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Prof. Dr. Med. Jörg Schirra

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Prof. Dr. Med. Jörg Schirra CURRICULUM VITAE and SUMMARY OF RESEARCH EXPERIENCE Prof. Dr. med. Jörg Schirra Personal data: Name Prof. Dr. med. Jörg Schirra Adress prof: Dept. of Internal Medicine II – Großhadern University of Munich, LMU Marchioninstr. 15 81377 Munich, Germany Phone.: +49-89-4400-72282, -73031 Fax.: +49-89-4400-75280 e-mail: [email protected] Education and occupational history: 1970 - 1974 Primary School Saarwellingen, Saarland, Germany 1974 - 1983 High School: Staatliches Humanistisches Gymnasium in Saarlouis/ Saarland 01/1984 - 03/1985 Compulsary Military Service (paratroops and medic) 04/1985 - 09/1991 Medical studies at 04/1985 - 09/1987 Albert-Ludwigs-University of Freiburg, Germany 10/1987 - 10/1991 Philipps-University of Marburg, Germany 24/03/1988 I. Staatsexamen (first state examen) 28/08/1990 II. Staatsexamen (second state examen) 09/1990 - 09/1991 Practical year at the Medical Hospital in Fulda, Germany 08/10/1991 III. Staatsexamen (third state examen), master of med sci 01/1988 - 07/1992 Doctoral theses (PhD) at the Institute of Neurochemistry of the University of Marburg 11/1991 - 10/1993 Research fellow in the Dept. of Gastroenterology, Philipps-University of Marburg, Prof. Dr. R. Arnold 11/1993 - 09/1996 Research fellow in the Clinical Research Unit of Gastrointestinal Endocrinology of the Deutsche Forschungsgemeinschaft, Dept. of Gastroenterology, Philipps-University of Marburg, Prof. Dr. B. Göke. 10/1996 - 05/2000 Research fellow in the Dept. of Gastroenterology, Philipps-University of Marburg, Prof. Dr. R. Arnold 17/05/2000 Master of internal medicine 17/10/2001 Postdoctoral lecture qualification (University of Marburg) 11/07/2002 Postdoctoral lecture qualification (University of Munich) Curriculum vitae · Prof. Dr. med. Jörg Schirra Jul-19 since 12/2001 Assistant Professor of Internal Medicine and Gastroenterology, Head of Gastrointestinal and Endocrine Research Unit (Clinical Research Unit CRU), Dept. of Internal Medicine II, Ludwig-Maximilans-University of Munich, Prof. Dr. B. Göke 12/2001 – 09-2010 Co-Head of Gastrointestinal Endoscopy, Dept. of Internal Medicine II, Ludwig-Maximilans-University of Munich. Associate Professor of Internal Medicine and Gastroenterology.. 12/2008 Extraordinary professorship at University of Munich since 10/2010 Head of Gastrointestinal Endoscopy and Gastrointestinal functional diagnostics, Senior Physician of the Dept. of Internal Medicine II, Ludwig- Maximilans-University of Munich. Associate Professor of Internal Medicine and Gastroenterology. 22.09.2014 Sub-specialization for Gastroenterology since 01.12.2015 Training authorization for Internal Medicine and Gastroenterology acc. to the education rules of the Bayerische Landesärztekammer since 01.11.2017 Deputy Hospital Director of the Dept. of Internal Medicine II, Ludwig- Maximilans-University of Munich Department of Internal Medicine II · Campus Großhadern · University of Munich · Germany 2 Curriculum vitae · Prof. Dr. med. Jörg Schirra Jul-19 SUMMARY OF RESEARCH EXPERIENCE: 1992 till this day Continuous daily experience in Clinical Research: human physiology, human pathophysiology and pharmacology: main focus: gastrointestinal endocrinology, gut hormones, brain-gut-axis, gastrointestinal motility, pancreatic physiology, diabetes mellitus, reflux disease, benigne and maligne biliary strictures 1993 – 1999 Head of the clinical research unit of the department of Gastroenterology at the University of Marburg. Responsible leader for conducting clinical studies within the Clinical Research Group for Gastrointestinal Endocrinology of the German Research Foundation (Deutsche Forschungsgemeinschaft, DFG) at the University of Marburg under Prof. Dr. Burkhard Göke. since 2001 Formation and establishment of the Clinical Research Unit (CRU) at the Dept. of Internal Medicine II – Großhadern, Ludwig-Maximilans-University of Munich. Head of the Unit. 11/2008 Co-founder of T.E.A.M.: Transluminal and Endoscopic Working group München (Transluminale und Endoskopische Arbeitsgemeinschaft München), an interdisciplinary working group of the LMU for development and conveyance of innovative endoscopic technology. 2013 Werner-Creutzfeldt-Preis of the Deutsche Diabetes Gesellschaft Supported by German Research Foundation (DFG) German Diabetes Foundation (Deutsche Diabetes Stiftung) Kempkes Foundation, Marburg, Germany Schebo Tech, Giessen, Germany Amylin Pharmaceuticals Inc., San Diego, USA Novartis Pharma, East Hanover, USA Merck & Co., Inc., Rahway, New Jersey, USA MSD Merck, Sharp & Dohme, Munich-Haar, Germany Membership of medical scientific societies: Deutsche Gesellschaft für Verdauungs- und Stoffwechselerkrankungen (DGVS) Deutsche Gesellschaft für Neurogastroenterologie und Motilität (DGNM) European Society of Neurogastroenterology (ESNM) European Association of the Study of Diabetes (EASD) Department of Internal Medicine II · Campus Großhadern · University of Munich · Germany 3 Curriculum vitae · Prof. Dr. med. Jörg Schirra Jul-19 Experience in conducting clinical trials: Since 1992 conduction of 27 clinical monocenter trials, phase 0 and phase I-studies, 22 of which as Clinical Trial Leader Participation in seven international multicenter trials, Phase I and II Conduction of Randomized Clinical Trials according to §40(1) No.5 AMG Establishment and conduction of controlled endoscopic studies in large animals (pigs) Participation in “Münchener Prüfarztkurs” as a teacher Continuing education in Clinical Trials: Instructor for clinical investigators (“Köln-Münchener Kurs für Prüfärzte”). Scientific Reviewer for American Journal of Physiology Circulation Diabetes Diabetologia Digestion Experimental and Clinical Endocrinology & Diabetes European Journal of Clinical Investigation European Journal of Gastroenterology and Hepatology Gut Neurogastroenterology and Motility New England Journal of Medicine Regulatory Peptides Schweizer Medizinische Wochenzeitschrift World Journal of Gastroenterology Department of Internal Medicine II · Campus Großhadern · University of Munich · Germany 4 Curriculum vitae · Prof. Dr. med. Jörg Schirra Jul-19 Publications (original papers, selection of 20): 1. Bawden S, Stephenson M, Falcone Y, Lingaya M, Ciampi E, Hunter K, Bligh F, Schirra J, Taylor M, Morris P, Macdonald I, Gowland P, Marciani L, Aithal GP. Increased liver fat and glycogen stores after consumption of high versus low glycaemic index food: A randomized crossover study. Diabetes Obes Metab. 2017;19:70-77 2. Aulinger B, Bedorf A, Kutscherauer G, de Heer J, Holst JJ, Göke B, Schirra J. Definig the role of GLP-1 in the enteroinsulinar axis in type 2 diabetes using DPP-4 inhibition and GLP-1 receptor blockade. Diabetes 2014;63:1079-1092 3. Schirra J, Göke B. GLP-1-a candidate humoral mediator for glucose control after Roux-en-Y gastriv bypass. Diabetes 2014;63:387-389 4. Steinert RE, Schirra J, Meyer-Gerspach AC, Kienle P, Fischer H, Schulte F, Göke B, Beglinger C. Effect of glucagon-like peptide-1 recpetor antagonism on appetite and food intake in healthy men. Am J Clin Nutr 2014;100:514-523 5. Kolligs FT, Schirra J. Endoscopic management of surgical biluiary complications. Z Gastroenterol. 2014;52:1413-22 6. Kniebühler G, Pongratz T, Betz CS, Göke B, Sroka R, Stepp H, Schirra J. Photodynamic therapy for cholangiocarcinoma using low dose mTHPC (Foscan®). Photodiagnosis Photodyn Ther. 2013;10:220-8. 7. Yan LM, Velkova A, Tatarek-Nossol M, Rammes G, Sibaev A, Andreetto E, Kracklauer M, Bakou M, Malideli E, Göke B, Schirra J, Storr M, Kapurniotu A. Selectively N-methylated soluble IAPP mimics as potent IAPP receptor agonists and nanomolar inhibitors of cytotoxic self-assembly of both IAPP and Aβ40. Angew Chem Int Ed Engl. 2013;52:10378-83 8. Micheletto F, Dalla Man C, Kolterman O, Chiquette E, Herrmann K, Schirra J, Kovatchev B, Cobelli C. In silico design of optimal ratio for co-administration of pramlintide and insulin in type 1 diabetes. Diabetes Technol Ther. 2013;15:802-9 9. Graser A, Melzer A, Lindner E, Nagel D, Herrmann K, Stieber P, Schirra J, Mansmann U, Reiser MF, Göke B, Kolligs FT. Magnetic resonance colonography for the detection of colorectal neoplasia in asymptomatic adults. Gastroenterology. 2013;144:743-750 10. Woerle HJ, Carneiro L, Derani A, Göke B, Schirra J. The role of endogenous incretin secretion as amplifier of glucose-stimulated insulin secretion in healthy subjects and patients with type 2 diabetes. Diabetes. 2012;61:2349-58 11. Nicolaus M, Brödl J, Linke R, Woerle HJ, Göke B, Schirra J. Endogenous GLP-1 regulates postprandial glycemia in humans: relative contributions of insulin, glucagon, and gastric emptying. J Clin Endocrinol Metab. 2011;96:229-36 12. Beglinger S, Drewe J, Schirra J, Göke B, D'Amato M, Beglinger C. Role of fat hydrolysis in regulating glucagon-like Peptide-1 secretion. J Clin Endocrinol Metab. 2010;95:879-86 13. Woerle HJ, Albrecht M, Linke R, Zschau S, Neumann C, Nicolaus M, Gerich JE, Göke B, Schirra J. Impaired hyperglycemia-induced delay in gastric emptying in patients with type 1 diabetes deficient for islet amyloid polypeptide. Diabetes Care. 2008;31:2325-31 14. Graser A, Stieber P, Nagel D, Schäfer C, Horst D, Becker CR, Nikolaou K, Lottes A, Geisbüsch S, Kramer H, Wagner AC, Diepolder H, Schirra J, Roth HJ, Seidel D, Göke B, Reiser MF, Kolligs FT Comparison of CT colonography, colonoscopy, sigmoidoscopy and faecal occult blood tests for the detection of advanced adenoma in an average risk population. Gut. 2009;58:241-8. Department of Internal Medicine II · Campus Großhadern
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