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Apnea and Rapid Eye Movement Sleep Excess in the Piglet During Recovery from Hyperthermia

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Apnea and Rapid Eye Movement Sleep Excess in the Piglet During Recovery from Hyperthermia 003 I-3998/93/3404-05 18$03.00/0 PEDIATRIC RESEARCH Vol. 34, No. 4. 1993 Copyright 0 1993 International Pediatric Research Foundation. Inc Pr~trr,llt,rl in L' S. :I Apnea and Rapid Eye Movement Sleep Excess in the Piglet during Recovery from Hyperthermia BARBARA C. GALLAND. DAVID P. G. BOLTON. AND BARRY J. TAYLOR Dc~purimcnic?/'Pcdiuiric:s und C%ild Hc~ulil~/B.C'.G.. B.J. T.1, und Dc~puritncnic?l'P/~~~.sio/c~,yj- 1D.P.G.8.1. L1ni~,c~r.cii!*c?/'Oiu,yo .Zfc~Clicu/ Sc./~oo/. Dlinedin. NCI{'%c,u/utld ABSTRACT. This investigation tested the hypothesis that per se could modify respiratory pattern and/or sleep state. In artificially induced mild hyperthermia and recovery from puppies, apnea induced by laryngeal stimulation becomes more hyperthermia in the developing newborn piglet (2-10 d of severe as the temperature is raised (7), and in premature human age) alter sleep state patterns and respiratory control. infants, raising the environmental temperature enhances the Continuous measurements of sleep state, respiratory pat- already unstable respiratory pattern characteristic of these in- tern, carbon dioxide production and oxygen consumption fants. i.e. apnea and periodic breathing (8-10). These patterns were made before, during, and after a 3-h period of sus- are particularly enhanced in REM sleep, a state associated with tained hyperthermia. During hyperthermia, rectal temper- depressed responsiveness to environmental stimuli. In several atures were raised a mild I-1.5"C above normal, well below species, total sleep time increases at the upper limits of thermo- the levels likely to cause severe physiologic distress in this neutrality (1 1, 12) and the total duration of REM sleep is species. This resulted in a disruption of the sleep state correlated with rises in ambient temperature up to this limit (1 3). pattern characterized by a decrease in duration of rapid The question this investigation addressed was whether the eye movement (REM) episodes, whereas immediately af- sleeping newborn showed changes in sleep state and respiratory terwards, during recovery, the amount of REM sleep in- control during and immediately after artificially induced mild creased. In some cases the amount of REM sleep in hyperthermia. We chose to conduct our investigations on the recovery more than doubled the basal level. Apneas were young piglet. This species shows postnatal development similar rarely observed during hyperthermia, but in recovery there to that of the human infant in terms of sleep state maturation was an increase in the total amount of time spent in apnea and cardiorespiratory behavior (14), and it is one of the few in both REM and non-rapid eye movement sleep states larger animals born with very limited insulation on the skin with a predominance in the REM state. Arousal responses surface. The experiments were simple and noninvasive, designed to chemostimulation were not affected at this time. We to measure respiration and sleep state during normal sleep, conclude that the sleeping newborn piglet does indeed show before, during. and after a period of sustained hyperthermia. marked changes in sleep state pattern (particularly REM During this hyperthermia, rectal temperatures were raised 1 to sleep) and in the amount of apnea recorded during and 1.5'C above normal. well below the levels likely to cause severe immediately after only a mild increase in core temperature. physiologic distress to this species (15). (Pediatr Res 34: 5 18-524, 1993) MATERIALS AND METHODS Abbreviations Twenty-four farm-bred piglets of mixed sex and from different vo2,oxygen consumption litters were separated from the sow 2 d after birth and thereafter vco2,carbon dioxide production raised on reconstituted milk powder. They were housed singly in REM, rapid eye movement a pen where environmental temperature was maintained between NREM, non-rapid eye movement 30.5 and 32.OoC.When possible, all piglets were studied during TST, total sleep time sleep at 2 and 4 d after birth (wk 1) and 7 and 10 d after birth SIDS, sudden infant death syndrome (wk 2). Mean body weights at 2 d were 1.01 + 0.05 kg, and at EOG, electrooculogram 10 d, 1.43 k 0.07 kg. Sleep Staging. NREM sleep. REM sleep, and the awake state were determined from the signals of standard bipolar EEG (C4/ A, or C3/Al positions) and EOG (referred to each outer canthus The reason for our interest in the relationship between hyper- of the eye) surface electrodes. NREM sleep was defined by high- thermia and respiratory stability is the suggestion that SIDS is voltage slow waves on the EEG and no eye movements on the associated with situations that could give rise to hyperthermia EOG. REM sleep was defined by low-voltage waves and eye (1-4) or with the postfebrile period (5) rather than hyperthermia movements, and wakefulness was defined by low-voltage mixed- itself. The prevalence of REM sleep in these conditions was frequency EEG pattern with movement artifacts in both the EEG investigated as a possible cause of respiratory instability, noting and EOG wave forms. Observations of behavior and respiratory that young SIDS victims have been reported as having had a pattern could be used to confirm identification of sleep state. significantly greater number of REM sleep epochs compared The signals were amplified (Grass 7DA, Grass Instrument Co., with controls (6). Quincy. MA) and relayed through the integrated hardware/ Experimental studies have suggested that mild hyperthermia software system of a MacLab (Analog Digital Instruments. Dune- din, New Zealand) for recording and display. TST was calcu- Received October 10, 199 1; accepted April 22. 1993. lated as the sum of NREM and REM sleep times within each Correspondence: Barbara C. Galland. Ph.D.. Department of Paediatrics and Child Health. P.O. Box 9 13. Dunedin, New Zealand. temperature study phase. Supported by the Cot Death Division of the National Children's Health Research Rrspiralorv Pattrrn. A respiband (model 150, Respitrace Co., Foundation of New Zealand. NY) was used to record respiratory pattern from the ribcage and HYPERTHERMIA. RESPIR ATION. AND REM SLEEP 5 19 abdomen. The output from the Respitrace was relayed through and during cooling after hyperthermia (recovery). The studies a MacLab system for recording and display. Respiratory pattern were performed at 2 and 4 d of age (wk 1) and at 7 and 10 d of was determined from the signal of the sum of the ribcage and age (wk 2). During wk 2, sedation was necessary (chloral hydrate: abdomen and each trace scanned to identify long expiratory 160 mg/kg dissolved in the milk feed) to be sure of sufficient pauses. A pause was defined as an apnea when the expiratory sleep time for the study. duration was greater than 4 times the average expiratory duration To evaluate the effects of sedation. another eight piglets (se- of the previous 10 breaths. dation control group) were investigated on d 4 according to the VO~and Vco2. Voz and VCO~were measured by indirect same protocol as the heated group (see below) except for sedation calorimetry using an adaptation of the method described by with chloral hydrate (160 mg/kg). The results were compared Lister et 01. (16) for use in neonatal studies. Animals slept in a with those recorded in the heated group on d 4 without sedation. cylindrical acrylic chamber, 10 L in volume. Each end was To evaluate any time-dependent changes independent of tapered to fit inlet and outlet respiratory tubing. The smaller warming, another eight animals (unheated group) were investi- piglet could turn freely within this chamber and the tubing could gated over a 6-h period on d 2, 4, 7, and 10 as for the heated be switched depending on which end the animal chose to sleep group, but they were kept in thermoneutral ambience. Here also at. Outside air was sucked through the chamber by means of a sedation was used during the wk-2 studies only. All the data vacuum pump (Ameda. Switzerland) at a steady rate of 4 L/min presented for the heated group are compared with data from as measured with a linear flow meter (rotameter). A large volume these animals. chamber was inserted in the line between the flow meter and the An additional three animals (blood gas group) were chronically pump to damp the pulsatile sucking action of this pump. Con- catheterized to allow blood gas analysis during the protocol for centrations of O2and COzwere measured by a mass spectrometer the heated group as described below. They were operated on 2 d (Perkin-Elmer 1 100. Perkin-Elmer Corp.. Norwalk. CT). Meas- before study with full sterile procedures under general anesthesia urements were continuous. although the single sample line of (1.5% halothane in oxygen): a catheter was tied into a carotid the mass spectrometer required the inflow and outflow ports to artery and brought subcutaneously to emerge at the back of the be sampled alternately. A MacLab system was used to record neck. They were dosed regularly with antibiotics and the catheters and display the signals. The measured outflow for O2 ranged flushed with heparinized saline (10 U/mL). All three animals between 20.5 and 19.9%. and for COz, between 0.4 and 0.9%. were studied on d 4, two on d 7, and one on d 10 and were The lowest and highest values for 02and CO?. respectively. were sedated as above. Blood samples (0.3 mL) were taken hourly and recorded during hyperthermia. Voz and Vco? were calculated as analyzed using an ABL330 Acid-Base Laboratory (Radiometer, the product of the differences between inflow and outflow gas Copenhagen.
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