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Supplemental Material Full list of significant differences in basal corticolimbic gene expression between C57BL/6J and DBA/2J vmPFC Amygdala Hippocampus C w_B6 w_B6 w_B6 C_B6vD2 y_B6vD2 ymbol ymbol ymbol t_mPF t_Am t_Hip_B6vD2 obeID_vmPF obeID_AMY obeID es es es old_High/Lo old_High/Lo old_High/Lo t t t Pr Gene_ID Gene_S t F Pr Gene_ID Gene_S t F Pr Gene_ID Gene_S t F 5720687 193742 Bat5 0.000000006 37.4 580736 101359 D330027H18Rik 0.0000002 13.9 7510148 233802 Thumpd1 0.0000005 17.7 106900020 18203 Ntan1 0.0000005 16.9 3710040 21952 Tnni1 0.0000002 2.1 106900020 18203 Ntan1 0.0000005 14.3 2940468 20713 Serpini1 0.0000006 38.1 2340239 54218 B3galt4 0.0000003 1.9 630091 73103 3110009E18Rik 0.0000008 ‐1.7 105690524 54722 Dfna5h 0.0000008 3.1 60577 12371 Casp9 0.0000006 11.7 104560161 17276 Mela 0.0000008 ‐76.4 1940280 233489 Picalm 0.000001 6.9 105390397 68585 Rtn4 0.0000008 ‐4.5 5390278 66526 2210012G02Rik 0.000001 2.6 101230408 22651 Zfp125 0.000001 6.6 1580097 233532 Rsf1 0.0000009 6.2 101850039 108686 Ccdc88a 0.000002 ‐9.2 100870215 16569 Kif3b 0.000002 8.5 60538 67529 Fgfr1op2 0.0000009 32.8 2970047 102060 Gadd45gip1 0.000002 ‐4.1 5340577 21672 Prdx2 0.000002 34.0 104560161 17276 Mela 0.000001 ‐77.7 101050546 654818 C030030A07Rik 0.000003 14.6 1240142 223696 Tomm22 0.000002 21.4 1980148 319259 9930021D14Rik 0.000001 ‐4.6 4670091 16651 Sspn 0.000003 12.2 106350020 75547 Akap13 0.000002 12.6 5720687 193742 Bat5 0.000002 40.8 5550020 14127 Fcer1g 0.000003 18.8 104070239 C230053E11Rik 0.000003 11.6 4560112 269400 Rtel1 0.000002 2.3 105080204 70402 2310056B04Rik 0.000005 6.8 5550020 14127 Fcer1g 0.000003 21.0 2650154 329504 Lcmt2 0.000003 3.2 104280450 74513 Neto2 0.000005 ‐1.6 60204 80891 Msr2 0.000005 9.3 5340577 21672 Prdx2 0.000003 36.5 101410746 94184 Pdxdc1 0.000005 20.2 102450035 67464 Entpd4 0.000005 8.2 7100026 75578 Fggy 0.000003 8.0 1980148 319259 9930021D14Rik 0.000006 ‐5.0 101410746 94184 Pdxdc1 0.000006 22.6 840079 53614 Reck 0.000004 2.9 1500142 20463 Cox7a2l 0.000006 36.5 105910039 214253 Etnk2 0.000006 14.0 100670538 D130052N13Rik 0.000004 30.3 101980600 LOC381946 0.000007 12.5 6520239 14043 Ext2 0.000007 1.6 105570333 24012 Rgs7 0.000004 6.0 1240411 74015 Fcho1 0.000007 ‐3.0 510315 20017 Rpo1‐2 0.000008 6.6 4670091 16651 Sspn 0.000005 7.8 2570162 94091 Trim11 0.000009 11.0 4210048 56365 Clcnkb 0.000008 ‐1.7 5550020 14127 Fcer1g 0.000005 19.5 50195 117592 B3galt6 0.000009 6.4 101940711 791292 ENSMUSG00000054123 0.000008 ‐2.7 50195 117592 B3galt6 0.000005 7.7 510315 20017 Rpo1‐2 0.000009 4.2 103060537 791088 ENSMUSG00000052691 0.000009 3.3 1090280 74196 Ttc27 0.000006 18.0 2190725 14964 H2‐D1 0.000009 ‐13.7 7510148 233802 Thumpd1 0.00001 16.0 6370114 67398 Srpr 0.000006 3.7 4070333 229211 Acad9 0.00001 ‐2.2 2690711 19175 Psmb6 0.00001 40.0 1570546 56392 Shoc2 0.000007 ‐6.2 5340577 21672 Prdx2 0.00001 24.8 6370114 67398 Srpr 0.00001 4.3 2650020 229228 Nudt6 0.000007 5.2 4390398 57376 Smarce1 0.00001 ‐2.7 104560161 17276 Mela 0.00001 ‐91.3 1580079 98258 Txndc9 0.000008 ‐1.9 106400035 79554 BC002216 0.00001 ‐9.7 102630056 66236 1500011B03Rik 0.00001 7.4 104150273 26570 Slc7a11 0.000008 3.7 106130162 17756 Mtap2 0.00001 13.4 3140129 67527 ILM3140129 0.00001 6.3 6660086 69577 Fastkd3 0.000009 5.1 2650685 215615 Rnpep 0.00001 2.1 60577 12371 Casp9 0.00001 12.1 460168 100213 Rusc2 0.000009 8.9 2230491 20674 Sox2 0.00001 ‐2.2 5270066 242747 MGC67181 0.00001 4.6 105910364 233103 4931406P16Rik 0.000009 2.5 1240075 19944 Rpl29 0.00001 7.0 1240075 19944 Rpl29 0.00001 5.9 2370563 67742 Samsn1 0.00001 2.8 100610632 217449 Ttc15 0.00001 1.7 2470685 79560 Ublcp1 0.00002 2.2 1500142 20463 Cox7a2l 0.00001 38.9 104920164 16554 Kif13b 0.00001 2.5 1580097 233532 Rsf1 0.00002 5.5 2260093 52443 Mrpl48 0.00001 6.8 106940014 319504 Nrcam 0.00001 11.1 1500142 20463 Cox7a2l 0.00002 33.0 5550156 20238 Atxn1 0.00001 5.3 5720687 193742 Bat5 0.00001 45.8 5910411 14760 Gpr19 0.00002 ‐2.7 103170273 LOC331139 0.00001 34.9 106860014 52535 Mett11d1 0.00002 5.7 5360487 27049 Etv3 0.00002 1.8 102810739 71263 Mro 0.00001 5.6 106350670 14210 Fin15 0.00002 5.0 1990451 21754 Tesk1 0.00002 17.9 105050176 66447 Mgst3 0.00001 3.7 6100075 328399 A930018M24Rik 0.00002 ‐3.4 103940079 78579 D530043N20Rik 0.00002 4.0 2260035 241919 Slc7a14 0.00001 ‐2.9 4230110 108073 Grm7 0.00002 ‐5.0 102060075 380706 LOC237831 0.00002 2.5 2940468 20713 Serpini1 0.00001 18.2 100050129 67464 Entpd4 0.00002 1.9 3140341 27267 Cars 0.00002 4.0 60204 80891 Msr2 0.00002 10.7 6510097 11546 Parp2 0.00002 2.8 103850064 14751 Gpi1 0.00002 2.3 105890324 66223 Mrpl35 0.00002 3.7 6900239 282619 Sbsn 0.00002 7.7 4010040 67304 3110070M22Rik 0.00002 1.6 104280605 21340 Taf1b 0.00002 11.3 5910411 14760 Gpr19 0.00002 ‐2.6 106020113 94062 Mrpl3 0.00002 4.9 106130162 17756 Mtap2 0.00002 21.5 2260121 66460 Sys1 0.00002 ‐2.2 5550403 78274 5330430C04Rik 0.00002 ‐1.3 104050563 19301 Pxmp2 0.00002 6.8 3520687 26951 Zw10 0.00002 1.4 102320746 27395 Mrpl15 0.00002 3.2 104670037 A830085I22Rik 0.00002 4.3 460168 100213 Rusc2 0.00002 6.3 1410446 75423 Arl5a 0.00003 11.7 460138 67216 Mboat2 0.00002 11.2 2690711 19175 Psmb6 0.00002 40.4 106400035 79554 BC002216 0.00003 ‐9.1 106770035 LOC243902 0.00002 4.0 102120139 5430404N14Rik 0.00002 5.3 5340100 69681 Cdk3 0.00003 1.5 1990451 21754 Tesk1 0.00002 23.1 5270671 17183 Matn4 0.00002 ‐3.9 105130184 100177 Zmym6 0.00003 6.2 104590600 99946 6720422M22Rik 0.00002 2.9 106020102 71513 9030607L20Rik 0.00002 5.9 2340440 259277 Klk8 0.00003 ‐4.6 6840056 22163 Tnfrsf4 0.00002 1.8 1780520 107581 Col16a1 0.00003 ‐2.8 6900239 282619 Sbsn 0.00003 10.7 100360465 414758 5830428H23Rik 0.00002 7.7 2650433 233066 AI428936 0.00003 1.8 103840575 68915 Vars2 0.00003 3.9 3840403 192650 Cabp7 0.00002 ‐2.2 60577 12371 Casp9 0.00003 9.8 106350670 14210 Fin15 0.00003 4.9 6350725 58248 1700123O20Rik 0.00002 4.5 3440048 53886 Cdkl2 0.00003 26.4 3800132 22222 Ubr1 0.00003 ‐2.9 6200048 66147 Necap2 0.00002 13.4 6660440 66628 Thg1l 0.00003 ‐3.4 940433 69367 Glrx2 0.00003 ‐1.6 670403 57357 Srd5a2l 0.00002 1.6 106040451 0.00003 ‐2.0 1980538 66567 2510022D24Rik 0.00004 4.0 101410746 94184 Pdxdc1 0.00002 19.4 3170204 244141 Nars2 0.00003 2.1 4670091 16651 Sspn 0.00003 10.6 106900020 18203 Ntan1 0.00002 18.3 105360301 72919 2900019A20Rik 0.00003 4.8 104150390 76816 Sdccag8 0.00004 ‐1.4 104070239 C230053E11Rik 0.00002 11.6 2360397 12042 Bcl10 0.00003 2.0 100050739 381538 Gm1027 0.00004 ‐5.0 6650324 21969 Top1 0.00002 ‐1.3 270139 99138 Stard7 0.00003 8.0 100460068 68699 1110033F14Rik 0.00004 2.8 2190725 14964 H2‐D1 0.00003 ‐9.2 106940019 20019 Rpo1‐4 0.00003 3.6 4670113 52123 Agpat5 0.00004 4.2 2320471 192136 5033411D12Rik 0.00003 2.0 1230053 215418 Axud1 0.00003 4.8 104280605 21340 Taf1b 0.00004 10.3 105910039 214253 Etnk2 0.00003 4.3 4060112 Krt1‐12 0.00003 4.6 5550400 72355 2210021J22Rik 0.00005 2.4 2480411 24135 Zfp68 0.00003 6.7 5900576 68342 Ndufb10 0.00003 12.5 2570162 94091 Trim11 0.00005 6.6 2690711 19175 Psmb6 0.00003 45.7 100630047 17933 Myt1l 0.00003 6.2 101500576 67201 Glod4 0.00005 4.7 101400180 329506 Ctdspl2 0.00003 3.1 104070239 C230053E11Rik 0.00004 7.9 2190725 14964 H2‐D1 0.00006 ‐13.9 6770037 65956 Ccl21c 0.00003 6.6 102120504 14312 Brd2 0.00004 2.4 103140193 5033414D05Rik 0.00006 3.6 3140129 67527 ILM3140129 0.00003 2.9 2900619 216635 Hbq1 0.00004 ‐3.6 101450400 56077 Dgke 0.00006 3.6 106350020 75547 Akap13 0.00003 6.0 2370044 116904 Alpk3 0.00004 ‐1.5 105340348 20515 Slc20a1 0.00006 6.9 106760253 16898 Rps2 0.00003 ‐12.5 103060039 LOC381212 0.00004 ‐3.2 107000132 23972 Papss2 0.00006 5.9 6520253 235574 Atp2c1 0.00003 8.1 6130180 11610 Agtrap 0.00004 4.1 610538 75541 1700019G17Rik 0.00006 3.0 102360600 238130 Dock4 0.00003 3.0 1780338 83965 Enpp5 0.00004 23.6 6660086 69577 Fastkd3 0.00007 4.2 6380280 193838 Eme2 0.00003 6.9 2940468 20713 Serpini1 0.00004 13.0 460138 67216 Mboat2 0.00007 8.8 6900010 22689 Zfp27 0.00003 3.7 100580408 59069 Tpm3 0.00005 1.7 104590600 99946 6720422M22Rik 0.00007 2.9 106760215 67412 C6orf174 0.00004 14.1 1780138 93695 Gpnmb 0.00005 8.4 100630484 320452 P4ha3 0.00007 ‐1.5 106770110 77480 Kidins220 0.00004 5.9 4200035 399558 Flrt2 0.00005 ‐2.3 2510259 12238 Commd3 0.00007 2.4 6380332 67157 2610301B20Rik 0.00004 3.0 2650278 12331 Cap1 0.00005 ‐2.3 106550458 78785 Clip4 0.00007 ‐1.3 100070215 D030041G16Rik 0.00004 4.0 102850408 105450 Mmrn2 0.00005 ‐1.6 6200048 66147 Necap2 0.00008 10.6 106100731 23971 Papss1 0.00004 2.1 105890239 19737 Rgs5 0.00005 ‐2.2 4480092 12804 Cntfr 0.00008 6.2 101050546 654818 C030030A07Rik 0.00004 8.4 2450619 54709 Eif3i 0.00005 2.5 1780338 83965 Enpp5 0.00008 23.8 7510148 233802 Thumpd1 0.00004 19.9 106760215 67412 C6orf174 0.00006 14.0 6350725 58248 1700123O20Rik 0.00008 5.0 5690725 56350 Arl3 0.00004 12.0 107000132 23972 Papss2 0.00006 7.0 106770035 LOC243902 0.00008 4.3 106180717 13171 Dbt 0.00004 9.1 5050338 20298 Ccl21a 0.00006 5.3 103390025 68427 Slc39a13 0.00008 ‐3.2 3190095 12452 Ccng2 0.00004 7.9 6840019 78928 Pigt 0.00006 ‐6.9 270139 99138 Stard7 0.00008 8.1 1450102 76688 Arfrp1 0.00004 ‐1.6 102630056 66236 1500011B03Rik 0.00006 9.7 4010619 21672 Prdx2 0.00008 4.7 1770458 72098 Tmem68 0.00005 3.7 6650520 242747 MGC67181 0.00006 4.6 2480411 24135 Zfp68 0.00008 6.4 5220088 216049 Zfp365 0.00005 2.4 2940524 69470 Tmem127 0.00006 1.3 5700605 72999 Insig2 0.00008 4.5 1980176 68350 0610009K11Rik 0.00005 8.8 6370114 67398 Srpr 0.00006 4.9 6020601 57315 Wdr46 0.00009 2.3 1240142 223696 Tomm22 0.00005 17.5 105080746 LOC239727 0.00006 ‐3.1 103170377 19270 Ptprg 0.00009 2.6 103060537 791088 ENSMUSG00000052691 0.00005 3.2 60538 67529 Fgfr1op2
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