drug for arterial blockage and blindness.” Professor Chris Semsarian Head of Molecular Cardiology Program “My team discovered that some cardiac genes cause sudden death in young people. This has helped us identify patients at risk and prevent fatal arrhythmias.” 4 Centenary Institute OUR OUR Strengths Focus Our strength is understanding disease CANCER mechanisms and applying this knowledge In cancer, we have projects specific to leukemia, to patient outcomes. melanoma, prostate, liver, breast and lung cancer We build on these skills and enhanced that stand to improve treatment and diagnostics knowledge by focusing on and enlarging our for all solid cancers by altering their blood supply. research efforts in three critical areas: cancer, inflammation and cardiovascular research. INFLAMMATION Centenary will continue to be a leader in the We excel at understanding how inflammation field through new competencies and use drives disease processes. Through studying the our strengths to help, support and synergise chief cellular components of inflammation, the with our stakeholders and promote the blood’s white cells and the lining of blood vessels importance of innovation and creativity for and how they react to injury, we have defined new Australia’s future. mechanisms and devised new drug candidates. CARDIOVASCULAR In cardiovascular disease we have projects “What do heart disease, identifying the genes causing sudden death diabetes, Alzheimer’s, stroke in the young, aortic aneurysms in the middle and cancer have in common? years and atheroma (causing stroke and heart attacks) in the elderly. Scientists have linked each of these to a condition known as chronic inflammation” – The Wall Street Journal. Understanding Disease... Finding a Cure 5 CENTENARY’S 30YearANNIVERSARY FOR THE PAST 30 YEARS, Centenary’s scientists have We are located on the border of the University demonstrated their passion for research through of Sydney Campus and the Royal Prince Alfred creativity and excellence by discovering improved Hospital. With many of our Faculty being professors diagnostics, treatments and cures for cancer, and clinicians, we are well positioned to ensure inflammation and cardiovascular diseases. In a virtuous cycle of bed to bench to bed and 2014, we produced over 100 publications in top translate our cutting edge research into practice. world-recognised journals such as Nature, Nature We capitalise on this geographical advantage Immunology, Nature Reviews Immunology, Nature and build these relationships with a focus on Communications, Immunity, Cell, Developmental multi-disciplinary collaboration to ensure that Cell, Ageing Cell, Journal of Investigative the Australian population receives the greatest Dermatology, PNAS and Current Biology. possible benefit. Our Faculty has access to some of the brightest minds with students being energised by the synergies created with our affiliated stakeholders. 6 Centenary Institute Scientific ADVISORY BOARD Professor Sir Marc Feldman (Chair) Professor Michael Good AO FMedSci, FAA, FRS Institute of Glycomics Head, Kennedy Institute of Rheumatology, Griffith University, Gold Coast Campus Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford Professor Richard Flavell FRS Professor Matthias W. Hentze, M.D. Department of Immunobiology Director Yale School of Medicine European Molecular Biology Laboratory Connecticut, USA Germany Professor Ian Frazer Professor Axel Ullrich TRI Ambassador and Chair of Max Planck Institute for Biochemistry TRI Foundation Board Department of Molecular Biology Translational Research Institute Germany The University of Queensland Diamantina Institute Understanding Disease... Finding a Cure 7 CENTENARY INSTITUTE Faculty Professor Mathew Vadas, Professor Wolfgang Weninger AO AAHMS MB BS, FRACP, FRCPA, PhD, DSc Assistant Director, Executive Director, Head, Immune Imaging, Head, Vascular Biology Program, The Centenary Institute The Centenary Institute Raymond E. Purves Professor Sydney Medical School, Discipline of Dermatology, University of Sydney Sydney Medical School, Department of Clinical Immunology, University of Sydney Royal Prince Alfred Hospital Head, Department of Dermatology, Professor Mathew Vadas trained in medicine (with First Class Honours) at the Royal Prince Alfred Hospital University of Sydney and as a physician at the Royal Prince Alfred Hospital, Professor Weninger is a preeminent Sydney before completing a doctorate at the Walter and Eliza Hall Institute clinician scientist in the fields of in Melbourne. He was a chief initiator and Inaugural Director of the Hanson dermatology and immunology. Professor Centre for Cancer Research in Adelaide (now Hanson Institute). He took up Weninger is a pioneer in the uncovering the position of Executive Director of the Centenary Institute in 2007 and has of immune cell behaviour during anti- seen the size and output of the Institute almost double since that time. pathogen and anti-tumour immune He is one of Australia’s most highly cited scientists with citations in excess of
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