Partial Liquid Ventilation Versus Conventional Mechanical Ventilation with High PEEP and Moderate Tidal Volume in Acute Respiratory Failure in Piglets
0031-3998/02/5202-0225 PEDIATRIC RESEARCH Vol. 52, No. 2, 2002 Copyright © 2002 International Pediatric Research Foundation, Inc. Printed in U.S.A. Partial Liquid Ventilation Versus Conventional Mechanical Ventilation with High PEEP and Moderate Tidal Volume in Acute Respiratory Failure in Piglets SIEGFRIED RÖDL, BERNDT URLESBERGER, IGOR KNEZ, DRAGO DACAR, AND GERFRIED ZOBEL Departments of Pediatrics [S.R., G.Z.], Neonatology [B.U.] and Cardiac Surgery [I.K., D.D.], University of Graz, A-8036 Graz, Austria ABSTRACT This prospective randomized pilot study aimed to test the measurements. When compared with control animals, partial hypotheses that partial liquid ventilation combined with a high liquid ventilation resulted in significantly better oxygenation positive end-expiratory pressure (PEEP) and a moderate tidal with improved cardiac output and oxygen delivery. Dead space volume results in improved gas exchange and lung mechanics ventilation appeared to be lower during partial liquid ventilation without negative hemodynamic influences compared with con- compared with conventional mechanical ventilation. No signifi- ventional mechanical ventilation in acute lung injury in piglets. cant differences were observed in airway pressures, pulmonary Acute lung injury was induced in 12 piglets weighing 9.0 Ϯ 2.4 compliance, and airway resistance between both groups. The kg by repeated i.v. injections of oleic acid and repeated lung results of this pilot study suggest that partial liquid ventilation lavages. Thereafter, the animals were randomly assigned either combined with high PEEP and moderate tidal volume improves to partial liquid ventilation (n ϭ 6) or conventional mechanical oxygenation, dead space ventilation, cardiac output, and oxygen ϭ ventilation (n 6) at a fractional concentration of inspired O2 of delivery compared with conventional mechanical ventilation in 1.0, a PEEP of 1.2 kPa, a tidal volume Ͻ 10 mL/kg body weight acute lung injury in piglets but has no significant influence on (bw), a respiratory rate of 24 breaths/min, and an inspiratory/ lung mechanics.
[Show full text]