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Negative Symptoms in Schizophrenia
Reward Processing Mechanisms of Negative Symptoms in Schizophrenia Gregory P. Strauss, Ph.D. Assistant Professor Department of Psychology University of Georgia Disclosures ACKNOWLEDGMENTS & DISCLOSURES ▪ Receive royalties and consultation fees from ProPhase LLC in connection with commercial use of the BNSS and other professional activities; these fees are donated to the Brain and Behavior Research Foundation. ▪ Last 12 Months: Speaking/consultation with Minerva, Lundbeck, Acadia What are negative symptoms and why are they important? Domains of psychopathology in schizophrenia Negative Symptoms ▪ Negative symptoms - reductions in goal-directed activity, social behavior, pleasure, and the outward expression of emotion or speech Cognitive Positive ▪ Long considered a core feature of psychotic disorders1,2 Deficits Symptoms ▪ Distinct from other domains of psychopathology (e.g., psychosis, disorganization) 3 ▪ Associated with a range of poor clinical outcomes (e.g., Disorganized Affective disease liability, quality of life, subjective well-being, Symptoms Symptoms recovery) 4-7 1. Bleuler E. [Dementia praecox or the group of schizophrenias]. Vertex Sep-Oct 2010;21(93):394-400. 2. Kraepelin E. Dementia praecox and paraphrenia (R. M. Barclay, Trans.). New York, NY: Krieger. 1919. 3. Peralta V, Cuesta MJ. How many and which are the psychopathological dimensions in schizophrenia? Issues influencing their ascertainment. Schizophrenia research Apr 30 2001;49(3):269-285. 4. Fervaha G, Remington G. Validation of an abbreviated quality of life scale for schizophrenia. Eur Neuropsychopharmacol Sep 2013;23(9):1072-1077. 5. Piskulic D, Addington J, Cadenhead KS, et al. Negative symptoms in individuals at clinical high risk of psychosis. Psychiatry research Apr 30 2012;196(2-3):220-224. -
University of Redlands Psychiatrist Referral List Most Major Insurances Accepted Including Medi-Medi and Other Government (909) 335-3026 Insurances
University of Redlands Psychiatrist Referral List Most major insurances accepted including medi-medi and other government (909) 335-3026 insurances. But not limited to Aetna HMO/PPO, Cigna, TRIWEST, MANAGED Inland Psychiatric Medical Group 1809 W. Redlands Blvd. HEALTH NETWORK, Universal care (only for brand new day), Blue Shield, IEHP, http://www.inlandpsych.com/ Redlands, CA 92373 PPO / Most HMO, MEDICARE, Blue Cross Blue Shield, KAISER (with referral), BLUE CROSS / ANTHEM, HeathNet Providers available at this SPECIALTIES location: Chatsuthiphan, Visit MD Anxiety Disorder, Appointments-weekend, Bipolar Disorders, Borderline Personality Disorders, Depression, Medication Management, Obsessive Compulsive Disorder - Ocd Belen, Nenita MD Adhd/Add, Anxiety Disorder, Appointments-weekend, Bipolar Disorders, Depression, Medication Management, Meet And Greet, Obsessive Compulsive Disorder - Ocd, Panic Disorders, Phobias, Ptsd Adhd/Add, Adoption Issues, Aids/Hiv, Anger Management, Anxiety Disorder, Bipolar Disorders, Borderline Personality Disorders, Desai, David MD Conduct/Disruptive Disorder, Depression, Dissociative Disorder, Medication Management Farooqi, Mubashir MD Addictionology (md Only), Adhd/Add, Anxiety Disorder, Appointments-evening, Appointments-weekend, Bipolar Disorders, Conduct/Disruptive Disorder, Depression, Obsessive Compulsive Disorder - Ocd, Ptsd Julie Wareham, MD General Psychiatry, Inpatient hospital coverage for adolescent, adult, chemical dependency and consult and liaison services. Sigrid Formantes, MD General Psychiatry, General Psychiatrist Neelima Kunam, MD General Psychiatry, Adult Psychiatrist General Psychiatry, Adult Psychiatrist John Kohut, MD General Psychiatry, Adult Psychiatrist Anthony Duk, MD InlandPsych Redlands, Inc. (909)798-1763 http://www.inlandpsychredlands.com 255 Terracina Blvd. St. 204, Most major health insurance plans accepted, including student insurance Redlands, CA 92373 Providers available at this SPECIALTIES location: * Paladugu, Geetha K. MD Has clinical experience in both inpatient and outpatient settings. -
First Episode Psychosis an Information Guide Revised Edition
First episode psychosis An information guide revised edition Sarah Bromley, OT Reg (Ont) Monica Choi, MD, FRCPC Sabiha Faruqui, MSc (OT) i First episode psychosis An information guide Sarah Bromley, OT Reg (Ont) Monica Choi, MD, FRCPC Sabiha Faruqui, MSc (OT) A Pan American Health Organization / World Health Organization Collaborating Centre ii Library and Archives Canada Cataloguing in Publication Bromley, Sarah, 1969-, author First episode psychosis : an information guide : a guide for people with psychosis and their families / Sarah Bromley, OT Reg (Ont), Monica Choi, MD, Sabiha Faruqui, MSc (OT). -- Revised edition. Revised edition of: First episode psychosis / Donna Czuchta, Kathryn Ryan. 1999. Includes bibliographical references. Issued in print and electronic formats. ISBN 978-1-77052-595-5 (PRINT).--ISBN 978-1-77052-596-2 (PDF).-- ISBN 978-1-77052-597-9 (HTML).--ISBN 978-1-77052-598-6 (ePUB).-- ISBN 978-1-77114-224-3 (Kindle) 1. Psychoses--Popular works. I. Choi, Monica Arrina, 1978-, author II. Faruqui, Sabiha, 1983-, author III. Centre for Addiction and Mental Health, issuing body IV. Title. RC512.B76 2015 616.89 C2015-901241-4 C2015-901242-2 Printed in Canada Copyright © 1999, 2007, 2015 Centre for Addiction and Mental Health No part of this work may be reproduced or transmitted in any form or by any means electronic or mechanical, including photocopying and recording, or by any information storage and retrieval system without written permission from the publisher—except for a brief quotation (not to exceed 200 words) in a review or professional work. This publication may be available in other formats. For information about alterna- tive formats or other CAMH publications, or to place an order, please contact Sales and Distribution: Toll-free: 1 800 661-1111 Toronto: 416 595-6059 E-mail: [email protected] Online store: http://store.camh.ca Website: www.camh.ca Disponible en français sous le titre : Le premier épisode psychotique : Guide pour les personnes atteintes de psychose et leur famille This guide was produced by CAMH Publications. -
Work-Up of Globus: Assessing the Benefits of Neck Ultrasound and Videofluorography
View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by Helsingin yliopiston digitaalinen arkisto Eur Arch Otorhinolaryngol (2017) 274:931–937 DOI 10.1007/s00405-016-4307-8 LARYNGOLOGY Work-up of globus: assessing the benefits of neck ultrasound and videofluorography 1 1 1 1 Pia Ja¨rvenpa¨a¨ • Taru Ilmarinen • Ahmed Geneid • Petra Pietarinen • 1 1 1 Teemu J. Kinnari • Heikki Rihkanen • Johanna Ruohoalho • Mari Markkanen- 1 1 2 1 Leppa¨nen • Leif Ba¨ck • Perttu Arkkila • Leena-Maija Aaltonen Received: 15 July 2016 / Accepted: 12 September 2016 / Published online: 17 September 2016 Ó Springer-Verlag Berlin Heidelberg 2016 Abstract Globus patients with normal ear, nose, and throat benefit to evaluate the globus etiology in patients whose (ENT) status are a diagnostic challenge. The symptom may ENT status was normal. Half the globus patients suffered be long lasting and cause concern about malignancy, from persistent symptoms after a 3- and 6-year follow-up, leading to possibly unnecessary further investigation. The indicating that globus may cause discomfort chronically. aim of the study was to assess whether radiological However, no patients developed malignancies during a examinations are useful in globus diagnostics, how often 3-year follow-up. patients suffer from persistent globus, and whether globus patients with normal ENT status develop a malignancy Keywords Globus Á Malignancy Á Globus diagnostics Á during a follow-up. We reviewed medical records of all 76 Follow-up globus patients referred to Helsinki University Hospital, Department of Otorhinolaryngology-Head and Neck Sur- gery in 2009. Patient history and findings in physical and Introduction radiological examinations were registered. -
The Hands to Say It
Issue 91, February 2008 www.proteinspotlight.org The hands to say it Vivienne Baillie Gerritsen When I was a little girl, I thought that my left-handed classmates were special. I envied their difference. And I used to marvel at the way they crouched over their desk, embracing something invisible as they did their best to avoid smudging ink all over their sheet of paper. Left-handedness is special. But so is right-handedness. Humans are not the only animals to make use of their hands – or claws, or paws, or hooves - but they are the only ones who show a marked preference for either the left one, or the right one. If this is so, there must be a reason for it. And not only must there be a reason but it must translate a certain structure of our brain: an asymmetry somewhere. Indeed, our brain is divided into two hemispheres which are dedicated to processing different activities. One side looks after our dreams, while the other is far more down to earth. LRRTM1 is the first protein to have been discovered which seems to be directly involved in this brain asymmetry. Consequently, it influences the handedness of a human-being and, more astonishingly, may also predispose individuals to psychotic troubles such as schizophrenia. don’t have a distinct preference for one hand over the other. The passing of roles from hand to mind expresses a particular brain structure. In turn, the progressive use of speech has continued to mould our brain into a shape peculiar to the human species. -
EEG Glossary
EEG Glossary The first attempt to systematically propose a syllabus for Activation procedure Any procedure designed to modu- electroencephalographers was made by O’Leary and Knott late EEG activity, for instance to enhance physiologi- who in 1955 published in the EEG Journal “Some Minimal cal waveforms or elicit abnormal paroxysmal activity. Essentials for Clinical Electroencephalographers” [1]. In the Examples include eye closing, hyperventilation, photic following decades, with the EEG being increasingly used in stimulation, natural or drug-induced sleep, sensory stimu- the experimental and clinical field, need to adopt a language lation (acoustic, somatosensory, or pain). as common as possible between various laboratories world- Activity, EEG An EEG wave or sequence of waves of wide became even more pressing. In fact, the multiplicity of cerebral origin. terms generated (and sometimes still generates) confusion Alpha band Frequency band of 8–13 Hz inclusive. Greek and misinterpretations, promoting misdiagnosis and making letter: α. it difficult to compare data between different laboratories. Alpha rhythm Rhythm at 8–13 Hz inclusive occurring To overcome this risk, in 1974 “A Glossary of Terms,” most during wakefulness over the posterior regions of the head, commonly used by “Clinical Electroencephalographers,” was generally with maximum amplitudes over the occipital published in the EEG Journal; this glossary was the result of areas. Amplitude varies but is mostly below 50 μV in the the work of a group of experts from the International Federation adult, but often much higher in children. Best seen with of Clinical Neurophysiology (IFCN) led by Chatrian [2]. the eyes closed, during physical relaxation and relative Thanks to this document, it was for the first time officially mental inactivity. -
Symmetry and Beauty in the Living World I Thank the Governing Body and the Director of the G.B
SYMMETRY AND BEAUTY IN THE LIVING WORLD I thank the Governing Body and the Director of the G.B. Pant Institute of Himalayan Environment & Development for providing me this opportunity to deliver the 17th Govind Ballabh Pant Memorial Lecture. Pt. Pant, as I have understood, was amongst those who contributed in multiple ways to shape and nurture the nation in general and the Himalayan area in particular. Established to honour this great ‘Son of the Mountains’, the Institute carries enormous responsibilities and expectations from millions of people across the region and outside. Undoubtedly the multidisciplinary skills and interdisciplinary approach of the Institute and the zeal of its members to work in remote areas and harsh Himalayan conditions will succeed in achieving the long term vision of Pt. Pant for the overall development of the region. My talk ‘Symmetry and Beauty in the Living World’ attempts to discuss aspects of symmetry and beauty in nature and their evolutionary explanations. I shall explain how these elements have helped developmental and evolutionary biologists to frame and answer research questions. INTRODUCTION Symmetry is an objective feature of the living world and also of some non-living entities. It forms an essential element of the laws of nature; it is often sought by human beings when they create artefacts. Beauty has to do with a subjective assessment of the extent to which something or someone has a pleasing appearance. It is something that people aspire to, whether in ideas, creations or people. Evolutionary biology tells us that it is useful to look for an evolutionary explanation of anything to do with life. -
The Clinical Presentation of Psychotic Disorders Bob Boland MD Slide 1
The Clinical Presentation of Psychotic Disorders Bob Boland MD Slide 1 Psychotic Disorders Slide 2 As with all the disorders, it is preferable to pick Archetype one “archetypal” disorder for the category of • Schizophrenia disorder, understand it well, and then know the others as they compare. For the psychotic disorders, the diagnosis we will concentrate on will be Schizophrenia. Slide 3 A good way to organize discussions of Phenomenology phenomenology is by using the same structure • The mental status exam as the mental status examination. – Appearance –Mood – Thought – Cognition – Judgment and Insight Clinical Presentation of Psychotic Disorders. Slide 4 Motor disturbances include disorders of Appearance mobility, activity and volition. Catatonic – Motor disturbances • Catatonia stupor is a state in which patients are •Stereotypy • Mannerisms immobile, mute, yet conscious. They exhibit – Behavioral problems •Hygiene waxy flexibility, or assumption of bizarre • Social functioning – “Soft signs” postures as most dramatic example. Catatonic excitement is uncontrolled and aimless motor activity. It is important to differentiate from substance-induced movement disorders, such as extrapyramidal symptoms and tardive dyskinesia. Slide 5 Disorders of behavior may involve Appearance deterioration of social functioning-- social • Behavioral Problems • Social functioning withdrawal, self neglect, neglect of • Other – Ex. Neuro soft signs environment (deterioration of housing, etc.), or socially inappropriate behaviors (talking to themselves in -
Glossary of Psychological Terms
Glossary of Psychological Terms From Gerrig, Richard J. & Philip G. Zimbardo. Psychology And Life, 16/e Published by Allyn and Bacon, Boston, MA. Copyright (c) 2002 by Pearson Education. Reprinted by permission of the publisher. http://www.apa.org/research/action/glossary.aspx#b ABCDEFGHIJKLMNOPRSTUVWYZ A A-B-A design Experimental design in which participants first experience the baseline condition (A), then experience the experimental treatment (B), and then return to the baseline (A). Abnormal psychology The area of psychological investigation concerned with understanding the nature of individual pathologies of mind, mood, and behavior. Absolute threshold The minimum amount of physical energy needed to produce a reliable sensory experience; operationally defined as the stimulus level at which a sensory signal is detected half the time. Accommodation The process by which the ciliary muscles change the thickness of the lens of the eye to permit variable focusing on near and distant objects. Accommodation According to Piaget, the process of restructuring or modifying cognitive structures so that new information can fit into them more easily; this process works in tandem with assimilation. Acquisition The stage in a classical conditioning experiment during which the conditioned response is first elicited by the conditioned stimulus. Action potential The nerve impulse activated in a neuron that travels down the axon and causes neurotransmitters to be released into a synapse. Acute stress A transient state of arousal with typically clear onset and offset patterns. Addiction A condition in which the body requires a drug in order to function without physical and psychological reactions to its absence; often the outcome of tolerance and dependence. -
Transcranial Direct Current Stimulation in Psychiatric Disorders
City University of New York (CUNY) CUNY Academic Works Publications and Research City College of New York 2015 Transcranial direct current stimulation in psychiatric disorders Gabriel Tortella University of São Paulo Roberta Casati Università degli Studi Milano Bicocca Luana V M Aparicio University of São Paulo Antonio Mantovani CUNY City College Natasha Senço University of São Paulo See next page for additional authors How does access to this work benefit ou?y Let us know! More information about this work at: https://academicworks.cuny.edu/cc_pubs/658 Discover additional works at: https://academicworks.cuny.edu This work is made publicly available by the City University of New York (CUNY). Contact: [email protected] Authors Gabriel Tortella, Roberta Casati, Luana V M Aparicio, Antonio Mantovani, Natasha Senço, Giordano D'Urso, Jerome Brunelin, Fabiana Guarienti, Priscila Mara Lorencini Selingardi, Débora Muszkat, Bernardo de Sampaio Pereira Junior, Leandro Valiengo, Adriano H. Moffa, Marcel Simis, Lucas Borrione, and Andre R. Brunoni This article is available at CUNY Academic Works: https://academicworks.cuny.edu/cc_pubs/658 World Journal of W J P Psychiatry Submit a Manuscript: http://www.wjgnet.com/esps/ World J Psychiatr 2015 March 22; 5(1): 88-102 Help Desk: http://www.wjgnet.com/esps/helpdesk.aspx ISSN 2220-3206 (online) DOI: 10.5498/wjp.v5.i1.88 © 2015 Baishideng Publishing Group Inc. All rights reserved. REVIEW Transcranial direct current stimulation in psychiatric disorders Gabriel Tortella, Roberta Casati, Luana V M Aparicio, -
Catatonia: an Under-Recognised, Acutely Treatable Condition in Young People with Intellectual Disability/ASD
Catatonia: an under-recognised, acutely treatable condition in young people with intellectual disability/ASD. Associate Professor David Dossetor The Children’s Hospital at Westmead Area Director for Mental Health Child Psychiatrist with a Special interest in Intellectual Disability A case example inaudible words in the consultation and didn’t A 15-year-old girl with Down Syndrome was referred to respond to questions. She had waxy flexibility and neurology due to a neurocognitive decline over a two- mild increased muscle tone. She drew a few small month period. She had been socially active, happy, indistinct pictures and was eventually able to write cheeky, talkative and an enthusiastic school attender. her name. She appeared to respond to unseen She had acquired basic self-care and hygiene skills, stimuli. There was no access to her internal mental and achieved primary school educational skills. At a state but she did laugh to herself regularly, out of school swimming carnival, the girl was severely context. It was not possible to assess her cognitive sunburnt. That night she became a little delirious and skills. was uncharacteristically incontinent; this incontinence persisted. The next day she was found sitting in bed The girl was diagnosed with a psychotic disorder with with arms out stiff and staring blankly. A GP review catatonic features and started on olanzapine 2.5mg revealed nothing, with a normal urine screen. Over the three times daily (tds), adding 0.5mg lorazepam tds next month she became progressively quieter until she a week later which was increased to 1mg tds two became mute. She also became apathetic and lost weeks later. -
2 Türk Psikiyatri Dergisi 2 Turkish Journal of Psychiatry
2 Türk Psikiyatri Dergisi 2 Turkish Journal of Psychiatry CİLT | Volume 27 GÜZ | Autumn 2016 EK | Supplement 2: 52. ULUSAL PSİKİYATRİ KONGRESİ TÜRKİYE SİNİR VE ABSTRACTS RUH SAĞLIĞI ISSN 1300 – 2163 DERNEĞİ 2 Türk Psikiyatri Dergisi 2 Mart, Haziran, Eylül ve Aralık aylarında olmak üzere yılda 4 sayı çıkar Turkish Journal of Psychiatry Four issues annually: March, June, September, December CİLT | Volume 27 GÜZ | Autumn 2016 Türkiye Sinir ve Ruh Sağlığı Derneği EK | Supplement 2 tarafından yayınlanmaktadır. ISSN 1300 – 2163 www.turkpsikiyatri.com Türk Psikiyatri Dergisi Bu Sayının Yayın Yönetmeni /Editor in Chief of this Issue Doç. Dr. Semra Ulusoy Kaymak Türkiye Sinir ve Ruh Sağlığı Derneği adına Sahibi ve Sorumlu Müdürü Kongre Başkanları Published by Turkish Association of Nervous and Mental Health Prof. Dr. M. Orhan Öztürk E. Timuçin Oral - Ekrem Cüneyt Evren Düzenleme Kurulu Yayın Yönetmeni/ Editor in Chief Ekrem Cüneyt Evren (Başkan) Prof. Dr. Aygün Ertuğrul Ercan Dalbudak Selim Tümkaya Yazışma Adresi / Corresponding Address Semra Ulusoy Kaymak PK 401, Yenişehir 06442 Ankara Sinan Aydın (Genç Üye) Yönetim Yeri / Editorial Office Bu Sayının Yayın Yönetmen Yardımcıları Kenedi Cad. 98/4, Kavaklıdere, Ankara / Assoc. Editors in Chief of this Issue Telefon: (0-312) 427 78 22 Faks: (0-312) 427 78 02 Sinan Aydın Esra Kabadayı Yayın Türü / Publication Category Selim Tümkaya Yaygın, Süreli, Bilimsel Yayın Yayın Hizmetleri / Publishing Services BAYT Bilimsel Araştırmalar Reklam / Advertisements Basın Yayın ve Tanıtım Ltd. Şti. Reklam koşulları ve diğer ayrıntılar için yayın yönetmeniyle Tel (0-312) 431 30 62, Faks: (0-312) 431 36 02 ilişkiye geçilmesi gerekmektedir. E-posta: [email protected] (Dergide yer alan yazılarda belirtilen görüşlerden yazarlar sorumludur.