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Chemical Threat Agents Call Poison Control 24/7 for Treatment Information 1.800.222.1222 Blood Nerve Blister Pulmonary Metals Toxins
CHEMICAL THREAT AGENTS CALL POISON CONTROL 24/7 FOR TREATMENT INFORMATION 1.800.222.1222 BLOOD NERVE BLISTER PULMONARY METALS TOXINS SYMPTOMS SYMPTOMS SYMPTOMS SYMPTOMS SYMPTOMS SYMPTOMS • Vertigo • Diarrhea, diaphoresis • Itching • Upper respiratory tract • Cough • Shock • Tachycardia • Urination • Erythema irritation • Metallic taste • Organ failure • Tachypnea • Miosis • Yellowish blisters • Rhinitis • CNS effects • Cyanosis • Bradycardia, bronchospasm • Flu-like symptoms • Coughing • Shortness of breath • Flu-like symptoms • Emesis • Delayed eye irritation • Choking • Flu-like symptoms • Nonspecific neurological • Lacrimation • Delayed pulmonary edema • Visual disturbances symptoms • Salivation, sweating INDICATIVE LAB TESTS INDICATIVE LAB TESTS INDICATIVE LAB TEST INDICATIVE LAB TESTS INDICATIVE LAB TESTS INDICATIVE LAB TESTS • Increased anion gap • Decreased cholinesterase • Thiodiglycol present in urine • Decreased pO2 • Proteinuria None Available • Metabolic acidosis • Increased anion gap • Decreased pCO2 • Renal assessment • Narrow pO2 difference • Metabolic acidosis • Arterial blood gas between arterial and venous • Chest radiography samples DEFINITIVE TEST DEFINITIVE TEST DEFINITIVE TEST DEFINITIVE TESTS DEFINITIVE TESTS • Blood cyanide levels • Urine nerve agent • Urine blister agent No definitive tests available • Blood metals panel • Urine ricinine metabolites metabolites • Urine metals panel • Urine abrine POTENTIAL AGENTS POTENTIAL AGENTS POTENTIAL AGENTS POTENTIAL AGENTS POTENTIAL AGENTS POTENTIAL AGENTS • Hydrogen Cyanide -
COMBINED LIST of Particularly Hazardous Substances
COMBINED LIST of Particularly Hazardous Substances revised 2/4/2021 IARC list 1 are Carcinogenic to humans list compiled by Hector Acuna, UCSB IARC list Group 2A Probably carcinogenic to humans IARC list Group 2B Possibly carcinogenic to humans If any of the chemicals listed below are used in your research then complete a Standard Operating Procedure (SOP) for the product as described in the Chemical Hygiene Plan. Prop 65 known to cause cancer or reproductive toxicity Material(s) not on the list does not preclude one from completing an SOP. Other extremely toxic chemicals KNOWN Carcinogens from National Toxicology Program (NTP) or other high hazards will require the development of an SOP. Red= added in 2020 or status change Reasonably Anticipated NTP EPA Haz list COMBINED LIST of Particularly Hazardous Substances CAS Source from where the material is listed. 6,9-Methano-2,4,3-benzodioxathiepin, 6,7,8,9,10,10- hexachloro-1,5,5a,6,9,9a-hexahydro-, 3-oxide Acutely Toxic Methanimidamide, N,N-dimethyl-N'-[2-methyl-4-[[(methylamino)carbonyl]oxy]phenyl]- Acutely Toxic 1-(2-Chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea (Methyl-CCNU) Prop 65 KNOWN Carcinogens NTP 1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) IARC list Group 2A Reasonably Anticipated NTP 1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) (Lomustine) Prop 65 1-(o-Chlorophenyl)thiourea Acutely Toxic 1,1,1,2-Tetrachloroethane IARC list Group 2B 1,1,2,2-Tetrachloroethane Prop 65 IARC list Group 2B 1,1-Dichloro-2,2-bis(p -chloropheny)ethylene (DDE) Prop 65 1,1-Dichloroethane -
Chemical Hygiene Plan Manual
CHEMICAL HYGIENE PLAN AND HAZARDOUS MATERIALS SAFETY MANUAL FOR LABORATORIES This is the Chemical Hygiene Plan specific to the following areas: Laboratory name or room number(s): ___________________________________ Building: __________________________________________________________ Supervisor: _______________________________________________________ Department: _______________________________________________________ Telephone numbers 911 for Emergency and urgent consultation 48221 Police business line 46919 Fire Dept business line 46371 Radiological and Environmental Management Revisied on: Enter a revision date here. All laboratory chemical use areas must maintain a work-area specific Chemical Hygiene Plan which conforms to the requirements of the OSHA Laboraotry Standard 29 CFR 19190.1450. Purdue University laboratories may use this document as a starting point for creating their work area specific CHP. Minimally this cover page is to be edited for work area specificity (non-West Lafayette laboratories are to place their own emergency, fire, and police telephone numbers in the space above) AND appendix K must be completed. This instruction and information box should remain. This model CHP is version 2010A; updates are to be found at www.purdue.edu/rem This page intentionally blank. PURDUE CHEMICAL HYGIENE PLAN AWARENESS CERTIFICATION For CHP of: ______________________________ Professor, building, rooms The Occupational Safety and Health Administration (OSHA) requires that laboratory employees be made aware of the Chemical Hygiene Plan at their place of employment (29 CFR 1910.1450). The Purdue University Chemical Hygiene Plan and Hazardous Materials Safety Manual serves as the written Chemical Hygiene Plan (CHP) for laboratories using chemicals at Purdue University. The CHP is a regular, continuing effort, not a standby or short term activity. Departments, divisions, sections, or other work units engaged in laboratory work whose hazards are not sufficiently covered in this written manual must customize it by adding their own sections as appropriate (e.g. -
Biochemical and Pathological Effects of Methylazoxymethanol Acetate, a Potent Carcinogen1
[CANCER RESEARCH 30, 801-812, March 1970] Biochemical and Pathological Effects of Methylazoxymethanol Acetate, a Potent Carcinogen1 Morris S. Zedeck, Stephen S. Sternberg, Richard W. Poynter, and Jane McGowan Divisions of Pharmacology and Cytology, Sloan-Kettering Institute for Cancer Research, New York, New York 10021 SUMMARY vealed that the agent is cleaved by the intestinal flora which possess a 0-o-glucosidase, and that the free agly Methylazoxymethanol acetate is known to induce tu cone methylazoxymethanol is the active carcinogen (13- mors in rodents. Effects produced by a single nonlethal 15, 34). Matsumoto et al. (19) synthesized MAM acetate3 dose on nucleic acid and protein synthesis have been in (Chart 1), which is stable and not dependent upon vestigated in rat and mouse liver, small intestine, and ,0-glucosidase cleavage for activity. Single or only a few kidney, the 3 organs most susceptible to carcinogenesis. doses of cycasin, or of the aglycone methylazoxymetha The agent induced early inhibition of thymidine incor nol, are required to induce tumors in rats which are pri poration into DNA of rat tissues. Rat liver was most sen marily of the kidney, intestinal tract, and liver (11, 15). sitive to this effect and was the only organ to show marked Aqueous extracts of cycad nut have also been shown to inhibition of RNA and protein synthesis. In mice, liver induce tumors of liver and kidneys in mice (21). The was more sensitive than small intestine or kidney and ex present investigation was undertaken to study the acute hibited an inhibition of RNA and protein synthesis; there pathological and biochemical effects produced by MAM were no changes observed in small intestine or kidney. -
Medicine with Deeper, More Biochemical Conception Of
Edinburgh Medical Journal May 1951 APPLICATIONS of chemical defence research IN MEDICINET? By Professor R. A. PETERS to be invited It is a great responsibility, as well as a great honour, to Cameron lecturers give this lecture ; and I expect that with other I this ancient seat of share a sense of awe upon standing here in is learning. For me it is an awe tinged with much feeling (it possible that this is partly because some forebears of my mother came from near to recent of the this ; it is in part due the perusal city) perhaps " address here Froude in on the Times of John Knox, given by 1865 " " entitled Influence of the Reformation upon the Scottish Character ; this address drives home to the Sassenach the sterner stuff of which all of us in the the Scots are made ; but I really think it is more that as south, even if we come as I do from a Medical School as ancient the Hospital of St Bartholomew, know full well that Edinburgh stands high indeed in the world of Medical Schools as Scotland itself stands in the world of intellect. Elsewhere I have discussed fully the historical background of our for me back researches upon Chemical Defence substances, which go to World War I.23 Again in my Dixon lecture,24 I have indicated some of the interest for pharmacology. The outlook for medicine has not the been reviewed so far. Therefore I propose to-day to discuss of British influence upon the future of therapeutics of the discovery anti-lewisite and of some of the other researches upon war gas but substances ; and to consider not only the leads towards therapy, the possible newer trends given to medicine itself. -
Amyl Nitrite Or 'Jungle Juice'
Young People and Other Drugs Amyl Nitrite or ‘Jungle Juice’ Amyl nitrite is an inhalant that belongs to a class As with any drug, the use of nitrites is not risk-free. of chemicals called alkyl nitrites. This group of Some of the harms associated with its use include: drugs can be called ‘poppers’. They are often injuries related to inhaling the vapour referred to by their brand name, with ‘Jungle (e.g., rashes, burns) Juice’ probably being the most well-known of these. allergic reactions accidents and falls Inhaling amyl nitrite relaxes the body and gives vision problems (isopropyl nitrite) a ‘rush’ that lasts for one to two minutes. It is commonly used to enhance sexual pleasure and in rare cases, blood disorders induce a feeling of euphoria and well-being. MOST IMPORTANTLY, AMYL NITRITE OR JUNGLE JUICE MUST NEVER BE DRUNK. Drinking amyl can result in death due to it interfering with the ability of the blood to transport oxygen. What is amyl nitrite? Over the years, to bypass legal restrictions, nitrites have been sold as such things as liquid incense or Amyl nitrite is an inhalant that belongs to a class of room odoriser. Jungle Juice, which can be sold as chemicals called alkyl nitrites. Amyl nitrite is a highly a leather cleaner, is a common product name of flammable liquid that is clear or yellowish in colour. amyl nitrite. It has a unique smell that is sometimes described as ‘dirty socks’. It is highly volatile and when exposed to the air evaporates almost immediately at How is Jungle Juice used? room temperature. -
Toxicological Profile for Glyphosate Were
A f Toxicological Profile for Glyphosate August 2020 GLYPHOSATE II DISCLAIMER Use of trade names is for identification only and does not imply endorsement by the Agency for Toxic Substances and Disease Registry, the Public Health Service, or the U.S. Department of Health and Human Services. GLYPHOSATE III FOREWORD This toxicological profile is prepared in accordance with guidelines developed by the Agency for Toxic Substances and Disease Registry (ATSDR) and the Environmental Protection Agency (EPA). The original guidelines were published in the Federal Register on April 17, 1987. Each profile will be revised and republished as necessary. The ATSDR toxicological profile succinctly characterizes the toxicologic and adverse health effects information for these toxic substances described therein. Each peer-reviewed profile identifies and reviews the key literature that describes a substance's toxicologic properties. Other pertinent literature is also presented, but is described in less detail than the key studies. The profile is not intended to be an exhaustive document; however, more comprehensive sources of specialty information are referenced. The focus of the profiles is on health and toxicologic information; therefore, each toxicological profile begins with a relevance to public health discussion which would allow a public health professional to make a real-time determination of whether the presence of a particular substance in the environment poses a potential threat to human health. The adequacy of information to determine a substance's -
Nerve Agent - Lntellipedia Page 1 Of9 Doc ID : 6637155 (U) Nerve Agent
This document is made available through the declassification efforts and research of John Greenewald, Jr., creator of: The Black Vault The Black Vault is the largest online Freedom of Information Act (FOIA) document clearinghouse in the world. The research efforts here are responsible for the declassification of MILLIONS of pages released by the U.S. Government & Military. Discover the Truth at: http://www.theblackvault.com Nerve Agent - lntellipedia Page 1 of9 Doc ID : 6637155 (U) Nerve Agent UNCLASSIFIED From lntellipedia Nerve Agents (also known as nerve gases, though these chemicals are liquid at room temperature) are a class of phosphorus-containing organic chemicals (organophosphates) that disrupt the mechanism by which nerves transfer messages to organs. The disruption is caused by blocking acetylcholinesterase, an enzyme that normally relaxes the activity of acetylcholine, a neurotransmitter. ...--------- --- -·---- - --- -·-- --- --- Contents • 1 Overview • 2 Biological Effects • 2.1 Mechanism of Action • 2.2 Antidotes • 3 Classes • 3.1 G-Series • 3.2 V-Series • 3.3 Novichok Agents • 3.4 Insecticides • 4 History • 4.1 The Discovery ofNerve Agents • 4.2 The Nazi Mass Production ofTabun • 4.3 Nerve Agents in Nazi Germany • 4.4 The Secret Gets Out • 4.5 Since World War II • 4.6 Ocean Disposal of Chemical Weapons • 5 Popular Culture • 6 References and External Links --------------- ----·-- - Overview As chemical weapons, they are classified as weapons of mass destruction by the United Nations according to UN Resolution 687, and their production and stockpiling was outlawed by the Chemical Weapons Convention of 1993; the Chemical Weapons Convention officially took effect on April 291997. Poisoning by a nerve agent leads to contraction of pupils, profuse salivation, convulsions, involuntary urination and defecation, and eventual death by asphyxiation as control is lost over respiratory muscles. -
Decision-Making in Chemical Warfare Agent (CWA) Response There Is a Lot of Fear Associated with Chemical Will Act Accordingly
Application Note: 102 Decision-Making in Chemical Warfare Agent (CWA) Response There is a lot of fear associated with Chemical will act accordingly. If the first responders Warfare Agents (CWAs). The misnomer over-react and immediately jump into full “Nerve Gas” quickly brings horrible images to encapsulation protection it could panic the the minds of many civilians. But if we lay aside public and cause unnecessary worry and the politics and fear, CWA detection should even injury. treated like other gas/vapor detection challenges. It should be a collaborative Over Protection Can Be Dangerous process encompassing physical clues, threat to the Responder scenario, biological clues, and a variety of Heat stress is the number one injury in sensing technologies. No one clue or HazMat response and immediately jumping technology is always correct. Experience and into full Level A encapsulation is a good way the use of multiple clues and technologies are of overheating oneself. Level A the keys to successful CWA response. encapsulation also makes one much more Understanding what the clues are and how to susceptible to slip, trip and fall injuries. layer them to make a decision is critical to Finally, over protection makes it harder to get successful CWA response. things done. When properly used, detection allows responders to respond at lower levels Why is Gas Detection Important? of Personal Protective Equipment (PPE) to Responders cannot rely on their senses for provide the highest levels of safety to decision-making. Without effectively knowing themselves and to the community that they how to use detection techniques responders protect. -
Warning: the Following Lecture Contains Graphic Images
What the новичок (Novichok)? Why Chemical Warfare Agents Are More Relevant Than Ever Matt Sztajnkrycer, MD PHD Professor of Emergency Medicine, Mayo Clinic Medical Toxicologist, Minnesota Poison Control System Medical Director, RFD Chemical Assessment Team @NoobieMatt #ITLS2018 Disclosures In accordance with the Accreditation Council for Continuing Medical Education (ACCME) Standards, the American Nurses Credentialing Center’s Commission (ANCC) and the Commission on Accreditation for Pre-Hospital Continuing Education (CAPCE), states presenters must disclose the existence of significant financial interests in or relationships with manufacturers or commercial products that may have a direct interest in the subject matter of the presentation, and relationships with the commercial supporter of this CME activity. The presenter does not consider that it will influence their presentation. Dr. Sztajnkrycer does not have a significant financial relationship to report. Dr. Sztajnkrycer is on the Editorial Board of International Trauma Life Support. Specific CW Agents Classes of Chemical Agents: The Big 5 The “A” List Pulmonary Agents Phosgene Oxime, Chlorine Vesicants Mustard, Phosgene Blood Agents CN Nerve Agents G, V, Novel, T Incapacitating Agents Thinking Outside the Box - An Abbreviated List Ammonia Fluorine Chlorine Acrylonitrile Hydrogen Sulfide Phosphine Methyl Isocyanate Dibotane Hydrogen Selenide Allyl Alcohol Sulfur Dioxide TDI Acrolein Nitric Acid Arsine Hydrazine Compound 1080/1081 Nitrogen Dioxide Tetramine (TETS) Ethylene Oxide Chlorine Leaks Phosphine Chlorine Common Toxic Industrial Chemical (“TIC”). Why use it in war/terror? Chlorine Density of 3.21 g/L. Heavier than air (1.28 g/L) sinks. Concentrates in low-lying areas. Like basements and underground bunkers. Reacts with water: Hypochlorous acid (HClO) Hydrochloric acid (HCl). -
Toxic Industrial Chemicals
J R Army Med Corps 2002; 148: 371-381 J R Army Med Corps: first published as 10.1136/jramc-148-04-06 on 1 December 2002. Downloaded from Toxic Industrial Chemicals Introduction location to another. Depending on the The first chemical warfare agent of the available routes of movement, and quantity modern era, chlorine, was released with of chemical to be moved, transport can occur devastating effect on 22 April 1915 at Ypres, by truck or rail tank cars, over water by barge Belgium. Along a 4 mile front, German or boat, over land through above- or below- soldiers opened the valves of 1,600 large and ground pipelines and by air. 4,130 small cylinders containing 168 tons of Toxic chemicals may be produced by the chlorine.The gas formed a thick white cloud burning of materials (e.g., the burning of that crossed the first allied trenches in less Teflon produces perfluoroisobutylene) or by than a minute.The allied line broke, allowing their reaction if spilled into water (e.g. silanes the Germans to advance deep into allied produce hydrogen chloride and cyanides, territory. If the Germans had been fully hydrogen cyanide). prepared to exploit this breakthrough, the course and possibly the outcome of WWI Toxic Industrial Chemicals may have been very different. (TICs) Chlorine is a commodity industrial A Toxic Industrial Chemical (TIC) is defined chemical with hundreds of legitimate uses; it as: is not a "purpose designed" chemical warfare an industrial chemical which has a LCt50 agent. Phosgene, another commodity value of less than 100,000 mg.min/m3 in industrial chemical, accounted for 80% of any mammalian species and is produced in the chemical fatalities during WWI. -
Interhalogen Compounds
INTERHALOGEN COMPOUNDS Smt. EDNA RICHARD Asst. Professor Department of Chemistry INTERHALOGEN COMPOUND An interhalogen compound is a molecule which contains two or more different halogen atoms (fluorine, chlorine, bromine, iodine, or astatine) and no atoms of elements from any other group. Most interhalogen compounds known are binary (composed of only two distinct elements) The common interhalogen compounds include Chlorine monofluoride, bromine trifluoride, iodine pentafluoride, iodine heptafluoride, etc Interhalogen compounds into four types, depending on the number of atoms in the particle. They are as follows: XY XY3 XY5 XY7 X is the bigger (or) less electronegative halogen. Y represents the smaller (or) more electronegative halogen. Properties of Interhalogen Compounds •We can find Interhalogen compounds in vapour, solid or fluid state. • A lot of these compounds are unstable solids or fluids at 298K. A few other compounds are gases as well. As an example, chlorine monofluoride is a gas. On the other hand, bromine trifluoride and iodine trifluoride are solid and liquid respectively. •These compounds are covalent in nature. •These interhalogen compounds are diamagnetic in nature. This is because they have bond pairs and lone pairs. •Interhalogen compounds are very reactive. One exception to this is fluorine. This is because the A-X bond in interhalogens is much weaker than the X-X bond in halogens, except for the F-F bond. •We can use the VSEPR theory to explain the unique structure of these interhalogens. In chlorine trifluoride, the central atom is that of chlorine. It has seven electrons in its outermost valence shell. Three of these electrons form three bond pairs with three fluorine molecules leaving four electrons.