Mammalian Molar Complexity Follows Simple, Predictable Patterns
Mammalian molar complexity follows simple, predictable patterns Keegan R. Seliga,1, Waqqas Khalida, and Mary T. Silcoxa aDepartment of Anthropology, University of Toronto Scarborough, Toronto, ON M1C 1A4, Canada Edited by Nils Chr. Stenseth, University of Oslo, Oslo, Norway, and approved November 19, 2020 (received for review May 4, 2020) Identifying developmental explanations for the evolution of com- been demonstrated that there are strong genetic controls that plex structures like mammalian molars is fundamental to studying account for the developmental cascade, with research linking the phenotypic variation. Previous study showed that a “morphoge- ICM and the sonic hedgehog (Shh) gene, among others (10). It netic gradient” of molar proportions was explained by a balance should be noted that there are cases where the ICM does between inhibiting/activating activity from earlier developing mo- not seem to account for molar size covariation. For example, lars, termed the inhibitory cascade model (ICM). Although this Roseman and Delezene (11) found that gorillas do not meet any model provides an explanation for variation in molar proportions, of the predictions of the ICM, and Carter and Worthington (12) what remains poorly understood is if molar shape, or specifically demonstrate that some hominoids and cercopithecins do not complexity (i.e., the number of cusps, crests), can be explained by meet all of the predictions either. However, Evans et al. (2) also the same developmental model. Here, we show that molar com- analyzed the ICM in apes and hominids and considered both the plexity conforms to the ICM, following a linear, morphogenetic deciduous premolars and a reversal of the inhibitory cascade gradient along the molar row.
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