Making Sense of Radiation Safety
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Radioisotopes and Radiopharmaceuticals
RADIOISOTOPES AND RADIOPHARMACEUTICALS Radioisotopes are the unstable form of an element that emits radiation to become a more stable form — they have certain special attributes. These make radioisotopes useful in areas such as medicine, where they are used to develop radiopharmaceuticals, as well as many other industrial applications. THE PRODUCTION OF TECHNETIUM-99m RADIOPHARMACEUTICALS: ONE POSSIBLE ROUTE IRRADIATED U-235 99 TARGETS MO PROCESSING FACILITY HOSPITAL RADIOPHARMACY (MIXING WITH BIOLOGICAL MOLECULES THAT BIND AT DIFFERENT LOCATIONS IN THE 99mTC IS IDEAL FOR DIAGNOSTICS BECAUSE OF BODY, SUPPORTING A WIDE ITS SHORT HALF-LIFE (6 HOURS) AND IDEAL GAMMA EMISSION RANGE OF MEDICAL NUCLEAR APPLICATIONS) REACTOR: 6 HOURS MAKES DISTRIBUTION DIFFICULT 99MO BULK LIQUID TARGET ITS PARENT NUCLIDE, MOLYBDENUM-99, IS PRODUCED; ITS HALF-LIFE (66 HOURS) MAKES 99 99m IRRADIATION IT SUITABLE FOR TRANSPORT MO/ TC GENERATORS 99MO/99mTC GENERATORS ARE PRODUCED AND DISTRIBUTED AROUND THE GLOBE 99MO/99TC GENERATOR MANUFACTURER Radioisotopes can occur naturally or be produced artificially, mainly in research reactors and accelerators. They are used in various fields, including nuclear medicine, where radiopharmaceuticals play a major role. Radiopharmaceuticals are substances that contain a radioisotope, and have properties that make them effective markers in medical diagnostic or therapeutic procedures. The chemical presence of radiopharmaceuticals can relay detailed information to medical professionals that can help in diagnoses and treatments. Eighty percent of all diagnostic medical scans worldwide use 99mTc, and its availability, at present, is dependent on the production of 99Mo in research reactors. Globally, the number of medical procedures involving the use of radioisotopes is growing, with an increasing emphasis on radionuclide therapy using radiopharmaceuticals for the treatment of cancer.. -
OPERATIONAL GUIDANCE on HOSPITAL RADIOPHARMACY: a SAFE and EFFECTIVE APPROACH the Following States Are Members of the International Atomic Energy Agency
OPERATIONAL GUIDANCE ON HOSPITAL RADIOPHARMACY: A SAFE AND EFFECTIVE APPROACH The following States are Members of the International Atomic Energy Agency: AFGHANISTAN GUATEMALA PAKISTAN ALBANIA HAITI PALAU ALGERIA HOLY SEE PANAMA ANGOLA HONDURAS PARAGUAY ARGENTINA HUNGARY PERU ARMENIA ICELAND PHILIPPINES AUSTRALIA INDIA POLAND AUSTRIA INDONESIA PORTUGAL AZERBAIJAN IRAN, ISLAMIC REPUBLIC OF QATAR BANGLADESH IRAQ REPUBLIC OF MOLDOVA BELARUS IRELAND ROMANIA BELGIUM ISRAEL RUSSIAN FEDERATION BELIZE ITALY SAUDI ARABIA BENIN JAMAICA SENEGAL BOLIVIA JAPAN SERBIA BOSNIA AND HERZEGOVINA JORDAN SEYCHELLES BOTSWANA KAZAKHSTAN BRAZIL KENYA SIERRA LEONE BULGARIA KOREA, REPUBLIC OF SINGAPORE BURKINA FASO KUWAIT SLOVAKIA CAMEROON KYRGYZSTAN SLOVENIA CANADA LATVIA SOUTH AFRICA CENTRAL AFRICAN LEBANON SPAIN REPUBLIC LIBERIA SRI LANKA CHAD LIBYAN ARAB JAMAHIRIYA SUDAN CHILE LIECHTENSTEIN SWEDEN CHINA LITHUANIA SWITZERLAND COLOMBIA LUXEMBOURG SYRIAN ARAB REPUBLIC COSTA RICA MADAGASCAR TAJIKISTAN CÔTE D’IVOIRE MALAWI THAILAND CROATIA MALAYSIA THE FORMER YUGOSLAV CUBA MALI REPUBLIC OF MACEDONIA CYPRUS MALTA TUNISIA CZECH REPUBLIC MARSHALL ISLANDS TURKEY DEMOCRATIC REPUBLIC MAURITANIA UGANDA OF THE CONGO MAURITIUS UKRAINE DENMARK MEXICO UNITED ARAB EMIRATES DOMINICAN REPUBLIC MONACO UNITED KINGDOM OF ECUADOR MONGOLIA GREAT BRITAIN AND EGYPT MONTENEGRO NORTHERN IRELAND EL SALVADOR MOROCCO ERITREA MOZAMBIQUE UNITED REPUBLIC ESTONIA MYANMAR OF TANZANIA ETHIOPIA NAMIBIA UNITED STATES OF AMERICA FINLAND NEPAL URUGUAY FRANCE NETHERLANDS UZBEKISTAN GABON NEW ZEALAND VENEZUELA GEORGIA NICARAGUA VIETNAM GERMANY NIGER YEMEN GHANA NIGERIA ZAMBIA GREECE NORWAY ZIMBABWE The Agency’s Statute was approved on 23 October 1956 by the Conference on the Statute of the IAEA held at United Nations Headquarters, New York; it entered into force on 29 July 1957. The Headquarters of the Agency are situated in Vienna. -
Nuclear Radiation 1. an Atom Contains Electrons, Protons and Neutrons
Nuclear Radiation 1. An atom contains electrons, protons and neutrons. Which of these particles a) are outside the nucleus b) are uncharged c) have a negative charge d) are nucleons e) are much lighter than the others? 2. Complete the table below. Name Symbol Charge What is it? Alpha particle β -1 Gamma ray An electromagnetic wave 3. How is an ionised material different from a material that is not ionised? National 5 Physics: Waves & Radiation 1 Absorption of Radiation 1. The figure below shows a Geiger tube used to detect radiation from a radioactive source. thick lead plate 0 4 2 5 start counter stop ON OFF reset Geiger tube radioactive source The following measurements were made using the apparatus above. Counts in 300 seconds Readings Average 1 No source present 102 94 110 2 Source present at fixed distance from tube a) No lead plate present 3466 3420 3410 b) Thick lead plate present 105 109 89 c) Aluminium sheet in place of the 1834 1787 1818 thick lead sheet a) Complete the table by calculating the average readings. b) Why are the readings on each line not the same? c) What can you say from the table about the effect on the radiation of: i. The lead plate? ii. The aluminium plate? d) Why is it possible to say from the readings that: i. gamma radiation is emitted by the source? ii. alpha and beta radiation might be emitted by the source? e) What further tests could you make using this arrangement to find out whether or not the source emits alpha radiation? National 5 Physics: Waves & Radiation 2 2. -
How Do Radioactive Materials Move Through the Environment to People?
5. How Do Radioactive Materials Move Through the Environment to People? aturally occurring radioactive materials Radionuclides can be removed from the air in Nare present in our environment and in several ways. Particles settle out of the our bodies. We are, therefore, continuously atmosphere if air currents cannot keep them exposed to radiation from radioactive atoms suspended. Rain or snow can also remove (radionuclides). Radionuclides released to them. the environment as a result of human When these particles are removed from the activities add to that exposure. atmosphere, they may land in water, on soil, or Radiation is energy emitted when a on the surfaces of living and non-living things. radionuclide decays. It can affect living tissue The particles may return to the atmosphere by only when the energy is absorbed in that resuspension, which occurs when wind or tissue. Radionuclides can be hazardous to some other natural or human activity living tissue when they are inside an organism generates clouds of dust containing radionu- where radiation released can be immediately clides. absorbed. They may also be hazardous when they are outside of the organism but close ➤ Water enough for some radiation to be absorbed by Radionuclides can come into contact with the tissue. water in several ways. They may be deposited Radionuclides move through the environ- from the air (as described above). They may ment and into the body through many also be released to the water from the ground different pathways. Understanding these through erosion, seepage, or human activities pathways makes it possible to take actions to such as mining or release of radioactive block or avoid exposure to radiation. -
Copyright by Arthur Bryan Crawford 2004
Copyright by Arthur Bryan Crawford 2004 The Dissertation Committee for Arthur Bryan Crawford Certifies that this is the approved version of the following dissertation: Evaluation of the Impact of Non -Uniform Neutron Radiation Fields on the Do se Received by Glove Box Radiation Workers Committee: Steven Biegalski, Supervisor Sheldon Landsberger John Howell Ofodike Ezekoye Sukesh Aghara Evaluation of the Impact of Non -Uniform Neutron Radiation Fields on the Dose Received by Glove Box Radiation Workers by Arthur Bryan Crawford, B.S., M.S. Dissertation Presented to the Faculty of the Graduate School of The University of Texas at Austin in Partial Fulfillment of the Requirements for the Degree of Doctor of Philosophy The University of Texas at Austin December, 2004 Dedication I was born to goodly parents Harvey E. Crawford and Johnnie Lee Young Crawford Acknowledgements I would like to express my gratitude to Dr. Sheldon Landsberger for his vision in starting a distance learning program at the University of Texas at Austin and for his support and encouragement on this quest. I would like to thank my advisor, Dr. Steven Biegalski, for his support and encouragement even though the topic area was new to him. I would like to thank the members of my dissertation committee for finding the time to review this dissertation. To the staff of the Nuclear Engineering Teaching Laboratory I say thank you for your kindness and support during those brief times that I was on cam pus. A special thanks to my past and present group leaders, David Seidel, Eric McNamara, and Bill Eisele and my Division Leader, Lee McAtee, at Los Alamos National Laboratory, for their support in being allowed to use time and material resources at the Lab oratory and for financial support in the form of tuition reimbursement and travel expenses. -
Industrial Radiography
RADIATION PROTECTION OF WORKERS Industrial Radiography RADIATION AND RADIOGRAPHS RADIOACTIVE SOURCES PROCEDURES RADIOGRAPHERS DO follow the procedures. Ionizing radiation can pen- Materials of higher den Sealed sources are small þ Safe storage Precautions þ DO use the appropriate equipment, including collimators. in size and contain material etrate objects and create sity absorb more radiation. þ DO confi rm that there are no other people working in the images on photographic The metal components are which emits penetrating area of radiography. fi lm. The technique is revealed inside this tele radiation continuously. Radioactive sources should be kept in a secure, fi re þ DO use clear working signs and signals. called radiography and phone because they have Special containers made þ DO set up the controlled area and the necessary barriers. the processed fi lms are absorbed more radiation of dense metal shielding resistant and adequately shielded storage location þ DO confi rm the location of the source, or that X rays are called radiographs. than the surrounding plastic. are necessary to store, not being generated, by use of a survey meter. when not in use, and should move and manipulate these þ DO secure and store the source or X ray machine when sources. Due to their small be kept separate from other not in use. materials. The storage loca- size and manoeuvrability, Portable and mobile radiographic þ DO wear your personal dosimeter. sealed sources can be containers. ~ tion for X ray machines that used in confined spaces. are not in use is not required to be shielded. OTHER WORKERS Iridium-192 is a common radioactive source used þ DO observe the access restrictions, however remote it may in gamma radiography. -
Radiation Basics
Environmental Impact Statement for Remediation of Area IV \'- f Susana Field Laboratory .A . &at is radiation? Ra - -.. - -. - - . known as ionizing radiatios bScause it can produce charged.. particles (ions)..- in matter. .-- . 'I" . .. .. .. .- . - .- . -- . .-- - .. What is radioactivity? Radioactivity is produced by the process of radioactive atmi trying to become stable. Radiation is emitted in the process. In the United State! Radioactive radioactivity is measured in units of curies. Smaller fractions of the curie are the millicurie (111,000 curie), the microcurie (111,000,000 curie), and the picocurie (1/1,000,000 microcurie). Particle What is radioactive material? Radioactive material is any material containing unstable atoms that emit radiation. What are the four basic types of ionizing radiation? Aluminum Leadl Paper foil Concrete Adphaparticles-Alpha particles consist of two protons and two neutrons. They can travel only a few centimeters in air and can be stopped easily by a sheet of paper or by the skin's surface. Betaparticles-Beta articles are smaller and lighter than alpha particles and have the mass of a single electron. A high-energy beta particle can travel a few meters in the air. Beta particles can pass through a sheet of paper, but may be stopped by a thin sheet of aluminum foil or glass. Gamma rays-Gamma rays (and x-rays), unlike alpha or beta particles, are waves of pure energy. Gamma radiation is very penetrating and can travel several hundred feet in air. Gamma radiation requires a thick wall of concrete, lead, or steel to stop it. Neutrons-A neutron is an atomic particle that has about one-quarter the weight of an alpha particle. -
Radionuclides (Including Radon, Radium and Uranium)
Radionuclides (including Radon, Radium and Uranium) Hazard Summary Uranium, radium, and radon are naturally occurring radionuclides found in the environment. No information is available on the acute (short-term) noncancer effects of the radionuclides in humans. Animal studies have reported inflammatory reactions in the nasal passages and kidney damage from acute inhalation exposure to uranium. Chronic (long-term) inhalation exposure to uranium and radon in humans has been linked to respiratory effects, such as chronic lung disease, while radium exposure has resulted in acute leukopenia, anemia, necrosis of the jaw, and other effects. Cancer is the major effect of concern from the radionuclides. Radium, via oral exposure, is known to cause bone, head, and nasal passage tumors in humans, and radon, via inhalation exposure, causes lung cancer in humans. Uranium may cause lung cancer and tumors of the lymphatic and hematopoietic tissues. EPA has not classified uranium, radon or radium for carcinogenicity. Please Note: The main sources of information for this fact sheet are EPA's Integrated Risk Information System (IRIS) (5), which contains information on oral chronic toxicity and the RfD for uranium, and the Agency for Toxic Substances and Disease Registry's (ATSDR's) Toxicological Profiles for Uranium, Radium, and Radon. (1) Uses Uranium is used in nuclear power plants and nuclear weapons. Very small amounts are used in photography for toning, in the leather and wood industries for stains and dyes, and in the silk and wood industries. (2) Radium is used as a radiation source for treating neoplastic diseases, as a radon source, in radiography of metals, and as a neutron source for research. -
6.2.43A Radiation-Dominated Model of the Universe
6 BIG BANG COSMOLOGY – THE EVOLVING UNIVERSE 6.2.43A radiation-dominated model of the Universe R We have just seen that in the early Universe, the dominant energy density is that due to the radiation within the Universe. The Friedmann equation that was described in Chapter 5 (Box 5.4) can be solved for such conditions and the way in which the scale factor varies with time for such a model is shown in Figure 6.7. One important feature of such a model is that the scale factor varies in the following way: R(t) ∝ t1/2 (6.17) 0 t −4 Because the energy density of radiation is dominant for times when R(t)/R(t0) < 10 , all cosmological models which start at t = 0 with R(0) = 0, will go through a phase Figure 6.73The evolution of the that is well described by this radiation-dominated model. Thus we are in the rather scale factor with time in a remarkable position that regardless of which type of cosmological model best cosmological model in which the dominant contribution to the describes the Universe at the present, we can be reasonably confident that we energy density arises from the know how the scale factor varied with time in the first few tens of thousands of radiation within the Universe years of the big bang. (i.e. during the radiation-dominated However, the temperature of the background radiation varies with scale factor era). according to T(t) ∝ 1/R(t) (Equation 6.6). It follows that during the radiation- dominated era the temperature of the background radiation varies with time according to T(t) ∝ t −1/2 (6.18) This describes how temperature changes with time in an expanding universe where the energy density of radiation is the dominant component. -
The International Commission on Radiological Protection: Historical Overview
Topical report The International Commission on Radiological Protection: Historical overview The ICRP is revising its basic recommendations by Dr H. Smith Within a few weeks of Roentgen's discovery of gamma rays; 1.5 roentgen per working week for radia- X-rays, the potential of the technique for diagnosing tion, affecting only superficial tissues; and 0.03 roentgen fractures became apparent, but acute adverse effects per working week for neutrons. (such as hair loss, erythema, and dermatitis) made hospital personnel aware of the need to avoid over- Recommendations in the 1950s exposure. Similar undesirable acute effects were By then, it was accepted that the roentgen was reported shortly after the discovery of radium and its inappropriate as a measure of exposure. In 1953, the medical applications. Notwithstanding these observa- ICRU recommended that limits of exposure should be tions, protection of staff exposed to X-rays and gamma based on consideration of the energy absorbed in tissues rays from radium was poorly co-ordinated. and introduced the rad (radiation absorbed dose) as a The British X-ray and Radium Protection Committee unit of absorbed dose (that is, energy imparted by radia- and the American Roentgen Ray Society proposed tion to a unit mass of tissue). In 1954, the ICRP general radiation protection recommendations in the introduced the rem (roentgen equivalent man) as a unit early 1920s. In 1925, at the First International Congress of absorbed dose weighted for the way different types of of Radiology, the need for quantifying exposure was radiation distribute energy in tissue (called the dose recognized. As a result, in 1928 the roentgen was equivalent in 1966). -
Radiation Safety in Fluoroscopy
Radiation Safety for New Medical Physics Graduate Students John Vetter, PhD Medical Physics Department UW School of Medicine & Public Health Background and Purpose of This Training . This is intended as a brief introduction to radiation safety from the perspective of a Medical Physicist. Have a healthy respect for radiation without an undue fear of it. The learning objectives are: . To point out the sources of ionizing radiation in everyday life and at work. To present an overview of the health effects of ionizing radiation. To show basic concepts and techniques used to protect against exposure to ionizing radiation. Further training in Radiation Safety can be found at: https://ehs.wisc.edu/radiation-safety-training/ Outline . Ionizing Radiation . Definition, Quantities & Units . Levels of Radiation Exposure . Background & Medical . Health Effects of Radiation Exposure . Stochastic & Deterministic . Limits on Radiation Exposure . Rationale for Exposure Limits . Minimizing Radiation Exposure . Time, Distance, Shielding, Containment Definition of Ionizing Radiation . Radiation can be thought of as energy in motion. Electromagnetic radiation is pure energy that moves at the speed of light in the form of photons and includes: radio waves; microwaves; infrared, visible and ultraviolet light; x-rays and γ-rays. A key difference between these forms of electromagnetic radiation is the amount of energy that each photon carries. Some ultraviolet light, and X-rays and Gamma-rays have enough energy to remove electrons from atoms as they are absorbed, forming positive and negatively charged ions. These forms of radiation are called ionizing radiation. Radio waves, microwaves, infrared and visible light do not have enough energy to ionize atoms. -
Chapter 12 Monographs of 99Mtc Pharmaceuticals 12
Chapter 12 Monographs of 99mTc Pharmaceuticals 12 12.1 99mTc-Pertechnetate I. Zolle and P.O. Bremer Chemical name Chemical structure Sodium pertechnetate Sodium pertechnetate 99mTc injection (fission) (Ph. Eur.) Technetium Tc 99m pertechnetate injection (USP) 99m ± Pertechnetate anion ( TcO4) 99mTc(VII)-Na-pertechnetate Physical characteristics Commercial products Ec=140.5 keV (IT) 99Mo/99mTc generator: T1/2 =6.02 h GE Healthcare Bristol-Myers Squibb Mallinckrodt/Tyco Preparation Sodium pertechnetate 99mTc is eluted from an approved 99Mo/99mTc generator with ster- ile, isotonic saline. Generator systems differ; therefore, elution should be performed ac- cording to the manual provided by the manufacturer. Aseptic conditions have to be maintained throughout the operation, keeping the elution needle sterile. The total eluted activity and volume are recorded at the time of elution. The resulting 99mTc ac- tivity concentration depends on the elution volume. Sodium pertechnetate 99mTc is a clear, colorless solution for intravenous injection. The pH value is 4.0±8.0 (Ph. Eur.). Description of Eluate 99mTc eluate is described in the European Pharmacopeia in two specific monographs de- pending on the method of preparation of the parent radionuclide 99Mo, which is generally isolated from fission products (Monograph 124) (Council of Europe 2005a), or produced by neutron activation of metallic 98Mo-oxide (Monograph 283) (Council of Europe 2005b). Sodium pertechnetate 99mTc injection solution satisfies the general requirements of parenteral preparations stated in the European Pharmacopeia (Council of Europe 2004). The specific activity of 99mTc-pertechnetate is not stated in the Pharmacopeia; however, it is recommended that the eluate is obtained from a generator that is eluted regularly, 174 12.1 99mTc-Pertechnetate every 24 h.