Metabolic Syndrome 3 out of 5 criteria for diagnosis

Pathological levels?

 Fasting glucose

  Waist circumference   Blood pressure  Triglycerides   HDL-Cholesterol

Our Routine Laboratory Tests

 Intact Proinsulin  Adiponectin  OxLDL / MDA Adduct  CRP (high sensitive)  IDK® TNFa  Haptoglobin

 Vitamin B1

Tests for your Research

 Adenosine  Resistin  ADMA Xpress  Relaxin  ADMA (Mouse/Rat)  OPG  AOPP  total sRANKL  Carbonylated Proteins  IDK® TNFa  RBP/RBP4  IDK® Zonulin

US: all products: Research Use Only. Not for use in diagnostic procedures. www.immundiagnostik.com Metabolic Syndrome

Adiponectin total (human) (ELISA) (K 6250)  Determination of the adiponectin level as a prevention for Type-2-Diabetes

Retinol-binding protein RBP/RBP4 (ELISA) (K 6110)  Influence on glucose homeostasis and the development of insulin sensitivity / resistance  Convenient marker for Type-2-Diabetes and for cardiovascular risk

Resistin (ELISA) (on request)  Link between adipositas and insulin resistance?

ID Vit® Vitamin B1 (colorimetric test) (KIF001)

 Diabetes patients exhibit a low Vitamin B1 plasma level Also available: Other Vitamin B ID Vit® tests

IDK® Zonulin (ELISA) (K 5601 )  Understanding the dynamic interaction between zonulin and diabetes. High zonulin levels are associated with Type-1-Diabetes

Vasoconstriction / Vasodilatation

Relaxin (ELISA) (K 9210)  Endogenous antagonist of endothelin. Vasodilatator, increases microcirculation

Urotensin II ( RUO) (on request)  Most powerful vasoconstrictor known

Oxidative Stress / Arteriosclerosis

ADMA Xpress (Asymmetric Dimethylarginine) (ELISA) (K 7860 )  Endogenous NO synthase inhibitor as prognostic factor of arteriosclerosis

Also available: ADMA (Mouse / Rat) ELISA (KR3001; RUO )

AOPP (Advanced Oxidation Protein Products) (Colorimetric MTP Assay) (KR7811w; RUO )  Biomarker for protein degradation by reactive oxygen species

Carbonyl Protein (ELISA) (K 7870)  Biomarker for oxidative stress  Ultra-sensitive assay with minimal sample volume

IDK® Calprotectin (MRP 8/14) (ELISA) (K 6935, K 6928 )  Granulocyte activation marker for diagnostics of inflammatory processes

S100A8/A9 (Mouse/Rat) MRP 8/14 / Calprotectin) (ELISA) (KR6936; RUO) worldwide unique  Granulocyte activation marker for diagnostics of inflammatory processes in research

CRP (high sensitive CRP) (ELISA) (K 9710s)  Risk marker of arteriosclerosis

Haptoglobin (ELISA) (KSA71001)  Increased oxidative stress and CVD risk in Hp 2-2 phenotype diabetes mellitus patients

IDK® MPO (ELISA) (K 6631B)  Indicates risk of myocardial infarction OxLDL / MDA Adduct (ELISA) (K 7810)  Marker for lipid peroxidation  Involved in the pathogenesis of arteriosclerosis and coronary heart disease

IDK® TNFa (Tumor Nekrose Faktor a) (ELISA) (K 9610)  Detection of the proinflammatory cytokine TNFa

Vascular Calcification

Osteoprotegerin (OPG) (ELISA) (K 1011)  Part of the OPG-/RANKL/sRANKL system which plays a role in the pathogenesis of vascular diseases  Serum OPG levels are associated with the presence and severity of coronary artery disease

Also available: OPG Mouse/Rat (ELISA) (KR1020; RUO)

total sRANKL (ELISA) (K 1016) worldwide unique  Part of the OPG-/RANKL/sRANKL system which plays a role in the pathogenesis of vascular diseases

Also available: sRANKL Mouse/Rat (ELISA) (K 1019; RUO)

PCR Assays:

MutaCHIP® ARTERO (KF390009) Cardiovascular Risk Genes

MutaCHIP® TOXO (KF390011) Detoxification enzymes

MutaGEL® ApoB100 (KE09023; RUO) PCR test for the detection of a mutation in codon 3500 in patients with hypercholesterolemia

MutaPLATE® / REAL Prothrombin (Factor II) (KF1901696, KF291696)

MutaPLATE® / REAL Factor V (KF1901796, KF291796)

MutaPLATE®MTHFR 2 (TM) (KF1901496) Mutations in the MTHFR gene should be analysed conjunctively as genetic risk factors for hyperhomocysteinemia

RUO: Research Use Only

For more information please visit our website www.immundiagnostik.com or contact our export department [email protected] FAX-Reply to: +49 62 51 84 94 30 Immundiagnostik AG

Please send me the following informative material:

q Product List 19 Brochures: Product List 2019

Immunoassays HPLC • LC-MS/MS Photometry Molecular Biology q Skeletal System

Immundiagnostik AG Stubenwald-Allee 8a 64625 Bensheim, Germany Phone: +49 (0) 62 51/70 19 00 Fax: +49 (0) 62 51/84 94 30 [email protected] www.immundiagnostik.com q Gastrointestinal Diseases q Cardiovascular and Renal Systems q Catalogue "IDK® Applied Bioscience & Research Products“ (Antibodies 19 q Complementary Medicine and Antigens) IDK® Applied Bioscience & Research Products q Oxidative Stress Antibodies

Antigens q Molecular Biology 2019-02-05 q HPLC Applications / LC-MS/MS Applications q Manuals of these products:

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Immundiagnostik AG Stubenwald-Allee 8a 64625 Bensheim, Germany Phone: +49 (0)6251 701900 Fax: +49 (0)6251 849430 [email protected] www.immundiagnostik.com www.immundiagnostik.com FOH 8 2019-08-19