Exploration of the Interaction of Probiotics and Prebiotics with The
MEDICAL SCIENCES – Exploration of the Interaction of Probiotics and Prebiotics with the Host using Omics Technologies – Borja Sanchez, Miguel Gueimonde, Abelardo Margolles, Francesca Turroni, Marco Ventura and Douwe van Sinderen EXPLORATION OF THE INTERACTION OF PROBIOTICS AND PREBIOTICS WITH THE HOST USING OMICS TECHNOLOGIES Borja Sánchez, Miguel Gueimonde and Abelardo Margolles Department of Microbiology and Biochemistry of Dairy Products, Dairy Research Institute of Asturias (IPLA-CSIC), Ctra. Infiesto s/n. 33300, Villaviciosa, Asturias, Spain. Francesca Turroni and Marco Ventura Laboratory of Probiogenomics, Department of Genetics, Biology of Microorganism, Anthropology and Evolution, University of Parma, Italy. Douwe van Sinderen Department of Microbiology and Alimentary Pharmabiotic Center, Bioscience Institute, National University or Ireland, Western Road, Cork, Ireland. Keywords: Probiotics, prebiotics, synbiotics, functional foods, omics, high-throughput, genomics, transcriptomics, proteomics, metabolomics, metagenomics, metaproteomics, gut microbiota, microbiome, cross-talk, Lactobacillus, Bifidobacterium. Contents 1. Introduction to gut microbiota, probiotics and prebiotics 2. Omics analysis in microbial biology 3. Genomics of human gut commensals, a focus on bifidobacteria and lactobacilli 4. Proteomics of the interaction between probiotics and the human host 5. Metabolomics and the interaction between the gut microbiota and host metabolism 6. Meta-omics analysis of the human microbiome 7. Conclusions and future trends Acknowledgements
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