Maternal and Paternal Depression Symptoms During NICU Stay and Transition Home
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Prepublication Release Maternal and Paternal Depression Symptoms During NICU Stay and Transition Home Craig F. Garfield, MD, MAPP, Young S. Lee, PhD, Liam Warner-Shifflett, Rebecca Christie, MA, Kathryn Jackson, MA, Emily Miller, MD DOI: 10.1542/peds.2020-042747 Journal: Pediatrics Article Type: Regular Article Citation: Garfield CF, Lee YS, Warner-Shifflett L, Christie R, Jackson K, Miller E. Maternal and paternal depression symptoms during NICU stay and transition home. Pediatrics. 2021; doi: 10.1542/peds.2020-042747 This is a prepublication version of an article that has undergone peer review and been accepted for publication but is not the final version of record. This paper may be cited using the DOI and date of access. This paper may contain information that has errors in facts, figures, and statements, and will be corrected in the final published version. The journal is providing an early version of this article to expedite access to this information. The American Academy of Pediatrics, the editors, and authors are not responsible for inaccurate information and data described in this version. Downloaded from©202 www.aappublications.org/news1 American Academy by of guest Pediatrics on September 24, 2021 Prepublication Release Maternal and Paternal Depression Symptoms During NICU Stay and Transition Home Craig F. Garfield, MD, MAPPa,b, Young S. Lee, PhDb, Liam Warner-Shifflettb, Rebecca Christie, MAb, Kathryn Jackson, MAb, Emily Miller, MDb Affiliations aAnn and Robert H. Lurie Children’s Hospital of Chicago, bNorthwestern University Feinberg School of Medicine Address Correspondence Craig Garfield, Professor of Pediatrics, Feinberg School of Medicine, 633 St. Clair, Suite 19- 059, Chicago, IL 60611, [[email protected]], 312-503-5465 Conflict of Interest Disclosures The authors have no conflicts of interest relevant to this article to disclose. Funding/Support All phases of this study were supported by Friends of Prentice Role of Funder/Sponsor The funders did not influence in any way the outcomes or reporting of the findings in this study. Clinical Trial Registration Registry number: NCT03505424 https://clinicaltrials.gov/ct2/show/NCT03505424 Abbreviations Neonatal Intensive Care Unit (NICU), Postpartum Depression (PPD), Edinburgh Postpartum Depression Scale (EPDS), Length of Stay (LOS), Gestational Age (GA), Receiver Operating Characteristic curves (ROCs), Area Under the Curve (AUC) Downloaded from©202 www.aappublications.org/news1 American Academy by of guest Pediatrics on September 24, 2021 Prepublication Release Article Summary Measuring mothers’ and fathers’ depressive symptoms from the NICU to home, this study examines differences and similarities in scores and probability across the transition home. What’s Known on This Subject Parents with premature infants face an increased risk of poor emotional functioning, anxiety, and mood disorders which can alter parenting and child outcomes. The trajectory of maternal and paternal depressive symptoms from NICU to home is not well understood. What This Study Adds In this prospective longitudinal cohort study of 431 mothers and fathers, 33% of mothers and 17% of fathers screened positive for depressive symptoms initially. The probability of reporting depressive symptoms decreased significantly for mothers but not for fathers once home. Contributors’ Statement: Craig F. Garfield: Dr. Garfield conceptualized and designed the study, coordinated and supervised data analysis, drafted the initial manuscript, reviewed and critically revised the manuscript and approved the final manuscript as submitted. Young S. Lee: Dr. Lee conceptualized and designed the study, carried out the initial analyses, reviewed and critically revised the manuscript, and approved the final manuscript as submitted. Liam Warner-Shifflett: Mr. Warner-Shifflett carried out the initial analyses, designed the data collection, reviewed and critically revised the manuscript, and approved the final manuscript as submitted. Katheryn Jackson: Ms. Jackson coordinated and supervised data analysis, reviewed and critically revised the manuscript, and approved the final manuscript as submitted. Rebecca Christie: Ms. Christie made substantial contributions to conception and design, coordinated and supervised data analysis, reviewed and critically revised the manuscript, and approved the final manuscript as submitted. Emily Miller: Dr. Miller made substantial contributions to conception and design, reviewed and critically revised the manuscript, and approved the final manuscript as submitted. All authors approved the final manuscript as submitted and agree to be accountable for all aspects of the work. Downloaded from©202 www.aappublications.org/news1 American Academy by of guest Pediatrics on September 24, 2021 Prepublication Release ABSTRACT Objective: To examine the trajectory and risk factors of depression symptoms among parents from NICU admission to 30-days post discharge. We hypothesized depression symptom scores would decrease from admission and then increase from discharge to 30-days. Methods: Prospective longitudinal cohort study of premature infants (<37 weeks gestational age) in NICU. English-speaking parents, irrespective of their relationship status/type, completed the validated Edinburgh Postpartum Depression Scale (EPDS) at four time points: NICU admission, discharge, 14-days and 30-days post-discharge. EPDS score change across time and probability of a positive screen (EPDS ≥ 10) were assessed using mixed effect regression models. Results: Of 431 parents enrolled [mothers, n=230 (53%)], 33% of mothers (n=57) and 17% of fathers (n=21) had a positive EPDS screening. Scores change was 1.9 points different between mothers and fathers [CI: (1.3,2.6); p<0.0001)] with mothers decreasing 2.9 points [CI: (2.1,3.7); p<0.0001)] and fathers decreasing 1.0 points [CI: (0.1, 2.0); p=0.04)]. Over time, mothers decreased 10.96 times [CI: (2.99,38.20); p=0.0003] while fathers decreased at a lower and non- significant rate [0.99 times (CI: (0.26,3.79), (p=0.9854)]. Admission or discharge screening improved 30-day depressive symptom prediction (AUC 0.66 baseline demographics only vs 0.84+initial (p<0.0001), and vs 0.80+discharge screening (p<0.001). Conclusions and Relevance: Mothers and fathers experience different depressive symptom trajectories from NICU to home. Screening parents for PPD during the NICU stay is likely to result in improved identification of parents at-risk for PPD after discharge. Focused attention on fathers appears warranted. Downloaded from©202 www.aappublications.org/news1 American Academy by of guest Pediatrics on September 24, 2021 Prepublication Release Introduction The neonatal intensive care unit (NICU) can be challenging for parents to navigate with their medically vulnerable infants. Parents of NICU infants may be predisposed to poor emotional functioning, anxiety, and mood disorders.1 “Pervasive uncertainty” was the phrase one qualitative study used to describe parents’ feelings from NICU discharge to home.2 While postpartum depression (PPD) is one of the most common complications of childbirth among mothers in general,3,4 parents in the NICU may have higher risks related to their infants’ medical vulnerability or the stress of a NICU stay.5 Mothers of premature infants PPD risk (28%-40%)6 is nearly double that of mothers of full-term infants, with rates typically decreasing over time yet remaining higher in the infant’s first year.7-9 Paternal PPD has received less attention10,11 despite a prevalence of 5-13% among fathers of full term infants.9,12-14 Paternal PPD among fathers with premature infants is less studied15 with recent literature concluding that paternal PPD among the premature population is 2%-19% higher than the rate among fathers of full-term infants in immediate postnatal period.9 Stress, self-reported and measured physiologically via salivary cortisol, is noted to increase as fathers transition with their infants from the NICU to home and may become a risk for increased depression16,17. While this research provides insight into the time-dependent risk of parental PPD, few studies have examined the trajectory of depression among large numbers of both parents through key clinical transition periods such as NICU admission, discharge, and at home. The importance of examining parental mental health is highlighted by its connection to childhood developmental outcomes. A 2019 American Academy of Pediatrics technical report conveyed the extensive evidence that adverse childhood experiences, such as parental Downloaded from©202 www.aappublications.org/news1 American Academy by of guest Pediatrics on September 24, 2021 Prepublication Release depression, may have long-lasting impacts on a child’s development and general health.3 In fact, maternal PPD and psychological distress is likely to increase a child’s risk for delayed or impaired cognitive, emotional, and linguistic development as well as subsequent behavioral problems.4,18 More recent research reveals that paternal PPD detrimentally influences parenting and positive enrichment activities such as reading and telling stories.19,20 Paternal PPD has also been associated with subsequent child behavioral and emotional problems,21 with one study reporting depressed fathers are more likely to spank their 1-year-old children.20 Even while evidence supports the linkage between parental mental health, childhood development, and the emotionally taxing NICU environment, the trajectory of maternal and paternal depression symptoms