UP-REGULATED UPON TGF-BETA TREATMENT UniGene Name UniGene Symbol Fold change Fold change number (MEAN) (STDE) of biological replicates periostin, osteoblast specific factor POSTN 54.44 5.38 n=4 fibronectin 1 FN1 7.96 0.98 n=4 formyl peptide receptor 1 /// formyl peptide receptor 1 FPR1 6.43 0.79 n=4 alcohol dehydrogenase IB (class I), beta polypeptide ADH1B 6.4 2.55 n=4 CD24 antigen (small cell lung carcinoma cluster 4 antigen) CD24 5.02 0.6 n=4 membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase, CALLA, CD10) MME 4.61 1.28 n=3 wingless-type MMTV integration site family, member 5A /// wingless-type MMTV integration site family, member 5A WNT5A 4.46 0.16 n=4 sulfatase 1 SULF1 4.39 0.27 n=4 dickkopf homolog 1 (Xenopus laevis) DKK1 3.96 1.05 n=4 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) CXCL1 3.77 1.03 n=3 immunoglobulin superfamily, member 4B IGSF4B 3.43 0.21 n=4 integrin, alpha 10 ITGA10 3.15 0.57 n=4 insulin-like growth factor binding 7 IGFBP7 2.7 0.4 n=3 decorin DCN 2.65 0.23 n=4 fibroblast activation protein, alpha FAP 2.65 0.35 n=4 sushi-repeat-containing protein, X-linked SRPX 2.57 0.28 n=4 chondroitin sulfate proteoglycan 2 (versican) CSPG2 2.53 0.2 n=4 collagen, type IV, alpha 2 COL4A2 2.52 0.14 n=4 5 FBLN5 2.31 0.2 n=4 serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 SERPINE2 2.29 0.25 n=4 follistatin-like 1 FSTL1 2.24 0.06 n=4 secreted protein, acidic, cysteine-rich () /// secreted protein, acidic, cysteine-rich (osteonectin) SPARC 2.24 0.32 n=4 collagen, type VI, alpha 1 COL6A1 2.07 0.1 n=4 growth arrest and DNA-damage-inducible, beta GADD45B 2.04 0.1 n=4 sushi, nidogen and EGF-like domains 1 SNED1 2.02 0.09 n=3 collagen, type IV, alpha 1 COL4A1 1.99 0.06 n=4 interferon-stimulated transcription factor 3, gamma 48kDa ISGF3G 1.91 0.09 n=3 golgin-67 GOLGIN-67 1.88 0.08 n=3

DOWN-REGULATED GENES UPON TGF-BETA TREATMENT UniGene Name UniGene Symbol Fold change Fold change number (MEAN) (STDE) of biological replicates keratin 15 KRT15 -9.45 -3.75 n=3 carbonic anhydrase II CA2 -5.01 -0.24 n=4 FXYD domain containing ion transport regulator 3 FXYD3 -3.48 -0.36 n=4 plasminogen activator, tissue PLAT -3.19 -0.61 n=4 fibroblast growth factor binding protein 1 FGFBP1 -3.07 -0.64 n=3 tumor-associated calcium signal transducer 1 TACSTD1 -2.71 -0.14 n=4 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 ST6GALNAC2 -2.33 -0.22 n=4 coxsackie virus and adenovirus receptor CXADR -2.3 -0.13 n=4 proprotein convertase subtilisin/kexin type 1 PCSK1 -1.98 -0.14 n=3 glycine dehydrogenase (decarboxylating; glycine decarboxylase, glycine cleavage system protein P) GLDC -1.92 -0.1 n=3 suppression of tumorigenicity 14 (colon carcinoma, matriptase, epithin) ST14 -1.92 -0.08 n=3 1, type 1, E-cadherin (epithelial) CDH1 -1.9 -0.06 n=3 palmdelphin PALMD -1.9 -0.02 n=3 S100 calcium binding protein A8 ( A) S100A8 -1.84 -0.04 n=3 cordon-bleu homolog (mouse) COBL -1.83 -0.03 n=3