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Predominant Mycotoxins, Pathogenesis, Control Measures, and Detection Methods in Fermented Pastes
toxins Review Predominant Mycotoxins, Pathogenesis, Control Measures, and Detection Methods in Fermented Pastes Guozhong Zhao 1, Yi-Fei Wang 1, Junling Chen 2 and Yunping Yao 1,* 1 State Key Laboratory of Food Nutrition and Safety, Key Laboratory of Food Nutrition and Safety, Ministry of Education, College of Food Science and Engineering, Tianjin University of Science & Technology, 300457 Tianjin, China; [email protected] (G.Z.); [email protected] (Y.-F.W.) 2 College of Food and Bioengineering, Henan University of Science and Technology, 471023 Luoyang, China; [email protected] * Correspondence: [email protected]; Tel.: +86-22-6091-2585 Received: 2 January 2020; Accepted: 21 January 2020; Published: 23 January 2020 Abstract: Fermented pastes are some of the most popular traditional products in China. Many studies reported a strong possibility that fermented pastes promote exposure to mycotoxins, including aflatoxins, ochratoxins, and cereulide, which were proven to be carcinogenic and neurotoxic to humans. The primary mechanism of pathogenicity is by inhibiting protein synthesis and inducing oxidative stress using cytochrome P450 (CYP) enzymes. The level of mycotoxin production is dependent on the pre-harvest or post-harvest stage. It is possible to implement methods to control mycotoxins by using appropriate antagonistic microorganisms, such as Aspergillus niger, Lactobacillus plantarum, and Saccharomyces cerevisiae isolated from ordinary foods. Also, drying products as soon as possible to avoid condensation or moisture absorption in order to reduce the water activity to lower than 0.82 during storage is also effective. Furthermore, organic acid treatment during the soaking process reduces toxins by more than 90%. -
Food Safety, Everyone's Business
7 June 2019 World Food Safety Day Food safety, everyone’s business A Guide to World Food Safety Day 2019 Get Started! The first ever World Food Safety Day (WFSD) will be celebrated on 7 June 2019 to draw attention and inspire action to help prevent, detect and manage foodborne risks, contributing to food security, human health, economic prosperity, agriculture, market access, tourism and sustainable development. Theme “Food safety, everyone’s business” Everyone has the right to safe, nutritious and sufficient food. Still today, almost one in ten people in the world fall ill after eating contaminated food. When food is not safe, children cannot learn, adults cannot work. Human development cannot take place. Safe food is critical to promoting health and ending hunger, two of the primary goals of the 2030 Agenda. There is no food security without food safety and in a world where the food supply chain has become more complex, any adverse food safety incident may have global negative effects on public health, trade and the economy. Yet food safety is taken for granted. It is often invisible until you get food poisoning. Unsafe food containing harmful bacteria, viruses, parasites or chemical substances, causes more than 200 diseases – ranging from diarrhoea to cancer. This international day is an opportunity to strengthen efforts to ensure that the food we eat is safe. Whether you produce, process, sell or prepare food, then you have a role in keeping it safe. Everybody along the food chain is responsible for food safety. For this inaugural WFSD all stakeholders are invited to raise global awareness about food safety in general and to highlight that everyone involved in food systems has a part to play. -
Suspect and Target Screening of Natural Toxins in the Ter River Catchment Area in NE Spain and Prioritisation by Their Toxicity
toxins Article Suspect and Target Screening of Natural Toxins in the Ter River Catchment Area in NE Spain and Prioritisation by Their Toxicity Massimo Picardo 1 , Oscar Núñez 2,3 and Marinella Farré 1,* 1 Department of Environmental Chemistry, IDAEA-CSIC, 08034 Barcelona, Spain; [email protected] 2 Department of Chemical Engineering and Analytical Chemistry, University of Barcelona, 08034 Barcelona, Spain; [email protected] 3 Serra Húnter Professor, Generalitat de Catalunya, 08034 Barcelona, Spain * Correspondence: [email protected] Received: 5 October 2020; Accepted: 26 November 2020; Published: 28 November 2020 Abstract: This study presents the application of a suspect screening approach to screen a wide range of natural toxins, including mycotoxins, bacterial toxins, and plant toxins, in surface waters. The method is based on a generic solid-phase extraction procedure, using three sorbent phases in two cartridges that are connected in series, hence covering a wide range of polarities, followed by liquid chromatography coupled to high-resolution mass spectrometry. The acquisition was performed in the full-scan and data-dependent modes while working under positive and negative ionisation conditions. This method was applied in order to assess the natural toxins in the Ter River water reservoirs, which are used to produce drinking water for Barcelona city (Spain). The study was carried out during a period of seven months, covering the expected prior, during, and post-peak blooming periods of the natural toxins. Fifty-three (53) compounds were tentatively identified, and nine of these were confirmed and quantified. Phytotoxins were identified as the most frequent group of natural toxins in the water, particularly the alkaloids group. -
Wrong Perception and Scanty Knowledge on Food Handling: a Recipe for Food Contamination and Poisoning.”
International Journal For Research In Health Sciences And Nursing ISSN: 2208-2670 “WRONG PERCEPTION AND SCANTY KNOWLEDGE ON FOOD HANDLING: A RECIPE FOR FOOD CONTAMINATION AND POISONING.” (1) SAMUEL AUGUSTINE TURAY BEIJING ADVANCED INNIVATION CENTER FOR FOOD NUTRITION AND HUMAN HEALTH (BEIJING TECHNOLOGY AND BUSINESS UNIVERSITY), BEIJING 100048, CHINA [email protected] (2) SHAN LIANG SCHOOL OF FOOD CHEMICAL ENGINEERING, (BEIJING TECHNOLOGY AND BUSINESS UNIVERSITY), BEIJING 100048, CHINA (3) MIN ZHANG ENGINEERING AND TECHNOLOGY RESEARCH CENTER FOR FOOD AADDICTIVES (BEIJING TECHNOLOGY AND BUSINESS UNIVERSITY), BEIJING 100048, CHINA (4) ADIKALI KABA SESAY BEIJING SPORT UNIVERSITY-CHINA [email protected] Abstract Food processing is of vital importance in maintaining proper health as well as avoiding food poisoning and food contamination. The study is focused on bringing to light the concept of food safety and food handling. It is believed by the researcher that Sierra Leoneans do have a little knowledge on handling food and this has resulted to series of infections. Keeping food is scientific and the illiteracy rate is high giving rise for more people not to be able to follow precautionary measures in handling food. The research also focused on bringing out the different methods of food contaminations. These vary from biological, chemical and physical means. The biological components covers bacterial, virus and parasites, while the chemicals level looks into Volume-3 | Issue-12 | December,2017 | Paper-3 29 International Journal For Research In Health Sciences And Nursing ISSN: 2208-2670 various toxin, natural and marine toxins were also covered. The methodology was mostly empirical as literatures were reviewed from other research done by other writers. -
Alpha-Tomatine Content in Tomato and Tomato Products Determined By
J. Agric. Food Chem. 1995, 43, 1507-151 1 1507 a-Tomatine Content in Tomato and Tomato Products Determined by HPLC with Pulsed Amperometric Detection Mendel Friedman* and Carol E. Levin Food Safety and Health Research Unit, Western Regional Research Center, Agricultural Research Service, U.S. Department of Agriculture, 800 Buchanan Street, Albany, California 94710 Tomato plants (Lycopersicon esculentum) synthesize the glycoalkaloid a-tomatine, possibly as a defense against insects and other pests. As part of an effort to improve the safety of plant foods, the usefulness of a new HPLC pulsed amperometric detection (PAD) method for the direct analysis of a-tomatine in different parts of the tomato plant; in store-bought and field-grown, including transgenic, tomatoes; in a variety of commercial and home-processed tomato products; and in eggplant and tomatillos was evaluated. The method was found to be useful for analysis of a variety of products including high-tomatine calyxes, flowers, leaves, roots, and stems of the tomato plant (14-130 mg/100 g of fresh weight), low-tomatine red tomatoes (0.03-0.08 mg/100 g), intermediate- tomatine tomatoes (0.1-0.8 mg/100 g), and high-tomatine fresh and processed green, including pickled and fried, tomatoes (0.9-55 mg/100 g). No experimental difficulties were encountered with extraction and analysis of tomatine in complex foods such as tomato juice, ketchup, salsa, sauce, and sun-dried tomatoes. Microwaving and frying did not significantly affect tomatine levels of tomato foods. The tomatine content of fresh market and transgenic delayed-ripening varieties was not different from the range ordinarily seen in tomato. -
Worldwide Regulations for Mycotoxins in Food and Feed 2003
FAO Worldwide Regulations Food and for mycotoxins in food Nutrition Paper and feed 2003 81 A F O F S I I A N T P A Contents List of Figures ........................................................................................................................................ iv List of Tables........................................................................................................................................... v Acknowledgements ................................................................................................................................ vi Foreword ............................................................................................................................................... vii Abbreviations .......................................................................................................................................viii Explanatory note ..................................................................................................................................... x 1. Introduction ................................................................................................................................... 1 2. Factors affecting the constitution of mycotoxin regulations in food and feed .............................. 3 2.1 Hazard identification and hazard characterization................................................................. 3 2.2 Exposure assessment............................................................................................................. -
Guidelines on Food Fortification with Micronutrients
GUIDELINES ON FOOD FORTIFICATION FORTIFICATION FOOD ON GUIDELINES Interest in micronutrient malnutrition has increased greatly over the last few MICRONUTRIENTS WITH years. One of the main reasons is the realization that micronutrient malnutrition contributes substantially to the global burden of disease. Furthermore, although micronutrient malnutrition is more frequent and severe in the developing world and among disadvantaged populations, it also represents a public health problem in some industrialized countries. Measures to correct micronutrient deficiencies aim at ensuring consumption of a balanced diet that is adequate in every nutrient. Unfortunately, this is far from being achieved everywhere since it requires universal access to adequate food and appropriate dietary habits. Food fortification has the dual advantage of being able to deliver nutrients to large segments of the population without requiring radical changes in food consumption patterns. Drawing on several recent high quality publications and programme experience on the subject, information on food fortification has been critically analysed and then translated into scientifically sound guidelines for application in the field. The main purpose of these guidelines is to assist countries in the design and implementation of appropriate food fortification programmes. They are intended to be a resource for governments and agencies that are currently implementing or considering food fortification, and a source of information for scientists, technologists and the food industry. The guidelines are written from a nutrition and public health perspective, to provide practical guidance on how food fortification should be implemented, monitored and evaluated. They are primarily intended for nutrition-related public health programme managers, but should also be useful to all those working to control micronutrient malnutrition, including the food industry. -
Preventive Controls for Animal Food Safety
Vol. 80 Thursday, No. 180 September 17, 2015 Part III Department of Health and Human Services Food and Drug Administration 21 CFR Parts 11, 16, 117, et al. Current Good Manufacturing Practice, Hazard Analysis, and Risk-Based Preventive Controls for Food for Animals; Final Rule VerDate Sep<11>2014 19:06 Sep 16, 2015 Jkt 235001 PO 00000 Frm 00001 Fmt 4717 Sfmt 4717 E:\FR\FM\17SER3.SGM 17SER3 mstockstill on DSK4VPTVN1PROD with RULES3 56170 Federal Register / Vol. 80, No. 180 / Thursday, September 17, 2015 / Rules and Regulations DEPARTMENT OF HEALTH AND Administration, 7519 Standish Pl., IX. Subpart A: Comments on Qualifications HUMAN SERVICES Rockville, MD 20855, 240–402–6246, of Individuals Who Manufacture, email: [email protected]. Process, Pack, or Hold Animal Food Food and Drug Administration A. Applicability and Qualifications of All SUPPLEMENTARY INFORMATION: Individuals Engaged in Manufacturing, Table of Contents Processing, Packing, or Holding Animal 21 CFR Parts 11, 16, 117, 500, 507, and Food (Final § 507.4(a), (b), and (d)) 579 Executive Summary B. Additional Requirements Applicable to Purpose and Coverage of the Rule Supervisory Personnel (Final § 507.4(c)) [Docket No. FDA–2011–N–0922] Summary of the Major Provisions of the Rule X. Subpart A: Comments on Proposed RIN 0910–AG10 Costs and Benefits § 507.5—Exemptions I. Background A. General Comments on the Proposed Current Good Manufacturing Practice, A. FDA Food Safety Modernization Act Exemptions Hazard Analysis, and Risk-Based B. Stages in the Rulemaking for the Animal B. Proposed § 507.5(a)—Exemption for Food Preventive Controls Rule Facilities Not Required To Register Preventive Controls for Food for C. -
Codex Alimentarius Commission C O D E X a L I M E N T a R I U S Issn 1020-8070
PM_21_2012_1pageEN.pdf 1 23/04/2013 11:18:05 CODEX ALIMENTARIUS COMMISSION C O D E X A L I M E N T A R I U S ISSN 1020-8070 C M Y www.codexalimentarius.org 21 Joint FAO/WHO Food Standards Programme CM 2013 MY CY Manual - Procedural CMY K The Procedural Manual of the Codex Alimentarius Commission is intended to help Member Governments participate effectively in the work of the joint CODEX ALIMENTARIUS COMMISSION FAO/WHO Food Standards Programme. The manual is particularly useful for national delegations attending Codex meetings and for international organizations attending as observers. It sets out the basic Rules of Procedure, PROCEDURAL MANUAL procedures for the elaboration of Codex standards and related texts, basic definitions and guidelines for the operation of Codex committees. Twenty-first edition Twenty-first edition It also gives the membership of the Codex Alimentarius Commission. FAO/WHO ISBN 978-92-5-107570-8 9 789251 075708 I3243E/1/03.13 PM_21_2013_2pageEN.pdf 1 08/05/2013 16:21:06 For further information on the activities of the Codex Alimentarius Commission, please contact: Secretariat of the Codex Alimentarius Commission Joint FAO/WHO Food Standards Programme Food and Agriculture Organization of the United Nations Viale delle Terme di Caracalla 00153 Rome, Italy E-mail (Internet): [email protected] Web site: www.codexalimentarius.org Codex publications may be obtained through the worldwide Sales Agents C of FAO or by writing to: M Y Sales and Marketing Group Food and Agriculture Organization of the United Nations CM Viale -
Environmental Contaminants in Food
Environmental Contaminants in Food December 1979 NTIS order #PB80-153265 Library of Congress Catalog Card Number 79-600207 For sale by the Superintendent of Documents, U.S. Government Printing Office Washington, D.C. 20402 Stock No. 052-003-00724-0 FOREWORD This report presents the major findings of an OTA assessment of Federal and State efforts to deal with the environmental contamination of food. Undertaken at the request of the House Committee on Interstate and Foreign Commerce, the study examines both regulatory approaches and monitoring strategies for coping with contaminated food. The assessment is concerned with chemical and radioactive contaminants that inadvertently find their way into the human food supply. To bring the scope of inquiry within manageable bounds, we excluded naturally occurring toxins such as fungal and microbial toxins. The Office of Technology Assessment was assisted by two advisory panels of scientists and representatives of public interest groups, agriculture, the chemical industry, fisheries, and State and foreign governments. The Food and Drug Ad- ministration, the Department of Agriculture, and the Environmental Protection Agency each designated staff members to attend panel meetings, provide back- ground information, and review draft reports, Background papers were commis- sioned concerning the scientific aspects of detecting and regulating environ- mental contaminants in food. The Congressional Research Service provided five analyses of previous food contamination episodes, Reviews of the draft report were provided by the advisory panels, Federal agencies, and a number of inter- ested individuals not previously involved with the assessment. Because this assessment addresses concerns of American citizens as well as policy makers and scientists, the summary of the report is also being published as a separate document. -
Host Factors Modulating Ochratoxin a Biosynthesis During Fruit Colonization by Aspergillus Carbonarius
Journal of Fungi Article Host Factors Modulating Ochratoxin A Biosynthesis during Fruit Colonization by Aspergillus carbonarius Uriel Maor 1,2, Omer Barda 1, Sudharsan Sadhasivam 1 , Yang Bi 3, Varda Zakin 1, Dov B. Prusky 1,3 and Edward Sionov 1,* 1 Institute of Postharvest and Food Sciences, The Volcani Center, Agricultural Research Organization, Rishon LeZion 7528809, Israel; [email protected] (U.M.); [email protected] (O.B.); [email protected] (S.S.); [email protected] (V.Z.); [email protected] (D.B.P.) 2 Institute of Biochemistry, Food Science and Nutrition, The Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot 7610001, Israel 3 College of Food Science and Engineering, Gansu Agricultural University, Lanzhou 730070, China; [email protected] * Correspondence: [email protected]; Tel.: +972-3-968-3693 Abstract: Aspergillus carbonarius is a strong and consistent ochratoxin A (OTA) producer and consid- ered to be the main source of this toxic metabolite in grapes and grape products such as wine, grape juice and dried vine fruit. OTA is produced under certain growth conditions and its accumulation is affected by several environmental factors, such as growth phase, substrate, temperature, water activity and pH. In this study, we examined the impact of fruit host factors on regulation and ac- cumulation of OTA in colonized grape berries, and assessed in vitro the impact of those factors on the transcriptional levels of the key genes and global regulators contributing to fungal colonization and mycotoxin synthesis. -
Fall TNP Herbals.Pptx
8/18/14 Introduc?on to Objecves Herbal Medicine ● Discuss history and role of psychedelic herbs Part II: Psychedelics, in medicine and illness. Legal Highs, and ● List herbs used as emerging legal and illicit Herbal Poisons drugs of abuse. ● Associate main plant and fungal families with Jason Schoneman RN, MS, AGCNS-BC representave poisonous compounds. The University of Texas at Aus?n ● Discuss clinical management of main toxic Schultes et al., 1992 compounds. Psychedelics Sacraments: spiritual tools or sacred medicine by non-Western cultures vs. Dangerous drugs of abuse vs. Research and clinical tools for mental and physical http://waynesword.palomar.edu/ww0703.htm disorders History History ● Shamanic divinaon ○ S;mulus for spirituality/religion http://orderofthesacredspiral.blogspot.com/2012/06/t- mckenna-on-psilocybin.html http://www.cosmicelk.net/Chukchidirections.htm 1 8/18/14 History History http://www.10zenmonkeys.com/2007/01/10/hallucinogenic- weapons-the-other-chemical-warfare/ http://rebloggy.com/post/love-music-hippie-psychedelic- woodstock http://fineartamerica.com/featured/misterio-profundo-pablo- amaringo.html History ● Psychotherapy ○ 20th century: un;l 1971 ● Recreaonal ○ S;mulus of U.S. cultural revolu;on http://qsciences.digi-info-broker.com http://www.uspharmacist.com/content/d/feature/c/38031/ http://en.wikipedia.org/nervous_system 2 8/18/14 Main Groups Main Groups Tryptamines LSD, Psilocybin, DMT, Ibogaine Other Ayahuasca, Fly agaric Phenethylamines MDMA, Mescaline, Myristicin Pseudo-hallucinogen Cannabis Dissociative