Metabolic Syndrome 3 out of 5 criteria for diagnosis Pathological levels? Fasting glucose Waist circumference Blood pressure Triglycerides HDL-Cholesterol Our Routine Laboratory Tests Intact Proinsulin Adiponectin OxLDL / MDA Adduct CRP (high sensitive) IDK® TNFa Haptoglobin Vitamin B1 Tests for your Research Adenosine Resistin ADMA Xpress Relaxin ADMA (Mouse/Rat) OPG AOPP total sRANKL Carbonylated Proteins IDK® TNFa RBP/RBP4 IDK® Zonulin US: all products: Research Use Only. Not for use in diagnostic procedures. www.immundiagnostik.com Metabolic Syndrome Adiponectin total (human) (ELISA) (K 6250) Determination of the adiponectin level as a prevention for Type-2-Diabetes Retinol-binding protein RBP/RBP4 (ELISA) (K 6110) Influence on glucose homeostasis and the development of insulin sensitivity / resistance Convenient marker for Type-2-Diabetes and for cardiovascular risk Resistin (ELISA) (on request) Link between adipositas and insulin resistance? ID Vit® Vitamin B1 (colorimetric test) (KIF001) Diabetes patients exhibit a low Vitamin B1 plasma level Also available: Other Vitamin B ID Vit® tests IDK® Zonulin (ELISA) (K 5601 ) Understanding the dynamic interaction between zonulin and diabetes. High zonulin levels are associated with Type-1-Diabetes Vasoconstriction / Vasodilatation Relaxin (ELISA) (K 9210) Endogenous antagonist of endothelin. Vasodilatator, increases microcirculation Urotensin II ( RUO) (on request) Most powerful vasoconstrictor known Oxidative Stress / Arteriosclerosis ADMA Xpress (Asymmetric Dimethylarginine) (ELISA) (K 7860 ) Endogenous NO synthase inhibitor as prognostic factor of arteriosclerosis Also available: ADMA (Mouse / Rat) ELISA (KR3001; RUO ) AOPP (Advanced Oxidation Protein Products) (Colorimetric MTP Assay) (KR7811w; RUO ) Biomarker for protein degradation by reactive oxygen species Carbonyl Protein (ELISA) (K 7870) Biomarker for oxidative stress Ultra-sensitive assay with minimal sample volume IDK® Calprotectin (MRP 8/14) (ELISA) (K 6935, K 6928 ) Granulocyte activation marker for diagnostics of inflammatory processes S100A8/A9 (Mouse/Rat) MRP 8/14 / Calprotectin) (ELISA) (KR6936; RUO) worldwide unique Granulocyte activation marker for diagnostics of inflammatory processes in research CRP (high sensitive CRP) (ELISA) (K 9710s) Risk marker of arteriosclerosis Haptoglobin (ELISA) (KSA71001) Increased oxidative stress and CVD risk in Hp 2-2 phenotype diabetes mellitus patients IDK® MPO (ELISA) (K 6631B) Indicates risk of myocardial infarction OxLDL / MDA Adduct (ELISA) (K 7810) Marker for lipid peroxidation Involved in the pathogenesis of arteriosclerosis and coronary heart disease IDK® TNFa (Tumor Nekrose Faktor a) (ELISA) (K 9610) Detection of the proinflammatory cytokine TNFa Vascular Calcification Osteoprotegerin (OPG) (ELISA) (K 1011) Part of the OPG-/RANKL/sRANKL system which plays a role in the pathogenesis of vascular diseases Serum OPG levels are associated with the presence and severity of coronary artery disease Also available: OPG Mouse/Rat (ELISA) (KR1020; RUO) total sRANKL (ELISA) (K 1016) worldwide unique Part of the OPG-/RANKL/sRANKL system which plays a role in the pathogenesis of vascular diseases Also available: sRANKL Mouse/Rat (ELISA) (K 1019; RUO) PCR Assays: MutaCHIP® ARTERO (KF390009) Cardiovascular Risk Genes MutaCHIP® TOXO (KF390011) Detoxification enzymes MutaGEL® ApoB100 (KE09023; RUO) PCR test for the detection of a mutation in codon 3500 in patients with hypercholesterolemia MutaPLATE® / REAL Prothrombin (Factor II) (KF1901696, KF291696) MutaPLATE® / REAL Factor V (KF1901796, KF291796) MutaPLATE®MTHFR 2 (TM) (KF1901496) Mutations in the MTHFR gene should be analysed conjunctively as genetic risk factors for hyperhomocysteinemia RUO: Research Use Only For more information please visit our website www.immundiagnostik.com or contact our export department [email protected] FAX-Reply to: +49 62 51 84 94 30 Immundiagnostik AG Please send me the following informative material: q 19 Brochures: Product List Product List 2019 Immunoassays HPLC • LC-MS/MS Photometry Molecular Biology q Skeletal System Immundiagnostik AG Stubenwald-Allee 8a 64625 Bensheim, Germany Phone: +49 (0) 62 51/70 19 00 Fax: +49 (0) 62 51/84 94 30 [email protected] www.immundiagnostik.com q Gastrointestinal Diseases q Cardiovascular and Renal Systems q Catalogue "IDK® Applied Bioscience & Research Products“ (Antibodies 19 q Complementary Medicine and Antigens) IDK® Applied Bioscience & Research Products q Oxidative Stress Antibodies Antigens q Molecular Biology 2019-02-05 q HPLC Applications / LC-MS/MS Applications q Manuals of these products: Name/Address: Phone: Fax: E-Mail: Date: Immundiagnostik AG Stubenwald-Allee 8a 64625 Bensheim, Germany Phone: +49 (0)6251 701900 Fax: +49 (0)6251 849430 [email protected] www.immundiagnostik.com www.immundiagnostik.com FOH 8 2019-08-19.