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Obstructive Sleep Apnea in Patients with Rheumatoid Arthritis: Correlation with Disease Activity and Pulmonary Function Tests

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Obstructive Sleep Apnea in Patients with Rheumatoid Arthritis: Correlation with Disease Activity and Pulmonary Function Tests The Egyptian Rheumatologist (2014) xxx, xxx–xxx Egyptian Society for Joint Diseases and Arthritis The Egyptian Rheumatologist www.rheumatology.eg.net www.sciencedirect.com ORIGINAL ARTICLE Obstructive sleep apnea in patients with rheumatoid arthritis: Correlation with disease activity and pulmonary function tests Neven Fouda a,*, Aya Abdel Dayem b a Rheumatology and Rehabilitation Department, Faculty of Medicine, Ain Shams University, P.O. Box 11566, Abbassia Square, Cairo, Egypt b Chest Department, Faculty of Medicine, Ain Shams University, P.O. Box 11566, Abbassia Square, Cairo, Egypt Received 8 April 2014; accepted 10 April 2014 KEYWORDS Abstract Aim of the work: To assess obstructive sleep apnea (OSA) as one of the common Rheumatoid arthritis; primary sleep disorders in patients with rheumatoid arthritis (RA) and study its correlation to Obstructive sleep apnea; disease activity and pulmonary function tests. Polysomnography; Patients and methods: This study included 30 female patients with RA who fulfilled the Disease activity score-28; American College of Rheumatology/European league against rheumatism classification criteria. Pulmonary function tests All the patients were subjected to full medical history, thorough clinical examination with evaluation of the disease activity using disease activity score-28 (DAS28), laboratory assessment of highly sensitive C-reactive protein (hsCRP), pulmonary function tests (PFTs) (FVC, FEV1 and FEV1/FVC) and one night polysomnography at the sleep laboratory. Results: Polysomnographic data revealed OSA in 14 RA patients (46.7%). Patients with OSA showed longer disease duration (7.0 ± 1.94 years), higher BMI (30.8 ± 2.48), hsCRP level (6.7 ± 0.6 mg/L) and DAS28 (4.9 ± 1.85) than patients with no OSA (4.0 ± 1.72 years, 20.3 ± 1.55, 4.9 ± 0.3 mg/L and 3.7 ± 1.28 respectively). There was non-significant difference between both groups regarding the PFTs (p > 0.05). The study showed a significant correlation between AHI (apnea-hypopnea index) and BMI, hsCRP and DAS28 (r = 0.45, 0.43 and 0.51, respectively) (p < 0.05). No significant correlation was detected between AHI and PFTs. Conclusion: Obstructive sleep apnea is commonly associated with RA patients; these findings possibly suggest common underlying pathological mechanisms which may be linked to chronic * Corresponding author. Address: Rheumatology and Rehabilitation Department, Ain Shams University, Lotfy Elsayed st., P.O. 11566, Cairo, Egypt. Tel.: +20 01224009123. E-mail address: [email protected] (N. Fouda). Peer review under responsibility of Egyptian Society for Joint Diseases and Arthritis. Production and hosting by Elsevier 1110-1164 Ó 2014 Production and hosting by Elsevier B.V. on behalf of Egyptian Society for Joint Diseases and Arthritis. http://dx.doi.org/10.1016/j.ejr.2014.04.002 Please cite this article in press as: Fouda N, Dayem AA Obstructive sleep apnea in patients with rheumatoid arthritis: Correlation with disease activity and pulmonary function tests, The Egyptian Rheumatologist (2014), http://dx.doi.org/10.1016/j.ejr.2014.04.002 2 N. Fouda, A.A. Dayem inflammation. Co-existence of OSA in RA patients may influence the disease activity and the level of circulating inflammatory markers. Considering diagnosis and treatment of this sleep disorder in RA patients may help in improved clinical care, better prognosis and avoid rheumatoid-associated morbidities. Ó 2014 Production and hosting by Elsevier B.V. on behalf of Egyptian Society for Joint Diseases and Arthritis. 1. Introduction sent was obtained from all patients after a full explanation of the study. Rheumatoid arthritis (RA) is a chronic, inflammatory disease that is characterized by joint pain and swelling and can lead to 2.1. Exclusion criteria disability and functional limitations [1,2]. In addition, more than half of patients with RA report sleep disturbance, a rate – Patients on anti-tumor necrosis factor (TNF) or corticoste- of prevalence that is 2–3 times greater than that found in the roid therapy. general population [3]. Such disturbed sleep may be due to – Patients on sedative or hypnotic drugs or with history of pain, depression, lack of exercise, or corticosteroid usage [4]. withdrawal of stimulants as coffee or tobacco. Cross-sectional studies have found that sleep disturbance – Patients with abnormalities in soft palate or upper airway. correlates with greater pain and disease activity [5]. It is often – Pregnancy. thought that difficulties with sleep are due to RA-related pain. However, sleep disturbance and pain may be bidirectionally related [6]. Sleep dysfunction and primary sleep disorders are 2.1. Clinical assessment increasingly recognized in people with RA [7]. The morbidity and mortality which may be associated with untreated sleep – Full history taking was performed laying stress on disease disorders, particularly obstructive sleep apnea (OSA), raise duration and symptoms suggestive of OSA e.g. day-time the priority of this aspect of patient care [8]. sleep, somnolence, morning headache, fatigue, waking up, Obstructive sleep apnea (OSA) is a significant public health breath holding, gasping or choking and loud snoring. concern and contributes to increased cardiovascular morbidity – Local examination of the chest, ear, nose and throat was and mortality [9]. It is defined by the American Academy of carried-out. Sleep Medicine [10] as repetitive episodes of upper airway – The BMI (kg/m2) was determined by weight (kg) and height obstruction occurring during sleep and usually associated with (m) (Quelet index). a reduction in oxygen saturation [11]. Symptoms of concern – The disease activity was assessed using disease activity score include sleep episodes during wakefulness, daytime sleepiness, 28 (DAS28) [17]. Patients with DAS28 score 62.6 were con- unrefreshing sleep, fatigue, insomnia, waking up breath hold- sidered in remission [18]. ing, gasping or choking and loud snoring [12]. Diagnosis of obstructive sleep apnea can be indicated by symptomatology and the presence of known risk factors as 2.2. Laboratory assessment increasing age, obesity and large neck circumference, although OSA can occur in individuals with none of these risk factors – Complete blood picture was assessed using coulter counter. [13]. Also a number of tools and methods are available for – Rheumatoid factor (RF) was evaluated by enzyme-linked the assessment of sleep health as self-reported questionnaire immunosorbent assay (ELISA). instruments [14]. However, the gold standard for diagnosis – Erythrocyte sedimentation rate (ESR) was determined of OSA is the overnight polysomnography (PSG) [15]. using Westergren Blot method. The aim of the work was to assess obstructive sleep apnea – Highly sensitive C-reactive protein (hsCRP) concentration (OSA) as one of common primary sleep disorders in patients was measured using a latex-particle enhanced turbidimetric with rheumatoid arthritis (RA) and study its correlation to dis- immunoassay [19]. Samples of peripheral venous blood ease activity and pulmonary function tests. were collected and stored at À80 °C until the time of assay. 2. Patients and methods 2.3. Pulmonary function tests The tests were done in the pulmonary laboratory. The best of 3 The present study is a cross sectional one that included 30 measures obtained while the patient is breathing room air by female patients with RA, fulfilling the American College of flow volume spirometry (Flow mate model 2500) were used Rheumatology/European league against rheumatism (ACR/ to calculate the following parameters: EULAR) criteria for classification of RA [16]. They were selected from patients attending the Rheumatology and Reha- – Forced vital capacity (FVC): amount of air that can be bilitation outpatient clinic in Ain Shams University Hospitals forcefully expelled from maximally inflated lung. (ASUH). – Forced expiratory volume in 1st second (FEV-1): Volume All the patients were on a stable disease-modifying drug of air expelled during the first second of FVC. regimen for three months prior to study entry. The study – Ratio of FEV-1 to FVC (FEV-1/FVC). was approved by the local ethics committee and written con- Please cite this article in press as: Fouda N, Dayem AA Obstructive sleep apnea in patients with rheumatoid arthritis: Correlation with disease activity and pulmonary function tests, The Egyptian Rheumatologist (2014), http://dx.doi.org/10.1016/j.ejr.2014.04.002 Obstructive sleep apnea in patients with rheumatoid arthritis 3 2.4. Polysomnography (PSG) (overnight sleep test) 58.33 ± 13.28) and highly sensitive C-reactive protein (hsCRP) ranged from 3–8 mg/L (mean 5.3 ± 0.58). The test was done in sleep laboratory in chest department in By using DAS28 for assessment of disease activity, there ASUH using the Somnomedic (Germany) system. The patient was 10 active patients (33.3%) with their DAS28 >2.6 (mean arrived about two hours before bed time without having made 4.26 ± 0.58). While the other 20 patients (66.7%) were inac- any changes in daily habits. The PSG consisted of 14 channel tive (mean 1.88 ± 0.40). Abnormal pulmonary function tests, continuous polygraphic recording from surface leads for 2 were detected in 10 patients (33.3%); all showed an obstructive electro-encephalography, 2 electro-oculography, chin electro- pattern (FEV-1/FVC ratio <80), while 20 patients (66.6%) myography, electro-cardiography, sensors for nasal airflow had normal PFTs. (thermistor), tracheal sounds (microphone), thoracic and Fourteen of our patients (46.7%) met the diagnostic criteria abdominal respiratory effort (piezo-electric), finger pulse oxim- for diagnosis of OSA by polysomnography (AHI P5) while in eter, leg movements, body position and light. the other 16 patients (53.3%) no evidence of OSA was Data obtained from this study were recorded. According to the results of polysomnography, the patients – Apnea index (AI): Complete cessation of airflow breathing were divided into 2 groups, patients with OSA (n = 14) and at the nostrils and mouth for at least 10 s or longer. patients without OSA (n = 16). Comparison between both – Hypopnea index (HI): Decrease in rate and depth of breath- groups showed that patients with OSA had longer disease dura- ing by 50% for 10 s or longer.
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