Duquesne University Duquesne Scholarship Collection Electronic Theses and Dissertations 2013 Classical Antifolates: Synthesis of 5-Substituted, 6-Substituted and 7-Substituted Pyrrolo[2,3-d]Pyrimidines as Targeted Anticancer Therapies Yiqiang Wang Follow this and additional works at: https://dsc.duq.edu/etd Recommended Citation Wang, Y. (2013). Classical Antifolates: Synthesis of 5-Substituted, 6-Substituted and 7-Substituted Pyrrolo[2,3-d]Pyrimidines as Targeted Anticancer Therapies (Doctoral dissertation, Duquesne University). Retrieved from https://dsc.duq.edu/etd/1335 This Immediate Access is brought to you for free and open access by Duquesne Scholarship Collection. It has been accepted for inclusion in Electronic Theses and Dissertations by an authorized administrator of Duquesne Scholarship Collection. For more information, please contact
[email protected]. CLASSICAL ANTIFOLATES: SYNTHESIS OF 5-SUBSTITUTED, 6-SUBSTITUTED AND 7-SUBSTITUTED PYRROLO[2,3- d]PYRIMIDINES AS TARGETED ANTICANCER THERAPIES A Dissertation Submitted to the Graduate School of Pharmaceutical Sciences Duquesne University In partial fulfillment of the requirements for the degree of Doctor of Philosophy By Yiqiang Wang May 2013 Copyright by Yiqiang Wang 2013 Name: Yiqiang Wang Dissertation: CLASSICAL ANTIFOLATES: SYNTHESIS OF 5-SUBSTITUTED, 6-SUBSTITUTED AND 7-SUBSTITUTED PYRROLO[2,3-d]PYRIMIDINES AS TARGETED ANTICANCER THERAPIES Degree: Doctor of Philosophy Date Feb 06, 2013 APPROVED & ACCEPTED Aleem Gangjee, Ph.D. (Committee Chair) Professor of Medicinal Chemistry Mylan School of Pharmacy Distinguished Professor Graduate School of Pharmaceutical Sciences Duquesne University, Pittsburgh, Pennsylvania APPROVED Marc W. Harrold, Ph.D. (Committee Member) Professor of Medicinal Chemistry Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, Pennsylvania APPROVED Patrick T.