Anti-MDH2 Monoclonal Antibody, Clone FQS25993(C) (DCABH-7382) This Product Is for Research Use Only and Is Not Intended for Diagnostic Use

Anti-MDH2 monoclonal antibody, clone FQS25993(C) (DCABH-7382) This product is for research use only and is not intended for diagnostic use.

PRODUCT INFORMATION

Product Overview Rabbit monoclonal to MDH2

Antigen Description E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as an ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin- independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53. Also component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways.

Immunogen Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) within Human MDH2 aa 100-200. The exact sequence is proprietary.Database link: P40926

Isotype IgG

Source/Host Rabbit

Species Reactivity Mouse, Rat, Human

Clone FQS25993(C)

Purity Tissue culture supernatant

Conjugate Unconjugated

Applications WB, IHC-P

Positive Control Jurkat, K562, HepG2 and HeLa cell lysates. Human infiltrating duct carcinoma of breast and mouse testis tissue.

Format Liquid

Size 100 μl

Buffer Preservative: 0.01% Sodium azide; Constituents: 40% Glycerol, 59% PBS, 0.05% BSA

Preservative 0.01% Sodium Azide

Storage Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid

45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]

Ship Shipped at 4°C.

GENE INFORMATION

Gene Name MDH2 malate dehydrogenase 2, NAD (mitochondrial) [ Homo sapiens ]

Official Symbol MDH2

Synonyms MDH2; malate dehydrogenase 2, NAD (mitochondrial); malate dehydrogenase, mitochondrial; MDH; MOR1; M-MDH; MGC:3559;

Entrez Gene ID 4191

Protein Refseq NP_005909

UniProt ID B3KTM1

Chromosome Location 7cen-q22

Pathway Citrate cycle (TCA cycle), organism-specific biosystem; Citrate cycle (TCA cycle), conserved biosystem; Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate, organism- specific biosystem; Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate, conserved biosystem; Citric acid cycle (TCA cycle), organism-specific biosystem;

Function L-malate dehydrogenase activity; L-malate dehydrogenase activity; L-malate dehydrogenase activity; malate dehydrogenase (NADP+) activity; nucleotide binding; oxidoreductase activity; protein self-association;

45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]