Human Infection with Gongylonema Pulchrum. a Case Report
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Linking Behavior, Co-Infection Patterns, and Viral Infection Risk with the Whole Gastrointestinal Helminth Community Structure in Mastomys Natalensis
ORIGINAL RESEARCH published: 17 August 2021 doi: 10.3389/fvets.2021.669058 Linking Behavior, Co-infection Patterns, and Viral Infection Risk With the Whole Gastrointestinal Helminth Community Structure in Mastomys natalensis Bram Vanden Broecke 1*, Lisse Bernaerts 1, Alexis Ribas 2, Vincent Sluydts 1, Ladslaus Mnyone 3, Erik Matthysen 1 and Herwig Leirs 1 1 Evolutionary Ecology Group, Department of Biology, University of Antwerp, Antwerp, Belgium, 2 Parasitology Section, Department of Biology, Healthcare and Environment, Faculty of Pharmacy and Food Science, IRBio (Research Institute of Biodiversity), University of Barcelona, Barcelona, Spain, 3 Pest Management Center, Sokoine University of Agriculture, Morogoro, Tanzania Edited by: Yadong Zheng, Infection probability, load, and community structure of helminths varies strongly between Lanzhou Institute of Veterinary and within animal populations. This can be ascribed to environmental stochasticity Research (CAAS), China or due to individual characteristics of the host such as their age or sex. Other, but Reviewed by: Mario Garrido, understudied, factors are the hosts’ behavior and co-infection patterns. In this study, we Ben-Gurion University of the used the multimammate mouse (Mastomys natalensis) as a model system to investigate Negev, Israel Si-Yang Huang, how the hosts’ sex, age, exploration behavior, and viral infection history affects their Yangzhou University, China infection risk, parasitic load, and community structure of gastrointestinal helminths. We Hannah Rose Vineer, hypothesized that the hosts’ exploration behavior would play a key role in the risk for University of Liverpool, United Kingdom infection by different gastrointestinal helminths, whereby highly explorative individuals *Correspondence: would have a higher infection risk leading to a wider diversity of helminths and a larger Bram Vanden Broecke load compared to less explorative individuals. -
Editorial Be Careful What You Eat!
Am. J. Trop. Med. Hyg., 101(5), 2019, pp. 955–956 doi:10.4269/ajtmh.19-0595 Copyright © 2019 by The American Society of Tropical Medicine and Hygiene Editorial Be Careful What You Eat! Philip J. Rosenthal* Department of Medicine, University of California, San Francisco, California The readership of the American Journal of Tropical ingestion of live centipedes.4 Centipedes purchased from the Medicine and Hygiene is well acquainted with the risks of same market used by the patients contained A. cantonensis infectious diseases acquired from foods contaminated with larvae; thus, in addition to slugs, snails, and some other pathogenic viruses, bacteria, protozoans, or helminths due to studied invertebrates, centipedes may be an intermediate improper hygiene. Less familiar may be uncommon infections host for the parasite. The patients appeared to respond to associated with ingestion of unusual uncooked foods, eaten ei- treatment with albendazole and dexamethasone. The value of ther purposely or inadvertantly. A number of instructive examples treatment, which might exacerbate meningitis due to dying have been published in the Journal within the last 2 years; these worms, has been considered uncertain; a recent perspective all involve helminths for which humans are generally not the de- also published in the Journal suggested that treatment early finitive host, but can become ill when they unwittingly become after presentation with disease is advisable to prevent pro- accidental hosts after ingestion of undercooked animal products. gression of illness, including migration of worms to the lungs.5 This issue of the Journal includes two reports on cases of Ingestion of raw centipedes is best avoided. -
Comparative Genomics of the Major Parasitic Worms
Comparative genomics of the major parasitic worms International Helminth Genomes Consortium Supplementary Information Introduction ............................................................................................................................... 4 Contributions from Consortium members ..................................................................................... 5 Methods .................................................................................................................................... 6 1 Sample collection and preparation ................................................................................................................. 6 2.1 Data production, Wellcome Trust Sanger Institute (WTSI) ........................................................................ 12 DNA template preparation and sequencing................................................................................................. 12 Genome assembly ........................................................................................................................................ 13 Assembly QC ................................................................................................................................................. 14 Gene prediction ............................................................................................................................................ 15 Contamination screening ............................................................................................................................ -
Internal Parasites of Sheep and Goats
Internal Parasites of Sheep and Goats BY G. DIKMANS AND D. A. SHORB ^ AS EVERY SHEEPMAN KNOWS, internal para- sites are one of the greatest hazards in sheep production, and the problem of control is a difficult one. Here is a discussion of some 40 of these parasites, including life histories, symptoms of infestation, medicinal treat- ment, and preventive measures. WHILE SHEEP, like other farm animals, suffer from various infectious and noiiinfectious diseases, the most serious losses, especially in farm flocks, are due to internal parasites. These losses result not so much from deaths from gross parasitism, although fatalities are not infre- quent, as from loss of condition, unthriftiness, anemia, and other effects. Devastating and spectacular losses, such as were formerly caused among swine by hog cholera, among cattle by anthrax, and among horses by encephalomyelitis, seldom occur among sheep. Losses due to parasites are much less seni^ational, but they are con- stant, and especially in farai flocks they far exceed those due to bacterial diseases. They are difficult to evaluate, however, and do not as a rule receive the attention they deserve. The principal internal parasites of sheep and goats are round- worms, tapeworms, flukes, and protozoa. Their scientific and com- mon names and their locations in the host are given in table 1. Another internal parasite of sheep, the sheep nasal fly, the grubs of which develop in the nasal pasisages and head sinuses, is discussed at the end of the article. ^ G. Dikmans is Parasitologist and D. A. Sborb is Assistant Parasitologist, Zoological Division, Bureau of Animal Industry. -
The Distribution of Lectins Across the Phylum Nematoda: a Genome-Wide Search
Int. J. Mol. Sci. 2017, 18, 91; doi:10.3390/ijms18010091 S1 of S12 Supplementary Materials: The Distribution of Lectins across the Phylum Nematoda: A Genome-Wide Search Lander Bauters, Diana Naalden and Godelieve Gheysen Figure S1. Alignment of partial calreticulin/calnexin sequences. Amino acids are represented by one letter codes in different colors. Residues needed for carbohydrate binding are indicated in red boxes. Sequences containing all six necessary residues are indicated with an asterisk. Int. J. Mol. Sci. 2017, 18, 91; doi:10.3390/ijms18010091 S2 of S12 Figure S2. Alignment of partial legume lectin-like sequences. Amino acids are represented by one letter codes in different colors. EcorL is a legume lectin originating from Erythrina corallodenron, used in this alignment to compare carbohydrate binding sites. The residues necessary for carbohydrate interaction are shown in red boxes. Nematode lectin-like sequences containing at least four out of five key residues are indicated with an asterisk. Figure S3. Alignment of possible Ricin-B lectin-like domains. Amino acids are represented by one letter codes in different colors. The key amino acid residues (D-Q-W) involved in carbohydrate binding, which are repeated three times, are boxed in red. Sequences that have at least one complete D-Q-W triad are indicated with an asterisk. Int. J. Mol. Sci. 2017, 18, 91; doi:10.3390/ijms18010091 S3 of S12 Figure S4. Alignment of possible LysM lectins. Amino acids are represented by one letter codes in different colors. Conserved cysteine residues are marked with an asterisk under the alignment. The key residue involved in carbohydrate binding in an eukaryote is boxed in red [1]. -
The Influence of Human Settlements on Gastrointestinal Helminths of Wild Monkey Populations in Their Natural Habitat
The influence of human settlements on gastrointestinal helminths of wild monkey populations in their natural habitat Zur Erlangung des akademischen Grades eines DOKTORS DER NATURWISSENSCHAFTEN (Dr. rer. nat.) Fakultät für Chemie und Biowissenschaften Karlsruher Institut für Technologie (KIT) – Universitätsbereich genehmigte DISSERTATION von Dipl. Biol. Alexandra Mücke geboren in Germersheim Dekan: Prof. Dr. Martin Bastmeyer Referent: Prof. Dr. Horst F. Taraschewski 1. Korreferent: Prof. Dr. Eckhard W. Heymann 2. Korreferent: Prof. Dr. Doris Wedlich Tag der mündlichen Prüfung: 16.12.2011 To Maya Index of Contents I Index of Contents Index of Tables ..............................................................................................III Index of Figures............................................................................................. IV Abstract .......................................................................................................... VI Zusammenfassung........................................................................................VII Introduction ......................................................................................................1 1.1 Why study primate parasites?...................................................................................2 1.2 Objectives of the study and thesis outline ................................................................4 Literature Review.............................................................................................7 2.1 Parasites -
Early Developmental Stages of Nematodes Occurring in Swine
EARLY DEVELOPMENTAL STAGES OF NEMATODES OCCURRING IN SWINE By JOSEPH E. ALICATA Junior Zoolofllst Zoological Division Bureau of Animal Industry UNITED STATES DEPARTMENT OF AGRICULTURE, WASHINGTON, D. C. Technical Bulletin No. 489 December 1935 UNITED STATES DEPARTMENT OF AGRICULTURE WASHINGTON, D. C. EARLY DEVELOPMENTAL STAGES OF NEMATODES OCCURRING IN SWINE By JOSEPH E. ALICATA Junior zoologist, Zoological Division, Bureau of Animal Industry CONTENTS Page Morphological and experimental data—Con. Page Introduction 1 Ascaridae. _ 44 Historical résumé 2 Ascaris suum Goeze, 1782 44 General remarks on life histories of groups Trichuridae 47 studied _. 4 Trichuris suis (Schrank, 1788) A. J. Abbreviations and symbols used in illus- Smith, 1908 47 trations __ 5 Trichostrongylidae 51 Morphological and experimental data 5 HyostrongylîLS rubidus (Hassall and Spiruridae 5 Stiles, 1892) HaU,.1921 51 Gongylonema pulchrum Molin, 1857.. 5 Strongylidae. _— — .-. 68 Oesophagostomum dentatum (Ru- Ascarops strongylina (Rudolphi, 1819) dolphi, 1803) Molin, 1861 68 Alicata and Mclntosh, 1933 21 Stephanurus dentatus Diesing, 1839..- 73 Physocephalus sexalatus (Molin, 1860) Strongyloididae 79 Diesing, 1861 27 Strongyloides ransomi Schwartz and Metastrongyhdae 33 AUcata, 1930. 79 Metastrongylus salmi Gedoelst, 1923— 33 Comparative morphology of eggs and third- Metastrongylus elongattbs (Dujardin, stage larvae of some nematodes occurring 1845) Railliet and Henry, 1911 37 in swine 85 Choerostrongylus pudendotectus (Wos- Summary 87 tokow, 1905) Skrjabin, 1924 41 Literature cited 89 INTRODUCTION The object of this bulletin is to present the result^ of an investiga- tion on the early developmental stages of nematodes of common occur- rence in domestic swine. Observations on the stages in the definitive host of two of the nematodes, Gongylonema pulchrum and Hyostrongy- lus rubidus, are only briefly given, however, since little is known of these stages in these nematodes. -
Differing Effects of Standard and Harsh Nucleic Acid Extraction Procedures on Diagnostic Helminth Real-Time Pcrs Applied to Human Stool Samples
pathogens Article Differing Effects of Standard and Harsh Nucleic Acid Extraction Procedures on Diagnostic Helminth Real-Time PCRs Applied to Human Stool Samples Tanja Hoffmann 1, Andreas Hahn 2 , Jaco J. Verweij 3 ,Gérard Leboulle 4, Olfert Landt 4, Christina Strube 5 , Simone Kann 6, Denise Dekker 7 , Jürgen May 7 , Hagen Frickmann 1,2,† and Ulrike Loderstädt 8,*,† 1 Department of Microbiology and Hospital Hygiene, Bundeswehr Hospital Hamburg, 20359 Hamburg, Germany; [email protected] (T.H.); [email protected] or [email protected] (H.F.) 2 Institute for Medical Microbiology, Virology and Hygiene, University Medicine Rostock, 18057 Rostock, Germany; [email protected] 3 Laboratory for Medical Microbiology and Immunology, Elisabeth Tweesteden Hospital, 5042 AD Tilburg, The Netherlands; [email protected] 4 TIB MOLBIOL, 12103 Berlin, Germany; [email protected] (G.L.); [email protected] (O.L.) 5 Institute for Parasitology, Centre for Infection Medicine, University of Veterinary Medicine Hannover, 30559 Hannover, Germany; [email protected] 6 Medical Mission Institute, 97074 Würzburg, Germany; [email protected] 7 Infectious Disease Epidemiology Department, Bernhard Nocht Institute for Tropical Medicine Hamburg, 20359 Hamburg, Germany; [email protected] (D.D.); [email protected] (J.M.) Citation: Hoffmann, T.; Hahn, A.; 8 Department of Hospital Hygiene & Infectious Diseases, University Medicine Göttingen, Verweij, J.J.; Leboulle, G.; Landt, O.; 37075 Göttingen, Germany Strube, C.; Kann, S.; Dekker, D.; * Correspondence: [email protected] May, J.; Frickmann, H.; et al. Differing † Hagen Frickmann and Ulrike Loderstädt contributed equally to this work. Effects of Standard and Harsh Nucleic Acid Extraction Procedures Abstract: This study aimed to assess standard and harsher nucleic acid extraction schemes for on Diagnostic Helminth Real-Time diagnostic helminth real-time PCR approaches from stool samples. -
Larva Migrans Importance Larva Migrans Is a Group of Clinical Syndromes That Result from the Movement of Overview Parasite Larvae Through Host Tissues
Larva Migrans Importance Larva migrans is a group of clinical syndromes that result from the movement of Overview parasite larvae through host tissues. The symptoms vary with the location and extent of the migration. Organisms may travel through the skin (cutaneous larva migrans) or internal organs (visceral larva migrans). Some larvae invade the eye (ocular larva migrans). Each form of the disease can be caused by a number of organisms. The Last Updated: December 2013 syndromes are loosely defined and the list of causative agents varies with the author. Cutaneous Larva Migrans Larval migration in the skin of the host causes cutaneous larva migrans. These infections are often acquired by skin contact with environmental sources of larvae, such as the soil. The larvae cause a pruritic, migrating dermatitis as they travel through the skin. Many of these infections are self-limiting. Animal hookworms are the most common cause of cutaneous larva migrans in humans. Ancylostoma braziliense is the most important species. Less often, cutaneous larva migrans is caused by A. caninum, A.,ceylanicum, A. tubaeforme, Uncinaria stenocephala or Bunostomum phlebotomum. In their usual hosts, the entry of hookworm larvae into the skin is followed by penetration of the dermis. In the dermis, the larvae enter via veins or lymphatic vessels, eventually reach the blood, and migrate through the lungs before reaching the intestines, where they mature into adults. In abnormal hosts such as humans, zoonotic hookworms can enter the epidermis, but most species cannot readily penetrate the dermis. Instead, these larvae remain trapped in the skin. and migrate for a time in the epidermis before dying. -
Appendix I. Therapeutic Recommendations (Reprinted from the Medical Letter) the Medical Letter® on Drugs and Therapeutics
Appendix I. Therapeutic Recommendations (Reprinted from The Medical Letter) The Medical Letter® On Drugs and Therapeutics Published by The Medical Letter, Inc .• 1000 Main Street, New Rochelle, NY. 10801 • A Nonprofit Publication Vol. 35 (Issue 911) December 10, 1993 DRUGS FOR PARASITIC INFECTIONS Parasitic infections are found throughout the world. With increasing travel, immigration, use of immunosuppressive drugs, and the spread of AIDS, physicians anywhere may see infections caused by previously unfamiliar parasites. The table below lists first-choice and alternative drugs for most parasitic infections. Adverse effects of antiparasitic drugs are listed on page 120. For information on the safety of antiparasitic drugs in pregnancy, see The Medical Letter Handbook of Antimicrobial Therapy, 1992, page 151. DRUGS FOR TREATMENT OF PARASITIC INFECTIONS Infection Drug Adult Dosage* Pediatric Dosage* AMEBIASIS (Entamoeba histolytica) a.ymptomatlc Drug of choice: lodoquinol' 650 mg tid x 20d 30-40 mg/kg/d in 3 doses x 20d OR Paromomycin 25-30 mg/kg/d in 3 doses x 7d 25-30 mg/kg/d in 3 doses x 7d Alternative: Diloxanide furoate' 500 mg tid x 10d 20 mg/kg/d in 3 doses x 10d mild to mod.rat. Int•• tlnal dl••••• Drugs of choice:3 Metronidazole 750 mg tid x 10d 35-50 mg/kg/d in 3 doses x 10d OR Tinidazole' 2 grams/d x 3d 50 mg/kg (max. 2 grams) qd x 3d s.v.r. Int•• tlnal dis.as. Drugs of choice:3 Metronidazole 750 mg tid x 10d 35-50 mg/kg/d in 3 doses x 10d OR Tinidazole' 600 mg bid x 5d 50 mg/kg (max. -
Helminth Parasites Among Rodents in the Middle East Countries: a Systematic Review and Meta-Analysis
animals Review Helminth Parasites among Rodents in the Middle East Countries: A Systematic Review and Meta-Analysis Md Mazharul Islam 1,2,* , Elmoubashar Farag 3,*, Mohammad Mahmudul Hassan 4, Devendra Bansal 3, Salah Al Awaidy 5, Abdinasir Abubakar 6 , Hamad Al-Romaihi 3 and Zilungile Mkhize-Kwitshana 7,8 1 Department of Animal Resources, Ministry of Municipality and Environment, Doha, P.O. Box 35081, Qatar 2 School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu Natal, Durban 4000, South Africa 3 Ministry of Public Health, Doha, P.O. Box 42, Qatar; [email protected] (D.B.); [email protected] (H.A.-R.) 4 Faculty of Veterinary Medicine, Chattogram Veterinary and Animal Sciences University, Khulshi, Chattogram 4225, Bangladesh; [email protected] 5 Ministry of Health, P.O. Box 393, PC 113 Muscat, Oman; [email protected] 6 Infectious Hazard Preparedness (IHP) Unit, WHO Health Emergencies Department (WHE), World Health Organization, Regional Office for the Eastern Mediterranean, Cairo 11371, Egypt; [email protected] 7 School of Life Sciences, College of Agriculture, Engineering & Science, University of KwaZulu Natal, Durban 40000, South Africa; [email protected] 8 South African Medical Research Council, Cape Town 7505, South Africa * Correspondence: [email protected] (M.M.I.); [email protected] (E.F.); Tel.: +974-66064382 (M.M.I.); +974-55543816 or +974-44070396 (E.F.) Received: 3 October 2020; Accepted: 30 October 2020; Published: 9 December 2020 Simple Summary: The review was conducted to establish an overview of rodent helminths in the Middle East as well as their public health importance. -
Zoonotic Infections – an Overview
14.1 CHAPTER 14 Zoonotic infections – an overview John M. Goldsmid 14.1 INTRODUCTION Zoonotic infections can be defined as infections of animals that are naturally transmissible to humans. As such they are worldwide and often spread with humans through their companion and domestic animals. However, when humans move to new areas or come into contact with different animal species (eg moving into newly cleared natural forest areas), then new zoonoses may emerge or are recognised, and it is significant that many of the new or newly recognised emerging infections of humans are zoonotic in origin1. The probable reasons for the emergence of new zoonotic diseases are many and include, as described by McCarthy and Moore2 for the Helminth zoonoses: “changes in social, dietary or cultural mores, environmental changes, and the improved recognition of heretofore neglected infections often coupled with an improved ability to diagnose infection”. Zoonotic infections may be very localised in their distribution and often reflect particular associations between the natural reservoir hosts and humans – they are thus often influenced by human dietary habits, behaviour and relationships with different animal species. For the practising physician, the knowledge that a disease is zoonotic, is of particular significance in the differential diagnosis (hence the need in all history taking, of asking the question of contact with animals), and in the prevention and control of such diseases. A list of the more important/significant zoonotic infections is given in Table 1 which also outlines the aetiological agent of the disease; its usual animal reservoir host and rough geographical distribution. In some cases, where the vector may serve as a reservoir, it is included under reservoir hosts.